Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3221 | 0.3525 |
Echinococcus granulosus | lamin | 0.0026 | 0.3221 | 0.3146 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0429 | 0.047 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0055 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.3221 | 0.3146 |
Onchocerca volvulus | 0.0026 | 0.3221 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.011 | 0.012 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0055 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3111 | 0.3405 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0055 | 1 | 0.5 |
Echinococcus multilocularis | lamin | 0.0026 | 0.3221 | 0.3146 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0055 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.3221 | 0.3146 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.9139 | 1 |
Onchocerca volvulus | 0.0026 | 0.3221 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0026 | 0.3221 | 0.2917 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.3221 | 0.3525 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.3221 | 0.3525 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.3221 | 0.2917 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0055 | 1 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.3221 | 0.3146 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0055 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.3221 | 0.3146 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 | > 200 uM | Cytotoxicity against mouse J774 cells assessed as reduction of cell viability after 48 hrs by resazurin dye-based fluorometric method | LITERATURE. | 27318121 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.