Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 3-hydroxy-3-methylglutaryl-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | nervana 2 | 0.039 | 0.3635 | 0.3635 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.0369 | 0.0369 |
Trichomonas vaginalis | CMGC family protein kinase | 0.069 | 0.8001 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.069 | 0.8001 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0441 | 0.4373 | 0.4373 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0211 | 0.1029 | 0.1029 |
Brugia malayi | Protein kinase domain containing protein | 0.0211 | 0.1029 | 0.1029 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.069 | 0.8001 | 0.8001 |
Trichomonas vaginalis | CMGC family protein kinase | 0.069 | 0.8001 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0441 | 0.4373 | 0.5247 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0211 | 0.1029 | 0.1029 |
Onchocerca volvulus | 0.014 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.069 | 0.8001 | 0.8001 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0441 | 0.4373 | 0.4373 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0828 | 1 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.039 | 0.3635 | 0.3635 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0402 | 0.3806 | 0.3806 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0211 | 0.1029 | 0.1029 |
Echinococcus multilocularis | nervana 2 | 0.039 | 0.3635 | 0.3635 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | carboxylesterase 5A | 0.0828 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0828 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0828 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0828 | 1 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0173 | 0.0474 | 0.0474 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0199 | 0.0858 | 0.1073 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.069 | 0.8001 | 0.8001 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.1029 | 0.1029 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.1029 | 0.1029 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0402 | 0.3806 | 0.4503 |
Echinococcus multilocularis | protein kinase c iota type | 0.0211 | 0.1029 | 0.1029 |
Entamoeba histolytica | protein kinase, putative | 0.064 | 0.7265 | 0.8944 |
Giardia lamblia | Kinase, CMGC CDK | 0.069 | 0.8001 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.069 | 0.8001 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0211 | 0.1029 | 0.1029 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.039 | 0.3635 | 0.3635 |
Brugia malayi | Choline O-acetyltransferase | 0.0173 | 0.0474 | 0.0474 |
Brugia malayi | cell division control protein 2 homolog | 0.069 | 0.8001 | 0.8001 |
Trichomonas vaginalis | CMGC family protein kinase | 0.069 | 0.8001 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.0441 | 0.4373 | 0.5247 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0211 | 0.1029 | 0.1029 |
Entamoeba histolytica | protein kinase 2, putative | 0.0402 | 0.3806 | 0.3983 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0402 | 0.3806 | 0.3806 |
Trichomonas vaginalis | AGC family protein kinase | 0.064 | 0.7265 | 0.908 |
Echinococcus granulosus | nervana 2 | 0.039 | 0.3635 | 0.3635 |
Trichomonas vaginalis | AGC family protein kinase | 0.064 | 0.7265 | 0.908 |
Echinococcus granulosus | NDR protein kinase | 0.0211 | 0.1029 | 0.1029 |
Giardia lamblia | Kinase, CMGC CDK | 0.069 | 0.8001 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.069 | 0.8001 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.069 | 0.8001 | 0.8001 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0601 | 0.6697 | 0.6697 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.1029 | 0.1029 |
Loa Loa (eye worm) | carboxylesterase | 0.0828 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.069 | 0.8001 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | acetylcholinesterase | 0.0828 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.069 | 0.8001 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0211 | 0.1029 | 0.1029 |
Echinococcus multilocularis | acetylcholinesterase | 0.0828 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.069 | 0.8001 | 0.8001 |
Onchocerca volvulus | 0.014 | 0 | 0.5 | |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0211 | 0.1029 | 0.1029 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0441 | 0.4373 | 0.4797 |
Trichomonas vaginalis | AGC family protein kinase | 0.064 | 0.7265 | 0.908 |
Brugia malayi | Protein kinase domain containing protein | 0.064 | 0.7265 | 0.7265 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.069 | 0.8001 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.069 | 0.8001 | 0.8001 |
Trichomonas vaginalis | AGC family protein kinase | 0.0211 | 0.1029 | 0.1286 |
Trichomonas vaginalis | AGC family protein kinase | 0.064 | 0.7265 | 0.908 |
Loa Loa (eye worm) | hypothetical protein | 0.0828 | 1 | 1 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0211 | 0.1029 | 0.1029 |
