Detailed information for compound 934151

Basic information

Technical information
  • TDR Targets ID: 934151
  • Name: 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chrom en-4-one
  • MW: 372.369 | Formula: C20H20O7
  • H donors: 0 H acceptors: 1 LogP: 3.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c2c(c1)oc(cc2=O)c1cc(OC)c(c(c1)OC)OC
  • InChi: 1S/C20H20O7/c1-22-12-8-15(23-2)19-13(21)10-14(27-16(19)9-12)11-6-17(24-3)20(26-5)18(7-11)25-4/h6-10H,1-5H3
  • InChiKey: GIKVSFNAEBQLGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4-chromenone
  • 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromone
  • 53350-26-8
  • 3',4',5',5,7-Pentamethoxyflavone
  • AIDS122783
  • ST5331680
  • AIDS-122783
  • 4H-1-Benzopyran-4-one, 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0033 0.019 0.0969
Toxoplasma gondii thioredoxin reductase 0.0044 0.028 0.6208
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0509 0.0509
Giardia lamblia Rrm3p helicase 0.1232 1 1
Trypanosoma brucei unspecified product 0.0015 0.0048 0.0002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0013 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.01 0.01
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.1232 1 1
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0951 0.0951
Echinococcus granulosus microtubule associated protein 2 0.0799 0.6455 0.6455
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Trichomonas vaginalis set domain proteins, putative 0.0275 0.2171 0.215
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0017 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.01 0.0739 0.5084
Loa Loa (eye worm) phosphofructokinase 0.0126 0.0951 0.4994
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.01 0.0074
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0006 0.0006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0285 0.0285
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.1898 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0046 0.002
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0046 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0046 0.0787
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.01 0.0054
Toxoplasma gondii exonuclease III APE 0.0022 0.01 0.2128
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0111 0.083 0.5735
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0105 0.0561
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0046 0.0906
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0951 0.0927
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0105 0.0059
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0046 0.0787
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.01 0.0739 0.7373
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0046 0.0046
Trypanosoma brucei unspecified product 0.0022 0.0105 0.0059
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.01
Mycobacterium ulcerans hypothetical protein 0.0184 0.1428 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0096 0.0709 0.0709
Plasmodium falciparum glutathione reductase 0.0044 0.028 1
Brugia malayi Pre-SET motif family protein 0.0242 0.1898 1
Echinococcus granulosus cpg binding protein 0.0035 0.0209 0.0209
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0105 0.0561
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2781 0.2748
Echinococcus granulosus dna polymerase kappa 0.0022 0.0105 0.0105
Schistosoma mansoni ap endonuclease 0.0022 0.01 0.01
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.01 0.0739 0.5084
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0046 0.002
Entamoeba histolytica hypothetical protein 0.0027 0.0143 0.0118
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0194 0.0992
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0025 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2781 0.2748
Plasmodium falciparum thioredoxin reductase 0.0044 0.028 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0211 0.0211
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0046 0.002
Brugia malayi Pre-SET motif family protein 0.0035 0.0211 0.108
Schistosoma mansoni dep domain containing protein 0.001 0.0006 0.0006
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0143 0.6743
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.108
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.02 0.4393
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0285 0.0285
Entamoeba histolytica DNA repair and recombination protein, putative 0.1232 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0105 0.0059
Giardia lamblia DINP protein human, muc B family 0.0022 0.0105 0.0059
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0105 0.0105
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.028 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0105 0.0424
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0046 0.0787
Onchocerca volvulus 0.0275 0.2171 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1232 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.1275 0.1235
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.0951 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0324 0.0279
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0105 0.0059
Onchocerca volvulus 0.0013 0.0026 0.0092
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0006 0.0006
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0143 0.4617
Echinococcus granulosus dna polymerase eta 0.0022 0.0105 0.0105
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1275 0.1252
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.1232 1 1
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0006 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0951 0.0927
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0046 0.0906
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.0739 0.5084
Schistosoma mansoni multidrug resistance protein 0.0013 0.0026 0.0026
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.1232 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0143 0.0098
Echinococcus multilocularis microtubule associated protein 2 0.0799 0.6455 0.6455
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.02 0.4393
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0211 0.0211
Trypanosoma brucei trypanothione reductase 0.0044 0.028 0.0235
Schistosoma mansoni smdr2 0.0013 0.0026 0.0026
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0105 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0106
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0143 0.0704
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0105 0.0521
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0006 0.0006
Onchocerca volvulus 0.0035 0.0211 0.0945
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.028 0.1448
Plasmodium vivax glutathione reductase, putative 0.0044 0.028 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1232 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0448 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0096 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0209 0.1631 0.8588
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0026 0.0026
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0026 0.0106
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.02 0.0174
Schistosoma mansoni regulator of G protein signaling 0.001 0.0006 0.0006
Leishmania major DNA polymerase kappa, putative 0.0022 0.0105 0.0079
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0951 0.4994
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1275 0.1235
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0026 0.0026
Leishmania major trypanothione reductase 0.0044 0.028 0.0255
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.1232 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Brugia malayi CXXC zinc finger family protein 0.0033 0.0194 0.0992
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0105 0.0079
Plasmodium falciparum thioredoxin reductase 0.0015 0.0046 0.0787
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0026 0.0026
Onchocerca volvulus 0.0096 0.0709 0.3248
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0105 0.0521
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.02 0.6846
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.0951 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.01 0.0527
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0105 0.0105
Brugia malayi 6-phosphofructokinase 0.0126 0.0952 0.5
Mycobacterium tuberculosis Probable reductase 0.01 0.0739 0.5084
Trypanosoma brucei mitochondrial DNA polymerase beta 0.035 0.2781 0.2748
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.01 0.0496
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0211 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.1428 1
Trichomonas vaginalis conserved hypothetical protein 0.1232 1 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0046 0.0046
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0046 0.0787
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0324 0.0279
Echinococcus multilocularis dna polymerase eta 0.0022 0.0105 0.0105
