Detailed information for compound 938229

Basic information

Technical information
  • TDR Targets ID: 938229
  • Name: 3-[(2-dimethylaminoacetyl)amino]-2-phenyl-N-[ (1S)-1-phenylpropyl]quinoline-4-carboxamide
  • MW: 466.574 | Formula: C29H30N4O2
  • H donors: 2 H acceptors: 3 LogP: 5.35 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H](c1ccccc1)NC(=O)c1c(NC(=O)CN(C)C)c(nc2c1cccc2)c1ccccc1
  • InChi: 1S/C29H30N4O2/c1-4-23(20-13-7-5-8-14-20)31-29(35)26-22-17-11-12-18-24(22)30-27(21-15-9-6-10-16-21)28(26)32-25(34)19-33(2)3/h5-18,23H,4,19H2,1-3H3,(H,31,35)(H,32,34)/t23-/m0/s1
  • InChiKey: LHMMQMRETANOJC-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(2-dimethylamino-1-oxoethyl)amino]-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
  • 3-[(2-dimethylaminoacetyl)amino]-2-phenyl-N-[(1S)-1-phenylpropyl]cinchoninamide
  • 3-(2-dimethylaminoethanoylamino)-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969
Echinococcus multilocularis tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi adenosine monophosphate deaminase 0.0027 0.0021 0.0014
Schistosoma mansoni survival motor neuron protein 0.0202 0.0744 0.1202
Schistosoma mansoni thymidine kinase 0.1511 0.6148 1
Trypanosoma brucei ingi protein (ORF1) 0.0052 0.0123 0.0286
Onchocerca volvulus 0.0112 0.0372 0.1894
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0151 0.0829
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Leishmania major ribonuclease H1, putative 0.0045 0.0094 0.0169
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Trypanosoma cruzi thymidylate kinase, putative 0.0303 0.1161 0.2658
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0248 0.0931 0.0926
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0444 0.3711
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0223 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0043 0.0084 0.0158
Onchocerca volvulus 0.0037 0.006 0.0207
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0065 0.0175 0.0277
Loa Loa (eye worm) hypothetical protein 0.0152 0.0537 0.1295
Onchocerca volvulus 0.0202 0.0744 0.3899
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0166 0.0161
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.038 0.1477 0.1472
Plasmodium falciparum adenosine deaminase 0.0084 0.0256 0.2057
Schistosoma mansoni adenosine deaminase-related 0.0084 0.0256 0.0407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0037 0.0051
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0065 0.0096
Brugia malayi hypothetical protein 0.0057 0.0144 0.032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0223 0.0488
Treponema pallidum exodeoxyribonuclease (exoA) 0.0098 0.0315 0.2071
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.0517 0.0512
Mycobacterium tuberculosis Hypothetical protein 0.0081 0.0242 0.166
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0065 0.0122
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0081 0.0242 0.0515
Plasmodium vivax thymidylate kinase, putative 0.0303 0.1161 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0931 0.2283
Brugia malayi gamma-secretase subunit aph-1 0.0758 0.3038 0.7578
Schistosoma mansoni hypothetical protein 0.0202 0.0744 0.1202
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.019 0.1181
Echinococcus granulosus AMP deaminase 2 0.0027 0.0021 0.0026
Plasmodium vivax plasmepsin IV, putative 0.0057 0.0144 0.1073
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0098 0.0315 0.0503
Brugia malayi hypothetical protein 0.0057 0.0144 0.032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0107 0.0229
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.0688 0.1686
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0444 0.3711
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0065 0.0096
Echinococcus granulosus intermediate filament protein 0.0112 0.0372 0.0597
Echinococcus multilocularis adenosine deaminase 0.0084 0.0256 0.025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.0688 0.1112
Toxoplasma gondii thymidylate kinase 0.0303 0.1161 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0098 0.0315 0.2317
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0048 0.0108 0.0437
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0065 0.0096
Loa Loa (eye worm) hypothetical protein 0.0074 0.0214 0.0483
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0061 0.0091
Brugia malayi RNA binding protein 0.0134 0.0463 0.1121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0111 0.0171
Schistosoma mansoni inositol monophosphatase 0.0076 0.0223 0.0353
Plasmodium falciparum plasmepsin V 0.0057 0.0144 0.1073
Entamoeba histolytica hypothetical protein 0.0147 0.0517 0.1156
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0149 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0065 0.0122
