Detailed information for compound 934952

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.524 | Formula: C20H27N5O4S
  • H donors: 3 H acceptors: 5 LogP: 1.78 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)CCCCCCC(=O)Nc1nnc(s1)c1ccc(cc1)N1CCOCC1
  • InChi: 1S/C20H27N5O4S/c26-17(5-3-1-2-4-6-18(27)24-28)21-20-23-22-19(30-20)15-7-9-16(10-8-15)25-11-13-29-14-12-25/h7-10,28H,1-6,11-14H2,(H,24,27)(H,21,23,26)
  • InChiKey: DMWVMQHFEBZGDB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.1127 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0219 0.4608 0.4545
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0219 0.4608 0.4545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Brugia malayi Tachykinin-like peptides receptor 99D 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0219 0.4608 0.4545
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0219 0.4608 0.4545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Brugia malayi conserved hypotetical protein 0.0207 0.4316 0.425
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0439 1 1
Echinococcus multilocularis orexin receptor type 2 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0077 0.1127 0.1127
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0207 0.4316 0.425
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Schistosoma mansoni biogenic amine (5HT) receptor 0.0219 0.4608 0.45
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0232 0.4925 0.4925
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.1127 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0219 0.4608 0.45
Onchocerca volvulus 0.0219 0.4608 0.0512
Schistosoma mansoni neuropeptide f receptor 76f 0.0219 0.4608 0.45
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0439 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0439 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0439 1 1
Echinococcus granulosus g protein coupled receptor 0.0219 0.4608 0.4545
Brugia malayi nuclear hormone receptor family member odr-7 0.0207 0.4316 0.425
Brugia malayi nuclear receptor RXR 0.0232 0.4925 0.4866
Brugia malayi ORL1-like opioid receptor 0.0219 0.4608 0.4545
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0439 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0232 0.4925 0.4866
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi Serotonin receptor 0.0219 0.4608 0.4545
Brugia malayi Dopamine receptor protein 1 0.0219 0.4608 0.4545
Echinococcus granulosus biogenic amine 5HT receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Onchocerca volvulus 0.0219 0.4608 0.0512
Brugia malayi RE15519p 0.0219 0.4608 0.4545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0219 0.4608 0.4545
Schistosoma mansoni thyroid hormone receptor 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0232 0.4925 0.4824
Echinococcus multilocularis G protein coupled receptor 139 0.0219 0.4608 0.4545
Loa Loa (eye worm) histone deacetylase 3 0.0077 0.1127 0.1127
Schistosoma mansoni histone deacetylase 0.0077 0.1127 0.095
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0219 0.4608 0.4545
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0439 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0219 0.4608 0.45
Echinococcus multilocularis neuropeptide receptor A26 0.0219 0.4608 0.4545
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Onchocerca volvulus 0.0219 0.4608 0.0512
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0439 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0232 0.4925 0.4866
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0219 0.4608 0.45
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0219 0.4608 0.4545
Schistosoma mansoni nuclear receptor 0.0207 0.4316 0.4203
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi Steroid receptor seven-up type 2 0.0439 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0219 0.4608 0.4545
Schistosoma mansoni biogenic amine (5HT) receptor 0.0219 0.4608 0.45
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus granulosus rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0219 0.4608 0.45
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0439 1 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.1127 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0207 0.4316 0.4316
Echinococcus granulosus G protein coupled receptor 139 0.0219 0.4608 0.4545
Echinococcus multilocularis thyroid hormone receptor alpha 0.0439 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0219 0.4608 0.4545
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0219 0.4608 0.45
Echinococcus granulosus sex peptide receptor 0.0219 0.4608 0.4545
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0219 0.4608 0.45
