Detailed information for compound 937245

Basic information

Technical information
  • TDR Targets ID: 937245
  • Name: (2R,3R,4S,5R)-2-[6-amino-2-[(Z)-hex-1-enyl]pu rin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
  • MW: 349.385 | Formula: C16H23N5O4
  • H donors: 4 H acceptors: 6 LogP: 0.65 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC/C=C\c1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
  • InChi: 1S/C16H23N5O4/c1-2-3-4-5-6-10-19-14(17)11-15(20-10)21(8-18-11)16-13(24)12(23)9(7-22)25-16/h5-6,8-9,12-13,16,22-24H,2-4,7H2,1H3,(H2,17,19,20)/b6-5-/t9-,12-,13-,16-/m1/s1
  • InChiKey: CGSZRCYBQDADPV-OHNRUJSOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S,5R)-2-[6-amino-2-[(Z)-hex-1-enyl]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-[6-amino-2-[(Z)-hex-1-enyl]-9-purinyl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-[6-amino-2-[(Z)-hex-1-enyl]purin-9-yl]-5-methylol-tetrahydrofuran-3,4-diol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosine A2a receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2a receptor   410 aa 346 aa 28.3 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2a receptor   410 aa 340 aa 27.9 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Echinococcus multilocularis allatostatin A receptor Adenosine A2a receptor   410 aa 372 aa 22.8 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2a receptor   410 aa 399 aa 28.1 %
Echinococcus granulosus allatostatin A receptor Adenosine A2a receptor   410 aa 368 aa 22.6 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2a receptor   410 aa 366 aa 25.4 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A2a receptor   410 aa 352 aa 23.6 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 337 aa 23.1 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 356 aa 23.9 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus allatostatin A receptor 0.003 0.0065 0.0065
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0065 0.0065
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0305 0.1297 0.3442
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0065 0.0065
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0103 0.0106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0065 0.0065
Schistosoma mansoni rab6-interacting 0.0021 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.004 0.004
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0065 0.0065
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0007 0.0007
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0079 0.0285 0.0285
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0501 0.0519
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.0219 0.0219
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0065 0.0065
Schistosoma mansoni neuropeptide receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0079 0.0285 0.0296
Brugia malayi Uncoordinated protein 44 0.0015 0 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0733 0.6354
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.2174 0.9647 1
Onchocerca volvulus 0.003 0.0065 0.0885
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0061 0.0063
Echinococcus multilocularis Biotin lipoyl attachment 0.0079 0.0285 0.0285
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0079 0.0285 0.0296
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0065 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0065 0.0065
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0065 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0065 0.0065
Mycobacterium ulcerans hypothetical protein 0.0038 0.0103 0.0272
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0091 0.0094
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0015 0.0002 0.0002
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0305 0.1297 0.1297
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0127 0.0501 0.0685
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0194 0.0799 0.0799
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0305 0.1297 0.3442
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0103 0.0106
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Mycobacterium tuberculosis Conserved protein 0.0038 0.0103 0.0272
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0103 0.0876
Brugia malayi Serotonin receptor 0.003 0.0065 0.0068
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0305 0.1297 0.1297
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0065 0.0065
Brugia malayi Doublecortin family protein 0.0021 0.0026 0.0027
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Brugia malayi larval opioid receptor 0.003 0.0065 0.0068
Brugia malayi Dopamine receptor 0.003 0.0065 0.0068
Brugia malayi Cytochrome P450 family protein 0.0024 0.0042 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0026 0.0027
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0119 0.0464 0.0464
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0858 0.3767 0.3767
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0079 0.0285 0.0285
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0079 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0036 0.0094 0.0094
Brugia malayi beta-lactamase family protein 0.0038 0.0103 0.0106
Onchocerca volvulus 0.003 0.0065 0.0885
Loa Loa (eye worm) hypothetical protein 0.0053 0.0168 0.0174
Onchocerca volvulus 0.003 0.0065 0.0885
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0065 0.0065
Onchocerca volvulus 0.0038 0.0103 0.1395
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0858 0.3767 1
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0065 0.0065
Mycobacterium leprae Probable lipase LipE 0.0038 0.0103 0.0272
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Schistosoma mansoni neuropeptide receptor 0.003 0.0065 0.0065
Brugia malayi Cation transporter family protein 0.0064 0.0219 0.0227
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0056 0.0467
Echinococcus granulosus neuropeptide s receptor 0.003 0.0065 0.0065
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0057 0.0187 0.0193
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0079 0.0285 0.0463
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0305 0.1297 0.1297
Loa Loa (eye worm) hypothetical protein 0.0053 0.0168 0.0174
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.004 0.004
Schistosoma mansoni amine GPCR 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0079 0.0285 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0103 0.0166
