Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0016 | 0.0632 | 0.2981 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0184 | 0.0184 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.1111 | 0.3783 | |
Mycobacterium ulcerans | thioesterase | 0.002 | 0.0934 | 0.443 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.1335 | 0.6376 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.1172 | 0.5599 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0797 | 0.5 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.1335 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.1335 | 0.6357 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0797 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.1335 | 0.6337 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0184 | 0.0184 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0797 | 0.4492 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0184 | 0.2306 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0184 | 0.0184 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0184 | 0.2306 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0023 | 0.0108 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0184 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0184 | 0.0184 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0184 | 0.2306 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0184 | 0.0184 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0184 | 0.2306 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0184 | 0.2306 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0797 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0024 | 0.1226 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.1226 | 0.5834 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0044 | 0.2634 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0008 | 0.0011 | 0.0052 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0046 | 0.2797 | 0.2797 |
Onchocerca volvulus | 0.0042 | 0.2525 | 0.9555 | |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2419 | 0.2277 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.0732 | 0.3495 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0184 | 0.2306 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0016 | 0.0632 | 0.2981 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.1335 | 0.6376 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.1172 | 0.5599 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0184 | 0.2306 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.0469 | 0.224 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0017 | 0.072 | 0.3708 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0184 | 0.0184 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0184 | 0.2306 |
Mycobacterium ulcerans | thioesterase TesA | 0.002 | 0.0934 | 0.443 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0036 | 0.2094 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0797 | 0.0625 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0797 | 0.0797 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0184 | 0.0184 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0184 | 0.0184 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0184 | 0.2306 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.1226 | 0.5834 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0184 | 0.0184 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.0181 | 0.0864 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.1335 | 0.6357 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0797 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0023 | 0.0056 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0797 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0024 | 0.1226 | 0.5856 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1111 | 0.1111 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.1226 | 0.5834 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0797 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0454 | 0.0276 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0797 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.1226 | 0.5834 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0797 | 0.0625 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.1335 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.0883 | 0.4188 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0797 | 0.3806 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0184 | 0.2306 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.1226 | 0.5856 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0797 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.0906 | 0.4329 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.1335 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0016 | 0.0632 | 0.2941 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0184 | 0.0184 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0797 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.0883 | 0.4155 |
Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.1203 | 0.1038 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0036 | 0.2094 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0024 | 0.1226 | 0.581 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.1111 | 0.0944 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0797 | 0.3774 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0184 | 0.2306 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0797 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.002 | 0.0934 | 0.4459 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0797 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0797 | 0.0625 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0184 | 0.0184 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0797 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.1111 | 0.5305 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0184 | 0.0184 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0184 | 0.2306 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0036 | 0.2094 | 1 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0184 | 0.0184 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0024 | 0.1226 | 0.1226 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0184 | 0.0184 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.0883 | 0.4188 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.002 | 0.0934 | 0.4398 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0797 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0024 | 0.1226 | 0.581 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0184 | 0.2306 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0797 | 0.5 |
Loa Loa (eye worm) | acyl carrier protein | 0.0011 | 0.0278 | 0.0096 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.1335 | 0.6376 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0036 | 0.2094 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0008 | 0.0075 | 0.0356 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.061 | 0.2574 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.1335 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0024 | 0.1226 | 0.5856 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T1/2 (ADMET) | = 4.21 hr | Half life in human plasma by TLC | ChEMBL. | 25440502 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.