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus granulosus g protein coupled receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Brugia malayi Histone deacetylase 1 0.0077 0.1127 0.1023
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus granulosus neuropeptide Y receptor 0.0219 0.4608 0.4545
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0219 0.4608 0.45
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0219 0.4608 0.4608
Schistosoma mansoni neuropeptide receptor 0.0219 0.4608 0.45
Echinococcus granulosus rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0219 0.4608 0.4545
Schistosoma mansoni hypothetical protein 0.0219 0.4608 0.45
Onchocerca volvulus 0.0219 0.4608 0.0512
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0232 0.4925 0.4866
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0207 0.4316 0.4316
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0207 0.4316 0.425
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0439 1 1
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Onchocerca volvulus 0.0219 0.4608 0.0512
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Loa Loa (eye worm) steroid hormone receptor 0.0439 1 1
Echinococcus multilocularis fmrfamide receptor 0.0219 0.4608 0.4545
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0219 0.4608 0.45
Echinococcus granulosus neuropeptide Y receptor 0.0219 0.4608 0.4545
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Onchocerca volvulus 0.0219 0.4608 0.0512
Echinococcus multilocularis dro:myosuppressin receptor 0.0219 0.4608 0.4545
Plasmodium falciparum histone deacetylase 1 0.0077 0.1127 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0219 0.4608 0.45
Schistosoma mansoni histamine h1 receptor 0.0219 0.4608 0.45
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0232 0.4925 0.4866
Schistosoma mansoni RAR-like nuclear receptor 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.4925 0.4925
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.1127 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0219 0.4608 0.4608
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0439 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0207 0.4316 0.425
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0207 0.4316 0.4203
Brugia malayi G-protein coupled receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0439 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0219 0.4608 0.4545
Echinococcus granulosus neuropeptides capa receptor 0.0219 0.4608 0.4545
Echinococcus multilocularis neuropeptide receptor 0.0219 0.4608 0.4545
Echinococcus granulosus alpha 1A adrenergic receptor 0.0219 0.4608 0.4545
Schistosoma mansoni coup transcription factor 0.0439 1 1
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Schistosoma mansoni nuclear hormone receptor 0.0207 0.4316 0.4203
Echinococcus granulosus thyroid hormone receptor alpha 0.0207 0.4316 0.425
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0219 0.4608 0.45
Echinococcus granulosus ecdysone induced protein 78C 0.0439 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0219 0.4608 0.4608
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Onchocerca volvulus 0.0219 0.4608 0.0512
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0207 0.4316 0.4203
Schistosoma mansoni hypothetical protein 0.0219 0.4608 0.45
Echinococcus granulosus Nuclear hormone receptor HR96 0.0207 0.4316 0.425
Echinococcus multilocularis rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Loa Loa (eye worm) histone deacetylase 1 0.0077 0.1127 0.1127
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Onchocerca volvulus 0.0219 0.4608 0.0512
Echinococcus multilocularis g-protein coupled receptor 0.0219 0.4608 0.4545
Brugia malayi hypothetical protein 0.0207 0.4316 0.425
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0439 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0439 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0439 1 1
Brugia malayi G-protein coupled receptor 0.0219 0.4608 0.4545
Brugia malayi GnHR receptor homolog 0.0219 0.4608 0.4545
Echinococcus multilocularis neuropeptide s receptor 0.0219 0.4608 0.4545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0439 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0219 0.4608 0.4608
Schistosoma mansoni adenoreceptor 0.0219 0.4608 0.45
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.1127 1
Schistosoma mansoni amine GPCR 0.0219 0.4608 0.45
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0439 1 1
Echinococcus granulosus serotonin receptor 0.0219 0.4608 0.4545
Onchocerca volvulus 0.0219 0.4608 0.0512
Brugia malayi tailless protein 0.0207 0.4316 0.425
