Detailed information for compound 933649

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.339 | Formula: C17H11NO3S
  • H donors: 0 H acceptors: 3 LogP: 3.92 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1nc2c(o1)cc1c(c2)C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C17H11NO3S/c1-2-22-17-18-13-7-11-12(8-14(13)21-17)16(20)10-6-4-3-5-9(10)15(11)19/h3-8H,2H2,1H3
  • InChiKey: LEABIPOFLSVOPG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0044 0.0067
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0184 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0151 0.0142
Echinococcus granulosus bloom syndrome protein 0.0194 0.2094 0.4188
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0104 0.1064 1
Echinococcus granulosus cpg binding protein 0.0072 0.0703 0.139
Echinococcus granulosus ATP dependent DNA helicase Q1 0.008 0.0795 0.1576
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0104 0.1064 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.008 0.0795 0.4257
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0333 0.0399
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0078 0.0133
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0078 0.0133
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0218 0.0518
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0333 0.0789
Brugia malayi jmjC domain containing protein 0.0017 0.0078 0.0319
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0363 0.3217
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0121 0.0243
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0139 0.033
Loa Loa (eye worm) hypothetical protein 0.0052 0.0479 0.1135
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0363 0.3217
Mycobacterium ulcerans ATP-dependent DNA helicase II UvrD2 0.0024 0.0151 0.196
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0706 0.0695
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0121 0.0221
Brugia malayi Bloom's syndrome protein homolog 0.0194 0.2094 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0443 0.31
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0443 0.0555
Trypanosoma cruzi kinesin, putative 0.0021 0.0121 0.0869
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Brugia malayi calpain 5 0.0021 0.0121 0.0528
Brugia malayi calpain family protein 1 0.007 0.0686 0.3238
Echinococcus multilocularis lamin 0.003 0.0218 0.0207
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0151 0.0885
Schistosoma mansoni cpg binding protein 0.0072 0.0703 0.1409
Leishmania major hypothetical protein, conserved 0.0017 0.0078 0.0448
Schistosoma mansoni cpg binding protein 0.0068 0.0658 0.132
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0347 0.2378
Trypanosoma cruzi DNA polymerase eta, putative 0.007 0.0681 0.6295
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0078 0.0156
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0616 0.1235
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0121 0.0869
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0692 0.1368
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0333 0.0647
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0091 0.0915 0.434
Schistosoma mansoni hypothetical protein 0.0091 0.0915 0.1836
Loa Loa (eye worm) hypothetical protein 0.0042 0.0363 0.086
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0642 0.1288
Leishmania major exosome subunit rrp6p homologue, putative 0.0024 0.0157 0.1215
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.008 0.0795 0.0785
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0091 0.0915 0.1817
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0636 0.7139 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0333 0.0399
Schistosoma mansoni cpg binding protein 0.0072 0.0703 0.1409
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0041 0.0347 0.3061
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0078 0.0448
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0078 0.0133
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0062 0.0147
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.033 0.0641
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0078 0.0348
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.1915 0.3827
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0121 0.0869
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0103 0.0091
Loa Loa (eye worm) hypothetical protein 0.0077 0.0764 0.1812
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.009
Toxoplasma gondii hypothetical protein 0.0093 0.0938 0.6821
Schistosoma mansoni DNA helicase recq5 0.008 0.0795 0.1595
Loa Loa (eye worm) hypothetical protein 0.0017 0.0078 0.0184
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0363 0.0353
Brugia malayi jmjC domain containing protein 0.0064 0.0616 0.2902
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0363 0.5461
Entamoeba histolytica exosome component 10, putative 0.0024 0.0157 0.0151
Echinococcus granulosus intermediate filament protein 0.003 0.0218 0.0417
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0443 0.3059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.009
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0121 0.0869
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0333 0.0399
