Detailed information for compound 934646

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 614.137 | Formula: C33H36ClN7O3
  • H donors: 0 H acceptors: 4 LogP: 4.48 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)c1nc(nnc1c1ccc(cc1)OC)N1CCN(CC1)C(=O)CN1CCN(CC1)c1ccc(cc1)Cl
  • InChi: 1S/C33H36ClN7O3/c1-43-28-11-3-24(4-12-28)31-32(25-5-13-29(44-2)14-6-25)36-37-33(35-31)41-21-19-40(20-22-41)30(42)23-38-15-17-39(18-16-38)27-9-7-26(34)8-10-27/h3-14H,15-23H2,1-2H3
  • InChiKey: ATKCICUHWIRZCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0053 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0574 0.0565
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0076 0.0612 0.0603
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0075 0.06 0.2767
Brugia malayi MH1 domain containing protein 0.002 0.0093 0.0263
Echinococcus granulosus lamin dm0 0.0021 0.01 0.0091
Loa Loa (eye worm) CXXC zinc finger family protein 0.0045 0.0325 0.05
Leishmania major exosome subunit rrp6p homologue, putative 0.0044 0.0315 0.1822
Schistosoma mansoni single-minded 0.0012 0.0013 0.0004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0229 0.0687
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0241 0.2137 1
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0044 0.0315 0.1504
Echinococcus multilocularis geminin 0.0424 0.3831 0.3825
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1974 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.079 0.3511
Onchocerca volvulus 0.0035 0.0229 0.108
Brugia malayi 3'-5' exonuclease family protein 0.0044 0.0315 0.0957
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0053 0.0044
Onchocerca volvulus 0.0039 0.0266 0.1312
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0053 0.0044
Echinococcus multilocularis bloom syndrome protein 0.0356 0.3207 0.32
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0229 0.1061
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0147 0.1268 0.5965
Schistosoma mansoni tar DNA-binding protein 0.005 0.0372 0.0364
Schistosoma mansoni survival motor neuron protein 0.0038 0.0261 0.0252
Schistosoma mansoni hypothetical protein 0.0646 0.5888 0.5885
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0229 0.0979
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.079 0.0782
Brugia malayi hypothetical protein 0.0039 0.0266 0.0805
Schistosoma mansoni patched 1 0.0041 0.0285 0.0276
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0.0013 0.5
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0285 0.0276
Mycobacterium leprae conserved hypothetical protein 0.0044 0.0315 1
Echinococcus multilocularis Smad4 0.002 0.0093 0.0084
Schistosoma mansoni hypothetical protein 0.0076 0.0612 0.0603
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0019 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0285 0.0888
Loa Loa (eye worm) hypothetical protein 0.0693 0.633 1
Schistosoma mansoni tar DNA-binding protein 0.005 0.0372 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0053 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0306 0.0954
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0053 0.0069
Onchocerca volvulus Huntingtin homolog 0.0098 0.0809 0.4645
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0285 0.0436
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.00000000056203 0.0000000017527
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0028 0.0163 0.0483
Brugia malayi beta-lactamase family protein 0.0035 0.0229 0.0687
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0072 0.0574 0.0894
Schistosoma mansoni hypothetical protein 0.0064 0.0495 0.0486
Onchocerca volvulus 0.0192 0.1681 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.019 0.1669 1
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0053 0.0044
Schistosoma mansoni lamin 0.0021 0.01 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0053 0.0069
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0086 0.0703 0.2172
Echinococcus granulosus transcription factor eb 0.0086 0.0703 0.0695
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.117 0.1162
Toxoplasma gondii histone lysine methyltransferase SET1 0.0086 0.0701 0.3251
Schistosoma mansoni intermediate filament proteins 0.0021 0.01 0.0091
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0495 0.0486
Echinococcus multilocularis lamin 0.0021 0.01 0.0091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0495 0.0769
Loa Loa (eye worm) TAR-binding protein 0.005 0.0372 0.0575
Loa Loa (eye worm) hypothetical protein 0.0201 0.177 0.2787
Schistosoma mansoni hypothetical protein 0.0019 0.0085 0.0076
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0053 0.0044
Echinococcus granulosus apoptotic protease activating factor 1 0.0025 0.0133 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0574 0.0565
Brugia malayi ecdysteroid receptor 0.0016 0.0053 0.0136
Brugia malayi CHE-14 protein 0.0041 0.0285 0.0862
Brugia malayi RNA binding protein 0.005 0.0372 0.1136
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.079 0.0782
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0013 0.0042
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0053 0.0044
Onchocerca volvulus Huntingtin homolog 0.0098 0.0809 0.4645
Schistosoma mansoni smad 0.002 0.0093 0.0084
Brugia malayi intermediate filament protein 0.0021 0.01 0.0285
