TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 397.512 | Formula: C26H27N3O
H donors: 2 H acceptors: 1 LogP: 4.96 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@H]1CCCN1CCc1c[nH]c2c1cccc2)NCc1ccc2c(c1)cccc2
InChi: 1S/C26H27N3O/c30-26(28-17-19-11-12-20-6-1-2-7-21(20)16-19)25-10-5-14-29(25)15-13-22-18-27-24-9-4-3-8-23(22)24/h1-4,6-9,11-12,16,18,25,27H,5,10,13-15,17H2,(H,28,30)/t25-/m1/s1
InChiKey: KYHOUNVEHRNHKW-RUZDIDTESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	serotonin receptor	0.003	0.0229	0.0229
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Echinococcus granulosus	adenosine deaminase	0.0724	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.003	0.0229	0.0229
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0724	1	1
Loa Loa (eye worm)	hypothetical protein	0.0488	0.6682	0.6682
Echinococcus multilocularis	nervana 2	0.002	0.0101	0.0101
Schistosoma mansoni	biogenic amine receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0229	0.0229
Onchocerca volvulus	AMP deaminase 2 homolog	0.0236	0.3132	0.3132
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Brugia malayi	Dopamine receptor	0.003	0.0229	0.0229
Echinococcus granulosus	nervana 2	0.002	0.0101	0.0101
Onchocerca volvulus		0.003	0.0229	0.0229
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0251	0.0251
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.003	0.0229	0.0229
Schistosoma mansoni	alpha-1 adrenergic receptor	0.003	0.0229	0.0229
Treponema pallidum	adenosine deaminase	0.0724	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.003	0.0229	0.0229
Brugia malayi	Phospholipase A2 family protein	0.0269	0.3603	0.3603
Echinococcus granulosus	somatostatin receptor	0.003	0.0229	0.0229
Brugia malayi	Serotonin receptor	0.003	0.0229	0.0229
Brugia malayi	adenosine monophosphate deaminase	0.0236	0.3132	0.3132
Trypanosoma cruzi	AMP deaminase 2, putative	0.0236	0.3132	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	dro:myosuppressin receptor	0.003	0.0229	0.0229
Schistosoma mansoni	neuropeptide receptor	0.003	0.0229	0.0229
Echinococcus granulosus	serine threonine protein kinase nrc	0.0021	0.0104	0.0104
Entamoeba histolytica	AMP deaminase, putative	0.0236	0.3132	0.3059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Echinococcus granulosus	g protein coupled receptor	0.003	0.0229	0.0229
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0023	0.0133	0.0095
Onchocerca volvulus		0.0236	0.3132	0.3132
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0229	0.0229
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Trypanosoma brucei	AMP deaminase, putative	0.0236	0.3132	1
Trichomonas vaginalis	adenosine deaminase, putative	0.0724	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	7tm_1 domain containing protein	0.003	0.0229	0.0229
Brugia malayi	G-protein coupled receptor	0.003	0.0229	0.0229
Brugia malayi	Tachykinin-like peptides receptor 99D	0.003	0.0229	0.0229
Trypanosoma brucei	AMP deaminase, putative	0.0236	0.3132	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0229	0.0229
Brugia malayi	follicle stimulating hormone receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	AMP deaminase	0.0236	0.3132	0.3132
Echinococcus multilocularis	somatostatin receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Onchocerca volvulus	Neuropeptide F receptor homolog	0.003	0.0229	0.0229
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0101	0.0101
Brugia malayi	larval opioid receptor	0.003	0.0229	0.0229
Schistosoma mansoni	amine GPCR	0.003	0.0229	0.0229
Echinococcus multilocularis	allatostatin A receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.003	0.0229	0.0229
Trypanosoma cruzi	Protein kinase B	0.0023	0.0133	0.0095
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0133	0.0133
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.003	0.0229	0.0229
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Brugia malayi	neuropeptide F receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0488	0.6682	0.6682
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0229	0.0229
Schistosoma mansoni	adenosine deaminase-related	0.0724	1	1
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3603	0.3603
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0724	1	1
Echinococcus granulosus	g-protein coupled receptor	0.003	0.0229	0.0229
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0229	0.0229
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.003	0.0229	0.0229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0229	0.0229
Echinococcus multilocularis	sex peptide receptor	0.003	0.0229	0.0229
Brugia malayi	RE15519p	0.003	0.0229	0.0229
Schistosoma mansoni	adenosine deaminase	0.0724	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0229	0.0229
Schistosoma mansoni	myosin xvIII	0.003	0.0229	0.0229
Plasmodium falciparum	AMP deaminase, putative	0.0236	0.3132	0.3059
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.003	0.0229	0.0229
Echinococcus granulosus	neuropeptide receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0229	0.0229
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0229	0.0229
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Mycobacterium ulcerans	adenosine deaminase	0.0724	1	0.5
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0021	0.0104	0.0104
Toxoplasma gondii	AMP deaminase	0.0236	0.3132	0.2955
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0229	0.0229
