TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 371.536 | Formula: C22H29NO2S
H donors: 1 H acceptors: 1 LogP: 5.21 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)cc(s1)CCCC(C)C
InChi: 1S/C22H29NO2S/c1-14(2)5-4-6-17-9-16-13-23-8-7-15-10-21(25-3)20(24)11-18(15)19(23)12-22(16)26-17/h9-11,14,19,24H,4-8,12-13H2,1-3H3/t19-/m0/s1
InChiKey: FKGFIIONFUBXKJ-IBGZPJMESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0817	0.6679	1
Onchocerca volvulus		0.0017	0	0.5
Chlamydia trachomatis	serine/threonine protein kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Entamoeba histolytica	protein kinase, putative	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.3371	0.5048
Echinococcus granulosus	Protein kinase C brain isozyme	0.0421	0.3371	0.5048
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0018	0.0009	0.0014
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0811	0.6629	1
Plasmodium falciparum	protein kinase, putative	0.0018	0.0009	0.0014
Entamoeba histolytica	protein kinase 2, putative	0.0809	0.6609	0.6609
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.1213	0.998	0.998
Onchocerca volvulus		0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.1215	1	1
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0817	0.6679	0.6679
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0421	0.3371	0.5048
Onchocerca volvulus		0.0017	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0019	0.002	0.002
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0019	0.002	0.003
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0809	0.6609	0.9896
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0018	0.0009	0.0014
Entamoeba histolytica	protein kinase, putative	0.0817	0.6679	0.6679
Echinococcus multilocularis	serine threonine protein kinase	0.0421	0.3371	0.5048
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0018	0.0009	0.0014
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0421	0.3371	0.5048
Schistosoma mansoni	serine/threonine kinase	0.0421	0.3371	0.5048
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.3371	0.5048
Chlamydia trachomatis	serine/threonine protein kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Mycobacterium leprae	PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0019	0.002	0.002
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0019	0.002	0.002
Trypanosoma cruzi	NIMA-related kinase, putative	0.0019	0.002	0.003
Mycobacterium tuberculosis	Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F)	0.0017	0	0.5
Leishmania major	serine/threonine-protein kinase a, putative	0.0019	0.002	1
Onchocerca volvulus		0.0017	0	0.5
Echinococcus multilocularis	protein kinase c iota type	0.0421	0.3371	0.5048
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro	0.0017	0	0.5
Giardia lamblia	Kinase, AGC PKA	0.0809	0.6609	1
Onchocerca volvulus		0.0017	0	0.5
Echinococcus multilocularis	activin receptor type	0.0018	0.0009	0.0014
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0017	0	0.5
Echinococcus granulosus	Glutaredoxin protein 5	0.0792	0.6471	0.9689
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0019	0.002	0.002
Mycobacterium ulcerans	anchored-membrane serine/threonine-protein kinase PknF	0.0017	0	0.5
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0809	0.6609	0.9896
Mycobacterium ulcerans	serine/threonine-protein kinase PknG	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0421	0.3371	0.3371
Loa Loa (eye worm)	AGC/AKT protein kinase	0.1215	1	1
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0421	0.3371	0.5048
Onchocerca volvulus		0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0421	0.3371	0.3371
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0792	0.6471	0.9689
Entamoeba histolytica	hypothetical protein	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.0017	0	0.5
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0817	0.6679	0.6679
Brugia malayi	Hr1 repeat family protein	0.0421	0.3371	0.3371
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0817	0.6679	0.6679
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H)	0.0017	0	0.5
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0019	0.002	0.002
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Leishmania major	protein kinase, putative	0.0019	0.002	1
Trichomonas vaginalis	AGC family protein kinase	0.0817	0.6679	0.6679
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Leishmania major	folate/biopterin transporter, putative	0.0019	0.002	1
Onchocerca volvulus		0.0017	0	0.5
Toxoplasma gondii	AGC kinase	0.1213	0.998	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0809	0.6609	0.997
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0421	0.3371	0.5048
Brugia malayi	protein kinase C II.	0.0421	0.3371	0.3371
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Mycobacterium ulcerans	membrane-anchored serine/threonine-protein kinase	0.0017	0	0.5