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0305 0.1297 0.3233
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0103 0.0132
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0026 0.0027
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0065 0.0065
Schistosoma mansoni lipoxygenase 0.0088 0.0325 0.0325
Schistosoma mansoni lamin 0.0029 0.0061 0.0061
Leishmania major hypothetical protein, conserved 0.0038 0.0103 0.0103
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0065 0.0065
Schistosoma mansoni polycystin 1-related 0.0021 0.0026 0.0026
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0079 0.0285 0.0285
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0034 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0034 0.0034
Treponema pallidum pyruvate carboxylase subunit B 0.0079 0.0285 0.5
Schistosoma mansoni amine GPCR 0.003 0.0065 0.0065
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0079 0.0285 0.0285
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0007 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0065 0.0065
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0038 0.0103 0.0106
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0065 0.0065
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0002 0.0002
Onchocerca volvulus 0.003 0.0065 0.0885
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0065 0.0065
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0501 0.0519
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0007
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0305 0.1297 0.3442
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0007 0.0007
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0035
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus granulosus lamin 0.0029 0.0061 0.0061
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0056 0.0056
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0065 0.0068
Echinococcus granulosus RUN 0.0021 0.0026 0.0026
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0103 0.0272
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0305 0.1297 0.1297
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0065 0.0065
Schistosoma mansoni rab6-interacting 0.0021 0.0026 0.0026
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0079 0.0285 0.0285
Trypanosoma brucei acetyl-CoA carboxylase 0.2253 1 1
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0079 0.0285 0.0285
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0305 0.1297 0.2103
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0007 0.0012
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0058 0.0191 0.0198
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Brugia malayi Flap endonuclease-1 0.0028 0.0056 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0065 0.0065
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0168 0.0174
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0219 0.0219
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.0219 0.0219
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0026 0.0026
Chlamydia trachomatis biotin carboxylase 0.0779 0.3415 1
Onchocerca volvulus 0.003 0.0065 0.0885
Brugia malayi Dopamine receptor protein 2 0.003 0.0065 0.0068
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0078 0.0282 0.0293
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0103 0.0272
Mycobacterium ulcerans hypothetical protein 0.0079 0.0285 0.0757
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0168 0.0174
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0056 0.0056
Schistosoma mansoni intermediate filament proteins 0.0029 0.0061 0.0061
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0305 0.1297 0.3442
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0219 0.0219
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0858 0.3767 1
Schistosoma mansoni neuropeptide receptor 0.003 0.0065 0.0065
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0061 0.0063
Schistosoma mansoni amine GPCR 0.003 0.0065 0.0065
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0065 0.0065
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0065 0.0065
Plasmodium falciparum MO15-related protein kinase 0.0127 0.0501 0.0685
Echinococcus multilocularis Ankyrin 0.0015 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0065 0.0065
Mycobacterium tuberculosis Conserved protein 0.0038 0.0103 0.0272
Echinococcus granulosus somatostatin receptor 0.003 0.0065 0.0065
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0305 0.1297 0.2905
Mycobacterium tuberculosis Conserved protein 0.0038 0.0103 0.0272
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0079 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0384 0.1649 1
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Echinococcus multilocularis g protein coupled receptor 0.003 0.0065 0.0065
Brugia malayi Death domain containing protein 0.0015 0 0.0001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0 0.0001
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0079 0.0285 0.0757
Brugia malayi beta-lactamase 0.0038 0.0103 0.0106
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Schistosoma mansoni opsin-like receptor 0.003 0.0065 0.0065
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.0282 0.0282
Schistosoma mansoni jun-related protein 0.0072 0.0255 0.0255
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0079 0.0285 0.0463
Echinococcus granulosus Ankyrin 0.0015 0.0001 0.0001
Echinococcus granulosus neuropeptide receptor 0.003 0.0065 0.0065
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0007 0.0012
Echinococcus granulosus g protein coupled receptor 0.003 0.0065 0.0065
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0065 0.0065
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0858 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0305 0.1297 0.3442
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0007 0.0007
Schistosoma mansoni acetyl-CoA carboxylase 0.2253 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0065 0.0068
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0065 0.0065
Echinococcus multilocularis RUN 0.0021 0.0026 0.0026
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0305 0.1297 0.3442
Schistosoma mansoni hypothetical protein 0.003 0.0065 0.0065
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.163 0.7218 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0103 0.0272
Schistosoma mansoni biogenic amine receptor 0.003 0.0065 0.0065
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0065 0.0065
