Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0125 | 1 | 1 |
Onchocerca volvulus | 0.0125 | 1 | 1 | |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0125 | 1 | 1 |
Onchocerca volvulus | 0.0125 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0125 | 1 | 1 |
Onchocerca volvulus | 0.0125 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0125 | 1 | 1 |
Onchocerca volvulus | 0.0125 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0125 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0125 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0125 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0125 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0125 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0125 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0125 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0125 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0125 | 1 | 1 |
Onchocerca volvulus | 0.0125 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0125 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0125 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0125 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0125 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0125 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0125 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0125 | 1 | 1 |
Onchocerca volvulus | 0.0125 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0125 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0125 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | BindingDB_Patents: In Vitro Inhibition Assay. An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+ and Mg2+) containing 10 mM HEPES and FLIPR Calcium 3 dye (3.1x107 cells in total volume 1.7 mL). Cells were aliquoted (200 uL of the cell suspension per tube, 8 tubes total) and 2 uL of the designated compound (with appropriate dilutions) were added to each of 6 tubes. As controls, 2 uL of DMSO (1% final concentration) were added to 2 other tubes. Cells were incubated for 30 min at 37 C. After dye loading, tubes were centrifuged at 6,000 rpm for 1 min, supernatant was removed and the cell pellet was re-suspended in 200 uL of HBSS+ (with Ca2+ and Mg2+) containing 10 mM HEPES. The test compound or DMSO (control) was added again at the same concentrations that were used during cell loading. The cell suspension was aliquoted into a 96-well Reading Plate (Corning) in a volume of 90 uL (105 cells/well). | ChEMBL. | No reference |
IC50 (binding) | > 10000 nM | BindingDB_Patents: In Vitro Inhibition Assay. An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+ and Mg2+) containing 10 mM HEPES and FLIPR Calcium 3 dye (3.1x107 cells in total volume 1.7 mL). Cells were aliquoted (200 uL of the cell suspension per tube, 8 tubes total) and 2 uL of the designated compound (with appropriate dilutions) were added to each of 6 tubes. As controls, 2 uL of DMSO (1% final concentration) were added to 2 other tubes. Cells were incubated for 30 min at 37 C. After dye loading, tubes were centrifuged at 6,000 rpm for 1 min, supernatant was removed and the cell pellet was re-suspended in 200 uL of HBSS+ (with Ca2+ and Mg2+) containing 10 mM HEPES. The test compound or DMSO (control) was added again at the same concentrations that were used during cell loading. The cell suspension was aliquoted into a 96-well Reading Plate (Corning) in a volume of 90 uL (105 cells/well). | ChEMBL. | No reference |
IC50 (binding) | > 10 uM | Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assay | ChEMBL. | 25254640 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.