TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 832.038 | Formula: C42H69N7O10
H donors: 7 H acceptors: 8 LogP: 3.89 Rotable bonds: 30
Rule of 5 violations (Lipinski): 3
SMILES: CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)OC)C(C)C)NC(=O)C1CCCN1C[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)CC(C)C)CC(=O)N)Cc1ccccc1)O)C
InChi: 1S/C42H69N7O10/c1-11-26(6)35(39(55)47-34(25(4)5)40(56)58-10)48-38(54)31-18-15-19-49(31)23-32(50)28(21-27-16-13-12-14-17-27)44-37(53)30(22-33(43)51)45-36(52)29(20-24(2)3)46-41(57)59-42(7,8)9/h12-14,16-17,24-26,28-32,34-35,50H,11,15,18-23H2,1-10H3,(H2,43,51)(H,44,53)(H,45,52)(H,46,57)(H,47,55)(H,48,54)/t26-,28-,29-,30-,31?,32+,34-,35-/m0/s1
InChiKey: BAUWWONEVLTNTD-PBUHUEOWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Human immunodeficiency virus 1	Human immunodeficiency virus type 1 protease	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	Get druggable targets OG5_131408	All targets in OG5_131408

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	Human immunodeficiency virus type 1 protease	99 aa	80 aa	27.5 %
Candida albicans	dethiobiotin synthetase	Human immunodeficiency virus type 1 protease	99 aa	90 aa	22.2 %
Mycobacterium leprae	Hypothetical protein	Human immunodeficiency virus type 1 protease	99 aa	86 aa	27.9 %
Candida albicans	dethiobiotin synthetase	Human immunodeficiency virus type 1 protease	99 aa	90 aa	22.2 %
Entamoeba histolytica	retroviral aspartyl protease domain-containing protein	Human immunodeficiency virus type 1 protease	99 aa	103 aa	31.1 %
Entamoeba histolytica	retroviral aspartyl protease domain-containing protein	Human immunodeficiency virus type 1 protease	99 aa	103 aa	31.1 %
Giardia lamblia	DNA-directed RNA polymerase subunit D	Human immunodeficiency virus type 1 protease	99 aa	90 aa	27.8 %
Echinococcus multilocularis	Chromobox protein 3	Human immunodeficiency virus type 1 protease	99 aa	95 aa	28.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0043	0.0099
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	beta adrenergic receptor kinase	0.002	0.006	0.0107
Plasmodium vivax	vivapain-2	0.0018	0.0043	0.1073
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.0088	0.0224
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0132	0.5
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0132	0.1863
Echinococcus granulosus	orexin receptor type 2	0.0025	0.0088	0.0224
Brugia malayi	hypothetical protein	0.0029	0.0118	0.0301
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0132	0.1863
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0066	0.0169
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0132	0.1863
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0088	0.0156
Schistosoma mansoni	follistatin	0.002	0.0057	0.0057
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0043	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0088	0.0156
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.0088	0.0224
Brugia malayi	G-protein coupled receptor	0.0025	0.0088	0.0224
Schistosoma mansoni	opsin-like receptor	0.0025	0.0088	0.0088
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0245	0.1542	1
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.006	0.0817
Trypanosoma cruzi	MFS transporter, putative	0.0029	0.0118	0.1646
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.002	0.0057	0.0146
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0043	0.011
Echinococcus granulosus	bloom syndrome protein	0.0023	0.0076	0.0193
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.0088	0.0088
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0066	0.0158
Echinococcus granulosus	serotonin receptor	0.0025	0.0088	0.0224
Schistosoma mansoni	hypothetical protein	0.0025	0.0088	0.0088
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0043	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0088	0.0224
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0132	0.1863
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0088	0.0224
Onchocerca volvulus		0.0038	0.0179	0.0444
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0112	0.0285
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0088	0.0156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0088	0.0088
Onchocerca volvulus		0.0025	0.0088	0.0213
Entamoeba histolytica	phosphofructokinase, putative	0.0116	0.0689	1
Onchocerca volvulus		0.0018	0.0043	0.0099
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0029	0.0118	0.0301
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0088	0.0224
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.002	0.006	0.0154
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0088	0.0224
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0088	0.0156
Brugia malayi	putative neuropeptide receptor NPR1	0.0025	0.0088	0.0224
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0116	0.0689	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0088	0.0088
Brugia malayi	secreted modular calcium-binding protein 1	0.002	0.0057	0.0146
Echinococcus granulosus	fmrfamide receptor	0.0025	0.0088	0.0224
Schistosoma mansoni	organic anion transporter	0.0029	0.0118	0.0118
Schistosoma mansoni	histamine h1 receptor	0.0025	0.0088	0.0088
Onchocerca volvulus	Putative organic anion transporter	0.0029	0.0118	0.0291
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0066	0.0169
Echinococcus granulosus	expressed protein	0.0398	0.2548	0.6494
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0066	0.0169
Echinococcus multilocularis	sodium bile acid cotransporter	0.0606	0.3924	0.6979
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.0088	0.0156
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0088	0.0224