Brugia malayi RNase H family protein 0.0045 0.0094 0.0196
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.006 0.0109
Loa Loa (eye worm) hypothetical protein 0.0992 0.4005 1
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.2701 0.2696
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0303 0.1161 1
Trypanosoma brucei thymidylate kinase, putative 0.0303 0.1161 0.2694
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0151 0.0237
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0102 0.0189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0065 0.0109
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0165
Entamoeba histolytica glycogenphosphorylase, putative 0.0048 0.0108 0.0201
Trichomonas vaginalis thymidylate kinase, putative 0.0303 0.1161 0.2672
Trichomonas vaginalis adenosine deaminase, putative 0.0084 0.0256 0.0565
Loa Loa (eye worm) hypothetical protein 0.013 0.0444 0.1062
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0065 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0065 0.0122
Schistosoma mansoni coup transcription factor 0.0038 0.0065 0.0096
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0065 0.0096
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0098 0.0315 0.0736
Schistosoma mansoni thyroid hormone receptor 0.0177 0.0639 0.1032
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0102 0.0189
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0151 0.1137
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0107 0.0165
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0151 0.0829
Plasmodium falciparum plasmepsin VI 0.0057 0.0144 0.1073
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0098 0.0315 0.0684
Brugia malayi thymidylate kinase 0.0303 0.1161 0.287
Echinococcus multilocularis gamma secretase subunit aph 1 0.0758 0.3038 0.3034
Trypanosoma brucei unspecified product 0.0052 0.0123 0.0286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.038 0.1477 0.2395
Toxoplasma gondii ribonuclease HI protein 0.0045 0.0094 0.0636
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0098 0.0315 0.0731
Giardia lamblia Deoxynucleoside kinase 0.0416 0.1626 0.3636
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0223 0.0488
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0065 0.0096
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0063 0.0058
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0165
Loa Loa (eye worm) hypothetical protein 0.0057 0.0144 0.0307
Giardia lamblia GTOR 0.0047 0.0102 0.002
Echinococcus multilocularis Glycosyl transferase, family 35 0.0112 0.037 0.0364
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0084 0.0256 0.2057
Trichomonas vaginalis ribonuclease H1, putative 0.0045 0.0094 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0065 0.0122
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0223 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Echinococcus multilocularis ribonuclease H1 0.0045 0.0094 0.0088
Entamoeba histolytica adenosine deaminase, putative 0.0084 0.0256 0.0547
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0175 0.0359
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0098 0.0315 0.2317
Brugia malayi beta-lactamase 0.0037 0.006 0.011
Chlamydia trachomatis thymidylate kinase 0.0303 0.1161 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0175 0.0359
Brugia malayi isocitrate dehydrogenase 0.0065 0.0175 0.04
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0537 0.1307
Brugia malayi TAR-binding protein 0.0134 0.0463 0.1121
Trichomonas vaginalis set domain proteins, putative 0.0248 0.0931 0.2138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Onchocerca volvulus 0.0164 0.0587 0.3055
Plasmodium vivax aspartyl proteinase, putative 0.0057 0.0144 0.1073
Plasmodium falciparum thymidylate kinase 0.0303 0.1161 1
Loa Loa (eye worm) hypothetical protein 0.0476 0.1874 0.4651
Schistosoma mansoni lipoxygenase 0.0056 0.014 0.022
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0151 0.0237
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0175 0.1352
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0111 0.0171
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.006 0.0109
Entamoeba histolytica adenosine deaminase, putative 0.0084 0.0256 0.0547
Toxoplasma gondii aspartyl protease ASP1 0.0057 0.0144 0.1073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0175 0.017
Loa Loa (eye worm) hypothetical protein 0.0084 0.0256 0.0588
Brugia malayi aspartic protease BmAsp-2, identical 0.0057 0.0144 0.032
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.0985
Schistosoma mansoni ap endonuclease 0.0098 0.0315 0.0503
Echinococcus multilocularis thymidylate kinase 0.0303 0.1161 0.1156
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0065 0.0059
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0063 0.0094
