Detailed information for compound 934362

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 410.895 | Formula: C19H27ClN4O4
  • H donors: 2 H acceptors: 3 LogP: 1.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C/1\NC(=O)N(C1=O)CC(CN1CCN(CC1)C)O.Cl
  • InChi: 1S/C19H26N4O4.ClH/c1-21-7-9-22(10-8-21)12-15(24)13-23-18(25)17(20-19(23)26)11-14-3-5-16(27-2)6-4-14;/h3-6,11,15,24H,7-10,12-13H2,1-2H3,(H,20,26);1H/b17-11-;
  • InChiKey: XEHCLXLWUICHFO-CULRIWENSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0106 0.1536
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0018 0.0018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0012 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0044 0.0046
Echinococcus granulosus endoplasmin 0.0026 0.0106 0.0113
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0118 0.0164
Brugia malayi nuclear receptor NHR-88 0.002 0.0044 0.0067
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0063 0.0062
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0099 0.1427
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0018 0.0239
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0351 0.0973
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0044 0.0049
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.4932 0.4931
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0212 0.2165 0.3331
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0049
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0685 0.4889
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0212 0.2165 0.2164
Trypanosoma brucei beta lactamase 0.0295 0.3074 0.8553
Brugia malayi hypothetical protein 0.0143 0.1399 0.2152
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0044 0.0042
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0685 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1113 0.1697
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0212 0.2165 0.3318
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0018 0.0045
Entamoeba histolytica hypothetical protein 0.0042 0.0284 0.1148
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.1606 0.4467
Echinococcus multilocularis heat shock protein 90 0.0026 0.0106 0.0105
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0179 0.0496
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0427 0.0639
Trichomonas vaginalis glucosylceramidase, putative 0.0605 0.65 1
Leishmania major trypanothione reductase 0.0047 0.0343 0.0951
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Leishmania major mitochondrial DNA polymerase beta 0.0342 0.3594 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0012 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0044 0.0067
Plasmodium falciparum thioredoxin reductase 0.0047 0.0343 0.2444
Loa Loa (eye worm) hypothetical protein 0.0175 0.1757 0.2689
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0044 0.0046
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0044 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.3594 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0063 0.0066
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0016
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0685 0.1036
Schistosoma mansoni ap endonuclease 0.0022 0.0063 0.0066
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0018 0.0008
Schistosoma mansoni microtubule-associated protein tau 0.0691 0.7448 0.8039
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0343 0.051
Schistosoma mansoni polycystin 1-related 0.0143 0.1399 0.1509
Trypanosoma brucei heat shock protein, putative 0.0033 0.0179 0.0496
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0029 0.0145 0.1026
Brugia malayi glutathione reductase 0.0047 0.0343 0.0527
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Onchocerca volvulus 0.0027 0.0118 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.0418 0.4439 0.6829
Echinococcus granulosus lamin 0.0027 0.0118 0.0126
Trichomonas vaginalis glucosylceramidase, putative 0.0418 0.4439 0.6829
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0685 0.4889
Schistosoma mansoni hypothetical protein 0.0038 0.0235 0.0252
Brugia malayi Doublecortin family protein 0.0143 0.1399 0.2152
Toxoplasma gondii hypothetical protein 0.0055 0.0429 0.6258
Mycobacterium ulcerans lipoprotein LpqF 0.0295 0.3074 0.4657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0212 0.2165 0.2336
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0018 0.0016
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0685 0.1948
Trichomonas vaginalis endoplasmin, putative 0.002 0.0041 0.006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0343 0.0518
Schistosoma mansoni lamin 0.0027 0.0118 0.0126
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0284 0.0283
Echinococcus multilocularis geminin 0.0577 0.6196 0.6195
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1145 0.3501
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0387 0.0584
Echinococcus granulosus RUN 0.0143 0.1399 0.1509
Trypanosoma brucei heat shock protein, putative 0.0033 0.0179 0.0496
Trypanosoma brucei RNA helicase, putative 0.028 0.2908 0.809
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0118 0.0835
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0284 0.0306
Plasmodium falciparum LCCL domain-containing protein 0.0143 0.1399 1
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0179 0.0496
Schistosoma mansoni heat shock protein 0.0033 0.0179 0.0192
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.1012 0.3053
Loa Loa (eye worm) hypothetical protein 0.0055 0.0427 0.0639
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0049
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1012 0.1532
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0044 0.0046
Loa Loa (eye worm) hypothetical protein 0.0143 0.1399 0.2138
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0179 0.0496
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0044 0.0046
Brugia malayi isocitrate dehydrogenase 0.0018 0.0018 0.0027
Schistosoma mansoni endoplasmin 0.0033 0.0179 0.0192
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0343 0.0951
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0397 0.4203 0.6465
Onchocerca volvulus Huntingtin homolog 0.0123 0.1174 0.2718
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0134
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0018 0.0117
