Detailed information for compound 933483

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.37 | Formula: C20H20O5
  • H donors: 1 H acceptors: 3 LogP: 3.85 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(/C=C/C(=O)O)ccc1OC(=O)CCc1ccccc1
  • InChi: 1S/C20H20O5/c1-2-24-18-14-16(9-12-19(21)22)8-11-17(18)25-20(23)13-10-15-6-4-3-5-7-15/h3-9,11-12,14H,2,10,13H2,1H3,(H,21,22)/b12-9+
  • InChiKey: AJOOYPYYZAPQCL-FMIVXFBMSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldo-keto reductase family 1, member C3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major aldo-keto reductase-like protein aldo-keto reductase family 1, member C3 323 aa 325 aa 34.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.086 0.1723
Loa Loa (eye worm) neuropeptide F receptor 0.083 0.9902 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.083 0.9902 0.9902
Echinococcus multilocularis alpha 1A adrenergic receptor 0.083 0.9902 0.9902
Brugia malayi MH2 domain containing protein 0.0254 0.2428 0.242
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.083 0.9902 0.9902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.083 0.9902 0.9902
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.008 0.0175 0.0136
Echinococcus multilocularis neuropeptide receptor A26 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.1241 0.2488
Echinococcus granulosus rhodopsin orphan GPCR 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Schistosoma mansoni biogenic amine receptor 0.083 0.9902 0.9902
Echinococcus multilocularis sex peptide receptor 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0707 0.1417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0709 0.1422
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.016 0.1203 0.6215
Schistosoma mansoni biogenic amine (5HT) receptor 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.1376 0.2758
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.1136 0.111
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0214 0.191 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.1187 0.1162
Onchocerca volvulus 0.083 0.9902 1
Schistosoma mansoni neuropeptide receptor 0.083 0.9902 0.9902
Echinococcus granulosus neuropeptide s receptor 0.083 0.9902 0.9902
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.083 0.9902 0.9902
Onchocerca volvulus 0.083 0.9902 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.016 0.1203 0.2411
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Schistosoma mansoni myosin xvIII 0.083 0.9902 0.9902
Loa Loa (eye worm) follicle stimulating hormone receptor 0.083 0.9902 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.008 0.0175 0.0719
Echinococcus multilocularis biogenic amine (5HT) receptor 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.1241 0.2488
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.083 0.9902 1
Echinococcus granulosus neuropeptide receptor A26 0.083 0.9902 0.9902
Echinococcus granulosus hypothetical protein 0.083 0.9902 0.9902
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0837 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0707 0.1417
Echinococcus multilocularis rhodopsin orphan GPCR 0.083 0.9902 0.9902
Echinococcus multilocularis rhodopsin orphan GPCR 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.0844 0.1692
Onchocerca volvulus 0.083 0.9902 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0214 0.191 0.3778
Schistosoma mansoni neuropeptide F-like receptor 0.083 0.9902 0.9902
Echinococcus multilocularis somatostatin receptor 0.083 0.9902 0.9902
Toxoplasma gondii target of rapamycin (TOR), putative 0.0163 0.1241 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0175 0.0351
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0451 0.4989 1
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0142 0.0284
Echinococcus multilocularis rhodopsin orphan GPCR 0.083 0.9902 0.9902
Schistosoma mansoni chromobox protein 0.0078 0.0142 0.0101
Echinococcus granulosus g protein coupled receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Echinococcus granulosus rhodopsin orphan GPCR 0.083 0.9902 0.9902
Brugia malayi larval opioid receptor 0.083 0.9902 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0214 0.191 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.086 0.1723
Echinococcus multilocularis serotonin receptor 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0148 0.1051 0.2106
Brugia malayi G-protein coupled receptor 0.083 0.9902 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0451 0.4989 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Brugia malayi Dopamine receptor 0.083 0.9902 1
Echinococcus granulosus allatostatin A receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.0156 0.1151 0.1125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.083 0.9902 0.9902
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.083 0.9902 0.9902
Echinococcus granulosus biogenic amine 5HT receptor 0.083 0.9902 0.9902
Brugia malayi neuropeptide F receptor 0.083 0.9902 1
Echinococcus granulosus neuropeptide Y receptor 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0175 0.0351
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.083 0.9902 0.9902
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0451 0.4989 1
Brugia malayi hypothetical protein 0.083 0.9902 1
Echinococcus multilocularis neuropeptide s receptor 0.083 0.9902 0.9902
Brugia malayi putative neuropeptide receptor NPR1 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0173 0.1378 0.7154
Echinococcus granulosus neuropeptides capa receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Brugia malayi GnHR receptor homolog 0.083 0.9902 1
Onchocerca volvulus 0.083 0.9902 1