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Echinococcus granulosus ribonuclease H1 0.0045 0.0094 0.0144
Schistosoma mansoni hypothetical protein 0.0303 0.1161 0.1881
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Treponema pallidum adenosine deaminase 0.0084 0.0256 0.1517
Echinococcus granulosus Glycosyl transferase family 35 0.0112 0.037 0.0593
Brugia malayi beta-NAC-like protein 0.0037 0.0061 0.0112
Trypanosoma brucei AMP deaminase, putative 0.0027 0.0021 0.005
Brugia malayi Bromodomain containing protein 0.004 0.0074 0.0145
Trichomonas vaginalis thymidine kinase, putative 0.1065 0.4308 1
Trypanosoma brucei Aph-1 protein, putative 0.0295 0.1128 0.2618
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0165
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0057 0.0144 0.1073
Schistosoma mansoni hypothetical protein 0.0274 0.104 0.1684
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0065 0.0122
Giardia lamblia Cytidine deaminase 0.0164 0.0587 0.1171
Echinococcus multilocularis solute carrier family 28 0.038 0.1477 0.1472
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0303 0.1161 1
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0463 0.0458
Trichomonas vaginalis esterase, putative 0.0037 0.006 0.0109
Schistosoma mansoni gamma-secretase subunit aph-1 0.0758 0.3038 0.4938
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0931 0.2294
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0537 0.1307
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0065 0.0059
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0065 0.0059
Trypanosoma cruzi thymidine kinase, putative 0.1065 0.4308 1
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0084 0.0256 0.2057
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0057 0.0144 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0061 0.0344
Toxoplasma gondii ABC1 family protein 0.0037 0.006 0.0336
Leishmania major dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.1375
Loa Loa (eye worm) hypothetical protein 0.0049 0.0111 0.0224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0065 0.0096
Echinococcus multilocularis thymidylate synthase 0.017 0.0611 0.0605
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0304
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.1375
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Schistosoma mansoni hypothetical protein 0.0104 0.0338 0.0541
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0338 0.0808
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0065 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0688 0.1112
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0364 0.1412 0.1407
Schistosoma mansoni adenosine deaminase 0.0084 0.0256 0.0407
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.006 0.0109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Brugia malayi carbohydrate phosphorylase 0.0112 0.037 0.0887
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0537 0.1295
Plasmodium falciparum plasmepsin X 0.0057 0.0144 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0061 0.0111
Brugia malayi Eukaryotic aspartyl protease family protein 0.0057 0.0144 0.032
Loa Loa (eye worm) inositol-1 0.0076 0.0223 0.0505
Schistosoma mansoni glycogen phosphorylase 0.0048 0.0108 0.0166
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0107 0.0215
Onchocerca volvulus 0.0164 0.0587 0.3055
Schistosoma mansoni thyroid hormone receptor 0.0177 0.0639 0.1032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.091 0.223
Trypanosoma cruzi thymidylate kinase, putative 0.0303 0.1161 0.2658
Echinococcus granulosus solute carrier family 28 0.038 0.1477 0.2395
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0151 0.0302
Plasmodium vivax aspartyl protease, putative 0.0057 0.0144 0.1073
Entamoeba histolytica hypothetical protein 0.0037 0.0061 0.0091
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0065 0.0096
Echinococcus multilocularis geminin 0.123 0.4989 0.4986
Schistosoma mansoni lamin 0.0112 0.0372 0.0597
Brugia malayi hypothetical protein 0.0147 0.0517 0.1256
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Onchocerca volvulus Putative thymidylate kinase 0.0303 0.1161 0.6149
Schistosoma mansoni inositol monophosphatase 0.0076 0.0223 0.0353
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Trichomonas vaginalis glycogen phosphorylase, putative 0.0112 0.037 0.0831
Mycobacterium ulcerans thymidylate kinase 0.0303 0.1161 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0098 0.0315 0.0524
Echinococcus multilocularis glycogen phosphorylase 0.0112 0.037 0.0364
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Trypanosoma cruzi Aph-1 protein, putative 0.0295 0.1128 0.2581
Echinococcus granulosus thymidine kinase 0.1511 0.6148 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0065 0.0233