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0792	0.6471	0.9689
Echinococcus granulosus	protein kinase c iota type	0.0421	0.3371	0.5048
Onchocerca volvulus		0.0017	0	0.5
Mycobacterium ulcerans	serine/threonine-protein kinase a PknA	0.0017	0	0.5
Echinococcus granulosus	nervana 2	0.0792	0.6471	0.9689
Entamoeba histolytica	protein kinase, putative	0.1215	1	1
Trichomonas vaginalis	AGC family protein kinase	0.1215	1	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0421	0.3371	0.3371
Trypanosoma brucei	protein kinase, putative	0.0019	0.002	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Entamoeba histolytica	p21-activated kinase	0.0019	0.002	0.002
Leishmania major	protein kinase, putative	0.0019	0.002	1
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0019	0.002	0.002
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.3371	0.5048
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0019	0.002	0.003
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0421	0.3371	0.5048
Echinococcus granulosus	protein kinase C gamma type	0.0421	0.3371	0.5048
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0017	0	0.5
Echinococcus granulosus	protein kinase c epsilon type	0.0421	0.3371	0.5048
Trichomonas vaginalis	AGC family protein kinase	0.0817	0.6679	0.6679
Mycobacterium tuberculosis	Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K)	0.0017	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0018	0.0009	0.0009
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0421	0.3371	0.3371
Onchocerca volvulus		0.0017	0	0.5
Leishmania major	protein kinase, putative	0.0018	0.0009	0.4818
Entamoeba histolytica	protein kinase, putative	0.1215	1	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0811	0.6629	0.9925
Entamoeba histolytica	protein kinase, putative	0.1213	0.998	0.998
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0019	0.002	0.002
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.1215	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0421	0.3371	0.3371
Onchocerca volvulus		0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0423	0.3391	0.3391
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.3371	0.5048
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0019	0.002	0.002
Trypanosoma brucei	protein kinase, putative	0.0018	0.0009	0.0009
Toxoplasma gondii	protein kinase domain-containing protein	0.0019	0.002	0.002
Echinococcus multilocularis	rac serine:threonine kinase	0.0811	0.6629	0.9925
Echinococcus granulosus	serine threonine protein kinase nrc	0.0809	0.6609	0.9896
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0017	0	0.5
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Brugia malayi	Protein kinase domain containing protein	0.0421	0.3371	0.3371
Trypanosoma cruzi	NIMA-related kinase, putative	0.0019	0.002	0.003
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0421	0.3371	0.3371
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0421	0.3371	0.5048
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0421	0.3371	0.5048
Echinococcus granulosus	serine/threonine protein kinase	0.0811	0.6629	0.9925
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0019	0.002	0.003
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0019	0.002	0.003
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Schistosoma mansoni	protein kinase	0.0018	0.0009	0.0014
Onchocerca volvulus		0.0017	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.3371	0.5048
Echinococcus granulosus	activin receptor type	0.0018	0.0009	0.0014
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0421	0.3371	0.5048
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0019	0.002	0.003
Trichomonas vaginalis	AGC family protein kinase	0.1215	1	1
Mycobacterium ulcerans	serine/threonine-protein kinase PknF_2	0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0811	0.6629	0.6629
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0017	0	0.5
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0019	0.002	0.003
Onchocerca volvulus		0.0017	0	0.5
Trypanosoma cruzi	Protein kinase B	0.0811	0.6629	1
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0018	0.0009	0.0014
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0019	0.002	1
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0421	0.3371	0.5048
Trichomonas vaginalis	AGC family protein kinase	0.0421	0.3371	0.3371
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0019	0.002	0.003
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0019	0.002	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0811	0.6629	0.6629
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0817	0.6679	0.6679
Onchocerca volvulus	Protein kinase homolog	0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_2	0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0019	0.002	0.003
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0019	0.002	0.003