Schistosoma mansoni neuropeptide receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.083 0.9902 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.007 0.0041 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0709 0.1422
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0175 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0994 0.1993
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Echinococcus granulosus orexin receptor type 2 0.083 0.9902 0.9902
Onchocerca volvulus 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Entamoeba histolytica hypothetical protein 0.0362 0.3827 0.7652
Brugia malayi sulfakinin receptor protein 0.083 0.9902 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.083 0.9902 0.9902
Brugia malayi G-protein coupled receptor 0.083 0.9902 1
Brugia malayi RE15519p 0.083 0.9902 1
Giardia lamblia GTOR 0.0214 0.191 0.9047
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Schistosoma mansoni neuropeptide receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.0297 0.2984 0.2985
Brugia malayi Heterochromatin protein 1 0.0078 0.0142 0.0102
Schistosoma mansoni amine GPCR 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.083 0.9902 0.9902
Echinococcus multilocularis G protein coupled receptor 139 0.083 0.9902 0.9902
Echinococcus multilocularis g-protein coupled receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.2428 0.242
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.007 0.0041 0.0082
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.083 0.9902 0.9902
Loa Loa (eye worm) G-protein coupled receptor 0.083 0.9902 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0297 0.2984 0.2985
Loa Loa (eye worm) phosphatidylinositol 3 0.0134 0.0866 0.0837
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Echinococcus multilocularis allatostatin A receptor 0.083 0.9902 0.9902
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.016 0.1203 0.1167
Echinococcus multilocularis chromobox protein 1 0.0078 0.0142 0.0101
Schistosoma mansoni histamine h1 receptor 0.083 0.9902 0.9902
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0536 0.0502
Schistosoma mansoni rhodopsin-like orphan GPCR 0.083 0.9902 0.9902
Echinococcus granulosus sex peptide receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) TYRA-2 protein 0.083 0.9902 1
Echinococcus multilocularis orexin receptor type 2 0.083 0.9902 0.9902
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0225 0.2045 1
Brugia malayi Dopamine receptor protein 1 0.083 0.9902 1
Schistosoma mansoni hypothetical protein 0.0108 0.0536 0.0498
Schistosoma mansoni hypothetical protein 0.083 0.9902 0.9902
Echinococcus multilocularis rhodopsin orphan GPCR 0.083 0.9902 0.9902
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0097 0.0384 0.1836
Echinococcus granulosus g protein coupled receptor 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.1241 0.2488
Brugia malayi hypothetical protein 0.083 0.9902 1
Brugia malayi Dopamine receptor protein 2 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0536 0.0502
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Brugia malayi hypothetical protein 0.0156 0.1151 0.1125
Echinococcus granulosus 7tm_1 domain containing protein 0.083 0.9902 0.9902
Schistosoma mansoni biogenic amine (5HT) receptor 0.083 0.9902 0.9902
Brugia malayi neuropeptide F receptor 0.083 0.9902 1
Echinococcus granulosus rhodopsin orphan GPCR 0.083 0.9902 0.9902
Brugia malayi hypothetical protein 0.083 0.9902 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.083 0.9902 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0207 0.1822 0.3601
Schistosoma mansoni amine GPCR 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Onchocerca volvulus 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Onchocerca volvulus 0.083 0.9902 1
Echinococcus granulosus rhodopsin orphan GPCR 0.083 0.9902 0.9902
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.1187 0.1162
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0214 0.191 0.1877
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0425 0.4652 0.9319
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.1241 0.2488
Echinococcus granulosus neuropeptide receptor 0.083 0.9902 0.9902
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.083 0.9902 0.9902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.083 0.9902 0.9902
Echinococcus multilocularis g protein coupled receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.0158 0.1187 0.1162
Schistosoma mansoni hypothetical protein 0.083 0.9902 0.9902
Loa Loa (eye worm) phosphatidylinositol 3 0.008 0.0175 0.0136
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.007 0.0041 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.083 0.9902 0.9902
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0134 0.0866 0.1668
Schistosoma mansoni neuropeptide F-like receptor 0.083 0.9902 0.9902
Onchocerca volvulus 0.083 0.9902 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.083 0.9902 0.9902
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.083 0.9902 0.9902
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0214 0.191 0.3778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.1241 0.2488
Echinococcus multilocularis neuropeptide receptor 0.083 0.9902 0.9902
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.016 0.1203 0.2348
Leishmania major phosphatidylinositol 3-related kinase, putative 0.008 0.0175 0.0719
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0142 0.0284
Schistosoma mansoni opsin-like receptor 0.083 0.9902 0.9902
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.008 0.0175 0.0135
Schistosoma mansoni hypothetical protein 0.083 0.9902 0.9902
