Detailed information for compound 937717

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 509.568 | Formula: C27H25F2N3O3S
  • H donors: 2 H acceptors: 1 LogP: 4.82 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1OC)C1N=C(SCc2ccc(cc2)F)NC(=C1C(=O)Nc1ccc(cc1)F)C
  • InChi: 1S/C27H25F2N3O3S/c1-16-24(26(33)31-21-11-9-20(29)10-12-21)25(18-6-13-22(34-2)23(14-18)35-3)32-27(30-16)36-15-17-4-7-19(28)8-5-17/h4-14,25H,15H2,1-3H3,(H,30,32)(H,31,33)
  • InChiKey: MCZVKJZRYZNLDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor 0.0029 0.0085 0.0069
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0073
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0063 0.0085
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0063 0.0061
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0122 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Trichomonas vaginalis cyclin A, putative 0.0048 0.0206 0.0572
Giardia lamblia Hypothetical protein 0.003 0.009 0.0373
Loa Loa (eye worm) hypothetical protein 0.0038 0.0139 0.0126
Echinococcus multilocularis 0.0713 0.4461 0.5718
Schistosoma mansoni site-1 peptidase (S08 family) 0.0038 0.0139 0.0221
Toxoplasma gondii subtilisin SUB7 0.0038 0.0139 0.3766
Schistosoma mansoni hypothetical protein 0.016 0.092 0.1631
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0063 0.0085
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0085 0.0125
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0063 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Plasmodium falciparum cyclin 0.003 0.009 0.2276
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1234 0.7791 1
Brugia malayi pregnancy-associated plasma protein-A 0.0061 0.0286 0.027
Schistosoma mansoni biogenic amine receptor 0.0026 0.0063 0.0085
Loa Loa (eye worm) cuticular endochitinase 0.0074 0.0368 0.0355
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0122 0.0106
Echinococcus granulosus g protein coupled receptor 0.0026 0.0063 0.0061
Onchocerca volvulus 0.0035 0.0122 0.0456
Onchocerca volvulus 0.0035 0.0122 0.0456
Trichomonas vaginalis cyclin B, putative 0.003 0.009 0.0223
Echinococcus multilocularis neuroendocrine convertase 2 0.0556 0.3453 0.4421
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0069 0.0341 0.0418
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0038 0.0139 0.6446
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0085 0.0125
Schistosoma mansoni hypothetical protein 0.0593 0.3693 0.6637
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0209 0.1233 0.2197
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0038 0.0139 0.0376
Echinococcus granulosus cyclins 0.003 0.009 0.0095
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0085 0.0073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Giardia lamblia Cyclin A 0.003 0.009 0.0373
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Toxoplasma gondii subtilisin SUB4 0.0038 0.0139 0.3766
Toxoplasma gondii subtilisin SUB1 0.0038 0.0139 0.3766
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0028 0.0413
Echinococcus multilocularis cyclins 0.003 0.009 0.0095
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0063 0.0051
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0063 0.0061
Echinococcus granulosus orexin receptor type 2 0.0026 0.0063 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Schistosoma mansoni opsin-like receptor 0.0026 0.0063 0.0085
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0152 0.7158
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0063 0.0061
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Entamoeba histolytica cyclin, putative 0.003 0.009 0.2106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Echinococcus multilocularis cyclin B3 1 0.003 0.009 0.0095
Loa Loa (eye worm) ube2i2 protein 0.0025 0.0057 0.0044
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0063 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Schistosoma mansoni amine GPCR 0.0026 0.0063 0.0085
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0171 0.0992 0.2937
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0073
Echinococcus multilocularis beta adrenergic receptor kinase 0.0097 0.0515 0.0641
Brugia malayi Protein set-1 0.0069 0.0341 0.0326
Echinococcus granulosus G protein coupled receptor kinase 1 0.0087 0.0451 0.0559
Brugia malayi hypothetical protein 0.0061 0.0286 0.027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0063 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0073
Giardia lamblia High cysteine membrane protein Group 2 0.0329 0.2 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0063 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0209 0.1233 0.3666
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Schistosoma mansoni amine GPCR 0.0026 0.0063 0.0085
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0538 0.3336 0.4271
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0038 0.0139 0.0221
Plasmodium falciparum subtilisin-like protease 1 0.0038 0.0139 0.3766
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0298 1
Entamoeba histolytica hypothetical protein, conserved 0.0035 0.0122 0.3015
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.009 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0139 0.0369
Brugia malayi Cyclin, N-terminal domain containing protein 0.003 0.009 0.0074
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) latrophilin receptor protein 2 0.016 0.092 0.0908
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0085 0.0069