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0088	0.0088
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.006	0.0154
Onchocerca volvulus		0.0025	0.0088	0.0213
Schistosoma mansoni	regulator of G protein signaling	0.002	0.006	0.006
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0043	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0179	0.0455
Schistosoma mansoni	organic anion transporter	0.0029	0.0118	0.0118
Brugia malayi	G-protein coupled receptor	0.0025	0.0088	0.0224
Echinococcus granulosus	axis inhibition protein axin	0.002	0.006	0.0154
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.002	0.0057	0.0146
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.006	0.006
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0179	0.0455
Onchocerca volvulus		0.002	0.0057	0.0135
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0043	0.011
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0088	0.0156
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0011
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0088	0.0156
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.0088	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0169
Brugia malayi	6-phosphofructokinase	0.0116	0.0689	0.1757
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0088	0.0224
Schistosoma mansoni	6-phosphofructokinase	0.0116	0.0689	0.0689
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0374	0.5385
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.0088	0.0088
Trichomonas vaginalis	esterase, putative	0.0038	0.0179	0.2543
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0066	0.0169
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0025	0.0088	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0118	0.0301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0066	0.0169
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.0088	0.0156
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.0088	0.0224
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.002	0.006	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0169
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.0088	0.0224
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0132	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0027	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0088	0.0156
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0014	0.0035
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.0689	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0066	0.0169
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0179	0.2543
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0606	0.3924	0.3924
Echinococcus multilocularis	bloom syndrome protein	0.0023	0.0076	0.0134
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0179	0.0455
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.006	0.006
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0179	1
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0132	0.6947
Echinococcus multilocularis	lamin	0.0029	0.0115	0.0205
Schistosoma mansoni	hypothetical protein	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.002	0.006	0.0154
Echinococcus multilocularis	sex peptide receptor	0.0025	0.0088	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0179	0.0455
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0088	0.0088
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0132	0.6923
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0043	0.0568
Schistosoma mansoni	z-protein (S1r protein)	0.002	0.006	0.006
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0025	0.0088	0.0224
Trypanosoma cruzi	cruzipain precursor, putative	0.0068	0.0374	0.5385
Brugia malayi	regulator of G-protein signaling egl-10	0.002	0.006	0.0154
Brugia malayi	Melatonin receptor type 1A	0.0025	0.0088	0.0224
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.0088	0.0224
Onchocerca volvulus		0.0025	0.0088	0.0213
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0066	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.006	0.0817
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0088	0.0156
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0066	0.0169
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0043	0.011
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0088	0.0224
Echinococcus multilocularis	Regulator of G protein signaling 20	0.002	0.006	0.0107
Brugia malayi	GnHR receptor homolog	0.0025	0.0088	0.0224
Onchocerca volvulus		0.0025	0.0088	0.0213
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0088	0.0156
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0088	0.0156
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0179	0.2543
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Schistosoma mansoni	hypothetical protein	0.0025	0.0088	0.0088
Mycobacterium ulcerans	6-phosphofructokinase	0.0116	0.0689	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0066	0.0066
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0066	0.0169
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0115	0.0293
Onchocerca volvulus		0.0029	0.0118	0.0291
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0088	0.0224
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0066	0.0158
Echinococcus granulosus	lamin dm0	0.0029	0.0115	0.0293
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0066	0.0169
Onchocerca volvulus		0.0025	0.0088	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Onchocerca volvulus		0.0025	0.0088	0.0213
Onchocerca volvulus		0.0018	0.0043	0.0099
Brugia malayi	beta-lactamase	0.0038	0.0179	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0088	0.0224
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0044	0.0044