Schistosoma mansoni amine GPCR 0.083 0.9902 0.9902
Brugia malayi G protein-coupled receptor 0.083 0.9902 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.083 0.9902 0.9902
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.083 0.9902 0.9902
Onchocerca volvulus 0.083 0.9902 1
Echinococcus multilocularis neuropeptide receptor 0.083 0.9902 0.9902
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.191 0.1896
Onchocerca volvulus 0.083 0.9902 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.083 0.9902 0.9902
Brugia malayi gonadotropin-releasing hormone receptor 2 0.083 0.9902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.191 0.3829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.1376 0.2758
Brugia malayi Melatonin receptor type 1A 0.083 0.9902 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.008 0.0175 0.0272
Brugia malayi hypothetical protein 0.083 0.9902 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.086 0.1723
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.083 0.9902 0.9902
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0697 0.8183 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0697 0.8183 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0748 0.8838 0.8921
Echinococcus granulosus neuropeptide FF receptor 2 0.083 0.9902 0.9902
Onchocerca volvulus 0.083 0.9902 1
Brugia malayi hypothetical protein 0.083 0.9902 1
Echinococcus granulosus rhodopsin orphan GPCR 0.083 0.9902 0.9902
Echinococcus multilocularis neuropeptide Y receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Schistosoma mansoni neuropeptide receptor 0.083 0.9902 0.9902
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.008 0.0175 0.0135
Echinococcus granulosus tm gpcr rhodopsin 0.083 0.9902 0.9902
Echinococcus granulosus tachykinin peptides receptor 99D 0.083 0.9902 0.9902
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.083 0.9902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0709 0.1422
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0697 0.8183 0.5
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.008 0.0175 0.0135
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.008 0.0175 0.0719
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.083 0.9902 0.9902
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Echinococcus granulosus neuropeptide receptor 0.083 0.9902 0.9902
Echinococcus granulosus G protein coupled receptor 139 0.083 0.9902 0.9902
Schistosoma mansoni opsin-like receptor 0.083 0.9902 0.9902
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.008 0.0175 0.0719
Echinococcus granulosus chromobox protein 1 0.0078 0.0142 0.0101
Brugia malayi putative neuropeptide receptor 0.083 0.9902 1
Onchocerca volvulus 0.083 0.9902 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.083 0.9902 0.9902
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0173 0.1378 0.7154
Schistosoma mansoni biogenic amine receptor 0.083 0.9902 0.9902
Brugia malayi Serotonin receptor 0.083 0.9902 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.007 0.0041 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.083 0.9902 0.9902
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.007 0.0041 0.0082
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0451 0.4989 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.1376 0.2758
Echinococcus granulosus rhodopsin orphan GPCR 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.191 0.3829
Schistosoma mansoni amine GPCR 0.083 0.9902 0.9902
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0386 0.4142 0.4159
Echinococcus multilocularis neuropeptide Y receptor 0.083 0.9902 0.9902
Trypanosoma cruzi target of rapamycin kinase 3 0.0173 0.1378 0.2703
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0837 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.083 0.9902 0.9902
Schistosoma mansoni amine GPCR 0.083 0.9902 0.9902
Onchocerca volvulus 0.083 0.9902 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.083 0.9902 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.1187 0.1162
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0214 0.191 0.1877
Echinococcus granulosus biogenic amine 5HT receptor 0.083 0.9902 0.9902
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.083 0.9902 0.9902
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0214 0.191 0.1877
Echinococcus granulosus fmrfamide receptor 0.083 0.9902 0.9902
Schistosoma mansoni peptide (allatostatin)-like receptor 0.083 0.9902 0.9902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.1376 0.2758
Schistosoma mansoni adenoreceptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0297 0.2984 0.2956
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0297 0.2984 0.2956
Echinococcus multilocularis g protein coupled receptor 0.083 0.9902 0.9902
Brugia malayi G protein-coupled receptor F59B2.13 0.083 0.9902 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.083 0.9902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.1376 0.2758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0709 0.1422
Schistosoma mansoni rhodopsin-like orphan GPCR 0.083 0.9902 0.9902
Echinococcus multilocularis rhodopsin orphan GPCR 0.083 0.9902 0.9902
Echinococcus multilocularis dro:myosuppressin receptor 0.083 0.9902 0.9902
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0314 0.3207 0.6429
Echinococcus granulosus 7TM GPCR rhodopsin 0.083 0.9902 0.9902
Echinococcus multilocularis chromobox protein 1 0.0078 0.0142 0.0101
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.016 0.1203 0.2348
Echinococcus multilocularis fmrfamide receptor 0.083 0.9902 0.9902
Onchocerca volvulus 0.083 0.9902 1