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.005 0.018
Loa Loa (eye worm) hypothetical protein 0.0041 0.0347 0.0824
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0121 0.0869
Loa Loa (eye worm) calpain 5 0.0021 0.0121 0.0287
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0078 0.0156
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0103 0.0184
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0333 0.0399
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0078 0.0184
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.172 0.8203
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1372 0.3252
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.008 0.0795 0.0785
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0121 0.0869
Echinococcus granulosus DNA methyltransferase 2, putative 0.0022 0.0128 0.0235
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0031 0.0063
Toxoplasma gondii DNA methyltransferase 2, putative 0.0022 0.0128 0.073
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.017 0.1826 1
Schistosoma mansoni hypothetical protein 0.0023 0.0139 0.0279
Brugia malayi CXXC zinc finger family protein 0.0068 0.0658 0.3107
Echinococcus multilocularis dna polymerase eta 0.007 0.0681 0.0671
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0363 0.3217
Schistosoma mansoni hypothetical protein 0.0185 0.1996 0.4004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.064 1
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0022 0.0128 0.0939
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0122 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0103 0.0206
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0121 0.0869
Echinococcus multilocularis calpain 0.0021 0.0121 0.011
Echinococcus granulosus ATP dependent DNA helicase Q5 0.008 0.0795 0.1576
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0706 0.3333
Echinococcus multilocularis cpg binding protein 0.0072 0.0703 0.0692
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0333 0.2921
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0147 0.0348
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.064 1
Schistosoma mansoni hypothetical protein 0.0017 0.0073 0.0146
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.064 0.4577
Loa Loa (eye worm) hypothetical protein 0.003 0.0218 0.0518
Entamoeba histolytica recQ family DNA helicase 0.0041 0.0347 0.042
Loa Loa (eye worm) hypothetical protein 0.009 0.0912 0.2163
Trypanosoma cruzi kinesin, putative 0.0021 0.0121 0.0869
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0095 0.0168
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0078 0.0348
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0333 0.0399
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0363 0.0862
Schistosoma mansoni DNA polymerase eta 0.007 0.0681 0.1367
Loa Loa (eye worm) hypothetical protein 0.005 0.0447 0.1059
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0121 0.0869
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0184 0.0173
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0333 0.0399
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0121 0.0869
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0369 0.0451
Leishmania major DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1372 0.3252
Brugia malayi jmjC domain containing protein 0.0068 0.066 0.3115
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0121 0.0243
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0333 0.1545
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0078 0.0066
Brugia malayi calpain 7 0.0021 0.0121 0.0528
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0131 0.1378 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0093 0.0938 0.5052
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0333 0.2921
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.066 0.1324
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0121 0.0869
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.007 0.0686 0.1626
Loa Loa (eye worm) hypothetical protein 0.0017 0.0078 0.0184
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0121 0.0243
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0443 0.0869
Echinococcus granulosus calpain A 0.0021 0.0121 0.0221
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0095 0.019
Leishmania major glycosyl hydrolase-like protein 0.0015 0.005 0.018
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0074 0.0727 0.1458
Loa Loa (eye worm) intermediate filament protein 0.003 0.0218 0.0518
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0333 0.0399
Schistosoma mansoni hypothetical protein 0.0091 0.0915 0.1836
Loa Loa (eye worm) acetyltransferase 0.0161 0.172 0.4078
Onchocerca volvulus 0.0042 0.0363 0.2298
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0333 0.0399
Leishmania major DNA polymerase eta, putative 0.007 0.0681 0.6295
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0121 0.0869
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0095 0.019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0363 0.4355
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Loa Loa (eye worm) hypothetical protein 0.0134 0.1411 0.3344
Entamoeba histolytica calpain large subunit domain III containing protein 0.0021 0.0121 0.01