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0118 0.0039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0343 0.0342
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0044 0.0042
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0106 0.0162
Echinococcus multilocularis heat shock protein 90 0.0033 0.0179 0.0178
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0018 0.0025
Toxoplasma gondii hypothetical protein 0.0027 0.0118 0.1708
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0044 0.0046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0044 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0145 0.0399
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0044 0.0067
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0063 0.0095
Loa Loa (eye worm) hypothetical protein 0.0143 0.1399 0.2138
Plasmodium falciparum cysteine repeat modular protein 1 0.0029 0.0145 0.1026
Brugia malayi photoreceptor-specific nuclear receptor 0.0257 0.2653 0.4081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0155
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0179 0.0496
Echinococcus granulosus microtubule associated protein 2 0.0691 0.7448 0.8039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0235 0.0343
Loa Loa (eye worm) hypothetical protein 0.0078 0.0685 0.1036
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0044 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0049
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0605 0.65 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0179 0.0496
Echinococcus multilocularis musashi 0.0027 0.0118 0.0117
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0179 0.0496
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0016
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0179 0.1275
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.1606 0.4467
Schistosoma mansoni lipoxygenase 0.0598 0.6423 0.6932
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0044 0.0046
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1012 0.1532
Schistosoma mansoni hypothetical protein 0.0042 0.0284 0.0306
Echinococcus granulosus heat shock protein 90 0.0033 0.0179 0.0192
Brugia malayi Probable ClpP-like protease 0.0078 0.0685 0.1053
Mycobacterium tuberculosis Probable reductase 0.0108 0.1012 0.1532
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0044 0.0067
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0685 0.0738
Brugia malayi hypothetical protein 0.0042 0.0284 0.0437
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0197 0.1993 1
Loa Loa (eye worm) glutathione reductase 0.0047 0.0343 0.051
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0044 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0099 0.0698
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0018 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0044 0.0067
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0018 0.0045
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0018 0.0117
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0204
Plasmodium falciparum heat shock protein 90 0.0033 0.0179 0.1275
Brugia malayi heat shock protein 90 0.0033 0.0179 0.0276
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0351 0.0973
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0387 0.0416
Brugia malayi hypothetical protein 0.0123 0.1174 0.1807
Schistosoma mansoni nuclear hormone receptor 0.002 0.0044 0.0046
Echinococcus multilocularis RUN 0.0143 0.1399 0.1398
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1012 0.1532
Schistosoma mansoni lipoxygenase 0.0855 0.9265 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0179 0.0496
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.4932 0.5323
Echinococcus granulosus heat shock protein 90 0.0026 0.0106 0.0113
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Trichomonas vaginalis glucosylceramidase, putative 0.0605 0.65 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0044 0.0049
Echinococcus granulosus neuropeptide s receptor 0.0463 0.4932 0.5323
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0049
Plasmodium vivax glutathione reductase, putative 0.0047 0.0343 0.2444
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Schistosoma mansoni ap endonuclease 0.0022 0.0063 0.0066
Loa Loa (eye worm) hypothetical protein 0.0197 0.1993 0.3052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0044 0.0067
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1012 0.1532
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0044 0.0067
Giardia lamblia Grp94/Hsp90 0.0026 0.0106 0.5893
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0012 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0605 0.65 1
Trichomonas vaginalis glucosylceramidase, putative 0.0605 0.65 1
Onchocerca volvulus 0.0143 0.1399 0.3258
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0044 0.0067
Echinococcus multilocularis muscleblind protein 0.0175 0.1757 0.1756
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0467 0.1296
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0018 0.0027
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0685 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.1174 0.1791
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0855 0.9265 0.9264
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0685 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.1174 0.2718
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0179 0.0274
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0032 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0605 0.65 1
Brugia malayi ecdysteroid receptor 0.002 0.0044 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0212 0.2165 0.2336
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0685 0.0683
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0106 0.0292
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0018 0.0045
Plasmodium falciparum glutathione reductase 0.0047 0.0343 0.2444
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0063 0.044
Schistosoma mansoni heat shock protein 0.0033 0.0179 0.0192
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0106 0.0113
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0012 0.0012
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1145 0.1734
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0106 0.0162