Leishmania major hypothetical protein, conserved 0.0035 0.0229 0.13
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0053 0.0136
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.0021 0.002
Echinococcus multilocularis apoptotic protease activating factor 1 0.0025 0.0133 0.0124
Schistosoma mansoni hypothetical protein 0.0229 0.2032 0.2024
Schistosoma mansoni hypothetical protein 0.004 0.0271 0.0262
Schistosoma mansoni hypothetical protein 0.004 0.0271 0.0262
Schistosoma mansoni hypothetical protein 0.0064 0.0495 0.0486
Loa Loa (eye worm) hypothetical protein 0.0041 0.0285 0.0436
Loa Loa (eye worm) pax transcription factor protein 2 0.0192 0.1681 0.2646
Loa Loa (eye worm) RNA binding protein 0.005 0.0372 0.0575
Schistosoma mansoni TGF-beta signal transducer Smad2 0.002 0.0093 0.0084
Echinococcus multilocularis aryl hydrocarbon receptor 0.004 0.0272 0.0263
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0574 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0053 0.0136
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0235
Echinococcus granulosus smad 0.002 0.0093 0.0084
Brugia malayi TAR-binding protein 0.005 0.0372 0.1136
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0013 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0033 0.0075
Schistosoma mansoni microtubule-associated protein tau 0.1089 1 1
Brugia malayi hypothetical protein 0.0025 0.0133 0.0387
Schistosoma mansoni hypothetical protein 0.0064 0.0495 0.0486
Trichomonas vaginalis esterase, putative 0.0035 0.0229 0.0713
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0028 0.0163 0.0244
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0053 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0053 0.0136
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0235
Loa Loa (eye worm) transcription factor SMAD2 0.0298 0.2671 0.4211
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.177 0.5508
Echinococcus granulosus tar DNA binding protein 0.005 0.0372 0.0364
Entamoeba histolytica recQ family helicase, putative 0.0072 0.0573 0.1907
Schistosoma mansoni hypothetical protein 0.0064 0.0495 0.0486
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0229 0.0347
Loa Loa (eye worm) MH2 domain-containing protein 0.0298 0.2671 0.4211
Echinococcus granulosus TGF beta signal transducer SmadC 0.002 0.0093 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.00000000056203 0.0000000017527
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0013 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0229 0.0713
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0028 0.0163 0.0483
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0053 0.0044
Schistosoma mansoni Smad4 0.002 0.0093 0.0084
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0028 0.0163 0.0154
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0035 0.0026
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0035 0.0026
Echinococcus multilocularis protein dispatched 1 0.0047 0.0339 0.033
Schistosoma mansoni tar DNA-binding protein 0.005 0.0372 0.0364
Entamoeba histolytica recQ family DNA helicase 0.0075 0.06 0.2102
Schistosoma mansoni hypothetical protein 0.004 0.0271 0.0262
Brugia malayi Bloom's syndrome protein homolog 0.0356 0.3207 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0347
Mycobacterium ulcerans ATP-dependent DNA helicase II UvrD2 0.0043 0.0306 0.8935
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0013 0.0042
Echinococcus multilocularis musashi 0.0021 0.01 0.0091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.00000000056203 0.0000000017527
Loa Loa (eye worm) hypothetical protein 0.0076 0.0612 0.0954
Loa Loa (eye worm) hypothetical protein 0.0147 0.1268 0.1992
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.01 0.0285
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0013 0.0042
Echinococcus granulosus dnaJ subfamily B 0.0646 0.5888 0.5885
Brugia malayi MH2 domain containing protein 0.0298 0.2671 0.8324
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0229 0.022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0053 0.0044
Loa Loa (eye worm) Smad1 0.002 0.0093 0.0133
Trypanosoma brucei ribosomal RNA processing protein 6 0.0044 0.0315 0.1782
Brugia malayi CXXC zinc finger family protein 0.0045 0.0325 0.0988
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0147 0.1268 0.1992
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0235
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0069
Echinococcus multilocularis transcription factor eb 0.0086 0.0703 0.0695
Mycobacterium ulcerans hypothetical protein 0.0044 0.0315 1
Brugia malayi PAS domain containing protein 0.0012 0.0013 0.0014
Mycobacterium tuberculosis Conserved protein 0.0035 0.0229 0.1061
Schistosoma mansoni hypothetical protein 0.0138 0.118 0.1172
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.0042
Echinococcus granulosus geminin 0.0424 0.3831 0.3825
Loa Loa (eye worm) hypothetical protein 0.0096 0.079 0.1236
Echinococcus granulosus aryl hydrocarbon receptor 0.004 0.0272 0.0263
Mycobacterium tuberculosis Probable ATP-dependent DNA helicase II UvrD2 0.0043 0.0306 0.1457
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0053 0.0044
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0053 0.0044
Onchocerca volvulus 0.0021 0.01 0.0292
Echinococcus granulosus X box binding protein 1 0.0229 0.2032 0.2024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0053 0.0044
