Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0.0649 | 1 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.0022 | 0.0157 | 0.0466 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0157 | 0.0024 |
Chlamydia trachomatis | DNA ligase | 0.0022 | 0.0157 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0403 | 0.0274 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0157 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0072 | 0.2081 | 0.1955 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.8017 | 0.799 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0403 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0403 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0201 | 0.6966 | 0.8496 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2081 | 0.2401 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0157 | 0.5269 | 0.5269 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0072 | 0.2081 | 0.1955 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.0022 | 0.0157 | 0.0466 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0201 | 0.6966 | 0.6918 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0366 | 0.4515 |
Brugia malayi | N-terminal motif family protein | 0.0188 | 0.6469 | 0.6469 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0157 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0157 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0157 | 0.5269 | 0.6379 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0072 | 0.2081 | 0.1955 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0281 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0403 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0366 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0403 | 0.0274 |
Entamoeba histolytica | hypothetical protein | 0.0122 | 0.3964 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2081 | 0.2401 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0403 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0.0649 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0057 | 0.1509 | 0.1509 |
Brugia malayi | hypothetical protein | 0.0122 | 0.3964 | 0.3964 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0122 | 0.3964 | 0.3868 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0403 | 0.0403 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0403 | 0.0403 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0042 | 0.0925 | 0.0959 |
Brugia malayi | topoisomerase | 0.0022 | 0.0157 | 0.0157 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0201 | 0.6966 | 0.6918 |
Echinococcus multilocularis | peregrin | 0.0035 | 0.0649 | 0.05 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0114 | 0.3641 | 0.3539 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0022 | 0.0157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0157 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.5269 | 0.5206 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0366 | 0.0236 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0042 | 0.0925 | 0.0959 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0035 | 0.0649 | 0.0523 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.1509 | 0.1687 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0229 | 0.8017 | 0.8017 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1588 | 0.1475 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0201 | 0.6966 | 0.8496 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0403 | 0.0274 |
Echinococcus granulosus | peregrin | 0.0035 | 0.0649 | 0.05 |
Brugia malayi | PHD-finger family protein | 0.0035 | 0.0649 | 0.0649 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0403 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0649 | 0.0614 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0403 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0403 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0022 | 0.0157 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0403 | 1 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0157 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2081 | 0.1975 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0233 | 0.8172 | 0.8143 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0403 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0366 | 0.0366 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0122 | 0.3964 | 0.475 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0157 | 0.0024 |
Brugia malayi | jmjC domain containing protein | 0.0114 | 0.3641 | 0.3641 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0022 | 0.0157 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0072 | 0.2081 | 0.2081 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0403 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.0649 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0403 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0022 | 0.0157 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0403 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0022 | 0.0157 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0035 | 0.0659 | 0.0659 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.6469 | 0.6422 |
Echinococcus granulosus | geminin | 0.0199 | 0.6863 | 0.6813 |
Entamoeba histolytica | hypothetical protein | 0.0122 | 0.3964 | 1 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0022 | 0.0157 | 0.0157 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0072 | 0.2081 | 0.1955 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0114 | 0.3641 | 0.3539 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0048 | 0.1164 | 0.1023 |
Echinococcus granulosus | jumonji domain containing protein | 0.0048 | 0.1164 | 0.1023 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0035 | 0.0649 | 0.05 |
Echinococcus multilocularis | geminin | 0.0199 | 0.6863 | 0.6813 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0201 | 0.6966 | 0.6926 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0035 | 0.0649 | 0.05 |
Onchocerca volvulus | 0.0028 | 0.0403 | 0.039 | |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0072 | 0.2081 | 0.1955 |
Schistosoma mansoni | jumonji domain containing protein | 0.009 | 0.2756 | 0.3242 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0157 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0233 | 0.8172 | 1 |
Treponema pallidum | DNA ligase (lig) | 0.0022 | 0.0157 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0042 | 0.0925 | 0.0781 |
Brugia malayi | Bromodomain containing protein | 0.0035 | 0.0649 | 0.0649 |
Entamoeba histolytica | hypothetical protein | 0.0122 | 0.3964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0157 | 0.0024 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0133 | 0.139 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0072 | 0.2049 | 0.1942 |
Entamoeba histolytica | hypothetical protein | 0.0122 | 0.3964 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0072 | 0.2081 | 0.1975 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2081 | 0.2401 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0403 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0122 | 0.3964 | 0.3868 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0233 | 0.8172 | 0.8143 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0035 | 0.0649 | 0.0614 |
Echinococcus multilocularis | GPCR, family 2 | 0.0072 | 0.2081 | 0.1955 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0188 | 0.6469 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0233 | 0.8172 | 0.8143 |
Schistosoma mansoni | hypothetical protein | 0.0199 | 0.6863 | 0.8366 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0649 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0157 | 0.0024 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0281 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0233 | 0.8172 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0403 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0366 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0229 | 0.8017 | 0.799 |
Onchocerca volvulus | 0.0057 | 0.1509 | 0.2143 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0366 | 1 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.0022 | 0.0157 | 0.0889 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0229 | 0.8017 | 0.8017 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0201 | 0.6966 | 0.8496 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0366 | 0.4515 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.3964 | 0.475 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0366 | 0.4247 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0022 | 0.0157 | 0.0157 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0022 | 0.0157 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.0403 | 0.0647 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0072 | 0.2081 | 0.2081 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0201 | 0.6966 | 0.6918 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0403 | 0.0403 |
Brugia malayi | DKFZp564C0469 protein | 0.0022 | 0.0157 | 0.0157 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0035 | 0.0659 | 0.0533 |
Schistosoma mansoni | hypothetical protein | 0.0199 | 0.6863 | 0.8366 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0157 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0201 | 0.6966 | 0.6918 |
Schistosoma mansoni | survival motor neuron protein | 0.0057 | 0.1509 | 0.1687 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0233 | 0.8172 | 0.8143 |
Schistosoma mansoni | P2X receptor subunit | 0.0233 | 0.8172 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0233 | 0.8172 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0233 | 0.8172 | 0.8143 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0403 | 0.0647 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0201 | 0.6966 | 0.6966 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0157 | 0.0157 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0366 | 0.4515 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0.0649 | 0.0779 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0042 | 0.0925 | 0.0781 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0403 | 0.0647 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0233 | 0.8172 | 0.8143 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0157 | 0.0024 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2081 | 0.2401 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0403 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0042 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0042 | 0.0925 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0649 | 0.0523 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.0649 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.