Detailed information for compound 932667

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.446 | Formula: C24H23F3N2O3
  • H donors: 1 H acceptors: 3 LogP: 4.59 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)C1CC1)Cc1cc(ccc1c1cc(CC(=O)O)c2n(c1)ccc2)C(F)(F)F
  • InChi: 1S/C24H23F3N2O3/c1-2-28(23(32)15-5-6-15)13-18-11-19(24(25,26)27)7-8-20(18)17-10-16(12-22(30)31)21-4-3-9-29(21)14-17/h3-4,7-11,14-15H,2,5-6,12-13H2,1H3,(H,30,31)
  • InChiKey: SYRZIEXWRATVPQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin D2 receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0009 0.0018 0.0011
Schistosoma mansoni phd/f-box containing protein 0.0021 0.0132 0.0267
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0009 0.0018 0.0285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0116 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.001 0.0031
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0116 0.011
Echinococcus multilocularis lysine specific demethylase 5A 0.0079 0.0666 0.0673
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0039 0.0033
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0116 0.0113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.1881 0.7352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.1881 0.7352
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0147 0.0142
Echinococcus granulosus lysine specific histone demethylase 1A 0.0067 0.0558 0.0553
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Loa Loa (eye worm) PXA domain-containing protein 0.0051 0.0409 0.1317
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0113 0.0107
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0116 0.0234
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0034 0.0029
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0116 0.0234
Brugia malayi regulator of G-protein signaling egl-10 0.0051 0.0409 0.0414
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0034 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0018 0.0034
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.0132 0.1456
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0519 0.6068
Echinococcus granulosus smad 0.0008 0.0015 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0034 0.0029
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0029 0.0226
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0116 0.0111
Brugia malayi regulator of G-protein signaling rgs-7 0.0051 0.0409 0.0414
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0116 0.011
Schistosoma mansoni smad1 5 8 and 0.0008 0.0015 0.0027
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0039 0.0033
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0039 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0034 0.011
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0116 0.0113
Echinococcus multilocularis beta adrenergic receptor kinase 0.0168 0.1485 0.1507
Onchocerca volvulus 0.0011 0.0034 0.0079
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.1881 0.7352
Schistosoma mansoni ATPase 0.0009 0.0018 0.0033
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0116 0.0113
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0957 0.8752 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus granulosus fmrfamide receptor 0.0019 0.0116 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0039 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0034 0.0066
Echinococcus granulosus g protein coupled receptor 0.0019 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.011
Loa Loa (eye worm) oxidoreductase 0.0008 0.001 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0034 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.0536 0.4872 1
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1081 0.3481
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0116 0.0113
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0116 0.0234
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.011
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0147 0.0144
Leishmania major P-type H -ATPase, putative 0.0009 0.0018 0.0103
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0031
Brugia malayi hypothetical protein 0.0009 0.0018 0.0009
Onchocerca volvulus 0.0019 0.0116 0.0344
Schistosoma mansoni DNA helicase recq5 0.0014 0.0069 0.0138
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0034 0.0066
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0162 0.1428 0.147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0029 0.0465
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0034 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.0132 0.0267
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0051 0.0409 0.1317
Schistosoma mansoni opsin-like receptor 0.0019 0.0116 0.0234
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0116 0.011
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0116 0.0111
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0101 0.0326
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0007 0.0005 0.0046
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0014 0.0069 0.0064
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0051 0.0409 0.0835
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0116 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0409 0.1568
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0039 0.0033
Onchocerca volvulus 0.0009 0.0018 0.0028
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0034 0.0025
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0039 0.0033
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0009 0.0018 0.0099
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0039 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0519 0.0582
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0009 0.0018 0.001
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0015 0.0049
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0116 0.0374
Brugia malayi PHD-finger family protein 0.003 0.0217 0.0214
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0018 0.0034
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0116 0.0113
Echinococcus multilocularis Smad4 0.0008 0.0015 0.001
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0009 0.0018 0.001
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0116 0.011
Brugia malayi glutaminase DH11.1 0.0284 0.2555 0.2638
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0101 0.1145
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni myosin xvIII 0.0019 0.0116 0.0234
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0116 0.0111
Schistosoma mansoni neuropeptide receptor 0.0019 0.0116 0.0234
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0162 0.1428 0.1449
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0069 0.0062
Brugia malayi hypothetical protein 0.0344 0.3104 0.3208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0034 0.011
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0034 0.0025
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0009 0.0018 0.0103
