Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0192 | 0.0381 | 0.0283 |
Plasmodium falciparum | glutathione reductase | 0.0213 | 0.0842 | 0.0747 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0192 | 0.0381 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0213 | 0.0842 | 0.0747 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0213 | 0.0842 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0192 | 0.0381 | 0.0283 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.018 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0613 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0192 | 0.0381 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0192 | 0.0381 | 0.0381 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0213 | 0.0842 | 0.0747 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0213 | 0.0842 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0613 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0192 | 0.0381 | 0.0283 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0192 | 0.0381 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0213 | 0.0842 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0192 | 0.0381 | 0.0283 |
Toxoplasma gondii | thioredoxin reductase | 0.0613 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0613 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0192 | 0.0381 | 0.0283 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0213 | 0.0842 | 0.0747 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0613 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0213 | 0.0842 | 0.0747 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.018 | 0.0102 | 0.0102 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0213 | 0.0842 | 0.0747 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0213 | 0.0842 | 0.0747 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0213 | 0.0842 | 0.0747 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0213 | 0.0842 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0192 | 0.0381 | 0.0283 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0613 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0613 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0613 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Trichomonas vaginalis | AGC family protein kinase | 0.0192 | 0.0381 | 0.378 |
Entamoeba histolytica | protein kinase , putative | 0.0192 | 0.0381 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0192 | 0.0381 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Trypanosoma brucei | aurora B kinase | 0.0192 | 0.0381 | 0.0283 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0213 | 0.0842 | 0.0747 |
Entamoeba histolytica | protein kinase, putative | 0.0192 | 0.0381 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0213 | 0.0842 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0613 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0192 | 0.0381 | 0.0283 |
Giardia lamblia | Aurora kinase | 0.0192 | 0.0381 | 0.378 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0192 | 0.0381 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0192 | 0.0381 | 0.378 |
Trichomonas vaginalis | AGC family protein kinase | 0.0192 | 0.0381 | 0.378 |
Plasmodium falciparum | thioredoxin reductase | 0.0613 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0213 | 0.0842 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0192 | 0.0381 | 0.0283 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Loa Loa (eye worm) | AUR protein kinase | 0.0192 | 0.0381 | 0.0381 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0213 | 0.0842 | 0.0747 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0213 | 0.0842 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0613 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0213 | 0.0842 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0613 | 1 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0213 | 0.0842 | 0.0747 |
Loa Loa (eye worm) | AUR protein kinase | 0.0192 | 0.0381 | 0.0381 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0213 | 0.0842 | 0.0747 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0213 | 0.0842 | 0.0747 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0213 | 0.0842 | 0.0747 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0213 | 0.0842 | 0.0747 |
Loa Loa (eye worm) | glutathione reductase | 0.0613 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.0842 | 0.0747 |
Toxoplasma gondii | aurora kinase | 0.0192 | 0.0381 | 0.0283 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0213 | 0.0842 | 0.0747 |
Trichomonas vaginalis | AGC family protein kinase | 0.0192 | 0.0381 | 0.378 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0213 | 0.0842 | 0.5 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0213 | 0.0842 | 0.0747 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.018 | 0.0102 | 0.0102 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0192 | 0.0381 | 0.0283 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0213 | 0.0842 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0213 | 0.0842 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.0192 | 0.0381 | 0.0283 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0192 | 0.0381 | 0.0283 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0213 | 0.0842 | 0.0747 |
Leishmania major | trypanothione reductase | 0.0613 | 1 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0192 | 0.0381 | 0.0283 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0213 | 0.0842 | 0.0747 |
Echinococcus multilocularis | aurora kinase A | 0.0192 | 0.0381 | 0.0283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | ChEMBL. | 25408835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.