Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0473455 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0473455 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0473455 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0473455 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0266759 | 0.22516 | 0.22516 |
Brugia malayi | flavodoxin family protein | 0.0473455 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0206696 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0434366 | 0.853467 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0473455 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0305848 | 0.371693 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0473455 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0473455 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0473455 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0473455 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0305848 | 0.371693 | 0.371693 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0473455 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0473455 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0473455 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0473455 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0473455 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0473455 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0473455 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0473455 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0434366 | 0.853467 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0473455 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0206696 | 0 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0473455 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0473455 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0473455 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0473455 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 34 nM | In vitro antimalarial activity of the compound against P. falciparum (W-2 strain) | ChEMBL. | 9767645 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 9767645 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.