Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.5375 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.5375 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.5375 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0038 | 0.5375 | 0.5375 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.5375 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.5375 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.5375 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.5375 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.5375 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 100 % | Antileishmanial activity against Leishmania donovani MHOM/IN/Dd8 promastigote carrying firefly luciferase gene infected in mouse J774A1 cells assessed as relative luminescence unit at 40 ug/mL after 72 hrs | ChEMBL. | 20371140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.