Plasmodium vivax JmjC domain containing protein 0.0021 0.0132 0.2334
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0018 0.0103
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0069 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni neuropeptide receptor 0.0019 0.0116 0.0234
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0018 0.0285
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0018 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0116 0.0234
Loa Loa (eye worm) hypothetical protein 0.0067 0.0558 0.1798
Mycobacterium ulcerans monoamine oxidase 0.0067 0.0558 0.0627
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0018 0.0285
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0116 0.0113
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0392 0.1502
Echinococcus multilocularis plexin a4 0.001 0.0032 0.0027
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0116 0.0113
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0116 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0116 0.0234
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0039 0.0033
Echinococcus multilocularis somatostatin receptor 0.0019 0.0116 0.0113
Onchocerca volvulus 0.0344 0.3104 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0051 0.0409 0.0411
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0039 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0034 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0116 0.0234
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0034 0.011
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.0105 0.1136
Loa Loa (eye worm) plexin A 0.001 0.0032 0.0102
Schistosoma mansoni amine oxidase 0.0067 0.0558 0.1142
Trichomonas vaginalis DNA helicase recq1, putative 0.0014 0.0069 0.0234
Echinococcus granulosus G protein coupled receptor kinase 1 0.0117 0.1013 0.1008
Echinococcus multilocularis serotonin receptor 0.0019 0.0116 0.0113
Loa Loa (eye worm) cytochrome P450 0.0011 0.0039 0.0124
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0018 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0116 0.0111
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0034 0.011
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0018 0.0087
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0116 0.0111
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0018 0.0013
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0116 0.011
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0116 0.0111
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0116 0.0111
Schistosoma mansoni regulator of G protein signaling 0.0051 0.0409 0.0835
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0018 0.0163
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0018 0.0033
Schistosoma mansoni amine GPCR 0.0019 0.0116 0.0234
Schistosoma mansoni protein phosphatase 2C 0.0021 0.0132 0.0267
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0018 0.0013
Schistosoma mansoni amine GPCR 0.0019 0.0116 0.0234
Brugia malayi PXA domain containing protein 0.0051 0.0409 0.0414
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0116 0.0111
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Loa Loa (eye worm) hypothetical protein 0.0108 0.0931 0.2998
Echinococcus multilocularis Regulator of G protein signaling 20 0.0051 0.0409 0.0411
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.011
Brugia malayi amine oxidase, flavin-containing family protein 0.0067 0.0558 0.0569
Entamoeba histolytica recQ family DNA helicase 0.0007 0.0005 0.0014
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0034 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0116 0.0234
Brugia malayi Regulator of G protein signaling domain containing protein 0.0051 0.0409 0.0414
Echinococcus multilocularis regulator of G protein signaling 3 0.0051 0.0409 0.0411
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0051 0.0409 0.0835
Entamoeba histolytica acyl-coA synthetase, putative 0.0008 0.001 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0116 0.0111
Leishmania major proton motive ATPase, putative 0.0009 0.0018 0.0103
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1899 0.3896
Echinococcus granulosus somatostatin receptor 0.0019 0.0116 0.0111
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0039 0.0033
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0069 0.1173
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0067 0.0558 1
Brugia malayi hypothetical protein 0.0067 0.0558 0.0569
Leishmania major hypothetical protein, conserved 0.0021 0.0132 0.1456
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0849 0.3297
Onchocerca volvulus 0.0019 0.0116 0.0344
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0116 0.0111
Brugia malayi jmjC domain containing protein 0.0021 0.0132 0.0127
Giardia lamblia Fructose-bisphosphate aldolase 0.0211 0.1881 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0067 0.0558 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.1881 0.7352
Onchocerca volvulus Alhambra homolog 0.003 0.0217 0.0669
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0067 0.0558 0.0627
Onchocerca volvulus 0.0009 0.0017 0.0024
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.001 0.0016
Brugia malayi Smad1 0.0008 0.0015 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0424
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0519 0.1061
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0018 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0034 0.0025
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0005 0.0045
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0116 0.0234
Brugia malayi GnHR receptor homolog 0.0019 0.0116 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0116 0.0113
Loa Loa (eye worm) hypothetical protein 0.0067 0.0558 0.1798
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0849 0.087
Echinococcus granulosus serotonin receptor 0.0019 0.0116 0.0111
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0018 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0558 0.0675
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0018 0.0034
Echinococcus granulosus cpg binding protein 0.0032 0.0228 0.0223
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0051 0.0409 0.0403
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0018 0.0013
Onchocerca volvulus 0.0019 0.0116 0.0344
Brugia malayi steroid hormone receptor 0.0011 0.0034 0.0025
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0116 0.0113
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0009 0.0018 0.001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0116 0.0111
Echinococcus multilocularis regulator of G protein signaling 0.0051 0.0409 0.0411
Leishmania major cytochrome p450-like protein 0.0011 0.0039 0.0345
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0034 0.0029
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0213 0.1899 0.6118
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0018 0.0009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0116 0.0113