Trypanosoma cruzi	AMP deaminase, putative	0.0236	0.3132	1
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	G protein coupled receptor 139	0.003	0.0229	0.0229
Echinococcus granulosus	alpha 1A adrenergic receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.003	0.0229	0.0229
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Echinococcus granulosus	fmrfamide receptor	0.003	0.0229	0.0229
Schistosoma mansoni	AMP deaminase	0.0236	0.3132	0.3132
Schistosoma mansoni	amine GPCR	0.003	0.0229	0.0229
Echinococcus multilocularis	neuropeptide s receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	neuropeptide FF receptor 2	0.003	0.0229	0.0229
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Schistosoma mansoni	amine GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	sex peptide receptor	0.003	0.0229	0.0229
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0229	0.0229
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	neuropeptide receptor A26	0.003	0.0229	0.0229
Schistosoma mansoni	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	allatostatin A receptor	0.003	0.0229	0.0229
Onchocerca volvulus	Phospholipase A2 homolog	0.0269	0.3603	0.3603
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0236	0.3132	0.3132
Schistosoma mansoni	amine GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0229	0.0229
Echinococcus granulosus	g protein coupled receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Brugia malayi	GnHR receptor homolog	0.003	0.0229	0.0229
Schistosoma mansoni	histamine h1 receptor	0.003	0.0229	0.0229
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.0724	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Schistosoma mansoni	amine GPCR	0.003	0.0229	0.0229
Brugia malayi	neuropeptide F receptor	0.003	0.0229	0.0229
Giardia lamblia	Kinase, AGC PKA	0.0021	0.0104	0.5
Brugia malayi	Melatonin receptor type 1A	0.003	0.0229	0.0229
Entamoeba histolytica	adenosine deaminase, putative	0.0724	1	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0023	0.0133	0.0133
Brugia malayi	G protein-coupled receptor	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Loa Loa (eye worm)	TYRA-2 protein	0.003	0.0229	0.0229
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	AMP deaminase 2	0.0236	0.3132	0.3132
Schistosoma mansoni	opsin-like receptor	0.003	0.0229	0.0229
Schistosoma mansoni	growth hormone secretagogue receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0488	0.6682	0.6682
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0229	0.0229
Brugia malayi	putative neuropeptide receptor NPR1	0.003	0.0229	0.0229
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	AMP deaminase 2	0.0236	0.3132	0.3132
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0229	0.0229
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.003	0.0229	0.0229
Brugia malayi	sulfakinin receptor protein	0.003	0.0229	0.0229
Leishmania major	adenine aminohydrolase	0.0724	1	1
Schistosoma mansoni	neuropeptide receptor	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Echinococcus multilocularis	adenosine deaminase	0.0724	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.003	0.0229	0.0229
Entamoeba histolytica	protein kinase, putative	0.0031	0.0251	0.0148
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Schistosoma mansoni	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	g-protein coupled receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0488	0.6682	0.6682
Onchocerca volvulus		0.003	0.0229	0.0229
Echinococcus multilocularis	G-protein coupled receptor, putative	0.003	0.0229	0.0229
Plasmodium falciparum	adenosine deaminase	0.0724	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.003	0.0229	0.0229
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.0236	0.3132	1
Echinococcus granulosus	serine/threonine protein kinase	0.0023	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Schistosoma mansoni	adenoreceptor	0.003	0.0229	0.0229
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0229	0.0229
Brugia malayi	G-protein coupled receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3603	0.3603
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	tachykinin peptides receptor 99D	0.003	0.0229	0.0229
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Schistosoma mansoni	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	7TM GPCR rhodopsin	0.003	0.0229	0.0229
Entamoeba histolytica	adenosine deaminase, putative	0.0724	1	1
Onchocerca volvulus		0.003	0.0229	0.0229
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0229	0.0229
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0229	0.0229
Echinococcus granulosus	neuropeptide receptor	0.003	0.0229	0.0229
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0229	0.0229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0229	0.0229
Echinococcus granulosus	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	orexin receptor type 2	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Trypanosoma cruzi	AMP deaminase, putative	0.0236	0.3132	1
Brugia malayi	putative neuropeptide receptor	0.003	0.0229	0.0229
Brugia malayi	Dopamine receptor protein 1	0.003	0.0229	0.0229
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.003	0.0229	0.0229
Echinococcus granulosus	serotonin receptor	0.003	0.0229	0.0229
Echinococcus granulosus	neuropeptide FF receptor 2	0.003	0.0229	0.0229