Brugia malayi | protein kinase C II. | 0.0211 | 0.1029 | 0.1029 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | protein kinase C gamma type | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | protein kinase c iota type | 0.0211 | 0.1029 | 0.1029 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0211 | 0.1029 | 0.1029 |
Trichomonas vaginalis | AGC family protein kinase | 0.0211 | 0.1029 | 0.1286 |
Onchocerca volvulus | 0.014 | 0 | 0.5 | |
Trypanosoma brucei | cdc2-related kinase 1 | 0.069 | 0.8001 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.014 | 0 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0173 | 0.0474 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.783 | 0.783 |
Echinococcus granulosus | acetylcholinesterase | 0.0828 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.039 | 0.3635 | 0.3635 |
Echinococcus granulosus | choline O acetyltransferase | 0.0173 | 0.0474 | 0.0474 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0402 | 0.3806 | 0.3806 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.069 | 0.8001 | 0.8001 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0441 | 0.4373 | 0.4373 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.069 | 0.8001 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0441 | 0.4373 | 0.4373 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.064 | 0.7265 | 0.7265 |
Onchocerca volvulus | 0.014 | 0 | 0.5 | |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.064 | 0.7265 | 0.9036 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0211 | 0.1029 | 0.1029 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0211 | 0.1029 | 0.1029 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.069 | 0.8001 | 0.8001 |
Schistosoma mansoni | serine/threonine kinase | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0211 | 0.1029 | 0.1029 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.0369 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0369 | 0.0369 |
Trichomonas vaginalis | AGC family protein kinase | 0.0211 | 0.1029 | 0.1286 |
Trichomonas vaginalis | AGC family protein kinase | 0.064 | 0.7265 | 0.908 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0173 | 0.0474 | 0.0474 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0211 | 0.1029 | 0.1029 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0828 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.069 | 0.8001 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.069 | 0.8001 | 0.8001 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.014 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.1029 | 0.1029 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.069 | 0.8001 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.014 | 0 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.069 | 0.8001 | 1 |
Onchocerca volvulus | 0.014 | 0 | 0.5 | |
Entamoeba histolytica | protein kinase, putative | 0.064 | 0.7265 | 0.8944 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0369 | 0.0369 |
Entamoeba histolytica | protein kinase, putative | 0.0601 | 0.6697 | 0.813 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.0369 | 0.0369 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0211 | 0.1029 | 0.1029 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0211 | 0.1029 | 0.1029 |
Schistosoma mansoni | choline o-acyltransferase | 0.0173 | 0.0474 | 0.0474 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.069 | 0.8001 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0211 | 0.1029 | 0.1029 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | cyclin dependent kinase | 0.069 | 0.8001 | 0.8001 |
Trichomonas vaginalis | AGC family protein kinase | 0.064 | 0.7265 | 0.908 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.069 | 0.8001 | 0.8001 |
Trichomonas vaginalis | AGC family protein kinase | 0.064 | 0.7265 | 0.908 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0211 | 0.1029 | 0.1029 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.069 | 0.8001 | 0.8001 |
Brugia malayi | Protein kinase domain containing protein | 0.069 | 0.8001 | 0.8001 |
Brugia malayi | Protein kinase domain containing protein | 0.0211 | 0.1029 | 0.1029 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.069 | 0.8001 | 0.8001 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.039 | 0.3635 | 0.3635 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0369 | 0.0369 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.039 | 0.3635 | 0.3635 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0601 | 0.6697 | 0.6697 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.069 | 0.8001 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0211 | 0.1029 | 0.1029 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0474 | 0.0474 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0211 | 0.1029 | 0.1029 |
Brugia malayi | Carboxylesterase family protein | 0.0828 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.1029 | 0.1029 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0441 | 0.4373 | 0.4797 |
Trichomonas vaginalis | AGC family protein kinase | 0.025 | 0.1596 | 0.1995 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.