Detailed information for compound 932568

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 460.479 | Formula: C26H24N2O6
  • H donors: 0 H acceptors: 3 LogP: 4.26 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ncc2c(c1c1cc(OC)c(c(c1)OC)OC)ccc(c2)OCc1ccccn1
  • InChi: 1S/C26H24N2O6/c1-30-21-12-16(13-22(31-2)25(21)32-3)23-20-9-8-19(34-15-18-7-5-6-10-27-18)11-17(20)14-28-24(23)26(29)33-4/h5-14H,15H2,1-4H3
  • InChiKey: SGWJKIHAJOXGJQ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Canis lupus famiaris Phosphodiesterase 5A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Serotonin receptor 0.0242 0.7039 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0242 0.7039 1
Onchocerca volvulus 0.0242 0.7039 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0242 0.7039 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0242 0.7039 1
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.1441 0.3665
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Brugia malayi ORL1-like opioid receptor 0.0242 0.7039 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0242 0.7039 1
Echinococcus granulosus neuropeptides capa receptor 0.0242 0.7039 1
Loa Loa (eye worm) neuropeptide F receptor 0.0242 0.7039 0.7019
Onchocerca volvulus 0.0242 0.7039 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0242 0.7039 0.7019
Brugia malayi GnHR receptor homolog 0.0242 0.7039 1
Loa Loa (eye worm) G-protein coupled receptor 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus multilocularis neuropeptide Y receptor 0.0242 0.7039 1
Echinococcus multilocularis g protein coupled receptor 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Onchocerca volvulus 0.0242 0.7039 0.5
Schistosoma mansoni hypothetical protein 0.0242 0.7039 1
Brugia malayi Melatonin receptor type 1A 0.0242 0.7039 1
Echinococcus granulosus neuropeptide receptor 0.0242 0.7039 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0242 0.7039 1
Brugia malayi hypothetical protein 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0242 0.7039 1
Echinococcus multilocularis serotonin receptor 0.0242 0.7039 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Brugia malayi Bloom's syndrome protein homolog 0.0145 0.3814 0.5373
Brugia malayi hypothetical protein 0.0242 0.7039 1
Brugia malayi hypothetical protein 0.0242 0.7039 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Onchocerca volvulus 0.0242 0.7039 0.5
Brugia malayi larval opioid receptor 0.0242 0.7039 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0242 0.7039 1
Echinococcus granulosus hypothetical protein 0.0242 0.7039 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0074 0.1441 0.3665
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0242 0.7039 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Onchocerca volvulus 0.0242 0.7039 0.5
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus granulosus neuropeptide Y receptor 0.0242 0.7039 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0077 0.1564 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Onchocerca volvulus 0.0242 0.7039 0.5
Echinococcus multilocularis fmrfamide receptor 0.0242 0.7039 1
Toxoplasma gondii hypothetical protein 0.0065 0.1139 0.5152
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0242 0.7039 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0242 0.7039 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0242 0.7039 1
Echinococcus granulosus neuropeptide s receptor 0.0242 0.7039 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0077 0.1564 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0242 0.7039 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0242 0.7039 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0242 0.7039 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1139 0.2858
Brugia malayi G-protein coupled receptor 0.0242 0.7039 1
Echinococcus granulosus g protein coupled receptor 0.0242 0.7039 1
Loa Loa (eye worm) neuropeptide F receptor 0.0242 0.7039 0.7019
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0242 0.7039 1
Schistosoma mansoni neuropeptide receptor 0.0242 0.7039 1
Brugia malayi sulfakinin receptor protein 0.0242 0.7039 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.1441 0.3665
Echinococcus granulosus rhodopsin orphan GPCR 0.0242 0.7039 1
Schistosoma mansoni DNA helicase recq1 0.006 0.0978 0.1389
Schistosoma mansoni hypothetical protein 0.0242 0.7039 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0242 0.7039 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0242 0.7039 1
Brugia malayi AKH receptor 0.0242 0.7039 1
Loa Loa (eye worm) RecQ helicase 0.0145 0.3814 0.3771
Schistosoma mansoni biogenic amine (5HT) receptor 0.0242 0.7039 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0242 0.7039 1
Brugia malayi G protein-coupled receptor 0.0242 0.7039 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0242 0.7039 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.006 0.0978 0.4422
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus multilocularis g-protein coupled receptor 0.0242 0.7039 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0242 0.7039 1
Echinococcus multilocularis serotonin receptor 0.0242 0.7039 1
Echinococcus multilocularis sex peptide receptor 0.0242 0.7039 1
Treponema pallidum ATP-dependent DNA helicase 0.003 0 0.5
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0074 0.1441 0.1969
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Onchocerca volvulus 0.0242 0.7039 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0242 0.7039 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.006 0.0978 0.0915
Echinococcus multilocularis neuropeptides capa receptor 0.0242 0.7039 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0242 0.7039 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0242 0.7039 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0242 0.7039 1
Echinococcus granulosus somatostatin receptor 0.0242 0.7039 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Trichomonas vaginalis DNA helicase recq, putative 0.0145 0.3814 1