Trypanosoma cruzi	AMP deaminase, putative	0.0236	0.3132	1
Onchocerca volvulus	Adenosine deaminase homolog	0.0724	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0229	0.0229
Trypanosoma cruzi	AMP deaminase, putative	0.0236	0.3132	1
Echinococcus multilocularis	serotonin receptor	0.003	0.0229	0.0229
Brugia malayi	Protein kinase domain containing protein	0.0033	0.028	0.028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Schistosoma mansoni	biogenic amine receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Brugia malayi	Serotonin receptor	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Brugia malayi	Dopamine receptor protein 2	0.003	0.0229	0.0229
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0229	0.0229
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Echinococcus granulosus	orexin receptor type 2	0.003	0.0229	0.0229
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0229	0.0229
Schistosoma mansoni	neuropeptide receptor	0.003	0.0229	0.0229
Plasmodium vivax	adenosine/AMP deaminase, putative	0.0236	0.3132	0.3059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0229	0.0229
Onchocerca volvulus	Phospholipase A2 homolog	0.0269	0.3603	0.3603
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0021	0.0104	0.0104
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0229	0.0229
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0229	0.0229
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Entamoeba histolytica	protein kinase, putative	0.0033	0.028	0.0177
Schistosoma mansoni	biogenic amine receptor	0.003	0.0229	0.0229
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.0236	0.3132	1
Echinococcus granulosus	neuropeptide receptor A26	0.003	0.0229	0.0229
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.003	0.0229	0.0229
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0724	1	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.028	0.0177
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.003	0.0229	0.0229
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.003	0.0229	0.0229
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Plasmodium vivax	adenosine deaminase, putative	0.0724	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0229	0.0229
Trypanosoma brucei	AMP deaminase, putative	0.0236	0.3132	1
Trichomonas vaginalis	adenosine deaminase, putative	0.0724	1	1
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.0724	1	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0229	0.0229
Schistosoma mansoni	opsin-like receptor	0.003	0.0229	0.0229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0229	0.0229
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0251	0.0251
Echinococcus granulosus	peptide allatostatin:somatostatin	0.003	0.0229	0.0229
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.003	0.0229	0.0229
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0133	0.0029
Brugia malayi	ORL1-like opioid receptor	0.003	0.0229	0.0229
Schistosoma mansoni	opsin-like receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0229	0.0229
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.003	0.0229	0.0229
Brugia malayi	AKH receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	dro:myosuppressin receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.003	0.0229	0.0229
Schistosoma mansoni	neuropeptide receptor	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0229	0.0229
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.003	0.0229	0.0229
Onchocerca volvulus		0.003	0.0229	0.0229
Schistosoma mansoni	hypothetical protein	0.003	0.0229	0.0229
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0229	0.0229
Echinococcus multilocularis	nervana 2	0.002	0.0101	0.0101
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.0236	0.3132	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.003	0.0229	0.0229
Echinococcus granulosus	nervana 2	0.002	0.0101	0.0101
Onchocerca volvulus		0.003	0.0229	0.0229
Echinococcus multilocularis	G protein coupled receptor 139	0.003	0.0229	0.0229
Echinococcus granulosus	g protein coupled receptor	0.003	0.0229	0.0229
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.003	0.0229	0.0229
Entamoeba histolytica	AMP deaminase, putative	0.0236	0.3132	0.3059
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0133	0.0029
Brugia malayi	hypothetical protein	0.003	0.0229	0.0229
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0229	0.0229
Trypanosoma cruzi	AMP deaminase, putative	0.0236	0.3132	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.003	0.0229	0.0229
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0229	0.0229
Echinococcus granulosus	neuropeptide s receptor	0.003	0.0229	0.0229

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	uM	Tested for its binding affinity in competition with [125I]-NDP-MSH on recombinant human Melanocortin 1 receptor; nb = no binding	ChEMBL.	11909712
Ki (binding)	uM	Tested for its binding affinity in competition with [125I]-NDP-MSH on recombinant Melanocortin 5 receptor; nb = no binding	ChEMBL.	11909712
Ki (binding)	= 166 uM	Binding affinity in competition with [125I]-NDP-MSH on recombinant melanocortin 4 receptor	ChEMBL.	11909712
Ki (binding)	= 752 uM	Binding affinity in competition with [125I]-NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL.	11909712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2113644

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 938227