Detailed information for compound 933312

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 416.265 | Formula: C20H18BrNO4
  • H donors: 1 H acceptors: 2 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1C2=C(C(=O)OC2)C(c2c1cc(OC)cc2)c1cccc(c1)Br
  • InChi: 1S/C20H18BrNO4/c1-25-14-5-6-15-16(10-14)22(7-8-23)17-11-26-20(24)19(17)18(15)12-3-2-4-13(21)9-12/h2-6,9-10,18,23H,7-8,11H2,1H3
  • InChiKey: KWTPYZVIVMRWIC-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone deacetylase 4 5 0.082 0.2536 0.2536
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0078 0.0153
Brugia malayi SH2 domain containing protein 0.0044 0.0039 0.0039
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0078 0.0267
Schistosoma mansoni roundabout 0.0042 0.0035 0.0035
Schistosoma mansoni septate junction protein 0.0042 0.0035 0.0035
Brugia malayi Protein kinase domain containing protein 0.0044 0.0039 0.0039
Trichomonas vaginalis histone deacetylase, putative 0.0942 0.293 1
Schistosoma mansoni tyrosine kinase 0.1694 0.5347 0.5347
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0081 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0065 0.011 0.011
Schistosoma mansoni histone deacetylase hda2 0.0398 0.118 0.118
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0081 0.0158 0.0158
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0087 0.0178 0.0178
Echinococcus multilocularis 0.0968 0.3012 0.3012
Echinococcus multilocularis histone deacetylase 7 0.082 0.2536 0.2536
Loa Loa (eye worm) TK protein kinase 0.0052 0.0067 0.0067
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0119 0.0119
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Echinococcus granulosus tyrosine kinase 0.0074 0.0136 0.0136
Brugia malayi Protein kinase domain containing protein 0.0044 0.0039 0.0039
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0044 0.0042 0.0042
Schistosoma mansoni ephrin receptor 0.0088 0.0182 0.0182
Brugia malayi Peroxidasin 0.0042 0.0035 0.0035
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0078 0.0153
Loa Loa (eye worm) hypothetical protein 0.0422 0.1255 0.1255
Echinococcus multilocularis histone deacetylase 8 0.0398 0.118 0.118
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0022 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Onchocerca volvulus 0.0044 0.0039 0.0144
Echinococcus granulosus twitchin 0.009 0.0187 0.0187
Trypanosoma cruzi histone deacetylase 1, putative 0.0942 0.293 0.5742
Echinococcus granulosus tyrosine protein kinase Fyn 0.0081 0.0158 0.0158
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0078 0.0078
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0042 0.0035 0.0127
Loa Loa (eye worm) hypothetical protein 0.0065 0.011 0.011
Schistosoma mansoni tyrosine kinase 0.005 0.0061 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0085 0.0085
Schistosoma mansoni tyrosine kinase 0.1662 0.5246 0.5246
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Schistosoma mansoni protein kinase 0.0035 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0035
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1618 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0065 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase Blk 0.0074 0.0136 0.0136
Schistosoma mansoni histone deacetylase hda2 0.0839 0.2596 0.2596
Schistosoma mansoni histone deacetylase 1 2 3 0.0398 0.118 0.118
Loa Loa (eye worm) hypothetical protein 0.0068 0.0116 0.0116
Brugia malayi P38 map kinase family protein 2 0.0394 0.1165 0.1165
Echinococcus granulosus tyrosine protein kinase Lyn 0.0084 0.0169 0.0169
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0035 0.0011 0.0011
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0119 0.0119
Schistosoma mansoni tyrosine kinase 0.1662 0.5246 0.5246
Schistosoma mansoni tyrosine kinase 0.1013 0.3157 0.3157
Loa Loa (eye worm) TK/EPH protein kinase 0.0103 0.0232 0.0232
Echinococcus multilocularis activin receptor type 0.0035 0.0011 0.0011
Echinococcus granulosus defective proboscis extension response 0.0065 0.011 0.011