Schistosoma mansoni smad1 5 8 and 0.0008 0.0015 0.0027
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0217 0.0211
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0015 0.001
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0116 0.0113
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0034 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0015 0.0049
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Brugia malayi jmjC domain containing protein 0.0142 0.1243 0.1278
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0116 0.0234
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0116 0.0234
Brugia malayi G-protein coupled receptor 0.0019 0.0116 0.011
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0009 0.0018 0.0087
Entamoeba histolytica acyl-CoA synthetase, putative 0.0008 0.001 0.0041
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0039 0.0036
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0018 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0116 0.0113
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0018 0.0087
Loa Loa (eye worm) calcium ATPase 0.0009 0.0018 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0034 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0116 0.0374
Plasmodium falciparum JmjC domain-containing protein, putative 0.0021 0.0132 0.2227
Toxoplasma gondii cation-transporting atpase family protein 0.0009 0.0018 0.0285
Mycobacterium tuberculosis Possible oxidoreductase 0.0067 0.0558 0.0675
Schistosoma mansoni hypothetical protein 0.0011 0.0039 0.0075
Echinococcus granulosus lysine specific demethylase 5A 0.0081 0.0682 0.0677
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0116 0.0111
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.0005 0.0005
Leishmania major calcium-translocating P-type ATPase 0.0009 0.0018 0.0103
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0069 0.0358
Trypanosoma cruzi copper-transporting ATPase, putative 0.0009 0.0018 0.0163
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0519 0.0513
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus granulosus orexin receptor type 2 0.0019 0.0116 0.0111
Schistosoma mansoni regulator of G protein signaling 0.0051 0.0409 0.0835
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0009 0.0018 0.0011
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0116 0.011
Schistosoma mansoni biogenic amine receptor 0.0019 0.0116 0.0234
Onchocerca volvulus 0.0019 0.0116 0.0344
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0018 0.0163
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0116 0.0111
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0585 0.533 0.5425
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.0105 0.1798
Brugia malayi hypothetical protein 0.0092 0.0781 0.08
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0034 0.0025
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.0063 0.052 0.1676
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0519 0.0582
Echinococcus multilocularis G protein coupled receptor 139 0.017 0.1503 0.1526
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0039 0.0033
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0018 0.0059
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0132 0.0424
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0424
Trypanosoma brucei cation-transporting ATPase, putative 0.0009 0.0018 0.0103
Brugia malayi MH1 domain containing protein 0.0008 0.0015 0.0006
Brugia malayi Cytochrome P450 family protein 0.0026 0.0175 0.0171
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0018 0.0087
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0217 0.3745
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0849 0.3297
Loa Loa (eye worm) jmjC domain-containing protein 0.0081 0.0682 0.2197
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni cpg binding protein 0.003 0.0212 0.0432
Schistosoma mansoni neuropeptide receptor 0.017 0.1503 0.3083
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0018 0.0034
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0009 0.0018 0.001
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0116 0.0111
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0009 0.0018 0.0011
Brugia malayi PHD-finger family protein 0.0012 0.0044 0.0036
Schistosoma mansoni opsin-like receptor 0.0019 0.0116 0.0234
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0039 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.1881 0.7352
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0116 0.0111
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0034 0.0028
Trypanosoma cruzi UDP-galactopyranose mutase 0.0067 0.0558 0.6557
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0116 0.0374
Schistosoma mansoni hypothetical protein 0.0425 0.3854 0.7911
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0039 0.0033
Echinococcus granulosus bloom syndrome protein 0.0014 0.0069 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0116 0.0113
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0039 0.0033
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0116 0.011
Schistosoma mansoni amine GPCR 0.0019 0.0116 0.0234
Trypanosoma cruzi UDP-galactopyranose mutase 0.0067 0.0558 0.6557
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0018 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0409 0.1568
Plasmodium vivax calcium-transporting ATPase, putative 0.0009 0.0018 0.0293
Echinococcus granulosus g protein coupled receptor 0.0019 0.0116 0.0111
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.0132 0.0126
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0519 0.0523
Brugia malayi jmjC domain containing protein 0.0021 0.0132 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0698
Schistosoma mansoni hypothetical protein 0.0019 0.0116 0.0234
Schistosoma mansoni glutaminase 0.0284 0.2555 0.5243
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus granulosus allatostatin A receptor 0.0019 0.0116 0.0111
Onchocerca volvulus 0.0019 0.0116 0.0344
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0217 0.0441
Leishmania major P-type H -ATPase, putative 0.0009 0.0018 0.0103
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0017
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0009 0.0018 0.001
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0018 0.0009
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0018 0.0034
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0116 0.0113
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0116 0.0234
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0521 0.1065
Brugia malayi hypothetical protein 0.0051 0.0409 0.0414
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0101 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0409 0.1568
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0039 0.0036
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0015 0.001
Loa Loa (eye worm) RecQ helicase 0.0014 0.0069 0.0223
Plasmodium falciparum copper-transporting ATPase 0.0009 0.0018 0.0158