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0065 0.0175 0.1352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Echinococcus multilocularis transcription factor btf3 0.0037 0.0061 0.0055
Onchocerca volvulus 0.0031 0.0037 0.0085
Brugia malayi RNase H family protein 0.0045 0.0094 0.0196
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0061 0.0091
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0065 0.0175 0.1052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0065 0.0122
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0223 0.047
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.1417
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0202 0.0744 0.1825
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0102 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0688 0.1112
Mycobacterium ulcerans cytidine deaminase 0.0164 0.0587 0.4794
Brugia malayi hypothetical protein 0.0148 0.0517 0.1258
Loa Loa (eye worm) intermediate filament protein 0.0112 0.0372 0.0881
Entamoeba histolytica hypothetical protein 0.0147 0.0517 0.1156
Plasmodium falciparum plasmepsin I 0.0057 0.0144 0.1073
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.006 0.0088
Echinococcus granulosus geminin 0.123 0.4989 0.8114
Schistosoma mansoni cathepsin D (A01 family) 0.0057 0.0144 0.0225
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0102 0.0237
Echinococcus multilocularis glycogen phosphorylase 0.0112 0.037 0.0364
Schistosoma mansoni transcription factor btf3 0.0037 0.0061 0.009
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0164 0.0587 0.4794
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0304
Giardia lamblia CDC8 0.0303 0.1161 0.2531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.0208
Leishmania major thymidine kinase, putative 0.1065 0.4308 1
Schistosoma mansoni hypothetical protein 0.123 0.4989 0.8114
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0057 0.0144 0.0138
Loa Loa (eye worm) thymidylate synthase 0.017 0.0611 0.1479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0065 0.0109
Schistosoma mansoni thymidylate kinase 0.0303 0.1161 0.1881
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0065 0.0233
Plasmodium falciparum plasmepsin III 0.0057 0.0144 0.1073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.0688 0.0683
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0065 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.0688 0.0683
Brugia malayi beta-lactamase family protein 0.0037 0.006 0.011
Leishmania major hypothetical protein, conserved 0.0037 0.006 0.0089
Plasmodium falciparum plasmepsin VIII, putative 0.0057 0.0144 0.1073
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0084 0.0256 0.1781
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.006 0.011
Schistosoma mansoni hypothetical protein 0.0139 0.0483 0.0777
Leishmania major basic transcription factor 3a, putative 0.0037 0.0061 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.0208
Onchocerca volvulus Glycogen phosphorylase homolog 0.0112 0.037 0.188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0688 0.1112
Echinococcus granulosus microtubule associated protein 2 0.0676 0.2701 0.4388
Loa Loa (eye worm) glycogen phosphorylase 0.0112 0.037 0.0875
Brugia malayi hypothetical protein 0.013 0.0444 0.1074
Plasmodium vivax ataxin-2 like protein, putative 0.013 0.0444 0.3711
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0065 0.0096
Echinococcus multilocularis thymidine kinase 0.1511 0.6148 0.6146
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Brugia malayi RNase H family protein 0.0045 0.0094 0.0196
Trypanosoma brucei RNA helicase, putative 0.0315 0.1208 0.2805
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Brugia malayi MH2 domain containing protein 0.0243 0.091 0.2241
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0175 0.017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0098 0.0315 0.0684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Echinococcus granulosus thymidylate synthase 0.017 0.0611 0.0985
Trichomonas vaginalis thymidine kinase, putative 0.1065 0.4308 1
Trypanosoma brucei ingi protein (ORF1) 0.0052 0.0123 0.0286
Trichomonas vaginalis ap endonuclease, putative 0.0098 0.0315 0.0703
Loa Loa (eye worm) hypothetical protein 0.011 0.0364 0.086
Schistosoma mansoni hypothetical protein 0.123 0.4989 0.8114
Loa Loa (eye worm) hypothetical protein 0.0054 0.0132 0.0278
Trypanosoma brucei hypothetical protein, conserved 0.0052 0.0123 0.0286
Brugia malayi steroid hormone receptor 0.0038 0.0065 0.0122
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.017 0.0611 0.5172
Brugia malayi exodeoxyribonuclease III family protein 0.0098 0.0315 0.0749
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0102 0.0189
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0063 0.0096