Loa Loa (eye worm)	cysteine protease	0.0018	0.0043	0.011
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.006	0.0107
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0118	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0118	0.0301
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0088	0.0156
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0043	0.0568
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0088	0.0088
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.002	0.0057	0.0146
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0066	0.0169
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Onchocerca volvulus		0.0025	0.0088	0.0213
Echinococcus multilocularis	serotonin receptor	0.0025	0.0088	0.0156
Echinococcus multilocularis	follistatin	0.002	0.0057	0.0102
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.0088	0.0224
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus granulosus	Regulator of G protein signaling 20	0.002	0.006	0.0154
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0179	0.0455
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0179	0.0318
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0115	0.0293
Leishmania major	hypothetical protein, conserved	0.0038	0.0179	0.2529
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.0088	0.0224
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0025	0.0088	0.0224
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.0088	0.0156
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0374	0.5385
Brugia malayi	PXA domain containing protein	0.002	0.006	0.0154
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0043	0.0043
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.0088	0.0224
Schistosoma mansoni	sodium-bile acid cotransporter	0.0257	0.1621	0.1621
Leishmania major	cathepsin L-like protease	0.0068	0.0374	0.5385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Echinococcus multilocularis	serotonin receptor	0.0025	0.0088	0.0156
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0115	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.006	0.0817
Leishmania major	ATP-dependent phosphofructokinase	0.0116	0.0689	1
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0088	0.0224
Echinococcus granulosus	agrin	0.002	0.0057	0.0146
Echinococcus granulosus	beta-adrenergic receptor kinase	0.002	0.006	0.0154
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.006	0.0154
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.002	0.0057	0.2052
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0088	0.0224
Brugia malayi	Dopamine receptor	0.0025	0.0088	0.0224
Brugia malayi	regulator of G-protein signaling rgs-7	0.002	0.006	0.0154
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0066	0.0066
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.0689	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.002	0.0057	0.0146
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0088	0.0224
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0066	0.0118
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0029	0.0118	0.021
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.0088	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0118	0.0301
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0043	0.011
Toxoplasma gondii	cathepsin CPL	0.0018	0.0043	0.1143
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0132	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0043	0.0568
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0066	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Onchocerca volvulus		0.0606	0.3924	1
Echinococcus granulosus	hypothetical protein	0.0025	0.0088	0.0224
Brugia malayi	PXA domain containing protein	0.002	0.006	0.0154
Onchocerca volvulus	Putative organic anion transporter	0.0029	0.0118	0.0291
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0029	0.0118	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0115	0.0293
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0029	0.0118	0.0301
Brugia malayi	prostaglandin transporter	0.0029	0.0118	0.0301
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.0088	0.0224
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0088	0.0088
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.0088	0.0224
Onchocerca volvulus		0.0025	0.0088	0.0213
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Entamoeba histolytica	phosphofructokinase, putative	0.0116	0.0689	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0043	0.0568
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0088	0.0156
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0066	0.0169
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0088	0.0156
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0179	0.2543
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0278	0.3982
Brugia malayi	Dopamine receptor protein 2	0.0025	0.0088	0.0224
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0179	0.2529
Brugia malayi	follicle stimulating hormone receptor	0.0025	0.0088	0.0224
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.006	0.0154
Onchocerca volvulus		0.0021	0.0066	0.0158
Onchocerca volvulus		0.0038	0.0179	0.0444
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0004	0.0011
Brugia malayi	Serotonin receptor	0.0025	0.0088	0.0224
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0066	0.0066
Brugia malayi	hypothetical protein	0.002	0.006	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	6-phosphofructokinase	0.0116	0.0689	0.1757
Entamoeba histolytica	hypothetical protein	0.002	0.006	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0118	0.0301