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0119 0.0234
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0065 0.011 0.011
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0394 0.1165 0.1165
Echinococcus multilocularis Immunoglobulin 0.0065 0.011 0.011
Brugia malayi Tyrosine-protein kinase abl-1 0.0132 0.0324 0.0324
Echinococcus granulosus Immunoglobulin 0.0065 0.011 0.011
Onchocerca volvulus 0.0057 0.0081 0.0298
Echinococcus multilocularis histone deacetylase 6 0.082 0.2536 0.2536
Echinococcus multilocularis epidermal growth factor receptor 0.314 1 1
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0602 0.1834 0.3595
Plasmodium falciparum histone deacetylase 2 0.082 0.2536 0.8658
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0035
Leishmania major 0.1618 0.5102 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0042 0.0042
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0081 0.0158 0.0158
Echinococcus multilocularis mitogen activated protein kinase 14 0.0394 0.1165 0.1165
Loa Loa (eye worm) hypothetical protein 0.0398 0.118 0.118
Echinococcus granulosus epidermal growth factor receptor 0.314 1 1
Brugia malayi Histone deacetylase family protein 0.082 0.2536 0.2536
Brugia malayi hypothetical protein 0.0068 0.0116 0.0116
Trypanosoma brucei histone deacetylase 3 0.082 0.2536 0.4971
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0081 0.0158 0.0158
Echinococcus multilocularis histone deacetylase 3 0.0942 0.293 0.293
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.044 0.1315 0.1315
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0042 0.0036 0.0036
Echinococcus multilocularis histone deacetylase 0.082 0.2536 0.2536
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1618 0.5102 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1694 0.5347 0.5347
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0044 0.0039 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0035 0.0035
Echinococcus multilocularis mitogen activated protein kinase 11 0.0394 0.1165 0.1165
Leishmania major histone deacetylase, putative 0.0942 0.293 0.5742
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0035
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1015 0.3164 0.3164
Schistosoma mansoni titin 0.0042 0.0035 0.0035
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0942 0.293 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0042 0.0036 0.0036
Schistosoma mansoni histone deacetylase 0.0942 0.293 0.293
Trichomonas vaginalis histone deacetylase, putative 0.0942 0.293 1
Trypanosoma brucei histone deacetylase 4 0.082 0.2536 0.4971
Loa Loa (eye worm) histone deacetylase 11 0.0398 0.118 0.118
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0602 0.1834 0.3595
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0394 0.1165 0.2283
Onchocerca volvulus 0.0044 0.0039 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0078 0.0267
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0044 0.0042 0.0042
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0042 0.0035 0.0035
Echinococcus granulosus tyrosine protein kinase shark 0.0044 0.0039 0.0039
Leishmania major protein kinase, putative 0.0035 0.0011 0.0021
Echinococcus multilocularis tyrosine protein kinase Abl 0.0132 0.0324 0.0324
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0119 0.0119
Echinococcus multilocularis tyrosine protein kinase shark 0.0044 0.0039 0.0039
Schistosoma mansoni nephrin 0.0044 0.0042 0.0042
Brugia malayi Histone deacetylase 1 0.0942 0.293 0.293
Echinococcus granulosus neuroglian 0.0044 0.0042 0.0042
Echinococcus granulosus mitogen activated protein kinase 11 0.0394 0.1165 0.1165
Plasmodium vivax histone deacetylase 2, putative 0.082 0.2536 0.8658
Echinococcus multilocularis neuroglian 0.0086 0.0177 0.0177
Loa Loa (eye worm) TK/EGFR protein kinase 0.314 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0178 0.0178
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0119 0.0119
