Detailed information for compound 934654

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.495 | Formula: C26H24N4O
  • H donors: 2 H acceptors: 2 LogP: 5.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)cccc2)Nc1cccc(c1)c1cccc(n1)N1CCCC1
  • InChi: 1S/C26H24N4O/c31-26(28-23-14-13-19-7-1-2-8-20(19)17-23)27-22-10-5-9-21(18-22)24-11-6-12-25(29-24)30-15-3-4-16-30/h1-2,5-14,17-18H,3-4,15-16H2,(H2,27,28,31)
  • InChiKey: QWLSDGPJFRNTFW-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0295 0.9678 0.9653
Brugia malayi Bloom's syndrome protein homolog 0.01 0.279 0.2315
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus granulosus rhodopsin orphan GPCR 0.0295 0.9678 1
Echinococcus multilocularis neuropeptide receptor 0.0295 0.9678 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0295 0.9678 1
Echinococcus multilocularis serotonin receptor 0.0295 0.9678 1
Brugia malayi hypothetical protein 0.0295 0.9678 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0295 0.9678 1
Loa Loa (eye worm) G-protein coupled receptor 0.0295 0.9678 0.9653
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Schistosoma mansoni opsin-like receptor 0.0295 0.9678 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0295 0.9678 1
Schistosoma mansoni amine GPCR 0.0295 0.9678 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0295 0.9678 1
Echinococcus granulosus neuropeptide Y receptor 0.0295 0.9678 1
Echinococcus granulosus neuropeptide receptor A26 0.0295 0.9678 1
Echinococcus multilocularis neuropeptide s receptor 0.0295 0.9678 1
Brugia malayi Melatonin receptor type 1A 0.0295 0.9678 1
Brugia malayi hypothetical protein 0.0295 0.9678 1
Echinococcus multilocularis sex peptide receptor 0.0295 0.9678 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0295 0.9678 1
Echinococcus granulosus g-protein coupled receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0068 0.1646 0.5
Echinococcus multilocularis g protein coupled receptor 0.0295 0.9678 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0295 0.9678 1
Trichomonas vaginalis DNA helicase recq, putative 0.01 0.279 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0295 0.9678 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0295 0.9678 0.9653
Schistosoma mansoni myosin xvIII 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni neuropeptide receptor 0.0295 0.9678 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus granulosus biogenic amine 5HT receptor 0.0295 0.9678 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0295 0.9678 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0295 0.9678 0.9653
Echinococcus granulosus rhodopsin orphan GPCR 0.0295 0.9678 1
Brugia malayi hypothetical protein 0.0295 0.9678 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0053 0.1144 0.5
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0295 0.9678 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Brugia malayi Serotonin receptor 0.0295 0.9678 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0295 0.9678 1
Brugia malayi Serotonin receptor 0.0295 0.9678 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0295 0.9678 1
Echinococcus granulosus G protein coupled receptor 139 0.0295 0.9678 1
Echinococcus multilocularis g protein coupled receptor 0.0295 0.9678 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0295 0.9678 1
Brugia malayi Dopamine receptor protein 2 0.0295 0.9678 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0295 0.9678 1
Echinococcus granulosus g protein coupled receptor 0.0295 0.9678 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0295 0.9678 1
Schistosoma mansoni neuropeptide receptor 0.0295 0.9678 1
Echinococcus granulosus neuropeptide s receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus granulosus tm gpcr rhodopsin 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Schistosoma mansoni biogenic amine receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Onchocerca volvulus 0.0295 0.9678 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0295 0.9678 0.9653
Echinococcus granulosus biogenic amine 5HT receptor 0.0295 0.9678 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0295 0.9678 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Onchocerca volvulus Neuropeptide F receptor homolog 0.0295 0.9678 0.5
Brugia malayi hypothetical protein 0.0295 0.9678 1
Schistosoma mansoni amine GPCR 0.0295 0.9678 1
Brugia malayi putative neuropeptide receptor NPR1 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Brugia malayi hypothetical protein 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni neuropeptide receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0295 0.9678 1
Brugia malayi RE15519p 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Schistosoma mansoni opsin-like receptor 0.0295 0.9678 1
Echinococcus granulosus neuropeptides capa receptor 0.0295 0.9678 1