Echinococcus granulosus gamma secretase subunit aph 1 0.0758 0.3038 0.4938
Echinococcus granulosus transcription factor btf3 0.0037 0.0061 0.009
Mycobacterium ulcerans thymidylate synthase 0.017 0.0611 0.5005
Leishmania major thymidylate kinase-like protein 0.0303 0.1161 0.2658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.0026
Mycobacterium ulcerans adenosine deaminase 0.0084 0.0256 0.1781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0175 0.017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0223 0.047
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.0089
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0444 0.0986
Plasmodium vivax hypothetical protein, conserved 0.0037 0.006 0.0336
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0149 0.0233
Plasmodium vivax aspartyl proteinase, putative 0.0057 0.0144 0.1073
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0098 0.0315 0.2071
Onchocerca volvulus 0.0476 0.1874 1
Giardia lamblia Thymidine kinase 0.1065 0.4308 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0107 0.0102
Echinococcus granulosus Na+ dependent nucleoside transporter 0.038 0.1477 0.2395
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0061 0.0111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0112 0.0372 0.0881
Echinococcus multilocularis cytidine deaminase 0.0164 0.0587 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.0026
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0065 0.0122
Schistosoma mansoni glycogen phosphorylase 0.0112 0.037 0.0593
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.1245
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Echinococcus multilocularis transfer RNA-Ile 0.1511 0.6148 0.6146
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0463 0.1109
Leishmania major adenine aminohydrolase 0.0084 0.0256 0.0547
Loa Loa (eye worm) isocitrate dehydrogenase 0.0065 0.0175 0.0387
Plasmodium vivax adenosine deaminase, putative 0.0084 0.0256 0.2057
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0108 0.0201
Brugia malayi Inositol-1 0.0076 0.0223 0.0519
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.006 0.0088
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0166 0.0261
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Echinococcus granulosus thymidylate kinase 0.0303 0.1161 0.1881
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.014 0.022
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.5172
Schistosoma mansoni phosphoglucomutase 0.0045 0.0094 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0065 0.0109
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0061 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.0208
Trichomonas vaginalis thymidine kinase, putative 0.1065 0.4308 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.0483 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0061 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0065 0.0122
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0032 0.0044
Brugia malayi cytidine deaminase, identical 0.0164 0.0587 0.1433
Trichomonas vaginalis thymidylate kinase, putative 0.0303 0.1161 0.2672
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0223 0.1767
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0107 0.0102
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0215
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.0688 0.1674
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0037 0.0138
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0084 0.0256 0.1781
Echinococcus granulosus tachykinin peptides receptor 99D 0.0364 0.1412 0.229
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0175 0.0407
Plasmodium vivax SET domain protein, putative 0.0031 0.0037 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.0089
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0065 0.0122
Schistosoma mansoni memapsin-2 (A01 family) 0.1419 0.577 0.9386
Toxoplasma gondii aspartyl protease ASP3 0.0057 0.0144 0.1073
Schistosoma mansoni intermediate filament proteins 0.0112 0.0372 0.0597
Trypanosoma cruzi Aph-1 protein, putative 0.0295 0.1128 0.2581
Echinococcus multilocularis GPCR, family 2 0.0048 0.0107 0.0102
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0444 0.0986
Echinococcus granulosus glycogen phosphorylase 0.0112 0.037 0.0593
Plasmodium vivax plasmepsin V, putative 0.0057 0.0144 0.1073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0065 0.0059
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0223 0.0353
Schistosoma mansoni hypothetical protein 0.0147 0.0517 0.0832
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.091 0.223
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0065 0.0096
Echinococcus multilocularis musashi 0.0112 0.0372 0.0367
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Trypanosoma cruzi thymidine kinase, putative 0.1065 0.4308 1