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0142 0.1243 0.1238
Echinococcus multilocularis cpg binding protein 0.0032 0.0228 0.0227
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0059
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0116 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0018 0.0033
Plasmodium vivax hypothetical protein, conserved 0.003 0.0217 0.3858
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0018 0.0013
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0018 0.0013
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0018 0.0087
Brugia malayi SWIRM domain containing protein 0.0067 0.0558 0.0569
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.001 0.0031
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0067 0.0558 1
Echinococcus granulosus peregrin 0.003 0.0217 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.1485 0.3045
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0039 0.0033
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0021 0.0132 0.2266
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0018 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0105 0.119
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0045 0.0652
Giardia lamblia Sgs1 DNA helicase, putative 0.0014 0.0069 0.0273
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0029 0.0465
Onchocerca volvulus 0.0019 0.0116 0.0344
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0034 0.0066
Mycobacterium leprae putative cytochrome p450 0.0011 0.0039 0.033
Brugia malayi ecdysteroid receptor 0.0011 0.0034 0.0025
Loa Loa (eye worm) RGS-3 protein 0.0051 0.0409 0.1317
Loa Loa (eye worm) Smad1 0.0008 0.0015 0.0049
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0067 0.0558 0.6252
Schistosoma mansoni neuropeptide receptor 0.0019 0.0116 0.0234
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0558 1
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0034 0.0028
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0018 0.0087
Schistosoma mansoni coup transcription factor 0.0011 0.0034 0.0066
Onchocerca volvulus 0.0019 0.0116 0.0344
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0009 0.0018 0.0103
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0014 0.0069 0.1086
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0018 0.0285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Giardia lamblia PHD finger protein 15 0.003 0.0217 0.1064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0009 0.0018 0.001
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0009 0.0018 0.0087
Onchocerca volvulus 0.0019 0.0116 0.0344
Plasmodium falciparum phd finger protein, putative 0.003 0.0217 0.3772
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0018 0.0013
Brugia malayi jmjC domain containing protein 0.0081 0.0682 0.0697
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0034 0.0025
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0116 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0039 0.0036
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0116 0.0111
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0116 0.0113
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0018 0.0013
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0034 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0034 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0034 0.011
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0142 0.1243 0.126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0105 0.119
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0116 0.0113
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0069 0.1173
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0132 0.1507
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0039 0.0033
Brugia malayi Cytochrome P450 family protein 0.0018 0.0101 0.0095
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0014 0.0069 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0034 0.011
Leishmania major cytochrome p450-like protein 0.0011 0.0039 0.0345
Schistosoma mansoni biogenic amine receptor 0.0019 0.0116 0.0234
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0009 0.0018 0.0099
Loa Loa (eye worm) hypothetical protein 0.0067 0.0558 0.1798
Entamoeba histolytica acyl-CoA synthetase, putative 0.0008 0.001 0.0041
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.0132 0.0128
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1081 0.3481
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0018 0.0009
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0039 0.0036
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0101 0.1145
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0116 0.0111
Schistosoma mansoni lozenge 0.0043 0.0335 0.0683
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Brugia malayi PXA domain containing protein 0.0051 0.0409 0.0414
Echinococcus granulosus regulator of G protein signaling 3 0.0051 0.0409 0.0403
Echinococcus granulosus neuropeptide receptor 0.017 0.1503 0.1498
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0039 0.0033
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0889 0.8132 1
Echinococcus granulosus sex peptide receptor 0.0019 0.0116 0.0111
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0018 0.0033
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0039 0.0033
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0211 0.1881 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0059
Entamoeba histolytica hypothetical protein 0.0051 0.0409 0.2165
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0034 0.0025
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.001 0.0133
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0051 0.0409 0.0835
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0059
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0018 0.0033
Echinococcus granulosus regulator of G protein signaling 3 0.0051 0.0409 0.0403
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0116 0.0234
Echinococcus multilocularis phd:f box containing protein 0.0021 0.0132 0.0128
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0116 0.0344
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0039 0.0036
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0162 0.1428 0.4599
Leishmania major hypothetical protein, conserved 0.0018 0.0105 0.1136
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0014 0.0069 0.0065
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0015 0.0027
Loa Loa (eye worm) runx1 0.0043 0.0335 0.1078
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0519 0.9021
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0034 0.0029
Loa Loa (eye worm) hypothetical protein 0.0067 0.0558 0.1798
Brugia malayi hypothetical protein 0.0018 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Treponema pallidum cation-transporting ATPase, P-type 0.0009 0.0018 0.0073
Brugia malayi Dopamine receptor 0.0019 0.0116 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0409 0.1568
Mycobacterium ulcerans glutaminase 0.0284 0.2555 0.2912