Onchocerca volvulus 0.003 0.0218 0.1238
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0363 0.0442
Echinococcus multilocularis zinc finger protein 0.0027 0.0191 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0214 0.1769
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0091 0.0915 0.0905
Schistosoma mansoni zinc finger protein 0.0027 0.0191 0.0383
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.064 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0447 0.1059
Schistosoma mansoni hypothetical protein 0.0447 0.4986 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.1915 0.9138
Trichomonas vaginalis DNA helicase recq, putative 0.0104 0.1064 0.143
Echinococcus multilocularis bloom syndrome protein 0.0194 0.2094 0.2085
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0363 0.0442
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0369 0.4426
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0363 0.3217
Entamoeba histolytica protein kinase, putative 0.0021 0.0121 0.01
Echinococcus multilocularis calpain 5 0.0021 0.0121 0.011
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0078 0.0184
Trypanosoma brucei glucosidase, putative 0.004 0.0333 0.2921
Echinococcus granulosus dna polymerase eta 0.007 0.0681 0.1347
Schistosoma mansoni hypothetical protein 0.0091 0.0915 0.1836
Leishmania major hypothetical protein, conserved 0.0017 0.0073 0.0401
Brugia malayi Bromodomain containing protein 0.0046 0.0404 0.1886
Schistosoma mansoni lamin 0.003 0.0218 0.0438
Leishmania major modification methylase-like protein 0.0022 0.0128 0.0939
Giardia lamblia Sgs1 DNA helicase, putative 0.008 0.0795 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0118
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0104 0.1064 1
Plasmodium vivax exosome complex exonuclease RRP6, putative 0.0024 0.0157 0.0932
Schistosoma mansoni hypothetical protein 0.0185 0.1996 0.4004
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0359 0.0348
Echinococcus granulosus Helicase RNase D C terminal HRDC domain 0.0024 0.0157 0.0293
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0027
Leishmania major DNA polymerase eta, putative 0.0041 0.0349 0.3079
Echinococcus multilocularis dnaJ subfamily B 0.0447 0.4986 0.498
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0333 0.0322
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0121 0.0869
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0078 0.0184
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0706 0.1415
Trypanosoma brucei unspecified product 0.0029 0.0214 0.1769
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0074 0.0727 0.1458
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0706 0.653
Trypanosoma brucei unspecified product 0.0029 0.0214 0.1769
Brugia malayi jmjC domain containing protein 0.0017 0.0078 0.0319
Entamoeba histolytica recQ family helicase, putative 0.0104 0.1064 0.143
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.008 0.0795 0.5748
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0503
Schistosoma mansoni calpain (C02 family) 0.0021 0.0121 0.0243
Trypanosoma brucei ISWI complex protein 0.0017 0.0073 0.0401
Loa Loa (eye worm) CXXC zinc finger family protein 0.0068 0.0658 0.1561
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0078 0.0066
Schistosoma mansoni blooms syndrome DNA helicase 0.0153 0.1629 0.3267
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0157 0.0151
Echinococcus granulosus calpain 0.0021 0.0121 0.0221
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0091 0.0915 0.1817
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0363 0.0729
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0151 0.0664
Brugia malayi jmjC domain containing protein 0.0017 0.0078 0.0319
Echinococcus granulosus lamin dm0 0.003 0.0218 0.0417
Leishmania major kinesin, putative 0.0021 0.0121 0.0869
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.009 0.0912 0.1217
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0078 0.0156
Onchocerca volvulus 0.005 0.0447 0.2915
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.008 0.0795 0.3764
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0443 0.31
Plasmodium vivax calpain, putative 0.0021 0.0121 0.0666
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0692 0.0681
Echinococcus granulosus calpain A 0.0074 0.0727 0.1439
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0363 0.4355
Schistosoma mansoni intermediate filament proteins 0.003 0.0218 0.0438
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0616 0.0605
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.013 0.136 1
Brugia malayi intermediate filament protein 0.003 0.0218 0.0995
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0078 0.0066
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0706 0.653
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0022 0.0128 0.073
Onchocerca volvulus Huntingtin homolog 0.0134 0.1411 1
Brugia malayi polk-prov protein 0.0013 0.0031 0.0097
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0333 0.0399
Trypanosoma brucei antigen, putative 0.0021 0.0121 0.0869
Treponema pallidum ATP-dependent DNA helicase 0.0041 0.0347 0.5
Loa Loa (eye worm) apoptosis regulator protein 0.0091 0.0915 0.217
Loa Loa (eye worm) calpain family protein 1 0.005 0.0447 0.1059