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0305 0.1297 0.1297
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0065 0.0068
Echinococcus multilocularis neuropeptide receptor 0.003 0.0065 0.0065
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.003 0.0065 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0065 0.0065
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0079 0.0285 0.0463
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0097
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0065 0.0885
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0015 0.0002 0.0002
Leishmania major cytochrome p450-like protein 0.0024 0.0042 0.0042
Echinococcus multilocularis allatostatin A receptor 0.003 0.0065 0.0065
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.0282 0.0282
Echinococcus granulosus lamin dm0 0.0029 0.0061 0.0061
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0065 0.0065
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0079 0.0285 0.0463
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0038 0.0103 0.0106
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0026 0.0027
Echinococcus multilocularis glycine receptor subunit beta 0.0064 0.0219 0.0219
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0002 0.0002
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0015 0.0002 0.0002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0007
Onchocerca volvulus 0.003 0.0065 0.0885
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0305 0.1297 0.3442
Loa Loa (eye worm) hypothetical protein 0.0028 0.0059 0.0061
Echinococcus granulosus orexin receptor type 2 0.003 0.0065 0.0065
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0065 0.0068
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0065 0.0065
Mycobacterium ulcerans pyruvate carboxylase 0.0858 0.3767 1
Brugia malayi G protein-coupled receptor 0.003 0.0065 0.0068
Brugia malayi intermediate filament protein 0.0029 0.0061 0.0063
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0065 0.0065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0103 0.0103
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0858 0.3767 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0007 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0329 0.0329
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0079 0.0285 0.0285
Brugia malayi G-protein coupled receptor 0.003 0.0065 0.0068
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0065 0.0065
Brugia malayi neuropeptide F receptor 0.003 0.0065 0.0068
Onchocerca volvulus 0.0053 0.0168 0.2289
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0061 0.0063
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0065 0.0065
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0056 0.009
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0079 0.0285 0.0757
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0065 0.0065
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Schistosoma mansoni hypothetical protein 0.0021 0.0026 0.0026
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0065 0.0065
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0 0.0001
Brugia malayi isocitrate dehydrogenase 0.0017 0.0007 0.0007
Echinococcus granulosus glycine receptor subunit beta 0.0064 0.0219 0.0219
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0858 0.3767 1
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0065 0.0065
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1152 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0002 0.0002
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0065 0.0068
Trichomonas vaginalis esterase, putative 0.0038 0.0103 0.0876
Brugia malayi sulfakinin receptor protein 0.003 0.0065 0.0068
Echinococcus granulosus neuropeptide receptor 0.003 0.0065 0.0065
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0065 0.0065
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0065 0.0065
Brugia malayi G-protein coupled receptor 0.003 0.0065 0.0068
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.0219 0.0219
Brugia malayi ORL1-like opioid receptor 0.003 0.0065 0.0068
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Brugia malayi hypothetical protein 0.007 0.0244 0.0253
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0273 0.1152 0.1194
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0079 0.0285 0.0386
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0219 0.0219
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0079 0.0285 0.0285
Onchocerca volvulus 0.007 0.0244 0.3325
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0065 0.0068
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0065 0.0065
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0858 0.3767 0.6111
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0079 0.0285 0.0285
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0079 0.0285 0.0285
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0042 0.0111
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0002 0.0002
Echinococcus multilocularis tumor protein p63 0.036 0.1542 0.1542
Trypanosoma brucei unspecified product 0.0564 0.2454 0.2454
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0079 0.0285 0.0285
Brugia malayi bZIP transcription factor family protein 0.0089 0.0329 0.0341
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0103 0.0876
Onchocerca volvulus 0.003 0.0065 0.0885
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0194 0.0799 0.0799
Brugia malayi Cytochrome P450 family protein 0.0035 0.0091 0.0094
Onchocerca volvulus 0.003 0.0065 0.0885
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0079 0.0285 0.0463
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0103 0.0272
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0733 0.6354
Echinococcus granulosus jun protein 0.0089 0.0329 0.0329
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0065 0.0065
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0026 0.0026
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0065 0.0068
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0027
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0065 0.0065
Echinococcus multilocularis sex peptide receptor 0.003 0.0065 0.0065
Echinococcus multilocularis serotonin receptor 0.003 0.0065 0.0065
Onchocerca volvulus 0.0038 0.0103 0.1395
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0079 0.0285 0.0285
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0057 0.0187 0.0187
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0103 0.0876