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0066	0.0169
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0062	0.0335	0.4816
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0088	0.0224
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.002	0.006	0.0817
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0043	0.0043
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0043	0.011
Leishmania major	cysteine peptidase A (CPA)	0.0018	0.0043	0.0549
Brugia malayi	Serotonin receptor	0.0025	0.0088	0.0224
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.002	0.006	0.0154
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0088	0.0088
Brugia malayi	sodium-independent organic anion transporter family protein	0.0029	0.0118	0.0301
Echinococcus granulosus	sex peptide receptor	0.0025	0.0088	0.0224
Echinococcus granulosus	cathepsin l1	0.0012	0.0004	0.0011
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.0088	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0169
Onchocerca volvulus	Putative organic anion transporter	0.0029	0.0118	0.0291
Brugia malayi	hypothetical protein	0.0029	0.0118	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0606	0.3924	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0132	0.1863
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.0088	0.0156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0014	0.0035
Echinococcus granulosus	sodium bile acid cotransporter	0.0606	0.3924	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0066	0.0066
Schistosoma mansoni	axis inhibition protein axin	0.002	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0017	0.0044
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0066	0.0169
Onchocerca volvulus		0.0029	0.0118	0.0291
Echinococcus multilocularis	somatostatin receptor	0.0025	0.0088	0.0156
Onchocerca volvulus		0.0025	0.0088	0.0213
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0066	0.0169
Loa Loa (eye worm)	phosphofructokinase	0.0116	0.0689	0.1757
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.0088	0.0156
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0179	0.2529
Onchocerca volvulus		0.0025	0.0088	0.0213
Onchocerca volvulus		0.0029	0.0118	0.0291
Entamoeba histolytica	hypothetical protein	0.002	0.006	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Onchocerca volvulus		0.0018	0.0043	0.0099
Schistosoma mansoni	hypothetical protein	0.0025	0.0088	0.0088
Leishmania major	cathepsin L-like protease	0.0018	0.0043	0.0549
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.0088	0.0156
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus granulosus	follistatin	0.002	0.0057	0.0146
Onchocerca volvulus	Phospholipase A2 homolog	0.0458	0.2945	0.7503
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0179	0.0455
Schistosoma mansoni	axis inhibition protein axin	0.002	0.006	0.006
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0066	0.0066
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.0088	0.0156
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0066	0.0169
Echinococcus multilocularis	agrin	0.002	0.0057	0.0102
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0132	0.6947
Brugia malayi	beta-lactamase family protein	0.0038	0.0179	0.0455
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0169
Entamoeba histolytica	hypothetical protein	0.002	0.006	0.0817
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0088	0.0224
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.0088	0.0088
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0004	0.0011
Schistosoma mansoni	amine GPCR	0.0025	0.0088	0.0088
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.002	0.0057	0.2052
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0088	0.0156
Onchocerca volvulus		0.0025	0.0088	0.0213
Onchocerca volvulus		0.0029	0.0118	0.0291
Echinococcus multilocularis	cysteine protease	0.0018	0.0043	0.0077
Brugia malayi	G protein-coupled receptor F59B2.13	0.0025	0.0088	0.0224
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0043	0.011
Brugia malayi	nuclear hormone receptor	0.0021	0.0066	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0088	0.0224
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0278	0.1757	0.1757
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0066	0.0118
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0066	0.0118
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0066	0.0169
Schistosoma mansoni	hypothetical protein	0.0181	0.1116	0.1116
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0179	0.2543
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0043	0.0568
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0116	0.0689	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0088	0.0088
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0066	0.0169
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0088	0.0156
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0066	0.0118
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0025	0.0088	0.0224
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0374	0.5385
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0088	0.0224
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0066	0.0118
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.0088	0.0088
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.0088	0.0156
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.0088	0.0088
Loa Loa (eye worm)	fibroinase	0.0018	0.0043	0.011
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.0088	0.0156
Onchocerca volvulus		0.0038	0.0179	0.0444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0043	0.0568
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0043	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.0088	0.0224