Echinococcus granulosus axis inhibition protein axin 0.0051 0.0409 0.0403
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0514 0.1655
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0849 1
Schistosoma mansoni eyes absent homolog 0.0092 0.0781 0.16
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0116 0.0111
Schistosoma mansoni hypothetical protein 0.0019 0.0116 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0018 0.0103
Schistosoma mansoni cpg binding protein 0.0032 0.0228 0.0464
Brugia malayi G-protein coupled receptor 0.0019 0.0116 0.011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0034 0.0028
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0018 0.0013
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0117 0.1013 0.1026
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0116 0.0111
Schistosoma mansoni Smad4 0.0008 0.0015 0.0027
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0116 0.0111
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0116 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0039 0.0036
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0101 0.1092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0008 0.0013 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0849 0.3297
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0009 0.0018 0.0099
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.0132 0.0128
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0014 0.0069 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0116 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0116 0.0113
Onchocerca volvulus 0.0019 0.0116 0.0344
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0116 0.0374
Echinococcus granulosus neuropeptide receptor 0.0019 0.0116 0.0111
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0039 0.0403
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0067 0.0558 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0034 0.011
Trypanosoma cruzi cation-transporting ATPase, putative 0.0009 0.0018 0.0163
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0392 0.1502
Onchocerca volvulus 0.0019 0.0116 0.0344
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0849 1
Echinococcus multilocularis peregrin 0.003 0.0217 0.0215
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0116 0.0374
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0116 0.0374
Brugia malayi jmjC domain containing protein 0.0021 0.0132 0.0127
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0092 0.0781 0.2516
Echinococcus multilocularis muscleblind protein 1 0.0108 0.0931 0.0943
Schistosoma mansoni plexin 0.0009 0.0017 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus multilocularis neuropeptide receptor 0.017 0.1503 0.1526
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0849 0.3297
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0018 0.0013
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.0132 0.0126
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0018 0.0034
Brugia malayi MH1 domain containing protein 0.0008 0.0015 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0039 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0105 0.1739
Brugia malayi A-kinase anchor protein 10, precursor 0.0051 0.0409 0.0414
Brugia malayi neuropeptide F receptor 0.0019 0.0116 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0849 0.3297
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0116 0.0113
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0018 0.0034
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0034 0.0028
Echinococcus multilocularis regulator of G protein signaling 3 0.0051 0.0409 0.0411
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0458 0.7967
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0059
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0069 0.0062
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0849 0.2712
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0039 0.0033
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0018 0.0059
Onchocerca volvulus 0.0019 0.0116 0.0344
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0009 0.0018 0.0163
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0067 0.0558 0.0563
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.1485 0.3045
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.0132 0.0267
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0116 0.0234
Schistosoma mansoni regulator of G protein signaling 0.0051 0.0409 0.0835
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0069 0.0765
Echinococcus multilocularis Protein lozenge 0.0043 0.0335 0.0335
Schistosoma mansoni smad 0.0008 0.0015 0.0027
Loa Loa (eye worm) glutaminase 2 0.0284 0.2555 0.8231
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0034 0.0028
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0039 0.0033
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.001 0.0137
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0018 0.0285
Onchocerca volvulus 0.0019 0.0116 0.0344
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0039 0.0639
Brugia malayi Melatonin receptor type 1A 0.0019 0.0116 0.011
Echinococcus granulosus phd:f box containing protein 0.0021 0.0132 0.0126
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0849 0.4507
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0015 0.001
Echinococcus multilocularis serotonin receptor 0.0019 0.0116 0.0113
Plasmodium vivax P-type ATPase4, putative 0.0009 0.0018 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0409 0.1568
Echinococcus multilocularis expressed protein 0.0419 0.38 0.3865
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0682 0.1397
Brugia malayi Dopamine receptor protein 2 0.0019 0.0116 0.011
Onchocerca volvulus 0.0067 0.0558 0.1772
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0034 0.0025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0034 0.0066
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0116 0.0374
Schistosoma mansoni biogenic amine receptor 0.0019 0.0116 0.0234
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0519 0.0627
Echinococcus granulosus beta-adrenergic receptor kinase 0.0168 0.1485 0.148
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0116 0.0111
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0051 0.0409 0.1317
Brugia malayi nuclear hormone receptor 0.0011 0.0034 0.0025
Brugia malayi Regulator of G protein signaling domain containing protein 0.0051 0.0409 0.0414
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.063 0.574 0.6555
Brugia malayi Dopamine receptor protein 1 0.0019 0.0116 0.011
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0021 0.0132 0.2266
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0034 0.0025
Trypanosoma cruzi proton motive ATPase 1, putative 0.0009 0.0018 0.0163
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0034 0.0028
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0069 0.071
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0116 0.0111
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0018 0.0103