Brugia malayi sulfakinin receptor protein 0.0026 0.0063 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0152 0.0412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0085 0.0073
Loa Loa (eye worm) hypothetical protein 0.1579 1 1
Schistosoma mansoni hypothetical protein 0.0026 0.0063 0.0085
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0063 0.0061
Schistosoma mansoni neuropeptide receptor 0.0026 0.0063 0.0085
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0209 0.1233 0.3666
Loa Loa (eye worm) hypothetical protein 0.003 0.009 0.0077
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0038 0.0139 0.6446
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0044
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0063 0.0061
Echinococcus granulosus furin 0.0884 0.5556 0.7126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Brugia malayi G-protein coupled receptor 0.0026 0.0063 0.0047
Brugia malayi larval opioid receptor 0.0026 0.0063 0.0047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) hypothetical protein 0.0347 0.2117 0.2106
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0122 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0063 0.0085
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0085 0.017
Brugia malayi hypothetical protein 0.0061 0.0286 0.027
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0063 0.0061
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0152 0.7158
Toxoplasma gondii subtilisin SUB6 0.0038 0.0139 0.3766
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Echinococcus granulosus GPCR family 2 0.016 0.092 0.1162
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0209 0.1233 0.3666
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0171 0.0992 0.2937
Brugia malayi neuropeptide F receptor 0.0026 0.0063 0.0047
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0038 0.0139 0.434
Toxoplasma gondii subtilisin SUB8 0.0038 0.0139 0.3766
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0273
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0122 0.0106
Echinococcus granulosus G2:mitotic specific cyclin B3 0.003 0.009 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Trichomonas vaginalis cyclin B, putative 0.0048 0.0206 0.0572
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0298 1
Trichomonas vaginalis cyclins, putative 0.0048 0.0206 0.0572
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0063 0.0061
Onchocerca volvulus 0.0038 0.0139 0.0584
Loa Loa (eye worm) subtilase 0.0038 0.0139 0.0126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0209 0.1233 0.3666
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Brugia malayi Zona pellucida-like domain containing protein 0.0035 0.0122 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0152 0.0412
Onchocerca volvulus 0.0061 0.0286 0.1724
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0063 0.0085
Brugia malayi Dopamine receptor protein 2 0.0026 0.0063 0.0047
Echinococcus granulosus voltage dependent calcium channel subunit 0.0035 0.0122 0.0136
Trichomonas vaginalis WD repeat domain, putative 0.0227 0.1352 0.4023
Plasmodium vivax SET domain protein, putative 0.0069 0.0341 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.003 0.009 0.0095
Brugia malayi hypothetical protein 0.0061 0.0286 0.027
Entamoeba histolytica chitinase, putative 0.0074 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0097 0.0515 0.0503
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.494 0.6334
Brugia malayi proprotein convertase 2 0.0556 0.3453 0.3442
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0085 0.0125
Echinococcus multilocularis cyclin B 0.0048 0.0206 0.0244
Schistosoma mansoni hypothetical protein 0.016 0.092 0.1631
Schistosoma mansoni adenoreceptor 0.0026 0.0063 0.0085
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.068 0.0854
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0209 0.1233 0.3666
Toxoplasma gondii rhoptry neck protein RON1 0.0061 0.0286 0.8282
Brugia malayi von Willebrand Factor 0.0035 0.0122 0.0106
Echinococcus multilocularis dna polymerase kappa 0.004 0.0152 0.0175
Trichomonas vaginalis cyclin D, putative 0.003 0.009 0.0223
Plasmodium vivax subtilisin-like protease 2, putative 0.0038 0.0139 0.3766
Echinococcus granulosus c4b binding protein beta chain 0.0061 0.0286 0.0346
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0035 0.0122 0.3259
Echinococcus granulosus C type lectin domian containing protein 0.0061 0.0286 0.0346
Echinococcus granulosus beta-adrenergic receptor kinase 0.0097 0.0515 0.0641
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0063 0.0085
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0085 0.0089
Trypanosoma cruzi cyclin 6, putative 0.0048 0.0206 1
Toxoplasma gondii subtilisin SUB11 0.0038 0.0139 0.3766
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0721 0.4513 0.5784
Onchocerca volvulus 0.0035 0.0122 0.0456
Echinococcus multilocularis cyclin b3 0.003 0.009 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.016 0.092 0.1162
Echinococcus multilocularis GPCR, family 2 0.016 0.092 0.1162
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0035 0.0122 0.3259
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0538 0.3336 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.068 0.0854
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0063 0.0061
Brugia malayi G protein-coupled receptor 0.0026 0.0063 0.0047
Onchocerca volvulus 0.0035 0.0122 0.0456
Loa Loa (eye worm) microfilarial chitinase 0.0063 0.0298 0.0286
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Entamoeba histolytica hypothetical protein 0.0035 0.0122 0.3015
