Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E synthase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | Get druggable targets OG5_131112 | All targets in OG5_131112 |
Schistosoma japonicum | ko:K00799 glutathione S-transferase [EC2.5.1.18], putative | Get druggable targets OG5_131112 | All targets in OG5_131112 |
Schistosoma japonicum | ko:K00799 glutathione S-transferase [EC2.5.1.18], putative | Get druggable targets OG5_131112 | All targets in OG5_131112 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.1922 | 0.6648 | 1 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.059 | 0.1103 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.1922 | 0.6648 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1922 | 0.6648 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1922 | 0.6648 | 1 |
Onchocerca volvulus | 0.0325 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1922 | 0.6648 | 0.6648 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0325 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1922 | 0.6648 | 1 |
Onchocerca volvulus | 0.0325 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0325 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1922 | 0.6648 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0325 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1922 | 0.6648 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0325 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0325 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1922 | 0.6648 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1922 | 0.6648 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1922 | 0.6648 | 1 |
Onchocerca volvulus | 0.0325 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1922 | 0.6648 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0325 | 0 | 0.5 |
Onchocerca volvulus | 0.0325 | 0 | 0.5 | |
Onchocerca volvulus | 0.0325 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1922 | 0.6648 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 63 nM | Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured after 1 min | ChEMBL. | 25260492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.