Detailed information for compound 937202

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 625.975 | Formula: C24H25ClN5O9PS
  • H donors: 1 H acceptors: 5 LogP: 3.41 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: [N-]=[N+]=N[C@H]1C[C@@H](O[C@@H]1COP(=O)(Oc1ccc(cc1)Cl)OCCS(=O)(=O)c1ccccc1)n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C24H25ClN5O9PS/c1-16-14-30(24(32)27-23(16)31)22-13-20(28-29-26)21(38-22)15-37-40(33,39-18-9-7-17(25)8-10-18)36-11-12-41(34,35)19-5-3-2-4-6-19/h2-10,14,20-22H,11-13,15H2,1H3,(H,27,31,32)/t20-,21+,22+,40?/m0/s1
  • InChiKey: WCFOYFGJJKXIBO-WQJRZSNASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.0044 0.0468 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0215 0.1459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.1219 0.1164
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0272 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0215 0.0166
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0272 0.5
Echinococcus multilocularis FTZ F1 alpha 0.007 0.1219 0.1256
Schistosoma mansoni chromobox protein 0.0069 0.1197 0.1231
Echinococcus granulosus chromobox protein 1 0.0069 0.1197 0.1261
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1093 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.1219 0.1164
Mycobacterium ulcerans beta-lactamase 0.0035 0.0215 0.7255
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0153
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0215 0.0166
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0153
Brugia malayi Carboxylesterase family protein 0.0132 0.3016 0.2972
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.1219 0.1164
Schistosoma mansoni DNA polymerase eta 0.0044 0.0468 0.044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.1127 0.1155
Echinococcus multilocularis acetylcholinesterase 0.0132 0.3016 0.3207
Schistosoma mansoni retinoic acid receptor RXR 0.007 0.1219 0.1256
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.1219 0.1256
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.1093 0.1118
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0272 0.2011
Leishmania major DNA polymerase eta, putative 0.0044 0.0468 0.392
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0977 0.0992
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0159 0.0138
Echinococcus multilocularis GPCR, family 2 0.0066 0.1127 0.1155
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.1219 0.1164
Brugia malayi Carboxylesterase family protein 0.0132 0.3016 0.2972
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.1219 0.1164
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0977 0.0992
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.1219 0.1286
Brugia malayi hypothetical protein 0.0037 0.0273 0.0211
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0159 0.0097
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.1219 0.1256
Loa Loa (eye worm) hypothetical protein 0.0044 0.0468 0.0408
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.1219 0.1286
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0272 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.5263 0.5233
Brugia malayi RNA binding protein 0.0061 0.0977 0.092
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.1093 1
Leishmania major DNA polymerase eta, putative 0.0031 0.0095 0.0287
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.1219 0.1256
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0977 0.0992
Loa Loa (eye worm) DR-78 0.0033 0.0159 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.1219 0.1164
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0159 0.0097
Schistosoma mansoni hypothetical protein 0.0066 0.1127 0.1155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.1219 0.1256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0625 0.0643
Schistosoma mansoni hypothetical protein 0.0349 0.9273 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0273 0.0228
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0215 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0625 0.0611
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0272 0.0211
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0159 0.0105
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0215 0.7288
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0159 0.0127
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0211
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0977 0.0992
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Echinococcus granulosus carboxylesterase 5A 0.0132 0.3016 0.323
Schistosoma mansoni thyroid hormone receptor 0.007 0.1219 0.1256
Brugia malayi Cytochrome P450 family protein 0.003 0.0065 0.0003
Brugia malayi nuclear receptor NHR-88 0.007 0.1219 0.1164
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.1219 0.1286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.1219 0.1164
Schistosoma mansoni hypothetical protein 0.0066 0.1127 0.1155
Loa Loa (eye worm) hypothetical protein 0.0066 0.1127 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.1219 0.1164
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Schistosoma mansoni thyroid hormone receptor 0.007 0.1219 0.1256
Schistosoma mansoni chromobox protein 0.0069 0.1197 0.1231
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.1219 0.1256
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0231 0.5864 0.6311
Schistosoma mansoni hypothetical protein 0.0143 0.3349 0.3568
Brugia malayi nuclear receptor RXR 0.0033 0.0159 0.0097
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.1093 1
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.1219 0.1256
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.1127 0.1185
Echinococcus granulosus geminin 0.0349 0.9273 1
Brugia malayi Latrophilin receptor protein 2 0.0066 0.1127 0.1071
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.1219 0.1932
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0273 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.1219 0.1164
Onchocerca volvulus 0.0041 0.0387 0.0516
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.1093 0.1036
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0273 0.0261
Onchocerca volvulus 0.0035 0.0215 0.0222
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0272 0.2011
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0977 0.0992
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.1219 0.1164
Echinococcus multilocularis geminin 0.0349 0.9273 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.1197 0.1231
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.1219 0.1164
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0159 0.0127
Echinococcus multilocularis acetylcholinesterase 0.0132 0.3016 0.3207
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0387 0.0353
