Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1214 | 0.6206 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0374 | 0.1875 | 0.1108 |
Echinococcus granulosus | thymidylate synthase | 0.0374 | 0.1875 | 0.1875 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0014 | 0.0014 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0014 | 0.0014 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1214 | 0.6206 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0018 | 0.0018 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1214 | 0.6206 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.195 | 1 | 1 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0014 | 0.0014 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.195 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0178 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0018 | 0.0018 |
Schistosoma mansoni | dihydrofolate reductase | 0.195 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0374 | 0.1875 | 0.1875 |
Echinococcus multilocularis | dihydrofolate reductase | 0.195 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.195 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.195 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0374 | 0.1875 | 0.1875 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0033 | 0.0033 |
Brugia malayi | hypothetical protein | 0.0178 | 0.0862 | 0.0862 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1214 | 0.6206 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.195 | 1 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0167 | 0.0803 | 0.018 |
Echinococcus granulosus | roundabout 2 | 0.0017 | 0.0033 | 0.0033 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0014 | 0.0014 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0374 | 0.1875 | 0.1875 |
Chlamydia trachomatis | dihydrofolate reductase | 0.195 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1214 | 0.6206 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0178 | 0.0862 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1214 | 0.6206 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0018 | 0.0018 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0033 | 0.0033 |
Echinococcus multilocularis | thymidylate synthase | 0.0374 | 0.1875 | 0.1875 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.195 | 1 | 1 |
Onchocerca volvulus | 0.0374 | 0.1875 | 1 | |
Echinococcus multilocularis | roundabout 2 | 0.0017 | 0.0033 | 0.0033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 93 uM | Inhibition of Staphylococcus aureus DNA gyrase assessed as reduction in enzyme-catalyzed supercoiling of relaxed circular pBR322 DNA by agarose gel electrophoresis | ChEMBL. | 25238555 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.