TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.495 | Formula: C26H24N4O
H donors: 2 H acceptors: 2 LogP: 5.27 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc2c(c1)cccc2)Nc1cccc(c1)c1cccc(n1)N1CCCC1
InChi: 1S/C26H24N4O/c31-26(28-23-14-13-19-7-1-2-8-20(19)17-23)27-22-10-5-9-21(18-22)24-11-6-12-25(29-24)30-15-3-4-16-30/h1-2,5-14,17-18H,3-4,15-16H2,(H2,27,28,31)
InChiKey: QWLSDGPJFRNTFW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0295	0.9678	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0295	0.9678	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0295	0.9678	1
Brugia malayi	AKH receptor	0.0295	0.9678	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0088	0.2361	1
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0053	0.1144	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	Dopamine receptor protein 2	0.0295	0.9678	1
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Echinococcus granulosus	serotonin receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	sulfakinin receptor protein	0.0295	0.9678	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.9678	1
Echinococcus granulosus	neuropeptide Y receptor	0.0295	0.9678	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.9678	1
Schistosoma mansoni	amine GPCR	0.0295	0.9678	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.9678	1
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0068	0.1646	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	follicle stimulating hormone receptor	0.0295	0.9678	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.9678	1
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Schistosoma mansoni	amine GPCR	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Echinococcus multilocularis	somatostatin receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus multilocularis	neuropeptides capa receptor	0.0295	0.9678	1
Schistosoma mansoni	opsin-like receptor	0.0295	0.9678	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Echinococcus multilocularis	fmrfamide receptor	0.0295	0.9678	1
Brugia malayi	Serotonin receptor	0.0295	0.9678	1
Schistosoma mansoni	hypothetical protein	0.0295	0.9678	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0295	0.9678	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0295	0.9678	0.9653
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.9678	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0295	0.9678	0.9653
Schistosoma mansoni	neuropeptide receptor	0.0295	0.9678	1
Echinococcus granulosus	neuropeptide receptor	0.0295	0.9678	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0295	0.9678	1
Echinococcus granulosus	G protein coupled receptor 139	0.0295	0.9678	1
Brugia malayi	G-protein coupled receptor	0.0295	0.9678	1
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0053	0.1144	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0295	0.9678	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0295	0.9678	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.9678	1
Echinococcus multilocularis	g protein coupled receptor	0.0295	0.9678	1
Echinococcus granulosus	g-protein coupled receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0295	0.9678	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus granulosus	biogenic amine 5HT receptor	0.0295	0.9678	1
Echinococcus granulosus	g protein coupled receptor	0.0295	0.9678	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0295	0.9678	1
Brugia malayi	Dopamine receptor protein 1	0.0295	0.9678	1
Echinococcus granulosus	g protein coupled receptor	0.0295	0.9678	1
Schistosoma mansoni	opsin-like receptor	0.0295	0.9678	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.9678	1
Schistosoma mansoni	adenoreceptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus granulosus	neuropeptides capa receptor	0.0295	0.9678	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0295	0.9678	0.9653
Echinococcus granulosus	7tm_1 domain containing protein	0.0295	0.9678	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0295	0.9678	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0041	0.0715	0.4422
Echinococcus granulosus	bloom syndrome protein	0.01	0.279	0.2315
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0295	0.9678	1
Schistosoma mansoni	neuropeptide receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Schistosoma mansoni	neuropeptide receptor	0.0295	0.9678	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0295	0.9678	0.9653
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0295	0.9678	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0295	0.9678	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.9678	1
Echinococcus multilocularis	neuropeptide receptor	0.0295	0.9678	1
Schistosoma mansoni	biogenic amine receptor	0.0295	0.9678	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0295	0.9678	1
Echinococcus granulosus	orexin receptor type 2	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0295	0.9678	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0295	0.9678	0.9653
Echinococcus granulosus	hypothetical protein	0.0295	0.9678	1
Entamoeba histolytica	recQ family helicase, putative	0.0053	0.1144	1
Schistosoma mansoni	DNA helicase recq1	0.0041	0.0715	0.0739
Echinococcus granulosus	fmrfamide receptor	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Schistosoma mansoni	hypothetical protein	0.0295	0.9678	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0295	0.9678	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.9678	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0295	0.9678	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0295	0.9678	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0295	0.9678	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.9678	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.9678	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0295	0.9678	1
Echinococcus granulosus	sex peptide receptor	0.0295	0.9678	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0295	0.9678	1
Schistosoma mansoni	amine GPCR	0.0295	0.9678	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.9678	1
Echinococcus multilocularis	sex peptide receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Schistosoma mansoni	myosin xvIII	0.0295	0.9678	1
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Echinococcus multilocularis	orexin receptor type 2	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0295	0.9678	0.9653
Echinococcus granulosus	tm gpcr rhodopsin	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Schistosoma mansoni	biogenic amine receptor	0.0295	0.9678	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.9678	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	neuropeptide F receptor	0.0295	0.9678	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0295	0.9678	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0295	0.9678	0.9653
Echinococcus granulosus	neuropeptide FF receptor 2	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	Dopamine receptor	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0295	0.9678	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.01	0.279	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.9678	1