Onchocerca volvulus 0.003 0.0212 0.0655
Toxoplasma gondii histone lysine-specific demethylase 0.0067 0.0558 0.9707
Echinococcus granulosus Regulator of G protein signaling 20 0.0051 0.0409 0.0403
Echinococcus multilocularis conserved hypothetical protein 0.1073 0.9821 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0105 0.1739
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0217 0.0215
Onchocerca volvulus 0.0019 0.0116 0.0344
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0116 0.0113
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0067 0.0558 0.1142
Brugia malayi cytochrome P450 0.0011 0.0039 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0175 0.0564
Echinococcus multilocularis sex peptide receptor 0.0019 0.0116 0.0113
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0018 0.0013
Echinococcus granulosus axis inhibition protein axin 0.0051 0.0409 0.0403
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0116 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0116 0.0113
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0039 0.0345
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0022 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0116 0.0111
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0039 0.0033
Toxoplasma gondii P-type ATPase4, putative 0.0009 0.0018 0.0285
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0018 0.0013
Brugia malayi Bromodomain containing protein 0.003 0.0217 0.0214
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0116 0.0113
Schistosoma mansoni cytochrome P450 0.0011 0.0039 0.0075
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0018 0.0163
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0034 0.0028
Plasmodium falciparum protoporphyrinogen oxidase 0.0067 0.0558 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0067 0.0558 1
Toxoplasma gondii P-type ATPase PMA1 0.0009 0.0018 0.0285
Brugia malayi G protein-coupled receptor 0.0019 0.0116 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0116 0.0234
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0211 0.1881 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0103 0.0887 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0116 0.0113
Mycobacterium ulcerans oxidoreductase 0.0067 0.0558 0.0627
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0039 0.0033
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Leishmania major UDP-galactopyranose mutase 0.0067 0.0558 0.6536
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0045 0.078
Loa Loa (eye worm) hypothetical protein 0.0051 0.0409 0.1317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0116 0.0234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.1881 0.7352
Leishmania major cytochrome p450-like protein 0.0018 0.0101 0.1092
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0034 0.0066
Mycobacterium ulcerans dehydrogenase 0.0067 0.0558 0.0627
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0018 0.0013
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0051 0.0409 0.0411
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0213 0.1899 0.1958
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni jumonji domain containing protein 0.0021 0.0132 0.0267
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0116 0.0234
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0116 0.0234
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.0132 0.0126
Schistosoma mansoni cpg binding protein 0.0032 0.0228 0.0464
Schistosoma mansoni hypothetical protein 0.0008 0.0013 0.0022
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0116 0.0234
Loa Loa (eye worm) hypothetical protein 0.0051 0.0409 0.1317
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0009 0.0018 0.0103
Brugia malayi Serotonin receptor 0.0019 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.0051 0.0409 0.1317
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0957 0.8752 1
Schistosoma mansoni hypothetical protein 0.0019 0.0116 0.0234
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0116 0.0111
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0116 0.0113
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0034 0.0029
Loa Loa (eye worm) hypothetical protein 0.0092 0.0781 0.2516
Echinococcus granulosus g protein coupled receptor 0.0019 0.0116 0.0111
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0116 0.0113
Schistosoma mansoni axis inhibition protein axin 0.0051 0.0409 0.0835
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0116 0.0113
Schistosoma mansoni ATPase 0.0009 0.0018 0.0033
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0009 0.0018 0.001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0067 0.0558 0.0553
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.0015
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0009 0.0018 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0849 0.3297
Echinococcus granulosus Smad4 0.0008 0.0015 0.001
Schistosoma mansoni jumonji domain containing protein 0.0121 0.1055 0.2162
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0849 0.3297
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0132 0.1507
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0009 0.0018 0.0087
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0039 0.0403
Brugia malayi Cytochrome P450 family protein 0.0018 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0326 0.032
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0009 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0051 0.0409 0.1317
Schistosoma mansoni opsin-like receptor 0.0019 0.0116 0.0234
Brugia malayi nuclear receptor NHR-88 0.0011 0.0034 0.0025
Schistosoma mansoni adenoreceptor 0.0019 0.0116 0.0234
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0039 0.0036
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0018 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0682 0.1397
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.001 0.006
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0018 0.0013
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0034 0.0066
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0018 0.0013
Entamoeba histolytica hypothetical protein 0.0051 0.0409 0.2165
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0017
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.063 0.574 0.7056
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0103 0.0887 0.1003
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0018 0.0009
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0162 0.1428 0.4599
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.3854 0.3921
Brugia malayi AF-10 protein 0.001 0.0029 0.002
Echinococcus multilocularis axis inhibition protein axin 0.0051 0.0409 0.0411
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0849 0.1739
Schistosoma mansoni regulator of G protein signaling 0.0051 0.0409 0.0835
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0029 0.0226
Brugia malayi sulfakinin receptor protein 0.0019 0.0116 0.011