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0066	0.0118
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0116	0.0689	1
Leishmania major	cathepsin L-like protease	0.0068	0.0374	0.5385
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0043	0.0568
Leishmania major	cathepsin L-like protease	0.0018	0.0043	0.0549
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.0088	0.0224
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0043	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0043	0.011
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	geminin	0.0181	0.1116	0.1985
Onchocerca volvulus		0.0018	0.0043	0.0099
Loa Loa (eye worm)	hypothetical protein	0.002	0.006	0.0154
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.006	0.0154
Echinococcus granulosus	axis inhibition protein axin	0.002	0.006	0.0154
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0132	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.006	0.006
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0004	0.0011
Echinococcus granulosus	sodium bile acid cotransporter	0.0606	0.3924	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0179	0.2529
Schistosoma mansoni	adenoreceptor	0.0025	0.0088	0.0088
Brugia malayi	cathepsin L-like precursor	0.0012	0.0004	0.0011
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0043	0.011
Schistosoma mansoni	amine GPCR	0.0025	0.0088	0.0088
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Brugia malayi	larval opioid receptor	0.0025	0.0088	0.0224
Leishmania major	cathepsin L-like protease	0.0068	0.0374	0.5385
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0066	0.0169
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0116	0.0689	1
Brugia malayi	steroid hormone receptor	0.0021	0.0066	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	musashi	0.0029	0.0115	0.0205
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0179	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.006	0.0817
Brugia malayi	SPARC precursor	0.002	0.0057	0.0146
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0043	0.0099
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0066	0.0066
Echinococcus granulosus	sodium bile acid cotransporter	0.0606	0.3924	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0132	0.1863
Schistosoma mansoni	coup transcription factor	0.0021	0.0066	0.0066
Echinococcus granulosus	somatostatin receptor	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0011
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0027	0.0069
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.002	0.0057	0.0146
Loa Loa (eye worm)	hypothetical protein	0.002	0.0057	0.0146
Brugia malayi	putative neuropeptide receptor	0.0025	0.0088	0.0224
Echinococcus granulosus	geminin	0.0181	0.1116	0.2845
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0088	0.0224
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0029	0.0118	0.021
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0088	0.0224
Schistosoma mansoni	regulator of G protein signaling	0.002	0.006	0.006
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0132	0.1863
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0025	0.0088	0.0224
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0043	0.0568
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0066	0.0169
Schistosoma mansoni	regulator of G protein signaling	0.002	0.006	0.006
Onchocerca volvulus		0.0018	0.0043	0.0099
Brugia malayi	Sodium Bile acid symporter family protein	0.0606	0.3924	1
Brugia malayi	Dopamine receptor protein 1	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0179	0.0455
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0066	0.0169
Onchocerca volvulus		0.0025	0.0088	0.0213
Onchocerca volvulus		0.0018	0.0043	0.0099
Loa Loa (eye worm)	6-phosphofructokinase	0.0116	0.0689	0.1757
Brugia malayi	phosphofructokinase	0.0116	0.0689	0.1757
Brugia malayi	neuropeptide F receptor	0.0025	0.0088	0.0224
Loa Loa (eye worm)	ctsf protein	0.0018	0.0043	0.011
Brugia malayi	hypothetical protein	0.002	0.006	0.0154
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0066	0.0169
Toxoplasma gondii	ABC1 family protein	0.0038	0.0179	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.006	0.0154
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.006	0.0154
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.002	0.0057	0.0146
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.0088	0.0088
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0017	0.0044
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.0088	0.0088
Loa Loa (eye worm)	RGS-3 protein	0.002	0.006	0.0154
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0043	0.011
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0025	0.0088	0.0213
Loa Loa (eye worm)	hypothetical protein	0.002	0.006	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.006	0.0107
Brugia malayi	neuropeptide F receptor	0.0025	0.0088	0.0224
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0118	0.0301
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0132	0.6947
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0066	0.0066
Echinococcus multilocularis	expressed protein	0.0398	0.2548	0.4532
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0088	0.0156
Brugia malayi	RE15519p	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0118	0.0301
Loa Loa (eye worm)	hypothetical protein	0.002	0.0057	0.0146
Schistosoma mansoni	amine GPCR	0.0025	0.0088	0.0088
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.006	0.0107
Brugia malayi	A-kinase anchor protein 10, precursor	0.002	0.006	0.0154
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0088	0.0088