Brugia malayi ube2i2 protein 0.0025 0.0057 0.0041
Echinococcus multilocularis C type lectin domian containing protein 0.0061 0.0286 0.0346
Trichomonas vaginalis cyclin B, putative 0.0048 0.0206 0.0572
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0868 0.1538
Trypanosoma brucei subtilisin peptidase 0.0038 0.0139 0.0376
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0063 0.0051
Plasmodium falciparum SET domain protein, putative 0.0069 0.0341 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0063 0.0085
Schistosoma mansoni cyclin B 0.0048 0.0206 0.0343
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0152 0.7158
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0063 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0152 0.0412
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0122 0.3259
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0063 0.0047
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0063 0.0061
Echinococcus granulosus neuropeptide receptor 0.0026 0.0063 0.0061
Echinococcus multilocularis serotonin receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Brugia malayi hypothetical protein 0.0061 0.0286 0.027
Brugia malayi celfurPC protein 0.0713 0.4461 0.4452
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0063 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0085 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Schistosoma mansoni histamine h1 receptor 0.0026 0.0063 0.0085
Echinococcus multilocularis cyclins 0.003 0.009 0.0095
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0085 0.0089
Loa Loa (eye worm) hypothetical protein 0.0884 0.5556 0.555
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.0868 0.1096
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0085 0.0089
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0038 0.0139 0.6446
Brugia malayi neuropeptide F receptor 0.0026 0.0063 0.0047
Brugia malayi RE15519p 0.0026 0.0063 0.0047
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.0025 0.0057 0.0073
Echinococcus granulosus cyclin B 0.0048 0.0206 0.0244
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0035 0.0122 0.3259
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Brugia malayi polk-prov protein 0.003 0.009 0.0074
Brugia malayi Serotonin receptor 0.0026 0.0063 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0085 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Trichomonas vaginalis cyclins, putative 0.0048 0.0206 0.0572
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0063 0.0061
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.009 0.0078
Trichomonas vaginalis cyclin B, putative 0.0048 0.0206 0.0572
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0063 0.0061
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0085 0.0125
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0063 0.0061
Schistosoma mansoni hypothetical protein 0.0171 0.0992 0.176
Giardia lamblia Furin precursor putative serine protease 0.0171 0.0992 0.4917
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0273
Brugia malayi steroid hormone receptor 0.0029 0.0085 0.0069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0063 0.0085
Schistosoma mansoni hypothetical protein 0.0227 0.1352 0.2411
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0085 0.0125
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0063 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0085 0.0089
Echinococcus granulosus neuropeptide receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0171 0.0992 0.2937
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.009 0.0244
Brugia malayi Zona pellucida-like domain containing protein 0.0035 0.0122 0.0106
Mycobacterium tuberculosis Possible chitinase 0.0063 0.0298 1
Onchocerca volvulus 0.0061 0.0286 0.1724
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative 0.0025 0.0057 0.0154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0085 0.0125
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Loa Loa (eye worm) endoprotease bli-4 0.0884 0.5556 0.555
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Brugia malayi endoprotease bli-4 precursor 0.0884 0.5556 0.5549
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0063 0.0061
Onchocerca volvulus 0.0035 0.0122 0.0456
Echinococcus multilocularis cyclins 0.003 0.009 0.0095
Echinococcus granulosus g protein coupled receptor 0.0026 0.0063 0.0061
Echinococcus granulosus fmrfamide receptor 0.0026 0.0063 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0085 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0122 0.0106
Schistosoma mansoni hypothetical protein 0.0035 0.0122 0.0191
Leishmania major chitinase 0.0074 0.0368 1
Echinococcus granulosus cyclins 0.003 0.009 0.0095
Echinococcus multilocularis cyclins 0.003 0.009 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0063 0.0061
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0063 0.0085
Schistosoma mansoni opsin-like receptor 0.0026 0.0063 0.0085
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0505 0.3129 0.312
Brugia malayi Cyclin, N-terminal domain containing protein 0.0048 0.0206 0.019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.016 0.092 0.0905
Brugia malayi ecdysteroid receptor 0.0029 0.0085 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0538 0.3336 1
Toxoplasma gondii histone lysine methyltransferase SET8 0.0069 0.0341 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0122 0.0106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) CUTiclin family member 0.0035 0.0122 0.011
Leishmania major DNA polymerase kappa, putative 0.002 0.0028 0.0331