Brugia malayi multidrug resistance protein 3 0.0013 0.0026 0.0106
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0209 0.1631 0.7508
Echinococcus multilocularis cpg binding protein 0.0035 0.0209 0.0209
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0951 0.0927
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0111 0.083 0.5735
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.01 0.2911
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0105 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Plasmodium vivax SET domain protein, putative 0.0035 0.0211 0.7261
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0194 0.0194
Schistosoma mansoni multidrug resistance protein 0.0013 0.0026 0.0026
Brugia malayi ABC transporter family protein 0.0013 0.0026 0.0106
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0143 0.4617
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0105 0.0105
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0105 0.0105
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0017 0.0055
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.01 0.0496
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0026 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0048 0.0002
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.0951 0.0951
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0412 0.0368
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.01 0.0054
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.01 0.039
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0951 0.4994
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.01 0.01
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.02 0.1701
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0006 0.0006
Brugia malayi N-terminal motif family protein 0.0209 0.1631 0.8588
Schistosoma mansoni dishevelled 0.001 0.0006 0.0006
Leishmania major mitochondrial DNA polymerase beta 0.035 0.2781 0.2762
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.02 0.6846
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.0739 0.5084
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.02 0.6846
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.01 0.5546
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0111 0.083 0.8502
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0046 0.002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.0739 0.5084
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0143 0.0118
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.02 0.4393
Loa Loa (eye worm) glutathione reductase 0.0044 0.028 0.1448
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0211 0.4632
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0143 1
Brugia malayi glutathione reductase 0.0044 0.028 0.1448
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.028 0.0235
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0105 0.0521
Loa Loa (eye worm) hypothetical protein 0.0022 0.0105 0.0521
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0951 0.0909
Toxoplasma gondii hypothetical protein 0.0056 0.0383 0.8542
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0048 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0046 0.0211
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0951 0.0927
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0026 0.0026
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0025 0.0025
Schistosoma mansoni microtubule-associated protein tau 0.0799 0.6455 0.6455
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0106
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.02 0.0174
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0016 0.0049
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0951 0.0927
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.0951 0.6598
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0105 0.0079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.028 0.1812
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.0951 0.0951
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0006 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.0111 0.083 0.5735
Plasmodium falciparum glutathione reductase 0.0015 0.0046 0.0787
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0951 0.0951
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0211 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Onchocerca volvulus 0.0033 0.0194 0.0868
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.01 0.0074
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.02 0.6846
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0026 0.0106
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Brugia malayi Thioredoxin reductase 0.0044 0.028 0.1448
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0048 0.0002
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0143 0.311
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.019 0.0969
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0105 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.01 0.0074
Leishmania major DNA polymerase eta, putative 0.0022 0.0105 0.0079
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0006 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.01 0.0074
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0143 0.0836
Schistosoma mansoni cpg binding protein 0.0035 0.0209 0.0209
Brugia malayi 6-phosphofructokinase 0.0126 0.0951 0.4994
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0026 0.0026
Schistosoma mansoni multidrug resistance protein 0.0013 0.0026 0.0026
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.0951 0.0927
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1232 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0026 0.0026
Schistosoma mansoni cpg binding protein 0.0035 0.0209 0.0209
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0046 0.0046
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0951 0.0909
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0105 0.0424
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1232 1 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0143 0.0704
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0096 0.0709 0.3715
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0046 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.01 0.0054
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0105 0.0079
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0143 0.1075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0211 0.0211
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0046 0.0143
Loa Loa (eye worm) hypothetical protein 0.0096 0.0709 0.3715
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0951 0.0927
Brugia malayi phosphofructokinase 0.0126 0.0951 0.4994
Brugia malayi Probable ATP-dependent helicase DHX35 0.0033 0.019 0.0969
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.01 0.2911
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0026 0.0453
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0324 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0951 0.0927
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0006 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0211 0.0211
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0105 0.0059
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Echinococcus multilocularis L aminoadipate semialdehyde 0.0096 0.0709 0.0709
Entamoeba histolytica hypothetical protein, conserved 0.1232 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0324 0.0279
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Schistosoma mansoni ap endonuclease 0.0022 0.01 0.01
Schistosoma mansoni dishevelled 0.001 0.0006 0.0006
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.0951 0.6548
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0026 0.0026
Trypanosoma brucei unspecified product 0.0015 0.0048 0.0002
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0046 0.1149
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.01 0.0054
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0026 0.0026
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0006 0.0006
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.02 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.01 0.0596
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.02 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0143 0.311
Schistosoma mansoni cpg binding protein 0.0033 0.0194 0.0194
Schistosoma mansoni DNA polymerase eta 0.0022 0.0105 0.0105
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.02 0.0155
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0017 0.0017
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0013 0.0037
Schistosoma mansoni hypothetical protein 0.1232 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) TP_TRANSPORTER: increase in Rhodamine 123 intracellular accumulation in AML-2/D100 cells ChEMBL. 15240100
IC50 (functional) = 0.4 uM TP_TRANSPORTER: drug resistance (vincristine) in AML-2/D100 cells ChEMBL. 15240100

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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