Treponema pallidum heat shock protein 90 0.0026 0.0106 0.1536
Trypanosoma brucei heat shock protein, putative 0.0033 0.0179 0.0496
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1145 0.1734
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0179 0.0604
Echinococcus multilocularis GPCR, family 2 0.0017 0.0012 0.0011
Brugia malayi Muscleblind-like protein 0.0175 0.1757 0.2702
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0044 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0044 0.0067
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0179 0.0496
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0427 0.0657
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0099 0.0698
Loa Loa (eye worm) doublecortin family protein 0.0143 0.1399 0.2138
Echinococcus granulosus Polycystic kidney disease protein 0.0143 0.1399 0.1509
Loa Loa (eye worm) hypothetical protein 0.0175 0.1757 0.2689
Echinococcus multilocularis endoplasmin 0.0026 0.0106 0.0105
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0343 0.2444
Trichomonas vaginalis glucosylceramidase, putative 0.0397 0.4203 0.6465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0044 0.0049
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0063 0.0097
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0118 0.0164
Schistosoma mansoni hypothetical protein 0.028 0.2908 0.3138
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0012 0.0011
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0099 0.0271
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0284 0.0306
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0012 0.0019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1145 0.1734
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0099 0.0698
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0197 0.1993 1
Onchocerca volvulus 0.0029 0.0145 0.0243
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0001 0.0002
Plasmodium falciparum endoplasmin, putative 0.002 0.0041 0.0281
Trypanosoma brucei heat shock protein, putative 0.0033 0.0179 0.0496
Schistosoma mansoni hypothetical protein 0.0143 0.1399 0.1509
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0044 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0397 0.4203 0.6465
Loa Loa (eye worm) endoplasmin 0.0033 0.0179 0.0258
Schistosoma mansoni rab6-interacting 0.0143 0.1399 0.1509
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0044 0.0046
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.4932 0.4931
Brugia malayi hypothetical protein 0.0143 0.1399 0.2152
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0049
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0044 0.0046
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0614 0.66 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0179 0.0496
Toxoplasma gondii thioredoxin reductase 0.0047 0.0343 0.4999
Brugia malayi MH2 domain containing protein 0.0117 0.1113 0.1712
Echinococcus multilocularis muscleblind protein 1 0.0175 0.1757 0.1756
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0044 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0397 0.4203 0.6465
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0018 0.0239
Brugia malayi Endoplasmin precursor 0.0033 0.0179 0.0276
Echinococcus multilocularis lipoxygenase domain containing protein 0.0143 0.1399 0.1398
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0614 0.66 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0118 0.1708
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0605 0.65 1
Trichomonas vaginalis glucosylceramidase, putative 0.0397 0.4203 0.6465
Leishmania major hypothetical protein, conserved 0.0029 0.0145 0.0399
Schistosoma mansoni loxhd1 0.0143 0.1399 0.1509
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0044 0.0049
Echinococcus granulosus heat shock protein 0.0033 0.0179 0.0192
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0044 0.0046
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0099 0.0271
Echinococcus granulosus lamin dm0 0.0027 0.0118 0.0126
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0063 0.0171
Trypanosoma brucei heat shock protein, putative 0.0033 0.0179 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0212 0.2165 0.2336
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0044 0.0067
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0106 0.0292
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0342 0.3594 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0044 0.0046
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0685 0.0738
Plasmodium vivax endoplasmin, putative 0.0033 0.0179 0.1275
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0387 0.0584
Onchocerca volvulus 0.0143 0.1399 0.3258
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0063 0.0171
Echinococcus granulosus GPCR family 2 0.0017 0.0012 0.0012
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0295 0.3074 1
Brugia malayi hypothetical protein 0.0025 0.0099 0.0152
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0106 0.0292
Onchocerca volvulus 0.0027 0.0118 0.0179
Brugia malayi intermediate filament protein 0.0027 0.0118 0.0182
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0044 0.0046
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0343 0.0369
Echinococcus multilocularis microtubule associated protein 2 0.0691 0.7448 0.7448
Schistosoma mansoni lamin 0.0027 0.0118 0.0126
Schistosoma mansoni thyroid hormone receptor 0.002 0.0044 0.0046
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Schistosoma mansoni intermediate filament proteins 0.0027 0.0118 0.0126
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0351 0.0973
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0063 0.0171
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0179 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0044 0.0049
Echinococcus granulosus tissue type plasminogen activator 0.0029 0.0145 0.0155
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0018 0.0045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0063 0.0171
Mycobacterium tuberculosis Conserved hypothetical protein 0.018 0.1808 0.2738
Trichomonas vaginalis glucosylceramidase, putative 0.0397 0.4203 0.6465
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0063 0.0078
Entamoeba histolytica hypothetical protein 0.0042 0.0284 0.1148
Schistosoma mansoni rab6-interacting 0.0143 0.1399 0.1509