Loa Loa (eye worm) hypothetical protein 0.016 0.092 0.0908
Schistosoma mansoni furin-1 (S08 family) 0.0385 0.2358 0.4228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0273
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Brugia malayi G-protein coupled receptor 0.0026 0.0063 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0085 0.0069
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0063 0.0047
Trypanosoma brucei RNA helicase, putative 0.0593 0.3693 1
Brugia malayi GnHR receptor homolog 0.0026 0.0063 0.0047
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0038 0.0139 0.434
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0063 0.0061
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0063 0.0085
Brugia malayi GCC2 and GCC3 family protein 0.0061 0.0286 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0028 0.0331
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Loa Loa (eye worm) CUTiclin-Like family member 0.0035 0.0122 0.011
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0063 0.0051
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0152 0.482
Entamoeba histolytica cyclin, putative 0.0048 0.0206 0.5405
Echinococcus granulosus cyclins 0.003 0.009 0.0095
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0038 0.0139 0.0158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0085 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0515 0.09
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Entamoeba histolytica cyclin family protein 0.003 0.009 0.2106
Brugia malayi Subtilase family protein 0.0038 0.0139 0.0123
Loa Loa (eye worm) hypothetical protein 0.0345 0.2106 0.2096
Schistosoma mansoni myosin xvIII 0.0026 0.0063 0.0085
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0025 0.0057 0.1151
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0063 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0085 0.0089
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0063 0.0061
Schistosoma mansoni biogenic amine receptor 0.0026 0.0063 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0063 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.003 0.009 0.0223
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0884 0.5556 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0035 0.0122 0.011
Onchocerca volvulus Putative endochitinase 0.0074 0.0368 0.2362
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0063 0.0061
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0063 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0085 0.0069
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0063 0.0051
Trichomonas vaginalis cyclins, putative 0.0048 0.0206 0.0572
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0035 0.0122 0.0191
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0063 0.0061
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0063 0.0061
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0025 0.0057 0.1151
Echinococcus granulosus collagen alpha 1VII chain 0.0035 0.0122 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Schistosoma mansoni hypothetical protein 0.016 0.092 0.1631
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0152 0.0412
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0152 0.041
Echinococcus granulosus sex peptide receptor 0.0026 0.0063 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0063 0.0085
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Toxoplasma gondii rhoptry neck protein RON9 0.0061 0.0286 0.8282
Giardia lamblia UBC3 0.0025 0.0057 0.0204
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0085 0.0089
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0063 0.0061
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0025 0.0057 0.2129
Leishmania major cyclin 0.0048 0.0206 0.5405
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0063 0.0047
Echinococcus granulosus g protein coupled receptor 0.0026 0.0063 0.0061
Schistosoma mansoni neuropeptide receptor 0.0026 0.0063 0.0085
Echinococcus multilocularis somatostatin receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0063 0.0298 0.0286
Schistosoma mansoni neuropeptide receptor 0.0026 0.0063 0.0085
Trichomonas vaginalis cyclins, putative 0.0025 0.006 0.013
Trichomonas vaginalis cyclin B3, putative 0.003 0.009 0.0223
Brugia malayi Melatonin receptor type 1A 0.0026 0.0063 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0152 0.0412
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0035 0.0122 0.0136
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0063 0.0061
Brugia malayi hypothetical protein 0.0061 0.0286 0.027
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0063 0.0051
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0016 0.5
Onchocerca volvulus Putative endochitinase 0.0074 0.0368 0.2362
Plasmodium falciparum subtilisin-like protease 2 0.0038 0.0139 0.3766
Echinococcus granulosus protein will die slowly 0.0227 0.1352 0.1718
Plasmodium vivax subtilisin-like protease 1 0.0038 0.0139 0.3766
Echinococcus granulosus Furin 1 0.0209 0.1233 0.1566
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0035 0.0122 0.0106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0063 0.0085
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0038 0.0139 0.434
Echinococcus granulosus membrane bound transcription factor site 1 0.0038 0.0139 0.0158
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1234 0.7791 1
Echinococcus multilocularis protein will die slowly 0.0227 0.1352 0.1718
Trichomonas vaginalis hypothetical protein 0.0171 0.0992 0.2937