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0078 0.0078
Brugia malayi protein-tyrosine kinase 0.0074 0.0136 0.0136
Schistosoma mansoni histone deacetylase 0.0942 0.293 0.293
Loa Loa (eye worm) hypothetical protein 0.0068 0.0116 0.0116
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0081 0.0158 0.0158
Brugia malayi Protein kinase domain containing protein 0.0848 0.2628 0.2628
Echinococcus multilocularis roundabout 2 0.0044 0.0042 0.0042
Brugia malayi histone deacetylase 1 (HD1) 0.0942 0.293 0.293
Schistosoma mansoni tyrosine kinase 0.1662 0.5246 0.5246
Echinococcus multilocularis ephrin type A receptor 4 A 0.0101 0.0225 0.0225
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0119 0.0234
Echinococcus granulosus mitogen activated protein kinase 14 0.0394 0.1165 0.1165
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0035
Echinococcus multilocularis histone deacetylase 1 0.0942 0.293 0.293
Loa Loa (eye worm) hypothetical protein 0.0108 0.0245 0.0245
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0042 0.0035 0.0035
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0119 0.0407
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.0158 0.0158
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0035 0.0011 0.0021
Echinococcus granulosus tyrosine protein kinase Btk29A 0.005 0.0061 0.0061
Echinococcus granulosus roundabout 2 0.011 0.0252 0.0252
Trypanosoma cruzi histone deacetylase, putative 0.0398 0.118 0.2313
Echinococcus granulosus microtubule associated protein 2 0.0715 0.22 0.22
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1618 0.5102 1
Trypanosoma cruzi histone deacetylase, putative 0.082 0.2536 0.4971
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0257 0.0727 0.0727
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.005 0.0061 0.0061
Echinococcus multilocularis c src tyrosine kinase 0.005 0.0061 0.0061
Echinococcus granulosus insulin receptor 0.1013 0.3157 0.3157
Toxoplasma gondii histone deacetylase HDAC5 0.0398 0.118 0.2313
Echinococcus granulosus tyrosine protein kinase Fyn 0.0081 0.0158 0.0158
Echinococcus granulosus histone deacetylase 6 0.0839 0.2596 0.2596
Loa Loa (eye worm) TK/INSR protein kinase 0.1013 0.3157 0.3157
Plasmodium vivax histone deacetylase 1, putative 0.0942 0.293 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0394 0.1165 0.2283
Brugia malayi histone deacetylase 3 (HD3) 0.0942 0.293 0.293
Leishmania major histone deacetylase, putative 0.082 0.2536 0.4971
Entamoeba histolytica protein kinase, putative 0.0062 0.0097 0.0332
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0035 0.0035
Brugia malayi ephrin receptor 1 precursor 0.0058 0.0086 0.0086
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0078 0.0267
Echinococcus granulosus tyrosine protein kinase Src64B 0.0081 0.0158 0.0158
Loa Loa (eye worm) histone deacetylase 3 0.0942 0.293 0.293
Echinococcus multilocularis tyrosine protein kinase Srms 0.0074 0.0136 0.0136
Echinococcus multilocularis Immunoglobulin 0.0065 0.011 0.011
Loa Loa (eye worm) TK protein kinase 0.0062 0.0097 0.0097
Brugia malayi Histone deacetylase family protein 0.082 0.2536 0.2536
Onchocerca volvulus Histone deacetylase 10 homolog 0.0398 0.118 0.4327
Echinococcus multilocularis hemicentin 1 0.0042 0.0035 0.0035
Trypanosoma brucei histone deacetylase 2 0.0398 0.118 0.2313
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0394 0.1165 0.2283
Brugia malayi fructose-1,6-bisphosphatase 0.1618 0.5102 0.5102
Trichomonas vaginalis histone deacetylase, putative 0.0942 0.293 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0035 0.0035
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0057 0.0081 0.0081
Toxoplasma gondii histone deacetylase HDAC4 0.0398 0.118 0.2313
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0035 0.0011 0.0011
Brugia malayi histone deacetylase 11 0.0398 0.118 0.118
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0044 0.0042 0.0042
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0078 0.0153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0035 0.0035