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0049
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0387 0.0945
Schistosoma mansoni coup transcription factor 0.002 0.0044 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0212 0.2165 0.2336
Trichomonas vaginalis glucosylceramidase, putative 0.0605 0.65 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0685 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0044 0.0067
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0179 0.0496
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0685 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0044 0.0067
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0118 0.0182
Schistosoma mansoni thyroid hormone receptor 0.002 0.0044 0.0046
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0063 0.3454
Brugia malayi Protein kinase domain containing protein 0.0029 0.0145 0.0223
Echinococcus granulosus intermediate filament protein 0.0027 0.0118 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0044 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0044 0.0042
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0106 0.0159
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0118 0.0835
Toxoplasma gondii exonuclease III APE 0.0022 0.0063 0.0901
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0044 0.0049
Trichomonas vaginalis glucosylceramidase, putative 0.0397 0.4203 0.6465
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.1606 0.4467
Loa Loa (eye worm) hypothetical protein 0.0123 0.1174 0.1791
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0044 0.0067
Loa Loa (eye worm) hypothetical protein 0.0257 0.2653 0.407
Echinococcus granulosus muscleblind protein 0.0175 0.1757 0.1895
Plasmodium vivax multidomain scavenger receptor, putative 0.0143 0.1399 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0106 0.0159
Echinococcus granulosus FTZ F1 alpha 0.002 0.0044 0.0046
Echinococcus granulosus lipoxygenase domain containing protein 0.0143 0.1399 0.1509
Echinococcus multilocularis heat shock protein 0.0033 0.0179 0.0178
Schistosoma mansoni hypothetical protein 0.0577 0.6196 0.6687
Echinococcus granulosus lipoxygenase domain containing protein 0.0143 0.1399 0.1509
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0427 0.0657
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0044 0.0046
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0018 0.0045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0063 0.0093
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1113 0.1697
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0044 0.0042
Schistosoma mansoni hypothetical protein 0.0577 0.6196 0.6687
Entamoeba histolytica hypothetical protein 0.0042 0.0284 0.1148
Brugia malayi Kringle domain containing protein 0.0029 0.0145 0.0223
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0179 0.0604
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0164
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.018 0.1808 0.2738
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0106 0.5893
Echinococcus multilocularis Polycystic kidney disease protein 0.0143 0.1399 0.1398
Trypanosoma brucei trypanothione reductase 0.0047 0.0343 0.0951
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0044 0.0042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1012 0.1532
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0179 0.2607
Trypanosoma brucei heat shock protein, putative 0.0033 0.0179 0.0496
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0295 0.3074 0.4657
Brugia malayi Thioredoxin reductase 0.0047 0.0343 0.0527
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0063 0.044
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0018
Onchocerca volvulus Glucosylceramidase homolog 0.0397 0.4203 1
Brugia malayi steroid hormone receptor 0.002 0.0044 0.0067
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0235 0.0361
Schistosoma mansoni endoplasmin 0.0033 0.0179 0.0192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0212 0.2165 0.2336
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0044 0.0046
Loa Loa (eye worm) TK/ROR protein kinase 0.0029 0.0145 0.0204
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0044 0.0042
Echinococcus multilocularis lamin dm0 0.0027 0.0118 0.0117
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0063 0.0901
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0351 0.0973
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0179 0.2607
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0685 0.1036
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0179 0.0258
Trichomonas vaginalis heat shock protein, putative 0.002 0.0041 0.006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0044 0.0046
Echinococcus granulosus geminin 0.0577 0.6196 0.6687
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0044 0.0067
Leishmania major hypothetical protein, conserved 0.0025 0.0099 0.0271
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0099 0.0271
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.3594 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0143 0.1399 0.1398
Entamoeba histolytica hypothetical protein 0.0042 0.0284 0.1148
Leishmania major heat shock protein 83-1 0.0033 0.0179 0.0496
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0155
Brugia malayi nuclear hormone receptor 0.002 0.0044 0.0067
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0063 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0044 0.0067
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0387 0.0386
Echinococcus multilocularis tissue type plasminogen activator 0.0029 0.0145 0.0143
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0063 0.0093
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0044 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0212 0.2165 0.2164
Toxoplasma gondii kringle domain-containing protein 0.0029 0.0145 0.21
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0685 1
Echinococcus multilocularis lamin 0.0027 0.0118 0.0117
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0063 0.0901
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0855 0.9265 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0106 0.0162

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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