Onchocerca volvulus		0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Trypanosoma brucei	rac serine-threonine kinase, putative	0.1215	1	1
Mycobacterium tuberculosis	Serine/threonine-protein kinase PknG (protein kinase G) (STPK G)	0.0017	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0817	0.6679	0.6679
Onchocerca volvulus		0.0017	0	0.5
Echinococcus granulosus	NDR protein kinase	0.0421	0.3371	0.5048
Trichomonas vaginalis	AGC family protein kinase	0.1215	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0817	0.6679	1
Onchocerca volvulus		0.0017	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0019	0.002	0.002
Echinococcus multilocularis	nervana 2	0.0792	0.6471	0.9689
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0018	0.0009	0.0014
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0019	0.002	0.002
Mycobacterium ulcerans	transmembrane serine/threonine-protein kinase PknQ	0.0017	0	0.5
Onchocerca volvulus	Kinase homolog	0.0017	0	0.5
Brugia malayi	p70 ribosomal S6 kinase beta	0.1213	0.998	0.998
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0019	0.002	0.003
Onchocerca volvulus		0.0017	0	0.5
Schistosoma mansoni	protein kinase	0.0018	0.0009	0.0014
Schistosoma mansoni	atypical protein kinase C	0.0421	0.3371	0.5048
Schistosoma mansoni	protein kinase	0.0018	0.0009	0.0014
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0817	0.6679	1
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0421	0.3371	0.5048
Onchocerca volvulus		0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.002	0.002
Echinococcus multilocularis	Glutaredoxin protein 5	0.0792	0.6471	0.9689
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus	Asator homolog	0.0017	0	0.5
Echinococcus multilocularis	protein kinase c epsilon type	0.0421	0.3371	0.5048
Onchocerca volvulus		0.0017	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0019	0.002	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.3371	0.5048
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0017	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.1215	1	1
Brugia malayi	Protein kinase domain containing protein	0.0421	0.3371	0.3371
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0421	0.3371	0.3371
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5
Echinococcus granulosus	twitchin	0.0029	0.0104	0.0156
Echinococcus granulosus	serine:threonine protein kinase N2	0.0421	0.3371	0.5048
Echinococcus multilocularis	nervana 2	0.0792	0.6471	0.9689
Trichomonas vaginalis	AGC family protein kinase	0.1215	1	1
Onchocerca volvulus		0.0017	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.3371	0.5048
Chlamydia trachomatis	serine/threonine-protein kinase	0.0017	0	0.5
Schistosoma mansoni	serine/threonine-protein kinase	0.0811	0.6629	0.9925
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0019	0.002	0.002
Echinococcus granulosus	nervana 2	0.0792	0.6471	0.9689
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0017	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0019	0.002	0.002
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0421	0.3371	0.3371
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0018	0.0009	0.0009
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E)	0.0017	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0421	0.3371	0.3371
Entamoeba histolytica	protein kinase domain containing protein	0.0018	0.0009	0.0009
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0809	0.6609	1
Entamoeba histolytica	hypothetical protein	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0404	0.3233	0.3233
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_3	0.0017	0	0.5
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0809	0.6609	1
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0019	0.002	0.002
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0421	0.3371	0.3371
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0019	0.002	0.002
Onchocerca volvulus		0.0017	0	0.5
Onchocerca volvulus		0.0017	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 34.9 %	Displacement of [3H]Ketanserin from 5HT2A receptor (unknown origin) transfected in HEK293T cells at 10 uM after 15 mins by liquid scintillation counting analysis	ChEMBL.	25308766
Inhibition (binding)	= 36.31 %	Displacement of [3H]8-OH-DPAT from 5HT1A receptor (unknown origin) transfected in HEK293T cells at 10 uM after 50 mins by liquid scintillation counting analysis	ChEMBL.	25308766
Inhibition (binding)	= 68.06 %	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells at 10 uM after 50 mins by liquid scintillation counting analysis	ChEMBL.	25308766
Inhibition (binding)	= 88.99 %	Displacement of [3H]Spiperone from D2 receptor (unknown origin) transfected in HEK293T cells at 10 uM after 50 mins by liquid scintillation counting analysis	ChEMBL.	25308766

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3344464

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 936062