Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.0469 | 0.224 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0184 | 0.2306 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.1335 | 0.6376 |
Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.1203 | 0.1038 |
Onchocerca volvulus | 0.0023 | 0.1111 | 0.3783 | |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0184 | 0.2306 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0184 | 0.0184 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0184 | 0.0184 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0797 | 0.4492 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0184 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.1226 | 0.5834 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0184 | 0.2306 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0023 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0454 | 0.0276 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.0883 | 0.4188 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1111 | 0.1111 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.1172 | 0.5599 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0797 | 0.0625 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0797 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.1335 | 0.6357 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0184 | 0.0184 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0184 | 0.2306 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 1 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0008 | 0.0011 | 0.0052 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.0883 | 0.4188 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0797 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0024 | 0.1226 | 0.5856 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0184 | 0.2306 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0184 | 0.2306 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.002 | 0.0934 | 0.4398 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0797 | 0.3806 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0797 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0184 | 0.0184 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0184 | 0.2306 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.061 | 0.2574 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0024 | 0.1226 | 0.581 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0037 | 0.2094 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.002 | 0.0934 | 0.4459 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0023 | 0.0108 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0011 | 0.0011 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0797 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0024 | 0.1226 | 0.5834 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0184 | 0.2306 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0184 | 0.0184 |
Onchocerca volvulus | 0.0043 | 0.2525 | 0.9555 | |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0797 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0017 | 0.072 | 0.3708 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0797 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.1226 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0024 | 0.1226 | 0.5856 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.0181 | 0.0864 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0184 | 0.0184 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.1172 | 0.5599 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 1 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.1335 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.0883 | 0.4155 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0037 | 0.2094 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0024 | 0.1226 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0008 | 0.0075 | 0.0356 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.1226 | 0.5834 |
Mycobacterium ulcerans | thioesterase | 0.002 | 0.0934 | 0.443 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0797 | 0.0797 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0184 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0184 | 0.0184 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0797 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0797 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.1335 | 0.6376 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0037 | 0.2094 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.1111 | 0.5305 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0184 | 0.0184 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.1335 | 0.6337 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0184 | 0.0184 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0797 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0016 | 0.0632 | 0.2981 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2419 | 0.2277 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0797 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0797 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0184 | 0.2306 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0184 | 0.2306 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.0732 | 0.3495 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.1111 | 0.0944 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0797 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0024 | 0.1226 | 0.1226 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0037 | 0.2094 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.1335 | 0.6376 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0184 | 0.0184 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0044 | 0.2634 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0016 | 0.0632 | 0.2941 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.1226 | 0.5856 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0797 | 0.3774 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.1335 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0797 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0797 | 0.0625 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0184 | 0.0184 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0046 | 0.2797 | 0.2797 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0184 | 0.2306 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.0906 | 0.4329 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0016 | 0.0632 | 0.2981 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.1335 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0797 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0184 | 0.2306 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.1335 | 0.6357 |
Mycobacterium ulcerans | thioesterase TesA | 0.002 | 0.0934 | 0.443 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0184 | 0.2306 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0184 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0184 | 0.0184 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0797 | 0.0625 |
Loa Loa (eye worm) | acyl carrier protein | 0.0011 | 0.0278 | 0.0096 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.1226 | 0.5834 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0184 | 0.0184 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.1335 | 0.6337 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.