Schistosoma mansoni biogenic amine receptor 0.0219 0.4608 0.45
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Schistosoma mansoni alpha-1 adrenergic receptor 0.0219 0.4608 0.45
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0219 0.4608 0.0512
Brugia malayi hypothetical protein 0.0232 0.4925 0.4866
Schistosoma mansoni opsin-like receptor 0.0219 0.4608 0.45
Echinococcus multilocularis g protein coupled receptor 0.0219 0.4608 0.4545
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.1127 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.4925 0.4925
Echinococcus multilocularis sex peptide receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Echinococcus multilocularis G-protein coupled receptor, putative 0.0219 0.4608 0.4545
Echinococcus multilocularis serotonin receptor 0.0219 0.4608 0.4545
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0439 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0219 0.4608 0.4545
Schistosoma mansoni amine GPCR 0.0219 0.4608 0.45
Loa Loa (eye worm) DR-78 0.0207 0.4316 0.4316
Brugia malayi Melatonin receptor type 1A 0.0219 0.4608 0.4545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0439 1 1
Echinococcus granulosus allatostatin A receptor 0.0219 0.4608 0.4545
Leishmania major histone deacetylase, putative 0.0077 0.1127 0.5
Brugia malayi G protein-coupled receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0207 0.4316 0.425
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0219 0.4608 0.4608
Echinococcus granulosus Nuclear hormone receptor HR96 0.0207 0.4316 0.425
Echinococcus granulosus peptide allatostatin:somatostatin 0.0219 0.4608 0.4545
Brugia malayi G protein-coupled receptor F59B2.13 0.0219 0.4608 0.4545
Onchocerca volvulus 0.0439 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0439 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0207 0.4316 0.4316
Brugia malayi neuropeptide F receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) G-protein coupled receptor 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0232 0.4925 0.4925
Brugia malayi follicle stimulating hormone receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Echinococcus granulosus 7tm_1 domain containing protein 0.0219 0.4608 0.4545
Schistosoma mansoni neuropeptide F-like receptor 0.0219 0.4608 0.45
Schistosoma mansoni steroid hormone receptor ad4bp 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.1127 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.1127 1
Brugia malayi Serotonin receptor 0.0219 0.4608 0.4545
Echinococcus multilocularis neuropeptides capa receptor 0.0219 0.4608 0.4545
Brugia malayi steroid hormone receptor 0.0439 1 1
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Schistosoma mansoni retinoic acid receptor RXR 0.0439 1 1
Echinococcus granulosus histone deacetylase 3 0.0077 0.1127 0.1023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0439 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0219 0.4608 0.4545
Schistosoma mansoni amine GPCR 0.0219 0.4608 0.45
Echinococcus multilocularis neuropeptide Y receptor 0.0219 0.4608 0.4545
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0207 0.4316 0.425
Onchocerca volvulus Bile acid receptor homolog 0.0439 1 1
Toxoplasma gondii histone deacetylase HDAC2 0.0077 0.1127 0.5
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Schistosoma mansoni biogenic amine receptor 0.0219 0.4608 0.45
Schistosoma mansoni nuclear receptor nhr-48 0.0207 0.4316 0.4203
Brugia malayi orphan nuclear receptor NR2E1 0.0207 0.4316 0.425
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0219 0.4608 0.4545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0219 0.4608 0.4545
Loa Loa (eye worm) G-protein coupled receptor 0.0219 0.4608 0.4608
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0439 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0439 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0219 0.4608 0.4545
Onchocerca volvulus 0.0219 0.4608 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0439 1 1
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0219 0.4608 0.4545
Brugia malayi putative neuropeptide receptor 0.0219 0.4608 0.4545
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0219 0.4608 0.4545
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0219 0.4608 0.45
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0219 0.4608 0.45
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0439 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0219 0.4608 0.4545
Brugia malayi nuclear receptor RXR 0.0207 0.4316 0.425
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi Nuclear hormone receptor E75 0.0207 0.4316 0.425