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0085 0.0089
Onchocerca volvulus Putative endochitinase 0.0074 0.0368 0.2362
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0063 0.0061
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0063 0.0061
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0063 0.0047
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0063 0.0061
Echinococcus granulosus serotonin receptor 0.0026 0.0063 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Echinococcus multilocularis cyclins 0.003 0.009 0.0095
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Schistosoma mansoni hypothetical protein 0.0026 0.0063 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0085 0.0073
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0087 0.0451 0.0559
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Echinococcus granulosus cyclins 0.003 0.009 0.0095
Brugia malayi endochitinase 0.0074 0.0368 0.0352
Echinococcus multilocularis membrane bound transcription factor site 1 0.0038 0.0139 0.0158
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.0025 0.0057 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0085 0.0069
Echinococcus multilocularis sex peptide receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0063 0.0047
Brugia malayi hypothetical protein 0.0061 0.0286 0.027
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0063 0.0061
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0063 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0721 0.4513 0.8116
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0085 0.0089
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0122 0.0106
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0069 0.0341 0.0418
Trypanosoma cruzi subtilisin peptidase 0.0038 0.0139 0.6446
Onchocerca volvulus 0.0061 0.0286 0.1724
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0063 0.0047
Schistosoma mansoni hypothetical protein 0.0026 0.0063 0.0085
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0152 0.041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Plasmodium vivax subtilisin-like serine protease, putative 0.0038 0.0139 0.3766
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0063 0.0061
Onchocerca volvulus 0.0061 0.0286 0.1724
Giardia lamblia DINP protein human, muc B family 0.002 0.0028 0.0059
Onchocerca volvulus 0.0061 0.0286 0.1724
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0152 0.0412
Brugia malayi hypothetical protein 0.0061 0.0286 0.027
Echinococcus multilocularis Furin 1 0.0209 0.1233 0.1566
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0063 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0139 0.0369
Trichomonas vaginalis cyclin B, putative 0.0048 0.0206 0.0572
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0063 0.0085
Schistosoma mansoni amine GPCR 0.0026 0.0063 0.0085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0085 0.0069
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0085 0.0125
Toxoplasma gondii subtilisin SUB2 0.0038 0.0139 0.3766
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0209 0.1233 0.3666
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0515 0.09
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0063 0.0047
Echinococcus granulosus allatostatin A receptor 0.0026 0.0063 0.0061
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0035 0.0122 0.3259
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0273
Toxoplasma gondii microneme protein MIC2 0.0035 0.0122 0.3259
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0063 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0111 0.0301
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0063 0.0061
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0069 0.0341 0.0329
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0122 0.0106
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Echinococcus granulosus dna polymerase kappa 0.004 0.0152 0.0175
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Brugia malayi Latrophilin receptor protein 2 0.016 0.092 0.0905
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0061 0.0286 0.0273
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Schistosoma mansoni cyclin B3 0.003 0.009 0.0134
Loa Loa (eye worm) hypothetical protein 0.0048 0.0206 0.0194
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0538 0.3336 0.4271
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0152 0.0412
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0085 0.0125
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0063 0.0085
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0038 0.0139 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0139 0.0369
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0063 0.0061
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0038 0.0139 0.434
Loa Loa (eye worm) chitinase I 0.0074 0.0368 0.0355
Echinococcus granulosus somatostatin receptor 0.0026 0.0063 0.0061
Trichomonas vaginalis cyclins, putative 0.0048 0.0206 0.0572
Echinococcus multilocularis serotonin receptor 0.0026 0.0063 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0063 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0085 0.0069
Brugia malayi putative neuropeptide receptor 0.0026 0.0063 0.0047
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0063 0.0061
Schistosoma mansoni hypothetical protein 0.0026 0.0063 0.0085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Onchocerca volvulus 0.0035 0.0122 0.0456
Trypanosoma cruzi CYC2-like cyclin, putative 0.0048 0.0206 1
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0152 0.0412
