Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bloom's syndrome protein homolog | 0.0075 | 0.3644 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0075 | 0.3644 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0031 | 0.0934 | 0.4422 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0075 | 0.3644 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0031 | 0.0934 | 0.4422 |
Echinococcus multilocularis | bloom syndrome protein | 0.0075 | 0.3644 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.006 | 0.2673 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.004 | 0.1495 | 0.5 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.004 | 0.1495 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0075 | 0.3644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0934 | 0.0934 |
Loa Loa (eye worm) | RecQ helicase | 0.0075 | 0.3644 | 0.3644 |
Entamoeba histolytica | recQ family helicase, putative | 0.004 | 0.1495 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0031 | 0.0934 | 0.0934 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0051 | 0.215 | 0.5 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0016 | 0.00000000078565 | 0.5 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0066 | 0.3084 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0031 | 0.0934 | 0.3494 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.005 | 0.2113 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.004 | 0.1495 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0031 | 0.0934 | 0.5 |
Schistosoma mansoni | DNA helicase recq1 | 0.0031 | 0.0934 | 0.3494 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 395.8 uM | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | ChEMBL. | 25438754 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.