Echinococcus granulosus tm gpcr rhodopsin 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Schistosoma mansoni biogenic amine receptor 0.0219 0.4608 0.45
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0439 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0219 0.4608 0.45
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi nuclear hormone receptor 0.0207 0.4316 0.425
Schistosoma mansoni neuropeptide receptor 0.0219 0.4608 0.45
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.1127 0.5
Echinococcus granulosus neuropeptide receptor 0.0219 0.4608 0.4545
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0207 0.4316 0.425
Echinococcus multilocularis rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0219 0.4608 0.45
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.1127 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Schistosoma mansoni growth hormone secretagogue receptor 0.0219 0.4608 0.45
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0439 1 1
Echinococcus granulosus FTZ F1 alpha 0.0439 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0207 0.4316 0.425
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Schistosoma mansoni neuropeptide F-like receptor 0.0219 0.4608 0.45
Echinococcus granulosus neuropeptide s receptor 0.0219 0.4608 0.4545
Onchocerca volvulus 0.0219 0.4608 0.0512
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0219 0.4608 0.4545
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0439 1 1
Echinococcus multilocularis somatostatin receptor 0.0219 0.4608 0.4545
Echinococcus granulosus somatostatin receptor 0.0219 0.4608 0.4545
Schistosoma mansoni neuropeptide receptor 0.0219 0.4608 0.45
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0219 0.4608 0.4545
Echinococcus granulosus neuropeptide receptor 0.0219 0.4608 0.4545
Echinococcus multilocularis g protein coupled receptor 0.0219 0.4608 0.4545
Echinococcus granulosus rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Loa Loa (eye worm) neuropeptide F receptor 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0219 0.4608 0.45
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Echinococcus granulosus neuropeptide FF receptor 2 0.0219 0.4608 0.4545
Brugia malayi nuclear receptor NHR-88 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Onchocerca volvulus 0.0219 0.4608 0.0512
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0207 0.4316 0.425
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0219 0.4608 0.45
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi Dopamine receptor protein 2 0.0219 0.4608 0.4545
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0219 0.4608 0.45
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0232 0.4925 0.4824
Echinococcus granulosus rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Echinococcus granulosus g-protein coupled receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Schistosoma mansoni hypothetical protein 0.0219 0.4608 0.45
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0219 0.4608 0.4545
Plasmodium vivax histone deacetylase 1, putative 0.0077 0.1127 0.5
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus multilocularis ecdysone induced protein 78C 0.0439 1 1
Echinococcus multilocularis serotonin receptor 0.0219 0.4608 0.4545
Onchocerca volvulus 0.0219 0.4608 0.0512
Brugia malayi larval opioid receptor 0.0219 0.4608 0.4545
Echinococcus granulosus neuropeptide receptor A26 0.0219 0.4608 0.4545
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0439 1 1
Echinococcus granulosus fmrfamide receptor 0.0219 0.4608 0.4545
Echinococcus granulosus tachykinin peptides receptor 99D 0.0219 0.4608 0.4545
Schistosoma mansoni histone deacetylase 0.0077 0.1127 0.095
Echinococcus granulosus orexin receptor type 2 0.0219 0.4608 0.4545
Brugia malayi photoreceptor-specific nuclear receptor 0.0439 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0439 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0207 0.4316 0.425
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Schistosoma mansoni opsin-like receptor 0.0219 0.4608 0.45
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0207 0.4316 0.425
Schistosoma mansoni zinc finger protein 0.0207 0.4316 0.4203
Schistosoma mansoni amine GPCR 0.0219 0.4608 0.45
Echinococcus granulosus 7TM GPCR rhodopsin 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus multilocularis histone deacetylase 1 0.0077 0.1127 0.1023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0219 0.4608 0.45
Schistosoma mansoni amine GPCR 0.0219 0.4608 0.45
Echinococcus multilocularis neuropeptides capa receptor 0.0219 0.4608 0.4545
Leishmania major histone deacetylase, putative 0.0077 0.1127 0.5
