Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Leishmania major | C-8 sterol isomerase-like protein | 0.0378 | 0.6127 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0171 | 0.1668 | 0.1668 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0102 | 0.0168 | 0.0168 |
Schistosoma mansoni | tyrosine kinase | 0.017 | 0.1629 | 0.1629 |
Schistosoma mansoni | tyrosine kinase | 0.017 | 0.1629 | 0.1629 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2138 | 0.2138 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0319 | 0.4856 | 0.4856 |
Brugia malayi | Protein kinase domain containing protein | 0.0102 | 0.0168 | 0.0168 |
Schistosoma mansoni | tyrosine kinase | 0.0319 | 0.4856 | 0.4856 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0319 | 0.4856 | 0.4856 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.017 | 0.1629 | 0.1629 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0171 | 0.1668 | 0.1668 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0378 | 0.6127 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0557 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0378 | 0.6127 | 0.6127 |
Echinococcus multilocularis | 0.0099 | 0.0099 | 0.0099 | |
Schistosoma mansoni | tyrosine kinase | 0.0102 | 0.0168 | 0.0168 |
Schistosoma mansoni | tyrosine kinase | 0.0171 | 0.1668 | 0.1668 |
Schistosoma mansoni | tyrosine kinase | 0.0102 | 0.0168 | 0.0168 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0319 | 0.4856 | 0.4856 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.6127 | 0.6127 |
Echinococcus multilocularis | insulin receptor | 0.0102 | 0.0168 | 0.0168 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0378 | 0.6127 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0171 | 0.1668 | 0.1668 |
Brugia malayi | Carboxylesterase family protein | 0.0557 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0171 | 0.1668 | 0.1668 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0557 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0557 | 1 | 1 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0102 | 0.0168 | 0.0168 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0557 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0557 | 1 | 1 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0319 | 0.4856 | 0.4856 |
Echinococcus granulosus | insulin receptor | 0.0102 | 0.0168 | 0.0168 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0557 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0557 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0102 | 0.0168 | 0.0168 |
Echinococcus granulosus | acetylcholinesterase | 0.0557 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0557 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.11 uM | Inhibition of acetylcholinesterase (unknown origin) assessed as inhibition of acetylcholine hydrolysis after 30 mins by Ellmann's method | ChEMBL. | 25222040 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.