Schistosoma mansoni ephrin receptor 0.0033 0.0007 0.0007
Echinococcus granulosus c src tyrosine kinase 0.005 0.0061 0.0061
Trypanosoma brucei protein kinase, putative 0.0056 0.0078 0.0153
Brugia malayi SRC-1 0.0081 0.0158 0.0158
Brugia malayi Protein kinase domain containing protein 0.0044 0.0039 0.0039
Schistosoma mansoni protein kinase 0.0035 0.0011 0.0011
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Echinococcus granulosus roundabout 2 0.0044 0.0042 0.0042
Schistosoma mansoni protein kinase 0.0035 0.0011 0.0011
Loa Loa (eye worm) TK/ABL protein kinase 0.0257 0.0727 0.0727
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0081 0.0158 0.0158
Schistosoma mansoni histone deacetylase 4 5 0.082 0.2536 0.2536
Toxoplasma gondii histone deacetylase HDAC3 0.0942 0.293 0.5742
Schistosoma mansoni tyrosine kinase 0.0044 0.0039 0.0039
Plasmodium falciparum histone deacetylase 1 0.0942 0.293 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0042 0.0035 0.0035
Echinococcus multilocularis neuroglian 0.0044 0.0042 0.0042
Plasmodium falciparum histone deacetylase, putative 0.082 0.2536 0.8658
Echinococcus granulosus histone deacetylase 0.082 0.2536 0.2536
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0035
Echinococcus multilocularis mitogen activated protein kinase 11 0.0394 0.1165 0.1165
Trypanosoma cruzi histone deacetylase, putative 0.082 0.2536 0.4971
Loa Loa (eye worm) TK protein kinase 0.0074 0.0136 0.0136
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1618 0.5102 0.5102
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0119 0.0119
Schistosoma mansoni cell adhesion molecule 0.0044 0.0042 0.0042
Brugia malayi SH2 domain containing protein 0.0044 0.0039 0.0039
Echinococcus multilocularis peroxidasin 0.0042 0.0035 0.0035
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0052 0.0067 0.0067
Echinococcus granulosus tyrosine kinase 0.0044 0.0039 0.0039
Plasmodium vivax protein kinase, putative 0.0036 0.0014 0.0049
Echinococcus multilocularis histone deacetylase 6 0.082 0.2536 0.2536
Echinococcus multilocularis histone deacetylase 6 0.0839 0.2596 0.2596
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0945 0.294 0.294
Plasmodium falciparum protein kinase, putative 0.0035 0.0011 0.0037
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0848 0.2628 0.2628
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0942 0.293 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0101 0.0225 0.0225
Echinococcus granulosus histone deacetylase 3 0.0942 0.293 0.293
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0074 0.0136 0.0136
Brugia malayi Fibronectin type III domain containing protein 0.0068 0.0116 0.0116
Schistosoma mansoni neuroglian 0.0044 0.0042 0.0042
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0602 0.1834 0.3595
Brugia malayi Prion-like- 0.0042 0.0035 0.0035
Echinococcus multilocularis insulin receptor 0.1013 0.3157 0.3157
Brugia malayi Protein kinase domain containing protein 0.0044 0.0039 0.0039
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0078 0.0153
Schistosoma mansoni cell adhesion molecule 0.0042 0.0035 0.0035
Echinococcus multilocularis tyrosine protein kinase HCK 0.0062 0.0097 0.0097
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.0158 0.0158
Giardia lamblia Histone deacetylase 0.0942 0.293 1
Echinococcus multilocularis lachesin 0.0042 0.0035 0.0035
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1618 0.5102 1
Echinococcus multilocularis tyrosine protein kinase otk 0.0042 0.0035 0.0035
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0602 0.1834 0.3595
Schistosoma mansoni tyrosine kinase 0.0081 0.0158 0.0158
Echinococcus granulosus tyrosine protein kinase Src42A 0.0081 0.0158 0.0158
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0078 0.0153
Leishmania major histone deacetylase, putative 0.0942 0.293 0.5742
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0119 0.0234