Toxoplasma gondii ABC1 family protein 0.0035 0.0229 0.0992
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0147 0.1268 0.126
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0229 0.0713
Echinococcus granulosus GPCR family 2 0.0064 0.0495 0.0486
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0147 0.1268 0.3937
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0053 0.0044
Brugia malayi Cell death protein 3 precursor 0.0025 0.0133 0.0387
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.177 0.5508
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0495 0.152
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0019 0.001
Brugia malayi nuclear hormone receptor 0.0016 0.0053 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0053 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0053 0.0136
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0147 0.1268 0.3937
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.0042
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0093 0.0133
Onchocerca volvulus Cell death protein 3 homolog 0.0025 0.0133 0.0493
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0076 0.0612 0.0603
Onchocerca volvulus 0.0025 0.0133 0.0493
Brugia malayi hypothetical protein 0.0098 0.0809 0.2502
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0021 0.0049
Brugia malayi hypothetical protein 0.0188 0.165 0.5133
Echinococcus granulosus lamin 0.0021 0.01 0.0091
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0075 0.06 0.3541
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.00000000056203 0.0000000017527
Schistosoma mansoni apoptosis regulator bax 0.0076 0.0612 0.0603
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0053 0.0136
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0013 0.0021 0.0049
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0229 0.1061
Echinococcus multilocularis dnaJ subfamily B 0.0646 0.5888 0.5885
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0229 0.1061
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0035 0.0041
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.019 0.1669 1
Brugia malayi hypothetical protein 0.0027 0.0158 0.0465
Schistosoma mansoni tar DNA-binding protein 0.005 0.0372 0.0364
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.00000000056203 0.0000000017527
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0229 0.1258
Brugia malayi Pax transcription factor protein 2 0.0192 0.1681 0.523
Schistosoma mansoni hypothetical protein 0.0076 0.0612 0.0603
Echinococcus multilocularis smad 0.002 0.0093 0.0084
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0076 0.0612 0.0603
Treponema pallidum ATP-dependent DNA helicase 0.0075 0.06 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0053 0.0136
Plasmodium vivax exosome complex exonuclease RRP6, putative 0.0044 0.0315 0.1387
Loa Loa (eye worm) hypothetical protein 0.0025 0.0133 0.0196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0347
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0285 0.0276
Echinococcus granulosus expressed conserved protein 0.009 0.0737 0.0728
Echinococcus multilocularis cpg binding protein 0.0048 0.0349 0.034
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.0021 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0133 0.0196
Toxoplasma gondii 3'-5' exonuclease domain-containing protein 0.0044 0.0315 0.1405
Brugia malayi isocitrate dehydrogenase 0.0013 0.0021 0.0039
Schistosoma mansoni smad1 5 8 and 0.002 0.0093 0.0084
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0285 0.0276
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.117 0.1162
Brugia malayi nuclear receptor NHR-88 0.0016 0.0053 0.0136
Echinococcus multilocularis caspase 2 0.0025 0.0133 0.0124
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0053 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0139
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.01 0.0144
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0306 0.1021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0038 0.0261 0.0788
Schistosoma mansoni hypothetical protein 0.0038 0.0261 0.0252
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0053 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.177 0.2787
Echinococcus multilocularis X box binding protein 1 0.0229 0.2032 0.2024
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0229 0.0713
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0053 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0053 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0574 0.0565
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0229 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0053 0.0136
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0053 0.0044
Schistosoma mansoni cpg binding protein 0.0045 0.0325 0.0316
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0147 0.1268 0.126
Brugia malayi beta-lactamase family protein 0.0035 0.0229 0.0687
Schistosoma mansoni hypothetical protein 0.0025 0.0133 0.0124
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0076 0.0612 0.1886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0053 0.0069
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0013 0.0042
Loa Loa (eye worm) hypothetical protein 0.0188 0.165 0.2597
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0013 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0306 0.1344