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0027 0.0021 0.005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0065 0.0096
Leishmania major hypothetical protein, conserved 0.013 0.0444 0.0986
Loa Loa (eye worm) hypothetical protein 0.0104 0.0338 0.0795
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0057 0.0144 0.0307
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0065 0.0175 0.0407
Giardia lamblia Glycogen phosphorylase 0.0112 0.037 0.0655
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.0517 0.0832
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.006 0.0157 0.034
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.017 0.0611 0.5005
Entamoeba histolytica glycogen phosphorylase, putative 0.0112 0.037 0.0813
Brugia malayi Intermediate filament tail domain containing protein 0.0112 0.0372 0.0894
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0063 0.0096
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0057 0.0144 0.1073
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.0876 0.7413
Echinococcus granulosus tar DNA binding protein 0.0134 0.0463 0.0745
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0065 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.019 0.1181
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.006 0.0138
Plasmodium vivax aspartyl protease, putative 0.0057 0.0144 0.1073
Trypanosoma brucei thymidine kinase 0.1065 0.4308 1
Brugia malayi cytoplasmic intermediate filament protein 0.006 0.0157 0.0354
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0164 0.0587 0.4794
Echinococcus multilocularis lamin 0.0112 0.0372 0.0367
Brugia malayi Isocitrate dehydrogenase 0.0065 0.0175 0.04
Onchocerca volvulus 0.0148 0.0517 0.2677
Echinococcus granulosus thymidine kinase 0.1511 0.6148 1
Brugia malayi beta-lactamase family protein 0.0037 0.006 0.011
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.0094 0.0169
Onchocerca volvulus 0.017 0.0611 0.3181
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0102 0.0189
Onchocerca volvulus 0.0057 0.0144 0.066
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0102 0.0158
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0098 0.0315 0.2575
Brugia malayi nuclear hormone receptor 0.0038 0.0065 0.0122
Loa Loa (eye worm) hypothetical protein 0.0057 0.0144 0.0307
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0175 0.1352
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0065 0.0175 0.0359
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0098 0.0315 0.0309
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0061 0.0098
Leishmania major hypothetical protein, conserved 0.0119 0.04 0.0883
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0102 0.0158
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0098 0.0315 0.2575
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0061 0.0344
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.0094 0.0169
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0304
Toxoplasma gondii aspartyl protease 0.0057 0.0144 0.1073
Trichomonas vaginalis cytidine deaminase, putative 0.0164 0.0587 0.1338
Entamoeba histolytica thymidine kinase, putative 0.1065 0.4308 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0065 0.0096
Schistosoma mansoni hypothetical protein 0.0315 0.1208 0.1958
Loa Loa (eye worm) thymidylate kinase 0.0303 0.1161 0.286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0065 0.0109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.0688 0.1112
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.2701 0.4388
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0065 0.0175 0.017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0065 0.0122
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0223 0.047
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0151 0.0829
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.006 0.0088
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0065 0.0096
Echinococcus multilocularis isocitrate dehydrogenase 0.0065 0.0175 0.017
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0164 0.0587 0.4969
Plasmodium falciparum plasmepsin II 0.0057 0.0144 0.1073
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0057 0.0144 0.0307
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0119 0.04 0.0883
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0065 0.0096
Loa Loa (eye worm) beta-lactamase 0.0037 0.006 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0074 0.0142
Schistosoma mansoni AMP deaminase 0.0027 0.0021 0.0026
Onchocerca volvulus 0.0248 0.0931 0.4912
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.006 0.0054
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0223 0.047
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0758 0.3038 0.7574