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.0076	0.1039
Schistosoma mansoni	lamin	0.0029	0.0115	0.0115
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0066	0.0169
Echinococcus multilocularis	sodium bile acid cotransporter	0.0606	0.3924	0.6979
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0088	0.0156
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0066	0.0158
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0043	0.011
Entamoeba histolytica	recQ family helicase, putative	0.0012	0.0006	0.002
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0017	0.003
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.0088	0.0088
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0169
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0066	0.0066
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0066	0.0169
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.0689	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0169
Echinococcus multilocularis	expressed protein	0.002	0.0057	0.0102
Echinococcus multilocularis	regulator of G protein signaling	0.002	0.006	0.0107
Brugia malayi	sulfakinin receptor protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	sodium bile acid cotransporter	0.0606	0.3924	0.6979
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0066	0.0169
Echinococcus multilocularis	lamin dm0	0.0029	0.0115	0.0205
Schistosoma mansoni	opsin-like receptor	0.0025	0.0088	0.0088
Brugia malayi	6-phosphofructokinase	0.0116	0.0689	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Leishmania major	cathepsin L-like protease	0.0018	0.0043	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0057	0.0146
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.006	0.0154
Schistosoma mansoni	hypothetical protein	0.0181	0.1116	0.1116
Loa Loa (eye worm)	hypothetical protein	0.0458	0.2945	0.7505
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0179	0.0179
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0043	0.011
Onchocerca volvulus		0.0025	0.0088	0.0213
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.002	0.006	0.0154
Brugia malayi	ecdysteroid receptor	0.0021	0.0066	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0179	0.0455
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.0088	0.0224
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0088	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0169
Brugia malayi	Phospholipase A2 family protein	0.0096	0.0561	0.1431
Loa Loa (eye worm)	hypothetical protein	0.002	0.006	0.0154
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.0088	0.0156
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0116	0.0689	0.3747
Brugia malayi	beta-lactamase family protein	0.0038	0.0179	0.0455
Onchocerca volvulus		0.0029	0.0115	0.0282
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.002	0.0057	0.2052
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0561	0.1431
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0088	0.0224
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0066	0.0169
Onchocerca volvulus		0.0029	0.0118	0.0291
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.002	0.006	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus granulosus	6 phosphofructokinase	0.0116	0.0689	0.1757
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0088	0.0156
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0349	0.2229	0.2229
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0088	0.0088
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0088	0.0088
Echinococcus multilocularis	G protein coupled receptor 139	0.0025	0.0088	0.0156
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0179	0.0455
Schistosoma mansoni	6-phosphofructokinase	0.0116	0.0689	0.0689
Echinococcus granulosus	cathepsin l1	0.0018	0.0043	0.011
Leishmania major	cathepsin L-like protease	0.0018	0.0043	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.0088	0.0088
Brugia malayi	Bloom's syndrome protein homolog	0.0023	0.0076	0.0193
Brugia malayi	sodium-independent organic anion transporter family protein	0.0029	0.0118	0.0301
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0043	0.0077
Onchocerca volvulus		0.0029	0.0115	0.0282
Brugia malayi	ORL1-like opioid receptor	0.0025	0.0088	0.0224
Onchocerca volvulus		0.0025	0.0088	0.0213
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0088	0.0088
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Schistosoma mansoni	myosin xvIII	0.0025	0.0088	0.0088
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0132	1
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0088	0.0088
Schistosoma mansoni	regulator of G protein signaling	0.002	0.006	0.006
Brugia malayi	sodium-independent organic anion transporter family protein	0.0029	0.0118	0.0301
Schistosoma mansoni	lamin	0.0029	0.0115	0.0115
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0088	0.0088
Loa Loa (eye worm)	agrin synaptic family protein	0.002	0.0057	0.0146
Echinococcus multilocularis	6 phosphofructokinase	0.0116	0.0689	0.1226
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0088	0.0156
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0088	0.0224
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0066	0.0169
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0088	0.0088
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0115	0.0293
Plasmodium vivax	vivapain-2	0.0018	0.0043	0.1073
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0118	0.6052
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0043	0.0077
Loa Loa (eye worm)	PXA domain-containing protein	0.002	0.006	0.0154
Brugia malayi	AKH receptor	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0179	0.2543