Schistosoma mansoni lamin 0.0021 0.01 0.0091
Loa Loa (eye worm) RecQ helicase 0.0356 0.3207 0.5059
Schistosoma mansoni smad1 5 8 and 0.002 0.0093 0.0084
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0053 0.0044
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0147 0.1268 0.126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0574 0.0565
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0804 0.0796
Echinococcus multilocularis TGF beta signal transducer SmadC 0.002 0.0093 0.0084
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0235
Schistosoma mansoni polymyositis/scleroderma autoantigen-related 0.0044 0.0315 0.0306
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0229 0.1061
Echinococcus granulosus survival motor neuron protein 1 0.0188 0.165 0.1643
Echinococcus multilocularis Helicase RNase D C terminal, HRDC domain 0.0044 0.0315 0.0306
Trichomonas vaginalis DNA helicase recq, putative 0.0356 0.3207 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0347
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0313 0.2806 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0646 0.5891 0.5887
Brugia malayi beta-lactamase 0.0035 0.0229 0.0687
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0021 0.0012
Schistosoma mansoni coup transcription factor 0.0016 0.0053 0.0044
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0053 0.0044
Loa Loa (eye worm) hypothetical protein 0.0138 0.118 0.1853
Echinococcus multilocularis lamin dm0 0.0021 0.01 0.0091
Schistosoma mansoni tar DNA-binding protein 0.005 0.0372 0.0364
Schistosoma mansoni cpg binding protein 0.0048 0.0349 0.034
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0229 0.13
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0053 0.0044
Onchocerca volvulus 0.0045 0.0325 0.1672
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0495 0.0486
Onchocerca volvulus 0.0035 0.0229 0.108
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.0021 0.0012
Onchocerca volvulus Protein cycle homolog 0.0028 0.0163 0.068
Brugia malayi RNA recognition motif domain containing protein 0.005 0.0372 0.1136
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.005 0.0372 0.0575
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.118 0.3662
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0229 0.1061
Schistosoma mansoni hypothetical protein 0.0076 0.0612 0.0603
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0096 0.0796 0.0788
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0053 0.0136
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0069
Brugia malayi Smad1 0.002 0.0093 0.0263
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0229 0.7137
Loa Loa (eye worm) hypothetical protein 0.0075 0.06 0.0934
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0053 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0069
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0093 0.0133
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0495 0.0486
Mycobacterium leprae Probable lipase LipE 0.0035 0.0229 0.7137
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0147 0.1268 0.126
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.0021 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0574 0.0565
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.00000000056203 0.0000000017527
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0069
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0053 0.0044
Echinococcus multilocularis GPCR, family 2 0.0064 0.0495 0.0486
Entamoeba histolytica recQ family helicase, putative 0.019 0.1669 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0053 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0053 0.0136
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0229 0.022
Trichomonas vaginalis DNA helicase recq, putative 0.019 0.1669 0.5204
Schistosoma mansoni hypothetical protein 0.004 0.0271 0.0262
Echinococcus granulosus Helicase RNase D C terminal HRDC domain 0.0044 0.0315 0.0306
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0053 0.0044
Mycobacterium tuberculosis Conserved protein 0.0035 0.0229 0.1061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0053 0.0044
Loa Loa (eye worm) intermediate filament protein 0.0021 0.01 0.0144
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0229 0.0713
Schistosoma mansoni cpg binding protein 0.0048 0.0349 0.034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0266 0.0407
Brugia malayi Isocitrate dehydrogenase 0.0013 0.0021 0.0039
Loa Loa (eye worm) hypothetical protein 0.0098 0.0809 0.1266
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0147 0.1268 0.4477
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0.001 0.0001
Trichomonas vaginalis DNA helicase recq1, putative 0.0356 0.3207 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0053 0.0044
Brugia malayi hypothetical protein 0.0028 0.0163 0.0483
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0086 0.0698 0.109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0053 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0053 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0053 0.0069
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0013 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0069
Schistosoma mansoni DNA helicase recq1 0.0147 0.1268 0.126