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0085 0.0069
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0063 0.0061
Brugia malayi neuroendocrine convertase 1 precursor 0.0556 0.3453 0.3442
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Echinococcus multilocularis cyclins 0.003 0.009 0.0095
Echinococcus granulosus cyclins 0.003 0.009 0.0095
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0063 0.0051
Trypanosoma cruzi cyclin, putative 0.0048 0.0206 1
Brugia malayi endochitinase 0.0074 0.0368 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0152 0.0412
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0085 0.0089
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0073
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0063 0.0051
Brugia malayi nuclear receptor NHR-88 0.0029 0.0085 0.0069
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0063 0.0061
Schistosoma mansoni hypothetical protein 0.0122 0.068 0.1198
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0035 0.0122 0.3259
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative 0.0025 0.0057 0.1244
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0085 0.0069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0073
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0035 0.0122 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0038 0.0139 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Toxoplasma gondii subtilisin SUB10 0.0038 0.0139 0.3766
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0085 0.0073
Schistosoma mansoni c4b-binding protein beta chain 0.0061 0.0286 0.0486
Loa Loa (eye worm) WD40 repeat protein 0.0227 0.1352 0.1341
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.016 0.092 0.1162
Schistosoma mansoni amine GPCR 0.0026 0.0063 0.0085
Brugia malayi AKH receptor 0.0026 0.0063 0.0047
Brugia malayi Endochitinase 0.0074 0.0368 0.0352
Brugia malayi Will die slowly protein 0.0227 0.1352 0.1338
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0063 0.0085
Plasmodium vivax apical sushi protein, putative 0.0061 0.0286 0.8282
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Echinococcus multilocularis c4b binding protein beta chain 0.0061 0.0286 0.0346
Toxoplasma gondii subtilisin SUB9 0.0038 0.0139 0.3766
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0085 0.0073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0085 0.0089
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0063 0.0085
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0035 0.0122 0.3259
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0038 0.0139 0.434
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0085 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0073
Schistosoma mansoni hypothetical protein 0.0035 0.0122 0.0191
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0152 0.7158
Onchocerca volvulus 0.0048 0.0206 0.1108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0085 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0063 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0152 0.0412
Brugia malayi ORL1-like opioid receptor 0.0026 0.0063 0.0047
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0122 0.0106
Trichomonas vaginalis cyclins, putative 0.003 0.009 0.0223
Brugia malayi Dopamine receptor 0.0026 0.0063 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0035 0.0122 0.011
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0038 0.0139 0.0158
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0063 0.0085
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0035 0.0122 0.0319
Plasmodium falciparum SUMO-conjugating enzyme UBC9 0.0025 0.0057 0.1244
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0063 0.0061
Trypanosoma brucei mitotic cyclin 6 0.0048 0.0206 0.0559
Brugia malayi Cyclin, N-terminal domain containing protein 0.0048 0.0206 0.019
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0016 0.0003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0085 0.0125
Brugia malayi latrophilin 2 splice variant baaae 0.0345 0.2106 0.2093
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0063 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0063 0.0085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Onchocerca volvulus 0.0035 0.0122 0.0456
Trypanosoma cruzi cyclin, putative 0.0048 0.0206 1
Schistosoma mansoni amine GPCR 0.0026 0.0063 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0085 0.0073
Plasmodium falciparum apical sushi protein 0.0061 0.0286 0.8282
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0038 0.0139 0.434
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0152 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0085 0.0069
Brugia malayi Dopamine receptor protein 1 0.0026 0.0063 0.0047
Brugia malayi Sushi domain 0.0061 0.0286 0.027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0085 0.0089
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Onchocerca volvulus Putative endochitinase 0.0074 0.0368 0.2362
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0152 0.482
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Schistosoma mansoni hypothetical protein 0.0345 0.2106 0.3773
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0063 0.0061
Schistosoma mansoni opsin-like receptor 0.0026 0.0063 0.0085
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0048 0.0206 0.5405
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0063 0.0085
Brugia malayi hypothetical protein 0.0035 0.0122 0.0106
Schistosoma mansoni coup transcription factor 0.0029 0.0085 0.0125
