Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0138 | 0.7431 | 0.7226 |
Brugia malayi | hypothetical protein | 0.0018 | 0.022 | 0.272 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.4787 | 0.4372 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0807 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0807 | 0.5 |
Schistosoma mansoni | alkaline phosphatase | 0.0181 | 1 | 1 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0181 | 1 | 1 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0181 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0807 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0807 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0807 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0149 | 0.8096 | 0.7944 |
Onchocerca volvulus | 0.0027 | 0.0737 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0807 | 1 |
Echinococcus multilocularis | alkaline phosphatase | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0737 | 0.9135 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0737 | 0.9135 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0138 | 0.7431 | 0.7226 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0181 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0737 | 0.9135 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0737 | 0.9135 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0807 | 0.5 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0181 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0807 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.0737 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0149 | 0.8096 | 0.7944 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0737 | 0.9135 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0807 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0807 | 0.5 |
Echinococcus granulosus | alkaline phosphatase | 0.0181 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0149 | 0.8096 | 0.7944 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0708 | 0.8775 |
Schistosoma mansoni | alkaline phosphatase | 0.0181 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.7431 | 0.7226 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 50 ug ml-1 | Antibacterial against Escherichia coli ATCC 25922 after 24 hrs by two-fold serial dilution method | ChEMBL. | 25306465 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.