Mycobacterium tuberculosis Conserved protein 0.0035 0.0229 0.1061
Echinococcus multilocularis microtubule associated protein 2 0.1089 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0229 0.0713
Loa Loa (eye worm) apoptosis regulator protein 0.0076 0.0612 0.0954
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0072 0.0574 0.1767
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0495 0.0486
Echinococcus multilocularis mothers against decapentaplegic 5 0.002 0.0093 0.0084
Schistosoma mansoni blooms syndrome DNA helicase 0.0281 0.2512 0.2505
Loa Loa (eye worm) hypothetical protein 0.005 0.037 0.0572
Onchocerca volvulus 0.0035 0.0229 0.108
Echinococcus granulosus bloom syndrome protein 0.0356 0.3207 0.32
Brugia malayi steroid hormone receptor 0.0016 0.0053 0.0136
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.079 0.2443
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.019 0.1669 1
Echinococcus granulosus Smad4 0.002 0.0093 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.00000000056203 0.0000000017527
Echinococcus granulosus mothers against decapentaplegic 5 0.002 0.0093 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0021 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0053 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.0042
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0238 0.2111 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0347
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0053 0.0044
Schistosoma mansoni aryl hydrocarbon receptor 0.0012 0.0019 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0053 0.0044
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0229 0.1061
Trypanosoma cruzi ribosomal RNA processing protein 6, putative 0.0044 0.0315 0.1822
Brugia malayi cytoplasmic intermediate filament protein 0.0011 0.001 0.0001
Onchocerca volvulus 0.0021 0.01 0.0292
Schistosoma mansoni caspase-7 (C14 family) 0.0025 0.0133 0.0124
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0069
Loa Loa (eye worm) beta-lactamase 0.0035 0.0229 0.0347
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0053 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0315 0.0982
Loa Loa (eye worm) 3'-5' exonuclease 0.0044 0.0315 0.0484
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0053 0.0044
Schistosoma mansoni hypothetical protein 0.0424 0.3831 0.3825
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0076 0.0612 0.0603
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0053 0.0136
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0347
Brugia malayi MH1 domain containing protein 0.002 0.0093 0.0263
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0069
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.004 0.0272 0.0416
Onchocerca volvulus 0.0038 0.0261 0.1278
Brugia malayi MH2 domain containing protein 0.002 0.0093 0.0263
Echinococcus granulosus cpg binding protein 0.0048 0.0349 0.034
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0053 0.0136
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0053 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0229 0.13
Echinococcus multilocularis survival motor neuron protein 1 0.0188 0.165 0.1643
Loa Loa (eye worm) hypothetical protein 0.0098 0.0809 0.1266
Echinococcus multilocularis expressed conserved protein 0.009 0.0737 0.0728
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0075 0.06 0.3541
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.0021 0.0012
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0229 0.1061
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0027 0.0158 0.0465
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0144
Echinococcus granulosus intermediate filament protein 0.0021 0.01 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.00000000056203 0.0000000017527
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0147 0.1268 0.5965
Schistosoma mansoni hypothetical protein 0.0424 0.3831 0.3825
Schistosoma mansoni smad1 5 8 and 0.002 0.0093 0.0084
Loa Loa (eye worm) hypothetical protein 0.0086 0.0698 0.109
Loa Loa (eye worm) hypothetical protein 0.0064 0.0495 0.0769
Echinococcus multilocularis protein patched 0.0041 0.0285 0.0276
Giardia lamblia Sgs1 DNA helicase, putative 0.0147 0.1268 0.5
Schistosoma mansoni DNA helicase recq5 0.0147 0.1268 0.126
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0021 0.0012
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0072 0.0573 0.2607
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0347
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0495 0.152
Schistosoma mansoni blooms syndrome DNA helicase 0.0075 0.06 0.0591
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0229 0.022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0053 0.0136
Echinococcus multilocularis tar DNA binding protein 0.005 0.0372 0.0364
Echinococcus granulosus caspase 2 0.0025 0.0133 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0574 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0053 0.0069
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0076 0.0612 0.0603
Brugia malayi MH2 domain containing protein 0.002 0.0093 0.0263

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 607 uM Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay ChEMBL. 25438754

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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