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0067 0.0067
Echinococcus multilocularis roundabout 2 0.011 0.0252 0.0252
Leishmania major histone deacetylase, putative 0.082 0.2536 0.4971
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0044 0.0042 0.0042
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase ABL1 0.0257 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0035
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0044 0.0039 0.0134
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0942 0.293 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0035 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.005 0.0061 0.0061
Plasmodium vivax histone deacetylase, putative 0.0398 0.118 0.4029
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0078 0.0078
Brugia malayi Protein kinase domain containing protein 0.0044 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.314 1 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0119 0.0234
Loa Loa (eye worm) hypothetical protein 0.0044 0.0042 0.0042
Echinococcus multilocularis mitogen activated protein kinase 14 0.0394 0.1165 0.1165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0116 0.0116
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0078 0.0153
Loa Loa (eye worm) hypothetical protein 0.0113 0.0263 0.0263
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1618 0.5102 0.5102
Echinococcus granulosus hemicentin 1 0.0042 0.0035 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0035 0.0035
Echinococcus granulosus histone deacetylase 1 0.0942 0.293 0.293
Onchocerca volvulus 0.0044 0.0039 0.0144
Schistosoma mansoni cell adhesion molecule 0.0044 0.0042 0.0042
Entamoeba histolytica protein kinase domain containing protein 0.0035 0.0011 0.0037
Brugia malayi MAP kinase sur-1 0.0056 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0068 0.0116 0.0116
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0081 0.0158 0.0158
Echinococcus granulosus histone deacetylase 6 0.082 0.2536 0.2536
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.0136 0.0136
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0044 0.0042 0.0042
Onchocerca volvulus 0.0044 0.0039 0.0144
Echinococcus multilocularis microtubule associated protein 2 0.0715 0.22 0.22
Trypanosoma cruzi histone deacetylase 1, putative 0.0942 0.293 0.5742
Loa Loa (eye worm) SRC-1 0.0081 0.0158 0.0158
Loa Loa (eye worm) histone deacetylase 7A 0.082 0.2536 0.2536
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0394 0.1165 0.2283
Brugia malayi Cytochrome P450 family protein 0.0058 0.0085 0.0085
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0035 0.0011 0.0021
Echinococcus granulosus activin receptor type 0.0035 0.0011 0.0011
Brugia malayi Protein kinase domain containing protein 0.1013 0.3157 0.3157
Schistosoma mansoni nephrin 0.0088 0.0183 0.0183
Onchocerca volvulus Tyrosine kinase homolog 0.0879 0.2728 1
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Echinococcus granulosus histone deacetylase 6 0.082 0.2536 0.2536
Echinococcus granulosus contactin 0.0044 0.0042 0.0042
Toxoplasma gondii histone deacetylase HDAC1 0.082 0.2536 0.4971
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0035 0.0011 0.0021
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1618 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0108 0.0245 0.0245
Echinococcus granulosus histone deacetylase 8 0.0398 0.118 0.118
Brugia malayi hypothetical protein 0.0044 0.0039 0.0039
Trichomonas vaginalis histone deacetylase, putative 0.0942 0.293 1
Echinococcus multilocularis tyrosine kinase 0.0044 0.0039 0.0039
Echinococcus granulosus tyrosine protein kinase HCK 0.0062 0.0097 0.0097
Echinococcus granulosus tyrosine protein kinase Srms 0.0044 0.0039 0.0039
Onchocerca volvulus 0.0827 0.256 0.9385
Echinococcus multilocularis hemicentin 1 0.0042 0.0035 0.0035
Echinococcus granulosus tyrosine protein kinase Blk 0.0074 0.0136 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0035
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1015 0.3164 0.3164
