Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.066 | 0.066 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1248 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1248 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1248 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1248 | 1 | 1 |
Onchocerca volvulus | 0.0157 | 0 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1248 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0634 | 0.4372 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1248 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1248 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1248 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1248 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 18 % | In vitro binding affinity towards human adenosine A2B receptor by [3H]-DPCPX displacement at 10 uM. | ChEMBL. | 12672250 |
Ki (binding) | = 20 nM | In vitro binding affinity towards human adenosine A1 receptor by [3H]-DPCPX displacement. | ChEMBL. | 12672250 |
Ki (binding) | = 81 nM | Inhibition of [125 I]-IABMECA binding to human adenosine A3 receptor | ChEMBL. | 12672250 |
Ki (binding) | = 125 nM | Tested for binding affinity towards human adenosine A2A receptor using [3H]-ZM-241,385 as radioligand | ChEMBL. | 12672250 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.