Entamoeba histolytica Thymidylate kinase, putative 0.0303 0.1161 0.2658
Trypanosoma cruzi cytidine deaminase-like protein 0.0164 0.0587 0.132
Onchocerca volvulus Adenosine deaminase homolog 0.0084 0.0256 0.1265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0065 0.0109
Brugia malayi hypothetical protein 0.0084 0.0254 0.0598
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.006 0.0109
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0065 0.0122
Echinococcus multilocularis thyroid hormone receptor alpha 0.0177 0.0639 0.0634
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.0517 0.0832
Brugia malayi intermediate filament protein 0.0112 0.0372 0.0894
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.006 0.0096
Plasmodium falciparum plasmepsin IX 0.0057 0.0144 0.1073
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0164 0.0587 0.132
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0061 0.0141
Onchocerca volvulus 0.0038 0.0065 0.0233
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0065 0.0096
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0463 0.1121
Trichomonas vaginalis glycogen phosphorylase, putative 0.0112 0.037 0.0831
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0107 0.0165
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0065 0.0096
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0065 0.0122
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0098 0.0315 0.0684
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0052 0.0123 0.0286
Loa Loa (eye worm) hypothetical protein 0.0057 0.0144 0.0307
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0098 0.0315 0.0684
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0065 0.0059
Brugia malayi Pre-SET motif family protein 0.0218 0.0807 0.1984
Trypanosoma brucei AMP deaminase, putative 0.0027 0.0021 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0111 0.0171
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0223 0.0488
Trypanosoma brucei ribonuclease H1 0.0045 0.0094 0.0218
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0065 0.0175 0.1352
Trichomonas vaginalis adenosine deaminase, putative 0.0084 0.0256 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0065 0.0122
Loa Loa (eye worm) aspartyl protease 6 0.0057 0.0144 0.0307
Plasmodium vivax aspartyl protease, putative 0.0057 0.0144 0.1073
Brugia malayi hypothetical protein 0.0081 0.0242 0.0568
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0048 0.0108 0.0437
Trypanosoma brucei AMP deaminase, putative 0.0027 0.0021 0.005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0151 0.0145
Trypanosoma brucei cytidine deaminase 0.0164 0.0587 0.1364
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0065 0.0233
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0061 0.0091
Treponema pallidum thymidylate kinase (tmk) 0.0303 0.1161 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0065 0.0122
Echinococcus multilocularis survival motor neuron protein 1 0.0992 0.4005 0.4001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0037 0.0051
Brugia malayi Pre-SET motif family protein 0.0031 0.0037 0.0054
Schistosoma mansoni thymidylate kinase 0.0303 0.1161 0.1881
Loa Loa (eye worm) runx1 0.006 0.0155 0.0335
Echinococcus granulosus GPCR family 2 0.0048 0.0107 0.0165
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0057 0.0144 0.0304
Entamoeba histolytica hypothetical protein 0.0147 0.0517 0.1156
Brugia malayi hypothetical protein 0.0476 0.1874 0.4659
Echinococcus granulosus cytidine deaminase 0.0164 0.0587 0.0947
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.014 0.0135
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.0483 0.0777
Echinococcus multilocularis AMP deaminase 2 0.0027 0.0021 0.0016
Onchocerca volvulus Ribonuclease H1 homolog 0.0045 0.0094 0.0391
Loa Loa (eye worm) hypothetical protein 0.0112 0.0372 0.0881
Brugia malayi Pepsin A precursor 0.0057 0.0144 0.032
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Leishmania major cytidine deaminase-like protein 0.0164 0.0587 0.132
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0102 0.0203
Loa Loa (eye worm) hypothetical protein 0.0052 0.0124 0.0257
Loa Loa (eye worm) hypothetical protein 0.0476 0.1874 0.4651
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0065 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0065 0.0109
Toxoplasma gondii LsmAD domain-containing protein 0.013 0.0444 0.3711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0038 0.0059
Brugia malayi hypothetical protein 0.0992 0.4005 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0065 0.0109
Schistosoma mansoni phosphoglucomutase 0.0045 0.0094 0.0144
Echinococcus multilocularis thymidine kinase 0.1511 0.6148 0.6146
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.006 0.0109
