Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.037 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1188 | 0.1188 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.037 | 0.1188 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.037 | 0.1188 | 0.1188 |
Brugia malayi | Carboxylesterase family protein | 0.2188 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0274 | 0.0723 | 0.0723 |
Schistosoma mansoni | tyrosine kinase | 0.0274 | 0.0723 | 0.0723 |
Echinococcus granulosus | neuroligin | 0.037 | 0.1188 | 0.1188 |
Brugia malayi | Protein kinase domain containing protein | 0.0151 | 0.013 | 0.013 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2188 | 1 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0274 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.2188 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2188 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2188 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2188 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.037 | 0.1188 | 0.1188 |
Echinococcus multilocularis | acetylcholinesterase | 0.2188 | 1 | 1 |
Onchocerca volvulus | 0.037 | 0.1188 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.037 | 0.1188 | 0.1188 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | carboxylesterase | 0.037 | 0.1188 | 0.1188 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.037 | 0.1188 | 0.1188 |
Schistosoma mansoni | tyrosine kinase | 0.0274 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.012 | 0.012 |
Echinococcus multilocularis | insulin receptor | 0.0274 | 0.0723 | 0.0723 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.037 | 0.1188 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.037 | 0.1188 | 0.1188 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.037 | 0.1188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2188 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.037 | 0.1188 | 0.1188 |
Echinococcus multilocularis | acetylcholinesterase | 0.2188 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2188 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.037 | 0.1188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1188 | 0.1188 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.037 | 0.1188 | 0.1188 |
Schistosoma mansoni | gliotactin | 0.037 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1188 | 0.1188 |
Schistosoma mansoni | acetylcholinesterase | 0.037 | 0.1188 | 0.1188 |
Onchocerca volvulus | 0.037 | 0.1188 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1188 | 0.1188 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0274 | 0.0723 | 0.0723 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.037 | 0.1188 | 0.1188 |
Echinococcus granulosus | insulin receptor | 0.0274 | 0.0723 | 0.0723 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0274 | 0.0723 | 0.0723 |
Brugia malayi | Carboxylesterase family protein | 0.037 | 0.1188 | 0.1188 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.037 | 0.1188 | 0.1188 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.037 | 0.1188 | 0.1188 |
Echinococcus granulosus | BC026374 protein S09 family | 0.037 | 0.1188 | 0.1188 |
Brugia malayi | hypothetical protein | 0.037 | 0.1188 | 0.1188 |
Onchocerca volvulus | 0.037 | 0.1188 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | carboxylesterase | 0.037 | 0.1188 | 0.1188 |
Onchocerca volvulus | 0.037 | 0.1188 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.037 | 0.1188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1188 | 0.1188 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.037 | 0.1188 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.037 | 0.1188 | 0.1188 |
Brugia malayi | Carboxylesterase family protein | 0.037 | 0.1188 | 0.1188 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.037 | 0.1188 | 0.1188 |
Onchocerca volvulus | 0.037 | 0.1188 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1287 nM | Agonist activity at human S1P1 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay | ChEMBL. | 25072873 |
EC50 (binding) | > 5000 nM | Agonist activity at human S1P3 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay | ChEMBL. | 25072873 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.