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0359 0.0699
Mycobacterium ulcerans hypothetical protein 0.0024 0.0157 0.2062
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0184 0.0347
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0091 0.0915 0.1836
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.1915 0.454
Trichomonas vaginalis DNA helicase recq, putative 0.0194 0.2094 0.2884
Trypanosoma cruzi ISWI complex protein 0.0017 0.0073 0.0401
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0078 0.0156
Echinococcus granulosus dna polymerase kappa 0.0042 0.0363 0.0708
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0349 0.3079
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0044 0.0033
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0706 0.0925
Trypanosoma brucei ribosomal RNA processing protein 6 0.0024 0.0157 0.1215
Plasmodium vivax JmjC domain containing protein 0.0017 0.0078 0.0343
Echinococcus multilocularis calpain family protein 1, d 0.005 0.0447 0.0436
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0078 0.0448
Entamoeba histolytica recQ family helicase, putative 0.0039 0.033 0.0395
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0706 0.653
Echinococcus multilocularis geminin 0.0185 0.1996 0.1987
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.064 0.5891
Schistosoma mansoni apoptosis regulator bax 0.0091 0.0915 0.1836
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0333 0.2921
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0103 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0214 0.1769
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0121 0.0869
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.066 0.1565
Onchocerca volvulus 0.0103 0.1058 0.7407
Schistosoma mansoni blooms syndrome DNA helicase 0.0041 0.0347 0.0697
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0121 0.0869
Echinococcus granulosus disco interacting protein 2 0.0042 0.0363 0.0706
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.172 0.1711
Schistosoma mansoni polymyositis/scleroderma autoantigen-related 0.0024 0.0157 0.0314
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0095 0.0084
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0078 0.0448
Loa Loa (eye worm) hypothetical protein 0.0091 0.0915 0.217
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0041 0.0347 0.3061
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0363 0.0353
Loa Loa (eye worm) hypothetical protein 0.008 0.0795 0.1885
Trichomonas vaginalis DNA helicase recq1, putative 0.0194 0.2094 0.2884
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0074 0.0727 0.0716
Loa Loa (eye worm) calpain 0.0021 0.0121 0.0287
Schistosoma mansoni lamin 0.003 0.0218 0.0438
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.005 0.0186
Loa Loa (eye worm) hypothetical protein 0.0048 0.0434 0.103
Brugia malayi calpain family protein 1 0.007 0.0686 0.3238
Loa Loa (eye worm) hypothetical protein 0.0134 0.1411 0.3344
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0363 0.1691
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0121 0.0869
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0333 0.0399
Echinococcus granulosus zinc finger protein 0.0027 0.0191 0.0361
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Onchocerca volvulus 0.003 0.0218 0.1238
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Loa Loa (eye worm) hypothetical protein 0.0017 0.0078 0.0184
Echinococcus granulosus histone acetyltransferase KAT2B 0.0154 0.164 0.3274
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.064 1
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0022 0.0128 0.0117
Brugia malayi Bromodomain containing protein 0.0088 0.0882 0.4183
Echinococcus granulosus phd:f box containing protein 0.0017 0.0078 0.0133
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0078 0.0156
Schistosoma mansoni DNA helicase recq1 0.008 0.0795 0.1595
Brugia malayi ImpB/MucB/SamB family protein 0.007 0.0681 0.3217
Echinococcus granulosus lamin 0.003 0.0218 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0022 0.0128 0.0257
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0039 0.033 0.2215
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0349 0.2392
Echinococcus multilocularis Helicase RNase D C terminal, HRDC domain 0.0024 0.0157 0.0146
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0121 0.0869
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.066 0.1304
Loa Loa (eye worm) calpain family protein 1 0.007 0.0686 0.1626
Onchocerca volvulus Huntingtin homolog 0.0134 0.1411 1
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.064 0.1283
Schistosoma mansoni zinc finger protein 0.0017 0.0073 0.0146
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0074
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0128 0.072
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.1915 0.1906
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0363 0.0729
Brugia malayi PHD-finger family protein 0.0033 0.0257 0.1182
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0121 0.011
Loa Loa (eye worm) hypothetical protein 0.007 0.0686 0.1626
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0636 0.7139 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0363 0.0442
