Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0073 | 0.3329 | 0.3329 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3329 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.3329 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.5413 | 0.5413 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.5413 | 0.5413 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3329 | 0.5 |
Onchocerca volvulus | 0.0157 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2908 | 0.2908 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5413 | 0.5413 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.2908 | 0.2908 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3329 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3329 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.5413 | 0.5413 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.3329 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.3329 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.3329 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2908 | 0.8733 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 200 uM | Antimicrobial activity against Escherichia coli ATCC 25922 after 12 to 16 hrs by broth micro-dilution method | ChEMBL. | 25282671 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.