Trypanosoma cruzi histone deacetylase, putative 0.082 0.2536 0.4971
Echinococcus granulosus tyrosine protein kinase Fyn 0.0081 0.0158 0.0158
Brugia malayi Immunoglobulin I-set domain containing protein 0.0945 0.294 0.294
Plasmodium vivax histone deacetylase, putative 0.082 0.2536 0.8658
Schistosoma mansoni cell adhesion molecule 0.0089 0.0185 0.0185
Schistosoma mansoni tyrosine kinase 0.0073 0.0136 0.0136
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0035 0.0011 0.0021
Echinococcus multilocularis epidermal growth factor receptor 0.1694 0.5347 0.5347
Echinococcus granulosus lachesin 0.0042 0.0035 0.0035
Entamoeba histolytica histone deacetylase, putative 0.0942 0.293 1
Onchocerca volvulus 0.0044 0.0039 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0078 0.0267
Trypanosoma brucei protein kinase, putative 0.0035 0.0011 0.0021
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0039 0.0039
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0044 0.0039 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.0715 0.22 0.22
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0081 0.0158 0.0158
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0078 0.0153
Trichomonas vaginalis histone deacetylase, putative 0.0942 0.293 1
Trichomonas vaginalis histone deacetylase, putative 0.0942 0.293 1
Toxoplasma gondii fructose-bisphospatase II 0.1618 0.5102 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0078 0.0153
Schistosoma mansoni tyrosine kinase 0.0081 0.0158 0.0158
Echinococcus multilocularis roundabout 2 0.0044 0.0042 0.0042
Echinococcus granulosus transcription factor Dp 1 0.004 0.0027 0.0027
Toxoplasma gondii histone deacetylase HDAC2 0.0942 0.293 0.5742
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0044 0.0042 0.0042
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.0067 0.0067
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0044 0.0042 0.0042
Schistosoma mansoni septate junction protein 0.0042 0.0035 0.0035
Echinococcus granulosus histone deacetylase 7 0.082 0.2536 0.2536
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.0158 0.0158
Trypanosoma brucei histone deacetylase 1 0.0942 0.293 0.5742
Toxoplasma gondii fructose-bisphospatase I 0.0602 0.1834 0.3595
Schistosoma mansoni vesicular amine transporter 0.0065 0.011 0.011
Schistosoma mansoni tyrosine kinase 0.1013 0.3157 0.3157
Echinococcus granulosus tyrosine protein kinase otk 0.0042 0.0035 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0078 0.0078
Trypanosoma brucei histone deacetylase, putative 0.082 0.2536 0.4971
Schistosoma mansoni tyrosine kinase 0.1694 0.5347 0.5347
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0078 0.0267
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0052 0.0067 0.0067
Echinococcus granulosus roundabout 2 0.0044 0.0042 0.0042
Onchocerca volvulus 0.0044 0.0039 0.0144
Echinococcus granulosus neuroglian 0.0086 0.0177 0.0177
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0042 0.0035 0.0035
Echinococcus granulosus epidermal growth factor receptor 0.1694 0.5347 0.5347
Brugia malayi Tyrosine-protein kinase abl-1 0.0132 0.0324 0.0324
Echinococcus granulosus peroxidasin 0.0042 0.0035 0.0035
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0065 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.005 0.0061 0.0061
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0048 0.0052 0.0052
Trypanosoma cruzi histone deacetylase, putative 0.0398 0.118 0.2313
Loa Loa (eye worm) histone deacetylase 1 0.0942 0.293 0.293
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0042 0.0042
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0065 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0942 0.293 0.293
Schistosoma mansoni tyrosine kinase 0.0044 0.0039 0.0039
Loa Loa (eye worm) histone deacetylase 0.082 0.2536 0.2536
Schistosoma mansoni tyrosine kinase 0.0245 0.0688 0.0688

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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