Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sirtuin 2 | Starlite/ChEMBL | References |
Homo sapiens | sirtuin 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | transcriptional regulatory protein sir2a | sirtuin 2 | 234 aa | 207 aa | 26.1 % |
Trypanosoma brucei | SIR2-like protein 4, putative | sirtuin 3 | 257 aa | 247 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | 0.1261 | 1 | 1 |
Onchocerca volvulus | 0.1261 | 1 | 1 | |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0269 | 0.0524 | 0.0524 |
Echinococcus multilocularis | carboxylesterase 5A | 0.092 | 0.6743 | 0.6743 |
Plasmodium falciparum | transporter, putative | 0.0214 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1261 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0269 | 0.0524 | 0.0524 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0269 | 0.0524 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.092 | 0.6743 | 0.6743 |
Echinococcus granulosus | acetylcholinesterase | 0.092 | 0.6743 | 0.6743 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0269 | 0.0524 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.092 | 0.6743 | 0.6743 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0214 | 0 | 0.5 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0269 | 0.0524 | 0.0524 |
Toxoplasma gondii | hypothetical protein | 0.0214 | 0 | 0.5 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0269 | 0.0524 | 0.0524 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0214 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.092 | 0.6743 | 0.6743 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.092 | 0.6743 | 0.6743 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0269 | 0.0524 | 0.5 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0269 | 0.0524 | 0.0524 |
Giardia lamblia | Hypothetical protein | 0.0269 | 0.0524 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0269 | 0.0524 | 0.0524 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0269 | 0.0524 | 0.0524 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1261 | 1 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.1261 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.092 | 0.6743 | 0.6743 |
Leishmania major | silent information regulator 2, putative | 0.0269 | 0.0524 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0269 | 0.0524 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.092 | 0.6743 | 0.6743 |
Plasmodium vivax | hypothetical protein, conserved | 0.0214 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.092 | 0.6743 | 0.6743 |
Loa Loa (eye worm) | transcriptional regulator | 0.0269 | 0.0524 | 0.0524 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1261 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0214 | 0 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0269 | 0.0524 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0214 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0214 | 0 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1261 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1261 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0214 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.092 | 0.6743 | 0.6743 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 1 | 1 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0269 | 0.0524 | 0.0524 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0269 | 0.0524 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0269 | 0.0524 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.1261 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.092 | 0.6743 | 0.6743 |
Plasmodium falciparum | amino acid transporter, putative | 0.0214 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.092 | 0.6743 | 0.6743 |
Loa Loa (eye worm) | hypothetical protein | 0.092 | 0.6743 | 0.6743 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 uM | Inhibition of catalytically active human SIRT3 (102 to 399 amino acids) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide by fluorescence assay | ChEMBL. | 25275824 |
IC50 (binding) | = 9.7 uM | Inhibition of full length human SIRT2 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide by fluorescence assay | ChEMBL. | 25275824 |
IC50 (binding) | = 40.9 uM | Inhibition of full length human SIRT1 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide by fluorescence assay | ChEMBL. | 25275824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.