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0045	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.006	0.0817
Onchocerca volvulus		0.0025	0.0088	0.0213
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus granulosus	intermediate filament protein	0.0029	0.0115	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0011
Schistosoma mansoni	amine GPCR	0.0025	0.0088	0.0088
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.0088	0.0088
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0057	0.1587
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.0088	0.0224
Brugia malayi	G protein-coupled receptor	0.0025	0.0088	0.0224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.0088	0.0156
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0088	0.0224
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.0088	0.0224
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0132	0.1863
Schistosoma mansoni	regulator of G protein signaling	0.002	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.002	0.006	0.0154
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0043	0.0077
Toxoplasma gondii	protease inhibitor PI2	0.002	0.0057	0.2052
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0043	0.011
Echinococcus granulosus	lamin	0.0029	0.0115	0.0293
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0088	0.0224
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.0088	0.0088
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0025	0.0088	0.0213
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0088	0.0156
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0066	0.0118
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.006	0.0107
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0088	0.0156
Leishmania major	cathepsin L-like protease	0.0018	0.0043	0.0549
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Schistosoma mansoni	agrin	0.002	0.0057	0.0057
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0066	0.0118
Loa Loa (eye worm)	RecQ helicase	0.0023	0.0076	0.0193
Echinococcus granulosus	allatostatin A receptor	0.0025	0.0088	0.0224
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0088	0.0224
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.0088	0.0224
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0066	0.0169
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.002	0.0057	0.2052
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0864	0.5623	1
Onchocerca volvulus		0.0025	0.0088	0.0213
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0043	0.0568
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.006	0.006
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0025	0.0088	0.0224
Brugia malayi	intermediate filament protein	0.0029	0.0115	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0088	0.0156
Onchocerca volvulus	Phospholipase A2 homolog	0.0096	0.0561	0.1421
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0066	0.0118
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.006	0.0107
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.002	0.006	0.0154
Onchocerca volvulus		0.0025	0.0088	0.0213
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.0076	0.1039
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.0689	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0088	0.0156
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0043	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Echinococcus multilocularis	cysteine protease	0.0018	0.0043	0.0077
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0066	0.0066
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0132	0.6923
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.0088	0.0224
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0088	0.0224
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0043	0.0568
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.006	0.0817
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.002	0.006	0.006
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0066	0.0169
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.0088	0.0224
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0374	0.5385
Onchocerca volvulus		0.0018	0.0043	0.0099
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0088	0.0088
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.006	0.0107
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0066	0.0169
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.0088	0.0156
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0088	0.0088
Schistosoma mansoni	opsin-like receptor	0.0025	0.0088	0.0088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0043	0.0568
Schistosoma mansoni	amine GPCR	0.0025	0.0088	0.0088
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0066	0.0169
Entamoeba histolytica	phosphofructokinase, putative	0.0116	0.0689	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0066	0.0169
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.006	0.006
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0088	0.0156
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0066	0.0066
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0088	0.0088
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0043	0.0568
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0066	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0224

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 66 nM	Binding affinity to HIV protease	ChEMBL.	1433192

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3349497

Bibliographic References

No literature references available for this target.

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Detailed information for compound 938052