Treponema pallidum	ATP-dependent DNA helicase	0.0021	0	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0295	0.9678	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus multilocularis	neuropeptide s receptor	0.0295	0.9678	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0295	0.9678	1
Echinococcus granulosus	allatostatin A receptor	0.0295	0.9678	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus multilocularis	g protein coupled receptor	0.0295	0.9678	1
Echinococcus multilocularis	g protein coupled receptor	0.0295	0.9678	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0295	0.9678	1
Echinococcus multilocularis	g-protein coupled receptor	0.0295	0.9678	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0041	0.0715	0.4422
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0295	0.9678	1
Schistosoma mansoni	amine GPCR	0.0295	0.9678	1
Brugia malayi	ORL1-like opioid receptor	0.0295	0.9678	1
Brugia malayi	G-protein coupled receptor	0.0295	0.9678	1
Brugia malayi	GnHR receptor homolog	0.0295	0.9678	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0295	0.9678	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0295	0.9678	0.5
Brugia malayi	RE15519p	0.0295	0.9678	1
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Trichomonas vaginalis	DNA helicase recq, putative	0.01	0.279	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0295	0.9678	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0067	0.1618	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0295	0.9678	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.9678	1
Brugia malayi	putative neuropeptide receptor	0.0295	0.9678	1
Echinococcus multilocularis	serotonin receptor	0.0295	0.9678	1
Schistosoma mansoni	histamine h1 receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0295	0.9678	1
Echinococcus granulosus	neuropeptides capa receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	larval opioid receptor	0.0295	0.9678	1
Echinococcus multilocularis	serotonin receptor	0.0295	0.9678	1
Echinococcus multilocularis	fmrfamide receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0295	0.9678	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0295	0.9678	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0295	0.9678	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.9678	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0295	0.9678	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0295	0.9678	1
Brugia malayi	G protein-coupled receptor	0.0295	0.9678	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.9678	1
Schistosoma mansoni	amine GPCR	0.0295	0.9678	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0295	0.9678	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0295	0.9678	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0295	0.9678	0.9653
Echinococcus multilocularis	neuropeptide receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0053	0.1144	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	putative neuropeptide receptor NPR1	0.0295	0.9678	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0295	0.9678	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Onchocerca volvulus		0.0295	0.9678	0.5
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Schistosoma mansoni	neuropeptide receptor	0.0295	0.9678	1
Brugia malayi	Serotonin receptor	0.0295	0.9678	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Giardia lamblia	Sgs1 DNA helicase, putative	0.0041	0.0715	0.5
Brugia malayi	Melatonin receptor type 1A	0.0295	0.9678	1
Echinococcus granulosus	neuropeptide s receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Schistosoma mansoni	DNA helicase recq5	0.0041	0.0715	0.0739
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0295	0.9678	1
Echinococcus multilocularis	bloom syndrome protein	0.01	0.279	0.2315
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.9678	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0295	0.9678	1
Echinococcus granulosus	neuropeptide receptor	0.0295	0.9678	1
Echinococcus granulosus	somatostatin receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Schistosoma mansoni	biogenic amine receptor	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0295	0.9678	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0295	0.9678	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus granulosus	g protein coupled receptor	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Schistosoma mansoni	blooms syndrome DNA helicase	0.0079	0.2047	0.2115
Echinococcus granulosus	neuropeptide receptor A26	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Loa Loa (eye worm)	RecQ helicase	0.01	0.279	0.2235
Onchocerca volvulus		0.0295	0.9678	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0295	0.9678	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0295	0.9678	0.9653
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0295	0.9678	1
Loa Loa (eye worm)	TYRA-2 protein	0.0295	0.9678	0.9653
Brugia malayi	Bloom's syndrome protein homolog	0.01	0.279	0.2315
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.9678	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0295	0.9678	1
Brugia malayi	hypothetical protein	0.0295	0.9678	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Brugia malayi	neuropeptide F receptor	0.0295	0.9678	1
Schistosoma mansoni	hypothetical protein	0.0295	0.9678	1
Schistosoma mansoni	opsin-like receptor	0.0295	0.9678	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0295	0.9678	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9678	0.9653
Echinococcus granulosus	neuropeptide Y receptor	0.0295	0.9678	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0295	0.9678	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0295	0.9678	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.9678	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0295	0.9678	1
Schistosoma mansoni	hypothetical protein	0.0295	0.9678	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0295	0.9678	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0295	0.9678	1
Onchocerca volvulus		0.0295	0.9678	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	< 15 %	Agonist activity at human CB1 receptor stably expressed in RD-HGA16 cells assessed as calcium mobilization at 10000 nM after 15 mins by FLIPR assay relative to CP55,940	ChEMBL.	25162172
IC50 (functional)	= 888 nM	Antagonist activity at human CB1 receptor stably expressed in RD-HGA16 cells assessed as inhibition of CP55,940-induced calcium mobilization after 15 mins by FLIPR assay	ChEMBL.	25162172
Inhibition (functional)	< 35 %	Antagonist activity at human CB2 receptor stably expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55,940-induced calcium mobilization at 10000 nM after 15 mins by FLIPR assay	ChEMBL.	25162172

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3341896

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 934654