Brugia malayi follicle stimulating hormone receptor 0.083 0.9902 1
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0142 0.0102
Brugia malayi hypothetical protein 0.083 0.9902 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.083 0.9902 0.9902
Echinococcus granulosus serotonin receptor 0.083 0.9902 0.9902
Echinococcus granulosus tm gpcr rhodopsin 0.083 0.9902 0.9902
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0451 0.4989 0.5018
Schistosoma mansoni opsin-like receptor 0.083 0.9902 0.9902
Schistosoma mansoni biogenic amine receptor 0.083 0.9902 0.9902
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0314 0.3207 0.6429
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.083 0.9902 1
Brugia malayi hypothetical protein 0.083 0.9902 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0214 0.191 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.0844 0.1692
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.1241 0.2488
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Echinococcus granulosus somatostatin receptor 0.083 0.9902 0.9902
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.083 0.9902 0.9902
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.083 0.9902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0175 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0175 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.083 0.9902 0.9902
Schistosoma mansoni chromobox protein 0.0078 0.0142 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.083 0.9902 0.9902
Echinococcus granulosus tm gpcr rhodopsin 0.083 0.9902 0.9902
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.083 0.9902 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.083 0.9902 0.9902
Echinococcus multilocularis G-protein coupled receptor, putative 0.083 0.9902 0.9902
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.083 0.9902 0.9902
Echinococcus granulosus chromobox protein 1 0.0078 0.0142 0.0101
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0108 0.0534 0.264
Brugia malayi Serotonin receptor 0.083 0.9902 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.008 0.0175 0.0272
Echinococcus multilocularis fmrfamide receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Loa Loa (eye worm) melatonin receptor type 1A 0.083 0.9902 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0214 0.191 0.3778
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Brugia malayi hypothetical protein 0.083 0.9902 1
Brugia malayi AKH receptor 0.083 0.9902 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0214 0.191 0.3778
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.083 0.9902 0.9902
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.016 0.1203 0.2411
Echinococcus multilocularis serotonin receptor 0.083 0.9902 0.9902
Echinococcus multilocularis g protein coupled receptor 0.083 0.9902 0.9902
Onchocerca volvulus 0.083 0.9902 1
Echinococcus multilocularis neuropeptides capa receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0707 0.1417
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.016 0.1203 0.1178
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0214 0.191 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.083 0.9902 0.9902
Echinococcus granulosus neuropeptide Y receptor 0.083 0.9902 0.9902
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.2428 0.242
Loa Loa (eye worm) G-protein coupled receptor 0.083 0.9902 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0451 0.4989 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.1241 0.2488
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.083 0.9902 1
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0451 0.4989 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.016 0.1203 0.2348
Schistosoma mansoni growth hormone secretagogue receptor 0.083 0.9902 0.9902
Schistosoma mansoni hypothetical protein 0.083 0.9902 0.9902
Echinococcus granulosus neuropeptides capa receptor 0.083 0.9902 0.9902
Onchocerca volvulus Neuropeptide F receptor homolog 0.083 0.9902 1
Loa Loa (eye worm) neuropeptide F receptor 0.083 0.9902 1
Brugia malayi hypothetical protein 0.083 0.9902 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.083 0.9902 0.9902
Onchocerca volvulus 0.083 0.9902 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.083 0.9902 0.9902
Echinococcus granulosus dro:myosuppressin receptor 0.083 0.9902 0.9902
Echinococcus granulosus g-protein coupled receptor 0.083 0.9902 0.9902
Echinococcus granulosus g protein coupled receptor 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.191 0.3829
Loa Loa (eye worm) hypothetical protein 0.083 0.9902 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.016 0.1203 0.2411
Echinococcus multilocularis tachykinin peptides receptor 99D 0.083 0.9902 0.9902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.083 0.9902 0.9902
Echinococcus multilocularis rhodopsin orphan GPCR 0.083 0.9902 0.9902
Echinococcus multilocularis neuropeptides capa receptor 0.083 0.9902 0.9902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0185 0.1528 0.3064
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.083 0.9902 0.9902
Brugia malayi hypothetical protein 0.083 0.9902 1
Onchocerca volvulus 0.083 0.9902 1
Brugia malayi ORL1-like opioid receptor 0.083 0.9902 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.191 0.1896
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0362 0.3827 0.7652

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.97 uM Inhibition of AKR1C3 (unknown origin) assessed as dehydrogenase activity of enzyme by NADPH fluorescence assay ChEMBL. 25182963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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