Echinococcus multilocularis microtubule associated protein 2 0.0536 0.4872 0.4957
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0039 0.0036
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0018 0.0034
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0015 0.001
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0018 0.0034
Schistosoma mansoni axis inhibition protein axin 0.0051 0.0409 0.0835
Schistosoma mansoni amine GPCR 0.0019 0.0116 0.0234
Trichomonas vaginalis glutaminase, putative 0.0284 0.2555 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0116 0.0234
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0162 0.1428 0.1423
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0034 0.0025
Loa Loa (eye worm) hypothetical protein 0.0051 0.0409 0.1317
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0018 0.0013
Echinococcus multilocularis protoporphyrinogen oxidase 0.0067 0.0558 0.0563
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Brugia malayi AKH receptor 0.0019 0.0116 0.011
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0116 0.0111
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0849 0.0844
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0116 0.0113
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.0132 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0039 0.0036
Leishmania major copper-transporting ATPase-like protein, putative 0.0009 0.0018 0.0103
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0849 0.2734
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0034 0.0028
Echinococcus multilocularis 0.0067 0.0558 0.0563
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0008 0.0013 0.0007
Brugia malayi hypothetical protein 0.0012 0.0046 0.0037
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0326 0.0326
Schistosoma mansoni smad1 5 8 and 0.0008 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0031
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0039 0.0345
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0558 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0014 0.0069 0.0065
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0069 0.0575 1
Schistosoma mansoni kinase 0.0051 0.0404 0.0826
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0018 0.0009
Entamoeba histolytica hypothetical protein 0.0051 0.0409 0.2165
Onchocerca volvulus 0.0019 0.0116 0.0344
Schistosoma mansoni hypothetical protein 0.001 0.0029 0.0055
Schistosoma mansoni hypothetical protein 0.0019 0.0116 0.0234
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0039 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0034 0.0029
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0116 0.0113
Brugia malayi hypothetical protein 0.0051 0.0409 0.0414
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0116 0.0234
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0034 0.0066
Echinococcus granulosus microtubule associated protein 2 0.0536 0.4872 0.4869
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0101 0.0326
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0116 0.0113
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0009 0.0018 0.0103
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0018 0.0163
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Brugia malayi MH2 domain containing protein 0.0008 0.0015 0.0006
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0018 0.0034
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0014 0.0069 0.1086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus granulosus muscleblind protein 0.0108 0.0931 0.0926
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0116 0.0113
Echinococcus multilocularis muscleblind protein 0.0108 0.0931 0.0943
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0009 0.0018 0.0285
Echinococcus granulosus regulator of G protein signaling 7 0.0051 0.0409 0.0403
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0018 0.0163
Schistosoma mansoni amine oxidase 0.0067 0.0558 0.1142
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0039 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0039 0.0036
Loa Loa (eye worm) glutaminase 0.0284 0.2555 0.8231
Brugia malayi RE15519p 0.0019 0.0116 0.011
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0039 0.0403
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0018 0.0034
Plasmodium vivax copper-transporting ATPase, putative 0.0009 0.0018 0.0293
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0116 0.0344
Schistosoma mansoni hypothetical protein 0.003 0.0217 0.0441
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0009 0.0018 0.0087
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0018 0.0034
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0116 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0116 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0039 0.0036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0034 0.0066
Brugia malayi putative neuropeptide receptor 0.0019 0.0116 0.011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0034 0.0029
Plasmodium vivax cation transporting ATPase, putative 0.0009 0.0018 0.0293
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0116 0.0234
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0069 0.071
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0018 0.0009
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0018 0.0013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0116 0.0113
Loa Loa (eye worm) hypothetical protein 0.0018 0.0105 0.0338
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0009 0.0018 0.0011
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0849 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0034 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Loa Loa (eye worm) hypothetical protein 0.0344 0.3104 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0039 0.0033
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0069 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Brugia malayi Muscleblind-like protein 0.0108 0.0931 0.0955
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0168 0.1485 0.4782
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0018 0.0034
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0018 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0116 0.0234
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.001 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0409 0.1568
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0849 1
Brugia malayi Serotonin receptor 0.1055 0.9658 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0116 0.0113
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Brugia malayi larval opioid receptor 0.0019 0.0116 0.011
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0116 0.0113
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.011
Schistosoma mansoni histamine h1 receptor 0.0019 0.0116 0.0234
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0116 0.0111
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0116 0.0374