Brugia malayi RE15519p 0.0242 0.7039 1
Echinococcus granulosus g protein coupled receptor 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Brugia malayi Tachykinin-like peptides receptor 99D 0.0242 0.7039 1
Brugia malayi hypothetical protein 0.0242 0.7039 1
Schistosoma mansoni amine GPCR 0.0242 0.7039 1
Echinococcus multilocularis neuropeptide receptor 0.0242 0.7039 1
Echinococcus granulosus fmrfamide receptor 0.0242 0.7039 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0242 0.7039 1
Schistosoma mansoni adenoreceptor 0.0242 0.7039 1
Echinococcus granulosus g protein coupled receptor 0.0242 0.7039 1
Echinococcus multilocularis bloom syndrome protein 0.0145 0.3814 0.5373
Echinococcus granulosus tm gpcr rhodopsin 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Echinococcus granulosus biogenic amine 5HT receptor 0.0242 0.7039 1
Echinococcus granulosus g-protein coupled receptor 0.0242 0.7039 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0242 0.7039 1
Schistosoma mansoni hypothetical protein 0.0242 0.7039 1
Brugia malayi hypothetical protein 0.0242 0.7039 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0242 0.7039 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.006 0.0978 0.1304
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0242 0.7039 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.1441 0.3665
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) TYRA-2 protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Schistosoma mansoni neuropeptide F-like receptor 0.0242 0.7039 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Brugia malayi follicle stimulating hormone receptor 0.0242 0.7039 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0242 0.7039 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0097 0.2211 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0242 0.7039 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0242 0.7039 1
Schistosoma mansoni amine GPCR 0.0242 0.7039 1
Brugia malayi hypothetical protein 0.0242 0.7039 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0069 0.0098
Echinococcus multilocularis G protein coupled receptor 139 0.0242 0.7039 1
Schistosoma mansoni biogenic amine receptor 0.0242 0.7039 1
Schistosoma mansoni neuropeptide receptor 0.0242 0.7039 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0242 0.7039 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0074 0.1441 0.2047
Brugia malayi G protein-coupled receptor F59B2.13 0.0242 0.7039 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.006 0.0978 0.1304
Echinococcus granulosus neuropeptides capa receptor 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.006 0.0978 0.1304
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Brugia malayi hypothetical protein 0.0242 0.7039 1
Echinococcus granulosus G protein coupled receptor 139 0.0242 0.7039 1
Onchocerca volvulus 0.0242 0.7039 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0242 0.7039 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0242 0.7039 1
Schistosoma mansoni histamine h1 receptor 0.0242 0.7039 1
Echinococcus granulosus sex peptide receptor 0.0242 0.7039 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus granulosus rhodopsin orphan GPCR 0.0242 0.7039 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0242 0.7039 1
Brugia malayi hypothetical protein 0.0242 0.7039 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0242 0.7039 1
Brugia malayi Dopamine receptor protein 1 0.0242 0.7039 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0074 0.1441 0.1969
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.006 0.0978 0.4422
Schistosoma mansoni hypothetical protein 0.0242 0.7039 1
Echinococcus multilocularis neuropeptide receptor A26 0.0242 0.7039 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.0658 0.1574
Echinococcus multilocularis g protein coupled receptor 0.0242 0.7039 1
Onchocerca volvulus 0.0242 0.7039 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.1441 0.3665
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0242 0.7039 1
Echinococcus multilocularis neuropeptide Y receptor 0.0242 0.7039 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.006 0.0978 0.1304
Onchocerca volvulus 0.0242 0.7039 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0242 0.7039 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0242 0.7039 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0242 0.7039 1
Entamoeba histolytica recQ family helicase, putative 0.0077 0.1564 1
Schistosoma mansoni amine GPCR 0.0242 0.7039 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0242 0.7039 1
Brugia malayi neuropeptide F receptor 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus multilocularis G-protein coupled receptor, putative 0.0242 0.7039 1
Schistosoma mansoni amine GPCR 0.0242 0.7039 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0242 0.7039 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0127 0.3227 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.1441 0.8643
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.0658 0.1574
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0242 0.7039 1
Giardia lamblia Sgs1 DNA helicase, putative 0.006 0.0978 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1139 0.2858
Echinococcus granulosus tm gpcr rhodopsin 0.0242 0.7039 1
Onchocerca volvulus 0.0242 0.7039 0.5
Echinococcus granulosus neuropeptide receptor 0.0242 0.7039 1
Schistosoma mansoni neuropeptide receptor 0.0242 0.7039 1
Brugia malayi Dopamine receptor 0.0242 0.7039 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0242 0.7039 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0242 0.7039 1
Brugia malayi hypothetical protein 0.0242 0.7039 1
Echinococcus multilocularis neuropeptide s receptor 0.0242 0.7039 1
Onchocerca volvulus 0.0242 0.7039 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0242 0.7039 1
Brugia malayi hypothetical protein 0.0242 0.7039 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.1441 0.3665