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0273
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0085 0.0069
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0085 0.0073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0063 0.0085
Schistosoma mansoni cyclins 0.003 0.009 0.0134
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0085 0.0069
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Onchocerca volvulus Putative endochitinase 0.0074 0.0368 0.2362
Toxoplasma gondii hypothetical protein 0.0023 0.0044 0.0841
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0085 0.0089
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0063 0.0085
Plasmodium falciparum subtilisin-like protease 3 0.0038 0.0139 0.3766
Onchocerca volvulus 0.0061 0.0286 0.1724
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0063 0.0051
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0085 0.017
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0085 0.0089
Echinococcus multilocularis cyclins 0.003 0.009 0.0095
Plasmodium falciparum thrombospondin-related anonymous protein 0.0035 0.0122 0.3259
Onchocerca volvulus 0.0061 0.0286 0.1724
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0076
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0721 0.4513 0.5784
Schistosoma mansoni biogenic amine receptor 0.0026 0.0063 0.0085
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0063 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0085 0.0069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0085 0.0089
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0063 0.0061
Echinococcus granulosus hypothetical protein 0.0026 0.0063 0.0061
Entamoeba histolytica cyclin family protein 0.003 0.009 0.2106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0139 0.0369
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0025 0.0057 0.2129
Echinococcus granulosus cyclin b3 0.003 0.009 0.0095
Plasmodium vivax thrombospondin-related anonymous protein 0.0035 0.0122 0.3259
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Entamoeba histolytica hypothetical protein, conserved 0.0035 0.0122 0.3015
Echinococcus granulosus cyclin B3 1 0.003 0.009 0.0095
Loa Loa (eye worm) hypothetical protein 0.0048 0.0206 0.0194
Onchocerca volvulus 0.0061 0.0286 0.1724
Treponema pallidum 76K protein 0.0035 0.0122 1
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0038 0.0139 0.5
Entamoeba histolytica elongation factor-2 kinase, putative 0.0035 0.0122 0.3015
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0063 0.0061
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0063 0.0085
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.0025 0.0057 0.0052
Trypanosoma brucei unspecified product 0.0034 0.0111 0.0301
Onchocerca volvulus 0.0227 0.1352 1
Echinococcus granulosus neuroendocrine convertase 2 0.0556 0.3453 0.4421
Schistosoma mansoni neuropeptide receptor 0.0026 0.0063 0.0085
Toxoplasma gondii subtilisin SUB5 0.0038 0.0139 0.3766
Brugia malayi Serotonin receptor 0.0026 0.0063 0.0047
Mycobacterium leprae Possible secreted protease 0.0038 0.0139 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0273
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0063 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0139 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0069 0.0341 0.0587
Brugia malayi Calcitonin receptor-like protein seb-1 0.0505 0.3129 0.3118
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0025 0.0057 0.1244
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0038 0.0139 0.0221
Toxoplasma gondii subtilisin SUB12 0.0038 0.0139 0.3766
Onchocerca volvulus 0.0061 0.0286 0.1724
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0063 0.0061
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0085 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0085 0.0069
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0868 0.1538
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0025 0.0057 0.1151
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0063 0.0061
Giardia lamblia G2/mitotic-specific cyclin B 0.0048 0.0206 0.0958
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0038 0.0139 0.434
Leishmania major subtilisin-like serine peptidase 0.0038 0.0139 0.3484
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.0025 0.0057 0.0122
Trichomonas vaginalis cyclin D, putative 0.003 0.009 0.0223
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0063 0.0047
Schistosoma mansoni hypothetical protein 0.016 0.092 0.1631
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0139 0.0369
Schistosoma mansoni site-1 peptidase (S08 family) 0.0038 0.0139 0.0221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0051
Onchocerca volvulus 0.0029 0.0085 0.017
Onchocerca volvulus 0.0061 0.0286 0.1724
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0063 0.0085
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0038 0.0139 0.0123
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0992 0.2937
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0085 0.0125
Loa Loa (eye worm) proprotein convertase 2 0.0209 0.1233 0.1222
Treponema pallidum hypothetical protein 0.0035 0.0122 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0273
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0063 0.0061
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0063 0.0047
Brugia malayi hypothetical protein 0.0026 0.0063 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0085 0.0069

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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