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Treponema pallidum fructose-bisphosphate aldolase 0.0211 0.1881 1
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0116 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0116 0.0111
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0018 0.0163
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0116 0.0374
Echinococcus multilocularis bloom syndrome protein 0.0014 0.0069 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0039 0.0036
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0009 0.0018 0.001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0558 0.1798
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0018 0.0163
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0039 0.033
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0116 0.0234
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0018 0.0033
Onchocerca volvulus 0.0019 0.0116 0.0344
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0143
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0217 0.0698
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.001 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.1881 0.7352
Echinococcus multilocularis regulator of G protein signaling 7 0.0051 0.0409 0.0411
Toxoplasma gondii propionate-CoA ligase 0.0008 0.001 0.0133
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0018 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0034 0.0025
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.001 0.006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0223
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0051 0.0409 0.1568
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.0105 0.1852
Brugia malayi MH2 domain containing protein 0.0124 0.1081 0.111
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0217 0.3745
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Brugia malayi neuropeptide F receptor 0.0019 0.0116 0.011
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0009 0.0018 0.0163
Schistosoma mansoni regulator of G protein signaling 0.0051 0.0409 0.0835
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0519 0.1061
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0018 0.0013
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0067 0.0558 0.1142
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0116 0.0111
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0116 0.0234
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0116 0.0374
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.011
Brugia malayi ORL1-like opioid receptor 0.0019 0.0116 0.011
Onchocerca volvulus 0.0019 0.0116 0.0344
Trypanosoma brucei polo-like protein kinase 0.0099 0.0849 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0116 0.0234
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0103 0.0887 0.108
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0034 0.0066
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0212 0.0684
Echinococcus multilocularis smad 0.0008 0.0015 0.001
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.001 0.0133
Schistosoma mansoni z-protein (S1r protein) 0.0051 0.0409 0.0835
Loa Loa (eye worm) hypothetical protein 0.0108 0.0931 0.2998
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0034 0.0025
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0116 0.011
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0018 0.0009
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0116 0.0113
Brugia malayi Cytochrome P450 family protein 0.0011 0.0039 0.003
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.001 0.006
Loa Loa (eye worm) hypothetical protein 0.0067 0.0558 0.1798
Echinococcus multilocularis 0.0011 0.0039 0.0034
Echinococcus multilocularis axis inhibition protein axin 0.0051 0.0409 0.0411
Brugia malayi plexin A 0.001 0.0032 0.0023
Echinococcus granulosus expressed protein 0.0419 0.38 0.3796
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0116 0.0113
Brugia malayi Bloom's syndrome protein homolog 0.0014 0.0069 0.0062
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.001 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0211 0.1881 0.7352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0116 0.0234
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0519 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0034 0.0025
Echinococcus granulosus plexin a4 0.001 0.0032 0.0026
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.001 0.0041
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0116 0.0374
Brugia malayi hypothetical protein 0.0019 0.0116 0.011
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0018 0.0087
Echinococcus granulosus dnaJ subfamily B 0.0425 0.3854 0.3851
Loa Loa (eye worm) hypothetical protein 0.0344 0.3104 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0101 0.0326
Echinococcus granulosus regulator of G protein signaling 7 0.0051 0.0409 0.0403
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Schistosoma mansoni DNA helicase recq1 0.0014 0.0069 0.0138
Schistosoma mansoni amine GPCR 0.0019 0.0116 0.0234
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0097 0.0195
Brugia malayi MH2 domain containing protein 0.0008 0.0015 0.0006
Brugia malayi jmjC domain containing protein 0.0021 0.0132 0.0127
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0132 0.0424
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0034 0.0079
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0039 0.0033
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0009 0.0018 0.0285
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0132 0.0424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0116 0.0113
Giardia lamblia Kinase, PLK 0.0099 0.0849 0.4459
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0034 0.0066
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0374
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0034 0.0079
Brugia malayi Plexin repeat family protein 0.0009 0.0017 0.0008
Onchocerca volvulus 0.0019 0.0116 0.0344
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0116 0.0111
Brugia malayi CXXC zinc finger family protein 0.003 0.0212 0.021
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0039 0.0036
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0009 0.0018 0.0158
Treponema pallidum hypothetical protein 0.0009 0.0018 0.0073

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change ChEMBL. 25437504
IC50 (functional) = 262 nM Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 to 5 uM preincubated for 1 hr followed by 50 nM PGD2 and 0.1 nM [35S]-GTPgammaS addition measured after 2 hrs by liquid scintillation counting analysis relative to control ChEMBL. 25437504
t1/2 (functional) Binding affinity to CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as dissociation half life at 10 X IC50 preincubated for 1 hr followed [35S]-GTPgammaS addition measured after 2 hrs by liquid scintillation counting analysis ChEMBL. 25437504

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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