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0065 0.0065
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0065 0.0065
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.0219 0.0219
Toxoplasma gondii pyruvate carboxylase 0.0858 0.3767 0.3767
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0007 0.0007
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0026 0.0026
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0305 0.1297 0.1297
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0259 0.2239
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0065 0.0065
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0079 0.0285 0.0757
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0065 0.0065
Toxoplasma gondii carbamoylphosphate synthetase 0.0194 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Schistosoma mansoni hypothetical protein 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0086 0.0318 0.033
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus granulosus geminin 0.0179 0.0733 0.0733
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0079 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0053 0.0172 0.0178
Schistosoma mansoni lipoxygenase 0.0126 0.0494 0.0494
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0042 0.0068
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0034 0.0034
Brugia malayi hypothetical protein 0.0053 0.0172 0.0178
Brugia malayi Cyclic-nucleotide gated cation channel 0.0015 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus granulosus glycine receptor subunit beta 0.0064 0.0219 0.0219
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0007 0.0007
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0057 0.0187 0.0187
Brugia malayi putative neuropeptide receptor 0.003 0.0065 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0065 0.0065
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.163 0.7218 1
Schistosoma mansoni lamin 0.0029 0.0061 0.0061
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0042 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1152 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0065 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1152 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0858 0.3767 1
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0079 0.0285 0.0386
Echinococcus granulosus hypothetical protein 0.003 0.0065 0.0065
Loa Loa (eye worm) GABA receptor subunit 0.0058 0.0191 0.0198
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0065 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0103 0.0166
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0065 0.0065
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0065 0.0065
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0015 0.0002 0.0002
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus multilocularis lamin dm0 0.0029 0.0061 0.0061
Onchocerca volvulus 0.003 0.0065 0.0885
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0056 0.0058
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0065 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0858 0.3767 0.3767
Onchocerca volvulus 0.003 0.0065 0.0885
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0002 0.0002
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0194 0.0799 0.1296
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0305 0.1297 0.3442
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0273 0.1152 0.1194
Brugia malayi Cytochrome P450 family protein 0.0024 0.0042 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0002 0.0002
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.2253 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0172 0.0278
Schistosoma mansoni hypothetical protein 0.0179 0.0733 0.0733
Brugia malayi GnHR receptor homolog 0.003 0.0065 0.0068
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0065 0.0068
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0065 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0065 0.0065
Brugia malayi hypothetical protein 0.0021 0.0026 0.0027
Echinococcus multilocularis g protein coupled receptor 0.003 0.0065 0.0065
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0065 0.0065
Schistosoma mansoni adenoreceptor 0.003 0.0065 0.0065
Schistosoma mansoni amine GPCR 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Onchocerca volvulus 0.003 0.0065 0.0885
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0065 0.0065
Echinococcus granulosus tumor protein p63 0.036 0.1542 0.1542
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0056 0.0056
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0079 0.0285 0.0386
Onchocerca volvulus 0.003 0.0065 0.0885
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0065 0.0065
Echinococcus multilocularis orexin receptor type 2 0.003 0.0065 0.0065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0007 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0065 0.0065
Brugia malayi Melatonin receptor type 1A 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0038 0.0103 0.0106
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.0034 0.0035
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.0219 0.0219
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0305 0.1297 0.2103
Echinococcus multilocularis somatostatin receptor 0.003 0.0065 0.0065
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0103 0.0272
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0042 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0172 0.0278
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0002 0.0002
Brugia malayi follicle stimulating hormone receptor 0.0275 0.1161 0.1203
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0061 0.0063
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0064 0.0219 0.0227
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0315 0.0315
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0079 0.0285 0.0463
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Brugia malayi Serotonin receptor 0.003 0.0065 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0065 0.0065
Onchocerca volvulus 0.003 0.0065 0.0885
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0065 0.0065
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.1019 0.2704
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.0733 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0065 0.0065
Echinococcus granulosus g protein coupled receptor 0.003 0.0065 0.0065
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0002 0.0002