Echinococcus multilocularis musashi 0.003 0.0218 0.0207
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0078 0.0258
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.005 0.018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.1915 0.1906
Echinococcus multilocularis lamin dm0 0.003 0.0218 0.0207
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0121 0.0869
Trypanosoma brucei kinesin, putative 0.0021 0.0121 0.0869
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.007 0.0686 0.1375
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0635 0.454
Brugia malayi 3'-5' exonuclease family protein 0.0024 0.0157 0.0699
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0616 0.0605
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0022 0.0128 0.054
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0218 0.0995
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0121 0.0869
Echinococcus granulosus geminin 0.0185 0.1996 0.3991
Echinococcus multilocularis disco interacting protein 2 0.0042 0.0363 0.0352
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0122 0.0111
Brugia malayi jmjC domain containing protein 0.0017 0.0078 0.0319
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.008 0.0795 0.3764
Schistosoma mansoni alpha glucosidase 0.004 0.0333 0.0668
Loa Loa (eye worm) hypothetical protein 0.038 0.4218 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0616 0.1215
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0091 0.0915 0.0905
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.172 0.345
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0333 0.227
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0369 0.1884
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0062 0.0245
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0042 0.0363 0.0727
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.008 0.0795 0.5748
Trypanosoma brucei unspecified product 0.0042 0.0363 0.3217
Schistosoma mansoni alpha-glucosidase 0.0153 0.1632 0.3273
Loa Loa (eye worm) RecQ helicase 0.0194 0.2094 0.4965
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0443 0.0555
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0363 0.0708
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0214 0.1769
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0706 0.1396
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0706 0.1673
Loa Loa (eye worm) hypothetical protein 0.007 0.0681 0.1615
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0121 0.0869
Toxoplasma gondii 3'-5' exonuclease domain-containing protein 0.0024 0.0157 0.0944
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.064 0.1263
Trypanosoma cruzi ribosomal RNA processing protein 6, putative 0.0024 0.0157 0.1215
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.009 0.0912 0.1217
Loa Loa (eye worm) 3'-5' exonuclease 0.0024 0.0157 0.0372
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0074 0.0727 0.1439
Echinococcus multilocularis calpain A 0.0074 0.0727 0.0716
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0121 0.0869
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0128 0.0111
Schistosoma mansoni alpha-glucosidase 0.0153 0.1632 0.3273
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.064 0.1283
Onchocerca volvulus 0.0068 0.0658 0.4471
Brugia malayi MH2 domain containing protein 0.0131 0.1372 0.6531
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.066 0.1324
Brugia malayi hypothetical protein 0.0134 0.1411 0.6718
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0333 0.0399
Trypanosoma brucei DNA polymerase eta, putative 0.007 0.0681 0.6295
Schistosoma mansoni polybromo-1 0.0011 0.0011 0.0022
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.033 0.0319
Schistosoma mansoni bromodomain containing protein 0.0075 0.0736 0.1477
Echinococcus granulosus calpain 5 0.0021 0.0121 0.0221
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0024 0.0157 0.0128
Echinococcus multilocularis hypothetical protein 0.0021 0.0121 0.011
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.005 0.018
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0706 0.653
Brugia malayi Disco-interacting protein 2 homolog 0.0042 0.0363 0.1687
Loa Loa (eye worm) ATP-dependent DNA helicase 0.008 0.0795 0.1885
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0363 0.5461
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0078 0.0066
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0121 0.0243
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.064 0.0629
Loa Loa (eye worm) hypothetical protein 0.0042 0.0361 0.0855
Echinococcus granulosus dnaJ subfamily B 0.0447 0.4986 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0157 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Giardia lamblia DINP protein human, muc B family 0.0042 0.0363 0.4348
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0363 0.3217
Trypanosoma cruzi ISWI complex protein 0.0017 0.0073 0.0401

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 80.08 % Cytotoxicity against human NCI-H522 cells assessed as cell growth level at 10 uM after 48 hrs by sulforhodamine B assay ChEMBL. 25240093

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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