Brugia malayi GnHR receptor homolog 0.0295 0.9678 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0295 0.9678 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus multilocularis rhodopsin orphan GPCR 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Onchocerca volvulus 0.0295 0.9678 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0295 0.9678 1
Brugia malayi Dopamine receptor 0.0295 0.9678 1
Schistosoma mansoni histamine h1 receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus multilocularis bloom syndrome protein 0.01 0.279 0.2315
Echinococcus granulosus serotonin receptor 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0295 0.9678 1
Schistosoma mansoni adenoreceptor 0.0295 0.9678 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0295 0.9678 1
Brugia malayi follicle stimulating hormone receptor 0.0295 0.9678 1
Echinococcus multilocularis G protein coupled receptor 139 0.0295 0.9678 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0295 0.9678 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0295 0.9678 0.9653
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0295 0.9678 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0295 0.9678 1
Loa Loa (eye worm) RecQ helicase 0.01 0.279 0.2235
Schistosoma mansoni hypothetical protein 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus granulosus rhodopsin orphan GPCR 0.0295 0.9678 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0295 0.9678 1
Schistosoma mansoni amine GPCR 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Treponema pallidum ATP-dependent DNA helicase 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0053 0.1144 0.5
Schistosoma mansoni biogenic amine receptor 0.0295 0.9678 1
Schistosoma mansoni neuropeptide F-like receptor 0.0295 0.9678 1
Echinococcus multilocularis g protein coupled receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni DNA helicase recq5 0.0041 0.0715 0.0739
Schistosoma mansoni amine GPCR 0.0295 0.9678 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni neuropeptide F-like receptor 0.0295 0.9678 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0295 0.9678 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0295 0.9678 0.9653
Schistosoma mansoni blooms syndrome DNA helicase 0.0079 0.2047 0.2115
Echinococcus multilocularis neuropeptide Y receptor 0.0295 0.9678 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0295 0.9678 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0295 0.9678 0.9653
Schistosoma mansoni neuropeptide f receptor 76f 0.0295 0.9678 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0053 0.1144 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0295 0.9678 1
Trichomonas vaginalis DNA helicase recq1, putative 0.01 0.279 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0295 0.9678 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0295 0.9678 1
Echinococcus granulosus dro:myosuppressin receptor 0.0295 0.9678 1
Brugia malayi G-protein coupled receptor 0.0295 0.9678 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0295 0.9678 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0295 0.9678 1
Echinococcus multilocularis orexin receptor type 2 0.0295 0.9678 1
Echinococcus multilocularis neuropeptides capa receptor 0.0295 0.9678 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0295 0.9678 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0295 0.9678 1
Entamoeba histolytica recQ family helicase, putative 0.0053 0.1144 1
Echinococcus multilocularis fmrfamide receptor 0.0295 0.9678 1
Brugia malayi sulfakinin receptor protein 0.0295 0.9678 1
Echinococcus granulosus allatostatin A receptor 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus multilocularis allatostatin A receptor 0.0295 0.9678 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0295 0.9678 1
Echinococcus granulosus fmrfamide receptor 0.0295 0.9678 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0295 0.9678 1
Echinococcus granulosus neuropeptides capa receptor 0.0295 0.9678 1
Echinococcus granulosus orexin receptor type 2 0.0295 0.9678 1
Brugia malayi Dopamine receptor protein 1 0.0295 0.9678 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0295 0.9678 1
Brugia malayi hypothetical protein 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Brugia malayi hypothetical protein 0.0295 0.9678 1
Brugia malayi hypothetical protein 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni neuropeptide receptor 0.0295 0.9678 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0295 0.9678 1
Schistosoma mansoni DNA helicase recq1 0.0041 0.0715 0.0739
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Onchocerca volvulus 0.0295 0.9678 0.5
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Brugia malayi neuropeptide F receptor 0.0295 0.9678 1
Echinococcus granulosus neuropeptide receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Brugia malayi neuropeptide F receptor 0.0295 0.9678 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0295 0.9678 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0295 0.9678 1
Echinococcus granulosus g protein coupled receptor 0.0295 0.9678 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0295 0.9678 1