Schistosoma mansoni cathepsin D (A01 family) 0.0057 0.0144 0.0225
Brugia malayi ecdysteroid receptor 0.0038 0.0065 0.0122
Entamoeba histolytica glycogen phosphorylase, putative 0.0112 0.037 0.0813
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0063 0.0146
Echinococcus granulosus lamin 0.0112 0.0372 0.0597
Toxoplasma gondii exonuclease III APE 0.0098 0.0315 0.2575
Echinococcus granulosus glycogen phosphorylase 0.0112 0.037 0.0593
Onchocerca volvulus 0.0112 0.0372 0.1894
Onchocerca volvulus 0.0037 0.006 0.0207
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0065 0.0096
Echinococcus granulosus survival motor neuron protein 1 0.0992 0.4005 0.6511
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Loa Loa (eye worm) hypothetical protein 0.0045 0.0092 0.0178
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0807 0.1973
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0242 0.0534
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0111 0.0105
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0053 0.0274
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0065 0.0175 0.0277
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0102 0.0097
Trypanosoma brucei PAB1-binding protein , putative 0.013 0.0444 0.1031
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1511 0.6148 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.5172
Echinococcus granulosus lamin dm0 0.0112 0.0372 0.0597
Entamoeba histolytica cytidine deaminase, putative 0.0164 0.0587 0.132
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0054 0.0132 0.0206
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0054 0.0132 0.0127
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0108 0.0201
Brugia malayi Bromodomain containing protein 0.0078 0.0232 0.0542
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0119 0.04 0.0883
Schistosoma mansoni lozenge 0.006 0.0155 0.0243
Echinococcus granulosus adenosine deaminase 0.0084 0.0256 0.0407
Plasmodium falciparum plasmepsin VII 0.0057 0.0144 0.1073
Schistosoma mansoni bromodomain containing protein 0.0066 0.0182 0.0286
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0165
Loa Loa (eye worm) RNA binding protein 0.0134 0.0463 0.1109
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.017 0.0611 0.5005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0065 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0065 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Schistosoma mansoni phosphoglucomutase 0.0045 0.0094 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0034 0.005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0223 0.1481
Schistosoma mansoni hypothetical protein 0.0058 0.0149 0.0233
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0151 0.0237
Trichomonas vaginalis ap endonuclease, putative 0.0098 0.0315 0.0703
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Schistosoma mansoni glycogen phosphorylase 0.0112 0.037 0.0593
Trichomonas vaginalis cytidine deaminase, putative 0.0164 0.0587 0.1338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0065 0.0059
Brugia malayi nuclear receptor NHR-88 0.0038 0.0065 0.0122
Brugia malayi aspartic protease BmAsp-1, identical 0.0057 0.0144 0.032
Echinococcus multilocularis lamin dm0 0.0112 0.0372 0.0367
Schistosoma mansoni lamin 0.0112 0.0372 0.0597
Trypanosoma brucei thymidylate kinase, putative 0.0303 0.1161 0.2694
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0102 0.0237
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0102 0.0189
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0037 0.0032
Brugia malayi Adenosine/AMP deaminase family protein 0.0084 0.0256 0.0601
Plasmodium falciparum plasmepsin IV 0.0057 0.0144 0.1073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0151 0.0829
Schistosoma mansoni ap endonuclease 0.0098 0.0315 0.0503
Loa Loa (eye worm) hypothetical protein 0.0052 0.0124 0.0257
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0065 0.0096
Onchocerca volvulus 0.0057 0.0144 0.066
Echinococcus multilocularis Protein lozenge 0.006 0.0155 0.0149
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0223 0.1208
Entamoeba histolytica hypothetical protein 0.0147 0.0517 0.1156
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0463 0.1109
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0303 0.1161 1
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0107 0.0229
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Onchocerca volvulus 0.0037 0.006 0.0207
Brugia malayi thymidylate synthase 0.017 0.0611 0.1491
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0102 0.0217

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 10.7 nM Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I]-[MePhe7]-NKB ChEMBL. 10090788

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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