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Brugia malayi Dopamine receptor protein 2 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Schistosoma mansoni growth hormone secretagogue receptor 0.0242 0.7039 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.1441 0.3665
Echinococcus multilocularis allatostatin A receptor 0.0242 0.7039 1
Echinococcus granulosus tm gpcr rhodopsin 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus multilocularis g protein coupled receptor 0.0242 0.7039 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0145 0.3814 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus granulosus peptide allatostatin:somatostatin 0.0242 0.7039 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0242 0.7039 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0098 0.225 0.5
Brugia malayi G-protein coupled receptor 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Onchocerca volvulus 0.0242 0.7039 0.5
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Onchocerca volvulus Neuropeptide F receptor homolog 0.0242 0.7039 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0242 0.7039 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0242 0.7039 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0242 0.7039 1
Schistosoma mansoni opsin-like receptor 0.0242 0.7039 1
Schistosoma mansoni neuropeptide F-like receptor 0.0242 0.7039 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0242 0.7039 0.7019
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Schistosoma mansoni blooms syndrome DNA helicase 0.0114 0.2798 0.3974
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0242 0.7039 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0242 0.7039 1
Echinococcus granulosus neuropeptide Y receptor 0.0242 0.7039 1
Trichomonas vaginalis DNA helicase recq, putative 0.0077 0.1564 0.3993
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.1441 0.3665
Echinococcus granulosus bloom syndrome protein 0.0145 0.3814 0.5373
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.1441 0.3665
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Schistosoma mansoni biogenic amine receptor 0.0242 0.7039 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0242 0.7039 1
Schistosoma mansoni DNA helicase recq5 0.006 0.0978 0.1389
Echinococcus granulosus orexin receptor type 2 0.0242 0.7039 1
Schistosoma mansoni biogenic amine receptor 0.0242 0.7039 1
Schistosoma mansoni myosin xvIII 0.0242 0.7039 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0242 0.7039 1
Brugia malayi putative neuropeptide receptor NPR1 0.0242 0.7039 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.1441 0.3665
Loa Loa (eye worm) hypothetical protein 0.006 0.0978 0.0915
Echinococcus multilocularis rhodopsin orphan GPCR 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus multilocularis orexin receptor type 2 0.0242 0.7039 1
Schistosoma mansoni opsin-like receptor 0.0242 0.7039 1
Brugia malayi Serotonin receptor 0.0242 0.7039 1
Onchocerca volvulus 0.0242 0.7039 0.5
Echinococcus granulosus serotonin receptor 0.0242 0.7039 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0242 0.7039 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0242 0.7039 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Schistosoma mansoni amine GPCR 0.0242 0.7039 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0242 0.7039 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.1441 0.3665
Onchocerca volvulus 0.0242 0.7039 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0242 0.7039 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.006 0.0978 0.1304
Echinococcus granulosus tachykinin peptides receptor 99D 0.0242 0.7039 1
Loa Loa (eye worm) G-protein coupled receptor 0.0242 0.7039 0.7019
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.1441 0.3665
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.006 0.0978 0.1304
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus multilocularis fmrfamide receptor 0.0242 0.7039 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0242 0.7039 0.7019
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0242 0.7039 1
Echinococcus multilocularis neuropeptides capa receptor 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0242 0.7039 1
Onchocerca volvulus 0.0242 0.7039 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0242 0.7039 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0077 0.1564 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Onchocerca volvulus 0.0242 0.7039 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1139 0.2858
Schistosoma mansoni opsin-like receptor 0.0242 0.7039 1
Brugia malayi putative neuropeptide receptor 0.0242 0.7039 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Echinococcus multilocularis neuropeptide receptor 0.0242 0.7039 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Echinococcus granulosus allatostatin A receptor 0.0242 0.7039 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0242 0.7039 1
Schistosoma mansoni neuropeptide receptor 0.0242 0.7039 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.1441 0.8643
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.1441 0.3665
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.1441 0.8643
Brugia malayi neuropeptide F receptor 0.0242 0.7039 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0242 0.7039 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0242 0.7039 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.7039 0.7019
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0242 0.7039 0.7019
Echinococcus granulosus dro:myosuppressin receptor 0.0242 0.7039 1
Echinococcus multilocularis somatostatin receptor 0.0242 0.7039 1
Echinococcus granulosus neuropeptide receptor A26 0.0242 0.7039 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 34 nM Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method ChEMBL. 25442307

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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