Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.4245 | 0.4245 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0051 | 0.5473 | 0.5473 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0043 | 0.4332 | 0.4332 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 1 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0051 | 0.5473 | 0.5 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.0051 | 0.5473 | 0.5473 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0051 | 0.5473 | 0.5473 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0051 | 0.5473 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 1 | 1 |
Giardia lamblia | ABC transporter | 0.005 | 0.5386 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 1 | 1 |
Trypanosoma brucei | ATP-binding cassette protein, putative | 0.0051 | 0.5473 | 0.5 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0051 | 0.5473 | 1 |
Leishmania major | ATP-binding cassette protein subfamily G, member 6, putative | 0.0051 | 0.5473 | 0.5 |
Trypanosoma brucei | ABC transporter, putative | 0.0051 | 0.5473 | 0.5 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0051 | 0.5473 | 0.5473 |
Brugia malayi | ABC transporter family protein | 0.0043 | 0.4332 | 0.4332 |
Leishmania major | ATP-binding cassette protein subfamily G, member 4, putative | 0.0051 | 0.5473 | 0.5 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0051 | 0.5473 | 0.5473 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0051 | 0.5473 | 0.5473 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Trypanosoma cruzi | ABC transporter, putative | 0.0051 | 0.5473 | 0.5 |
Schistosoma mansoni | ABC transporter | 0.0043 | 0.4332 | 0.4332 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0051 | 0.5473 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Plasmodium falciparum | ABC transporter G family member 2 | 0.0051 | 0.5473 | 0.5 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0051 | 0.5473 | 0.5473 |
Plasmodium vivax | ABC transporter G family member 2, putative | 0.0051 | 0.5473 | 0.5 |
Mycobacterium tuberculosis | Probable conserved transmembrane ATP-binding protein ABC transporter | 0.0043 | 0.4245 | 1 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.0051 | 0.5473 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG84 | 0.0051 | 0.5473 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10.24 uM | Inhibition of BuChE (unknown origin) using butyrylthiocholine iodide as substrate incubated for 25 mins by Ellman's method | ChEMBL. | 25260958 |
IC50 (binding) | = 23.21 uM | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 25 mins by Ellman's method | ChEMBL. | 25260958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.