Echinococcus granulosus sex peptide receptor 0.0295 0.9678 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0067 0.1618 1
Echinococcus granulosus hypothetical protein 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Brugia malayi ORL1-like opioid receptor 0.0295 0.9678 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0295 0.9678 1
Echinococcus multilocularis g-protein coupled receptor 0.0295 0.9678 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0295 0.9678 1
Echinococcus multilocularis serotonin receptor 0.0295 0.9678 1
Loa Loa (eye worm) TYRA-2 protein 0.0295 0.9678 0.9653
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0295 0.9678 1
Echinococcus multilocularis fmrfamide receptor 0.0295 0.9678 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0295 0.9678 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0088 0.2361 1
Schistosoma mansoni hypothetical protein 0.0295 0.9678 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0295 0.9678 1
Schistosoma mansoni biogenic amine receptor 0.0295 0.9678 1
Schistosoma mansoni hypothetical protein 0.0295 0.9678 1
Schistosoma mansoni amine GPCR 0.0295 0.9678 1
Onchocerca volvulus 0.0295 0.9678 0.5
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni biogenic amine (5HT) receptor 0.0295 0.9678 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0295 0.9678 1
Brugia malayi putative neuropeptide receptor 0.0295 0.9678 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Brugia malayi larval opioid receptor 0.0295 0.9678 1
Schistosoma mansoni opsin-like receptor 0.0295 0.9678 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0041 0.0715 0.5
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Onchocerca volvulus 0.0295 0.9678 0.5
Onchocerca volvulus 0.0295 0.9678 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0295 0.9678 1
Echinococcus granulosus bloom syndrome protein 0.01 0.279 0.2315
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0295 0.9678 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0295 0.9678 1
Echinococcus multilocularis neuropeptides capa receptor 0.0295 0.9678 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0715 0.4422
Loa Loa (eye worm) G-protein coupled receptor 0.0295 0.9678 0.9653
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0295 0.9678 1
Brugia malayi G protein-coupled receptor 0.0295 0.9678 1
Echinococcus granulosus tm gpcr rhodopsin 0.0295 0.9678 1
Echinococcus granulosus neuropeptide Y receptor 0.0295 0.9678 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0295 0.9678 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0295 0.9678 1
Echinococcus granulosus neuropeptide receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Brugia malayi hypothetical protein 0.0295 0.9678 1
Schistosoma mansoni hypothetical protein 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus granulosus somatostatin receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus multilocularis somatostatin receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0295 0.9678 1
Echinococcus multilocularis neuropeptide receptor A26 0.0295 0.9678 1
Brugia malayi G-protein coupled receptor 0.0295 0.9678 1
Echinococcus granulosus g protein coupled receptor 0.0295 0.9678 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus multilocularis dro:myosuppressin receptor 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653
Echinococcus multilocularis neuropeptide FF receptor 2 0.0295 0.9678 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0295 0.9678 1
Brugia malayi hypothetical protein 0.0295 0.9678 1
Echinococcus multilocularis neuropeptide receptor 0.0295 0.9678 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0295 0.9678 1
Loa Loa (eye worm) neuropeptide F receptor 0.0295 0.9678 0.9653
Echinococcus granulosus tm gpcr rhodopsin 0.0295 0.9678 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0295 0.9678 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0715 0.4422
Onchocerca volvulus 0.0295 0.9678 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0295 0.9678 1
Brugia malayi AKH receptor 0.0295 0.9678 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0295 0.9678 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.9678 0.9653

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) < 15 % Agonist activity at human CB1 receptor stably expressed in RD-HGA16 cells assessed as calcium mobilization at 10000 nM after 15 mins by FLIPR assay relative to CP55,940 ChEMBL. 25162172
IC50 (functional) = 888 nM Antagonist activity at human CB1 receptor stably expressed in RD-HGA16 cells assessed as inhibition of CP55,940-induced calcium mobilization after 15 mins by FLIPR assay ChEMBL. 25162172
Inhibition (functional) < 35 % Antagonist activity at human CB2 receptor stably expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55,940-induced calcium mobilization at 10000 nM after 15 mins by FLIPR assay ChEMBL. 25162172

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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