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.0494 0.0494
Schistosoma mansoni amine GPCR 0.003 0.0065 0.0065
Brugia malayi hypothetical protein 0.0021 0.0026 0.0027
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0079 0.0285 0.0296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0103 0.0272
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1152 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0042 0.0043
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0305 0.1297 0.3442
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0007
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0858 0.3767 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.028 0.028
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0065 0.0068
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0079 0.0285 0.0463
Leishmania major carboxylase, putative 0.0858 0.3767 0.3767
Echinococcus granulosus intermediate filament protein 0.0029 0.0061 0.0061
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0858 0.3767 0.3767
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0168 0.0174
Onchocerca volvulus 0.003 0.0065 0.0885
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0065 0.0065
Schistosoma mansoni flap endonuclease-1 0.0025 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0065 0.0065
Mycobacterium ulcerans lipase LipD 0.0038 0.0103 0.0272
Mycobacterium ulcerans beta-lactamase 0.0038 0.0103 0.0272
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0056 0.0067
Onchocerca volvulus 0.003 0.0065 0.0885
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0065 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0733 0.6354
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0103 0.0103
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0002 0.0002
Schistosoma mansoni biogenic amine receptor 0.003 0.0065 0.0065
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0103 0.0106
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0065 0.0065
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0002 0.0002
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0079 0.0285 0.0757
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0776 0.6729
Loa Loa (eye worm) hypothetical protein 0.0058 0.0191 0.0198
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0007 0.0007
Echinococcus granulosus sex peptide receptor 0.003 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0179 0.0733 0.0733
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0065 0.0068
Echinococcus granulosus serotonin receptor 0.003 0.0065 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0103 0.0876
Schistosoma mansoni neuropeptide receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0065 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1152 1
Echinococcus granulosus fmrfamide receptor 0.003 0.0065 0.0065
Onchocerca volvulus 0.0029 0.0061 0.0827
Echinococcus multilocularis neuropeptide receptor 0.003 0.0065 0.0065
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0002 0.0002
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0194 0.0799 0.2122
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0065 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0065 0.0065
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0034 0.0034
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0103 0.0272
Echinococcus multilocularis g protein coupled receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0065 0.0068
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0026 0.0026
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0079 0.0285 0.0386
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0007 0.0007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Schistosoma mansoni biogenic amine receptor 0.003 0.0065 0.0065
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0065 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0172 0.0228
Toxoplasma gondii ABC1 family protein 0.0038 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Echinococcus multilocularis geminin 0.0179 0.0733 0.0733
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0065 0.0065
Loa Loa (eye worm) beta-lactamase 0.0038 0.0103 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0776 0.6729
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0733 0.6354
Loa Loa (eye worm) hypothetical protein 0.0038 0.0103 0.0106
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0305 0.1297 0.2103
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1152 1
Echinococcus multilocularis fmrfamide receptor 0.003 0.0065 0.0065
Schistosoma mansoni loxhd1 0.0021 0.0026 0.0026
Leishmania major hypothetical protein, conserved 0.0053 0.0172 0.0172
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.0219 0.0219
Echinococcus multilocularis musashi 0.0029 0.0061 0.0061
Leishmania major carbamoyl-phosphate synthase, putative 0.0194 0.0799 0.0799
Echinococcus granulosus g-protein coupled receptor 0.003 0.0065 0.0065
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0194 0.0799 0.1476
Onchocerca volvulus 0.003 0.0065 0.0885
Plasmodium falciparum flap endonuclease 1 0.0028 0.0056 0.0067
Echinococcus granulosus Biotin lipoyl attachment 0.0079 0.0285 0.0285
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0172 0.0228
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0042 0.0043
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0103 0.0272
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0079 0.0285 0.0757
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0305 0.1297 0.3442
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0172 0.0228
Brugia malayi neuropeptide F receptor 0.003 0.0065 0.0068
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0065 0.0885
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0858 0.3767 0.3767
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0002 0.0002
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0172 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0733 0.6354
Schistosoma mansoni myosin xvIII 0.003 0.0065 0.0065
Schistosoma mansoni histamine h1 receptor 0.003 0.0065 0.0065
Brugia malayi hypothetical protein 0.0035 0.0087 0.009
Brugia malayi AKH receptor 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0858 0.3767 1
Brugia malayi MH2 domain containing protein 0.0127 0.0501 0.0519
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0065 0.0068
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Echinococcus granulosus GPCR family 2 0.0017 0.0007 0.0007