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.5263 0.5233
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0272 0.5
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.3016 0.3207
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0977 0.092
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0272 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0211
Schistosoma mansoni ap endonuclease 0.0037 0.0272 0.0227
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0215 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0272 0.0105
Mycobacterium ulcerans hypothetical protein 0.0035 0.0215 0.7255
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0095 0.0287
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.5619 1
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.3349 0.3307
Loa Loa (eye worm) hypothetical protein 0.007 0.1219 0.1164
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0211
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0272 0.0456
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1197 0.2008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0272 0.2011
Schistosoma mansoni hypothetical protein 0.0066 0.1127 0.1155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0625 0.0566
Brugia malayi Heterochromatin protein 1 0.0069 0.1197 0.1141
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1197 0.2008
Brugia malayi nuclear hormone receptor 0.0033 0.0159 0.0097
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0903 0.0845
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.1219 0.1256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0625 0.0643
Brugia malayi beta-lactamase 0.0035 0.0215 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0625 0.0611
Loa Loa (eye worm) hypothetical protein 0.007 0.1219 0.1164
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.2572 0.2724
Toxoplasma gondii ABC1 family protein 0.0035 0.0215 0.7288
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0273 0.0228
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0301 0.0258
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0159 0.0097
Brugia malayi tailless protein 0.0033 0.0159 0.0097
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0625 0.0566
Leishmania major hypothetical protein, conserved 0.0035 0.0215 0.1459
Brugia malayi nuclear hormone receptor 0.007 0.1219 0.1164
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Mycobacterium ulcerans lipase LipD 0.0035 0.0215 0.7255
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0215 0.7255
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0159 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.1219 0.1286
Schistosoma mansoni hypothetical protein 0.0349 0.9273 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0325 0.0264
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0211
Echinococcus multilocularis chromobox protein 1 0.0069 0.1197 0.1231
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0409 0.0687
Schistosoma mansoni nuclear hormone receptor 0.007 0.1219 0.1256
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.1127 0.1071
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0159 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0211
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0159 0.0138
Echinococcus granulosus retinoic acid receptor rxr beta a 0.007 0.1219 0.1286
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.1219 0.1256
Echinococcus granulosus tar DNA binding protein 0.0061 0.0977 0.1023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0153
Mycobacterium leprae Probable lipase LipE 0.0035 0.0215 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0159 0.0138
Brugia malayi nuclear receptor NHR-88 0.0033 0.0159 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0625 0.0611
Onchocerca volvulus 0.0234 0.5959 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0272 0.026
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0977 0.092
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0153
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0159 0.0097
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.1219 0.1286
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.1219 0.1256
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0272 0.0456
Echinococcus granulosus acetylcholinesterase 0.0132 0.3016 0.323
Brugia malayi Cytochrome P450 family protein 0.003 0.0065 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0153
Trichomonas vaginalis set domain proteins, putative 0.0234 0.5959 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.1219 0.1256
Schistosoma mansoni lipoxygenase 0.0081 0.1561 0.1627
Loa Loa (eye worm) hypothetical protein 0.0143 0.3349 0.3307
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0215 0.0361
Loa Loa (eye worm) hypothetical protein 0.007 0.1219 0.1164
Brugia malayi chromobox protein homolog 3 0.0039 0.0325 0.0264
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0159 0.0105
Brugia malayi hypothetical protein 0.0033 0.0159 0.0097
Trichomonas vaginalis esterase, putative 0.0035 0.0215 0.0361
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0159 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.1219 0.1164
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0409 0.0687
Loa Loa (eye worm) hypothetical protein 0.007 0.1219 0.1164
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0215 0.0166
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Onchocerca volvulus Bile acid receptor homolog 0.007 0.1219 0.1932
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0468 0.0408
Loa Loa (eye worm) hypothetical protein 0.007 0.1219 0.1164
Brugia malayi beta-lactamase family protein 0.0035 0.0215 0.0153
Brugia malayi ecdysteroid receptor 0.007 0.1219 0.1164
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0273 0.0228
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0022
Loa Loa (eye worm) hypothetical protein 0.0132 0.3016 0.2972
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.1219 0.1164
Schistosoma mansoni lipoxygenase 0.0117 0.2572 0.2724
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0409 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.1219 0.1164
Brugia malayi Cytochrome P450 family protein 0.0059 0.0903 0.0845
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0273 0.0211
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0231 0.5864 0.6298
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.514 0.511
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0977 0.0992
Echinococcus granulosus chromobox protein 1 0.0069 0.1197 0.1261
Brugia malayi ecdysone receptor 0.0033 0.0159 0.0097
Loa Loa (eye worm) hypothetical protein 0.007 0.1219 0.1164
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0215 0.0153
