Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0156 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.7939 | 0.5611 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0134 | 0.7939 | 0.7939 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.7939 | 0.7939 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.7939 | 0.5611 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.7939 | 0.7939 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0134 | 0.7939 | 0.5611 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0106 | 0.5304 | 0.5392 |
Loa Loa (eye worm) | glutamate receptor | 0.0127 | 0.7241 | 0.7241 |
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 0.7939 | 0.7939 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0115 | 0.6119 | 0.733 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0127 | 0.7241 | 0.8977 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.7939 | 0.5611 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.7939 | 0.5611 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0144 | 0.8878 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.7939 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.7939 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.7939 | 0.879 |
Echinococcus granulosus | carboxylesterase 5A | 0.0134 | 0.7939 | 0.5611 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 13 uM | Cytostatic concentration required to inhibit CEM/0 cells proliferation by 50% | ChEMBL. | 10514282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.