Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable isocitrate dehydrogenase | 0.0103 | 0.066 | 0.0835 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.1905 | 0.1905 |
Schistosoma mansoni | microtubule-associated protein tau | 0.071 | 0.6546 | 0.8279 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0001 | 0.0001 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0103 | 0.066 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.0154 | 0.0194 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0795 | 0.7362 | 0.7362 |
Mycobacterium tuberculosis | Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) | 0.0103 | 0.066 | 0.0834 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0154 | 0.0195 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0072 | 0.0072 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0851 | 0.7906 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.0981 | 0.124 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0276 | 0.0276 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0103 | 0.066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0177 | 0.0224 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0103 | 0.066 | 0.5 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0103 | 0.066 | 0.0835 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0851 | 0.7906 | 1 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0103 | 0.066 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0276 | 0.0349 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.0154 | 0.0194 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0103 | 0.066 | 0.0834 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0001 | 0.0001 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0157 | 0.0199 |
Brugia malayi | Isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0103 | 0.066 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0001 | 0.0001 |
Schistosoma mansoni | lamin | 0.0111 | 0.0732 | 0.0926 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0276 | 0.0349 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0851 | 0.7906 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.0737 | 0.0933 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.3217 | 0.4069 |
Onchocerca volvulus | 0.0047 | 0.0117 | 0.0992 | |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0103 | 0.066 | 0.0835 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Echinococcus multilocularis | musashi | 0.0111 | 0.0732 | 0.0732 |
Schistosoma mansoni | unc-13 (munc13) | 0.0103 | 0.066 | 0.0835 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0111 | 0.0732 | 0.0926 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0396 | 0.0501 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0103 | 0.066 | 0.0835 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0103 | 0.066 | 0.066 |
Echinococcus granulosus | intermediate filament protein | 0.0111 | 0.0732 | 0.0732 |
Echinococcus granulosus | geminin | 0.0367 | 0.3217 | 0.3217 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0103 | 0.066 | 0.0835 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0851 | 0.7906 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0851 | 0.7906 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0072 | 0.0092 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0001 | 0.0001 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Echinococcus multilocularis | geminin | 0.0367 | 0.3217 | 0.3217 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Brugia malayi | hypothetical protein | 0.0232 | 0.1905 | 0.241 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0712 | 0.0901 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0851 | 0.7906 | 0.7906 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0072 | 0.0072 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0111 | 0.0732 | 0.0926 |
Loa Loa (eye worm) | intermediate filament protein | 0.0111 | 0.0732 | 0.0926 |
Trypanosoma brucei | RNA helicase, putative | 0.0136 | 0.0981 | 0.124 |
Schistosoma mansoni | intermediate filament proteins | 0.0111 | 0.0732 | 0.0926 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.0737 | 0.0933 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0154 | 0.0195 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0059 | 0.0234 | 0.0296 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0154 | 0.0194 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0117 | 0.0148 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0157 | 0.0199 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0276 | 0.0349 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0103 | 0.066 | 0.066 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0851 | 0.7906 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0103 | 0.066 | 0.0835 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0851 | 0.7906 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0396 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.066 | 0.0835 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0001 | 0.0001 |
Echinococcus multilocularis | tumor protein p63 | 0.1067 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Echinococcus granulosus | lamin dm0 | 0.0111 | 0.0732 | 0.0732 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0156 | 0.1172 | 0.1483 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.0154 | 0.0194 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.1905 | 0.1905 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0117 | 0.0148 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0276 | 0.0276 |
Brugia malayi | RNA binding protein | 0.0064 | 0.0276 | 0.0349 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0059 | 0.0234 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0737 | 0.0933 |
Brugia malayi | intermediate filament protein | 0.0111 | 0.0732 | 0.0926 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1172 | 0.1483 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0117 | 0.0148 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Echinococcus multilocularis | lamin | 0.0111 | 0.0732 | 0.0732 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.0737 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.1905 | 0.241 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.1844 | 0.2332 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Echinococcus granulosus | microtubule associated protein 2 | 0.071 | 0.6546 | 0.6546 |
Echinococcus multilocularis | lamin dm0 | 0.0111 | 0.0732 | 0.0732 |
Onchocerca volvulus | 0.0156 | 0.1172 | 1 | |
Schistosoma mansoni | lamin | 0.0111 | 0.0732 | 0.0926 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.071 | 0.6546 | 0.6546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0072 | 0.0092 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0072 | 0.0092 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0001 | 0.0001 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0276 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Onchocerca volvulus | 0.0111 | 0.0732 | 0.6241 | |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0103 | 0.066 | 0.066 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.3217 | 0.4069 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0103 | 0.066 | 0.066 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0001 | 0.0001 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0053 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0732 | 0.0926 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0053 | 0.0177 | 0.0177 |
Echinococcus granulosus | lamin | 0.0111 | 0.0732 | 0.0732 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0103 | 0.066 | 0.0835 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.0396 | 0.0501 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0154 | 0.0194 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0276 | 0.0349 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0851 | 0.7906 | 1 |
Onchocerca volvulus | 0.0111 | 0.0732 | 0.6241 | |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0103 | 0.066 | 0.0835 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.0154 | 0.0194 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0001 | 0.0001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.