Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0175 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 272.18 mM kg-1 | Bronchosecretory activity measured as tracheal secretion of phenol red in mouse after oral administration | ChEMBL. | 3820227 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.