Brugia malayi sulfakinin receptor protein 0.0219 0.4608 0.4545
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0219 0.4608 0.4545
Echinococcus granulosus rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0219 0.4608 0.4545
Loa Loa (eye worm) TYRA-2 protein 0.0219 0.4608 0.4608
Echinococcus multilocularis FTZ F1 alpha 0.0439 1 1
Schistosoma mansoni nuclear hormone receptor 0.0207 0.4316 0.4203
Trypanosoma brucei histone deacetylase 1 0.0077 0.1127 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.4925 0.4925
Brugia malayi hypothetical protein 0.0207 0.4316 0.425
Echinococcus granulosus rhodopsin orphan GPCR 0.0219 0.4608 0.4545
Echinococcus multilocularis nuclear receptor nhr 48 0.0207 0.4316 0.425
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0439 1 1
Schistosoma mansoni opsin-like receptor 0.0219 0.4608 0.45
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0115 0.0115
Entamoeba histolytica histone deacetylase, putative 0.0077 0.1127 0.5
Brugia malayi ecdysone receptor 0.0207 0.4316 0.425
Brugia malayi histone deacetylase 3 (HD3) 0.0077 0.1127 0.1023
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Onchocerca volvulus 0.0219 0.4608 0.0512
Echinococcus multilocularis fmrfamide receptor 0.0219 0.4608 0.4545
Schistosoma mansoni nuclear hormone receptor 0.0439 1 1
Brugia malayi nuclear hormone receptor 0.0439 1 1
Schistosoma mansoni hypothetical protein 0.0219 0.4608 0.45
Loa Loa (eye worm) hypothetical protein 0.0232 0.4925 0.4925
Brugia malayi Dopamine receptor 0.0219 0.4608 0.4545
Onchocerca volvulus 0.0219 0.4608 0.0512
Toxoplasma gondii histone deacetylase HDAC3 0.0077 0.1127 0.5
Echinococcus granulosus histone deacetylase 1 0.0077 0.1127 0.1023
Echinococcus multilocularis g protein coupled receptor 0.0219 0.4608 0.4545
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0439 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0439 1 1
Schistosoma mansoni myosin xvIII 0.0219 0.4608 0.45
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0219 0.4608 0.4608
Echinococcus granulosus dro:myosuppressin receptor 0.0219 0.4608 0.4545
Onchocerca volvulus Neuropeptide F receptor homolog 0.0219 0.4608 0.0512
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus granulosus hypothetical protein 0.0219 0.4608 0.4545
Brugia malayi nuclear receptor NHR-88 0.0207 0.4316 0.425
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi putative neuropeptide receptor NPR1 0.0219 0.4608 0.4545
Echinococcus multilocularis histone deacetylase 3 0.0077 0.1127 0.1023
Giardia lamblia Histone deacetylase 0.0077 0.1127 0.5
Schistosoma mansoni neuropeptide receptor 0.0219 0.4608 0.45
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Echinococcus granulosus tm gpcr rhodopsin 0.0219 0.4608 0.4545
Echinococcus multilocularis allatostatin A receptor 0.0219 0.4608 0.4545
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0219 0.4608 0.45
Echinococcus multilocularis neuropeptide receptor 0.0219 0.4608 0.4545
Echinococcus multilocularis neuropeptide FF receptor 2 0.0219 0.4608 0.4545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.4316 0.4316
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi AKH receptor 0.0219 0.4608 0.4545
Loa Loa (eye worm) hypothetical protein 0.0219 0.4608 0.4608
Brugia malayi neuropeptide F receptor 0.0219 0.4608 0.4545
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.1127 1
Onchocerca volvulus 0.0219 0.4608 0.0512
Echinococcus granulosus g protein coupled receptor 0.0219 0.4608 0.4545
Schistosoma mansoni nuclear receptor 0.0207 0.4316 0.4203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0219 0.4608 0.45
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0219 0.4608 0.45
Brugia malayi nuclear receptor NHR-67 0.0207 0.4316 0.425
Brugia malayi Nuclear hormone receptor E75 0.0207 0.4316 0.425
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0439 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0219 0.4608 0.45
Schistosoma mansoni thyroid hormone receptor 0.0439 1 1
Brugia malayi hypothetical protein 0.0232 0.4925 0.4866
Onchocerca volvulus 0.0219 0.4608 0.0512
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0439 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0439 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0219 0.4608 0.4545
Brugia malayi hypothetical protein 0.0219 0.4608 0.4545
Brugia malayi histone deacetylase 1 (HD1) 0.0077 0.1127 0.1023

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 5000 nM Inhibition of HDAC1/HDAC2 in human HeLa cell extract incubated for 5 mins prior to substrate addition measured after 30 mins by microtitre plate reader analysis ChEMBL. 25311567

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.