Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | somatostatin receptor 5 | Starlite/ChEMBL | References |
Homo sapiens | somatostatin receptor 4 | Starlite/ChEMBL | References |
Homo sapiens | somatostatin receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | somatostatin receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | somatostatin receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 5 | 364 aa | 392 aa | 19.4 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 4 | 388 aa | 372 aa | 20.7 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 1 | 391 aa | 368 aa | 21.5 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 2 | 369 aa | 411 aa | 18.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0251 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0251 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0251 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0251 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0251 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0251 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0251 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0251 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0251 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0251 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0251 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0251 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0251 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0251 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0251 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0251 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0251 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0251 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0251 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0251 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0251 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0251 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0251 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0251 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0251 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0251 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0251 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0251 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0251 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0251 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1000 nM | Binding affinity towards cloned human somatostatin 1 (hsst) receptor | ChEMBL. | 9544214 |
IC50 (binding) | = 1000 nM | Binding affinity towards cloned human somatostatin 2 (hsst) receptor | ChEMBL. | 9544214 |
IC50 (binding) | = 1000 nM | Binding affinity towards cloned human somatostatin 4 (hsst) receptor | ChEMBL. | 9544214 |
IC50 (binding) | = 1380 nM | Binding affinity towards cloned human somatostatin 3 (hsst) receptor | ChEMBL. | 9544214 |
IC50 (binding) | = 3700 nM | Binding affinity towards cloned human somatostatin 5 (hsst) receptor | ChEMBL. | 9544214 |
IC50 (functional) | = 98.65 uM | Compound was tested for in vitro SRIF inhibition of GH release in rats | ChEMBL. | 9544214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.