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0079 0.0285 0.0285
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0168 0.0168
Brugia malayi Protein kinase domain containing protein 0.0016 0.0002 0.0002
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0305 0.1297 0.1297
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0079 0.0285 0.0285
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0079 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0103 0.0103
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0007 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0007 0.0007
Brugia malayi Carboxyl transferase domain containing protein 0.2174 0.9647 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0065 0.0065
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0103 0.0272
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0065 0.0065
Echinococcus granulosus flap endonuclease 1 0.0028 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0079 0.0285 0.0296
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0057 0.0187 0.0193
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.2253 1 1
Schistosoma mansoni hypothetical protein 0.003 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0024 0.004 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0065 0.0065
Brugia malayi beta-lactamase family protein 0.0038 0.0103 0.0106
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0065 0.0065
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0079 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0038 0.0103 0.0106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0103 0.0272
Onchocerca volvulus 0.003 0.0065 0.0885
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0079 0.0285 0.0296
Echinococcus multilocularis GPCR, family 2 0.0017 0.0007 0.0007
Echinococcus multilocularis jun protein 0.0089 0.0329 0.0329
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0858 0.3767 0.6111
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0065 0.0065
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0007 0.0007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0002 0.0002
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0079 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0065 0.0065
Schistosoma mansoni aspartate carbamoyltransferase 0.0194 0.0799 0.0799
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0329 0.0329
Onchocerca volvulus 0.0021 0.0026 0.0355
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Echinococcus multilocularis lamin 0.0029 0.0061 0.0061
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0315 0.0315
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0065 0.0065
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0384 0.1649 1
Schistosoma mansoni hypothetical protein 0.0072 0.0255 0.0255
Onchocerca volvulus 0.0038 0.0103 0.1395
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0103 0.0103
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.0219 0.0219
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0065 0.0068
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0065 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0103 0.0876
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0858 0.3767 0.3767
Onchocerca volvulus 0.0021 0.0026 0.0355
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0065 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0733 0.6354
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0065 0.0065
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0065 0.0065
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0078 0.0282 0.0293
Echinococcus granulosus g protein coupled receptor 0.003 0.0065 0.0065
Echinococcus multilocularis serotonin receptor 0.003 0.0065 0.0065
Leishmania major acetyl-CoA carboxylase, putative 0.2253 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0259 0.2239
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0068 0.0236 0.0245
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0065 0.0065
Echinococcus multilocularis fmrfamide receptor 0.003 0.0065 0.0065
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0079 0.0285 0.0757
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0094 0.0097
Plasmodium falciparum carbamoyl phosphate synthetase 0.0194 0.0799 0.1099
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0275 0.1161 0.1203
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0194 0.0799 0.1296
Onchocerca volvulus 0.0029 0.0061 0.0827
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0172 0.0172
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0065 0.0065
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0079 0.0285 0.0296
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0065 0.0068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0733 0.6354
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Schistosoma mansoni opsin-like receptor 0.003 0.0065 0.0065
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0858 0.3767 0.3767
Echinococcus multilocularis glycine receptor subunit beta 0.0064 0.0219 0.0219
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0194 0.0799 0.0799
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.2253 1 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.0219 0.0227
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0305 0.1297 0.3442
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0079 0.0285 0.0757
Brugia malayi RE15519p 0.003 0.0065 0.0068
Schistosoma mansoni pyruvate carboxylase 0.0858 0.3767 0.3767
Brugia malayi Dopamine receptor protein 1 0.003 0.0065 0.0068
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0079 0.0285 0.0285
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0194 0.0799 0.1099
Brugia malayi hypothetical protein 0.003 0.0065 0.0068
Trypanosoma cruzi acetyl-CoA carboxylase 0.1395 0.6165 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) nM Vasorelaxation as Adenosine A2A receptor activity in rat aorta ChEMBL. 8863798
EC50 (functional) > 1 nM Adenosine A1 receptor mediated negative chronotropic activity in spontaneously beating rat atria ChEMBL. 8863798
Ki (binding) = 618 nM Displacement of [3H]-CHA from Adenosine A1 receptor of rat brain ChEMBL. 8863798
Ki (binding) = 757 nM Displacement of [3H]-CGS- 51680 from Adenosine A2A receptor of rat striatum. ChEMBL. 8863798
Ratio (binding) < 0.01 Ratio of inhibition of ADP-induced rabbit platelet aggregation and Adenosine A2a receptor binding ChEMBL. 8863798

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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