Onchocerca volvulus 0.0033 0.0159 0.0127
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Schistosoma mansoni ap endonuclease 0.0037 0.0272 0.0227
Schistosoma mansoni nuclear receptor 0.0033 0.0159 0.0105
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0033 0.0159 0.0105
Brugia malayi steroid hormone receptor 0.007 0.1219 0.1164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.1219 0.1164
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0325 0.0545
Loa Loa (eye worm) hypothetical protein 0.007 0.1219 0.1164
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.1093 0.1036
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0215 0.0361
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.3016 0.3207
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.1219 0.1164
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.1219 0.1256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0625 0.0611
Brugia malayi conserved hypotetical protein 0.0033 0.0159 0.0097
Schistosoma mansoni nuclear receptor 0.0033 0.0159 0.0105
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.1219 0.1164
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0095 0.1534
Brugia malayi nuclear receptor RXR 0.0037 0.0273 0.0211
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1093 1
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0272 0.0211
Loa Loa (eye worm) RNA binding protein 0.0061 0.0977 0.092
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0159 0.0105
Loa Loa (eye worm) beta-lactamase 0.0035 0.0215 0.0153
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.3016 0.2972
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.1219 0.1286
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0159 0.0105
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0159 0.0105
Toxoplasma gondii exonuclease III APE 0.0037 0.0272 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0215 0.0361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0625 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.1219 0.1164
Brugia malayi beta-lactamase family protein 0.0035 0.0215 0.0153
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1093 1
Brugia malayi hypothetical protein 0.0033 0.0159 0.0097
Schistosoma mansoni coup transcription factor 0.007 0.1219 0.1256
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0159 0.0097
Onchocerca volvulus 0.0033 0.0159 0.0127
Echinococcus granulosus GPCR family 2 0.0066 0.1127 0.1185
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0215 0.0361
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0159 0.0105
Loa Loa (eye worm) hypothetical protein 0.0374 1 1
Loa Loa (eye worm) carboxylesterase 0.0132 0.3016 0.2972
Loa Loa (eye worm) CYP4Cod1 0.003 0.0065 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.1219 0.1164
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0325 0.0409
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0468 0.392
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0215 0.1459
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.1219 0.1256
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0272 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0215 0.0199
Brugia malayi TAR-binding protein 0.0061 0.0977 0.092
Brugia malayi Steroid receptor seven-up type 2 0.007 0.1219 0.1164
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0159 0.0138
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.1219 0.1286
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0977 0.092
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0272 0.0227
Brugia malayi hypothetical protein 0.0037 0.0273 0.0211
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.1197 0.1141
Echinococcus granulosus acetylcholinesterase 0.0132 0.3016 0.323
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0159 0.0138
Onchocerca volvulus 0.0035 0.0215 0.0222
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.1219 0.1256
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0468 0.392
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0272 0.2011
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0065 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0063 0.0034
Brugia malayi nuclear receptor NHR-67 0.0033 0.0159 0.0097
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0215 0.1459
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0159 0.0097
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.1219 0.1932
Loa Loa (eye worm) steroid hormone receptor 0.007 0.1219 0.1164
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.2572 0.2749
Loa Loa (eye worm) hypothetical protein 0.007 0.1219 0.1164
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.1219 0.1256
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.1219 0.1164
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0159 0.0105
Onchocerca volvulus 0.007 0.1219 0.1932
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.1093 0.1118
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.1219 0.1164
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0301 0.0291
Loa Loa (eye worm) hypothetical protein 0.0132 0.3016 0.2972
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0273 0.0211
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0159 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0325 0.0545
Schistosoma mansoni zinc finger protein 0.0033 0.0159 0.0105
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0153
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0065 0.0003
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0159 0.0097
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.1093 0.1148
Echinococcus multilocularis dna polymerase eta 0.0044 0.0468 0.044
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.1219 0.1256
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0159 0.0105
Echinococcus granulosus FTZ F1 alpha 0.007 0.1219 0.1286
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.1219 0.1256
Brugia malayi Pre-SET motif family protein 0.0206 0.514 0.511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.1219 0.1164
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0215 0.0361
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.1127 0.1071
Schistosoma mansoni hypothetical protein 0.0066 0.1127 0.1155
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0097
Onchocerca volvulus 0.0035 0.0215 0.0222
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0159 0.0097
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0215 0.7255

Activities

Activity type Activity value Assay description Source Reference
T1/2 (ADMET) = 0.35 hr Half life in human plasma by TLC ChEMBL. 25440502

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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