Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0112 | 0.1923 | 0.0917 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0112 | 0.1923 | 0.6707 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0112 | 0.1923 | 0.0917 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0122 | 0.2303 | 0.1368 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0122 | 0.2303 | 0.2404 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0112 | 0.1923 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0122 | 0.2303 | 0.1368 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0112 | 0.1923 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0122 | 0.2303 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.009 | 0.115 | 0.0332 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0112 | 0.1923 | 0.2008 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0112 | 0.1923 | 0.2008 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0112 | 0.1923 | 0.5 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0322 | 0.9576 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0122 | 0.2303 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0122 | 0.2303 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0112 | 0.1923 | 0.6707 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.009 | 0.115 | 0.1201 |
Trichomonas vaginalis | AGC family protein kinase | 0.0122 | 0.2303 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.009 | 0.115 | 0.1201 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0112 | 0.1923 | 0.0917 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0112 | 0.1923 | 0.2008 |
Loa Loa (eye worm) | AUR protein kinase | 0.0122 | 0.2303 | 0.1449 |
Leishmania major | trypanothione reductase | 0.0322 | 0.9576 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0122 | 0.2303 | 0.1302 |
Entamoeba histolytica | protein kinase, putative | 0.0122 | 0.2303 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0112 | 0.1923 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0112 | 0.1923 | 0.0917 |
Brugia malayi | glutathione reductase | 0.0322 | 0.9576 | 0.9537 |
Trichomonas vaginalis | AGC family protein kinase | 0.0122 | 0.2303 | 1 |
Treponema pallidum | NADH oxidase | 0.0112 | 0.1923 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0112 | 0.1923 | 0.0917 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0122 | 0.2303 | 0.1368 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0112 | 0.1923 | 0.0873 |
Trichomonas vaginalis | AGC family protein kinase | 0.0122 | 0.2303 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0112 | 0.1923 | 0.5 |
Brugia malayi | cell division control protein 2 homolog | 0.009 | 0.115 | 0.0332 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0334 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0322 | 0.9576 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0112 | 0.1923 | 0.2008 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Plasmodium falciparum | thioredoxin reductase | 0.0322 | 0.9576 | 1 |
Toxoplasma gondii | aurora kinase | 0.0122 | 0.2303 | 0.1368 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0112 | 0.1923 | 0.0917 |
Plasmodium falciparum | glutathione reductase | 0.0322 | 0.9576 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0322 | 0.9576 | 0.953 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0122 | 0.2303 | 0.1591 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.009 | 0.115 | 0.1201 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0322 | 0.9576 | 1 |
Giardia lamblia | Aurora kinase | 0.0122 | 0.2303 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0112 | 0.1923 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0122 | 0.2303 | 0.1368 |
Echinococcus multilocularis | aurora kinase A | 0.0122 | 0.2303 | 0.1368 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0112 | 0.1923 | 0.5 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0122 | 0.2303 | 0.1591 |
Entamoeba histolytica | protein kinase, putative | 0.0122 | 0.2303 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Trypanosoma brucei | trypanothione reductase | 0.0322 | 0.9576 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0334 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0112 | 0.1923 | 0.1177 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0112 | 0.1923 | 0.2008 |
Leishmania major | protein kinase, putative | 0.0122 | 0.2303 | 0.2404 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0122 | 0.2303 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0122 | 0.2303 | 0.1449 |
Trypanosoma brucei | aurora B kinase | 0.0122 | 0.2303 | 0.2404 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0122 | 0.2303 | 1 |
Schistosoma mansoni | protein kinase | 0.0122 | 0.2303 | 0.1302 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0112 | 0.1923 | 0.0917 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.009 | 0.115 | 0.0169 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.009 | 0.115 | 0.0169 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.009 | 0.115 | 0.1201 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.009 | 0.115 | 0.1201 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0112 | 0.1923 | 0.2008 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.009 | 0.115 | 0.0169 |
Loa Loa (eye worm) | AUR protein kinase | 0.0122 | 0.2303 | 0.1449 |
Brugia malayi | serine/threonine kinase 12 | 0.0122 | 0.2303 | 0.1591 |
Loa Loa (eye worm) | glutathione reductase | 0.0322 | 0.9576 | 0.953 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0322 | 0.9576 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0322 | 0.9576 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0322 | 0.9576 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0322 | 0.9576 | 0.9537 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0112 | 0.1923 | 0.6707 |
Echinococcus granulosus | aurora kinase A | 0.0122 | 0.2303 | 0.1368 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.009 | 0.115 | 0.1201 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.009 | 0.115 | 0.1201 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0112 | 0.1923 | 0.0917 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.009 | 0.115 | 0.1201 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0112 | 0.1923 | 0.2008 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0112 | 0.1923 | 0.0917 |
Plasmodium falciparum | glutathione reductase | 0.0112 | 0.1923 | 0.0917 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0112 | 0.1923 | 0.2008 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0322 | 0.9576 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0122 | 0.2303 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 4 mM | Binding affinity to BCL-XL (unknown origin) | ChEMBL. | 25313317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.