Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1526 | 0.1974 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5079 | 0.6814 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.7417 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 0.5 |
Brugia malayi | hypothetical protein | 0.0726 | 0.0884 | 0.0773 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0726 | 0.0884 | 0.1142 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1526 | 0.1974 | 0.1196 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7417 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.7417 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7417 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.7417 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7417 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7417 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5079 | 0.6814 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7417 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0726 | 0.0884 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Echinococcus granulosus | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Loa Loa (eye worm) | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Mycobacterium ulcerans | thymidylate synthase | 0.1526 | 0.1974 | 0.1877 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7417 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 38.6 nM | Inhibition of solubilized, purified rat liver HMG-CoA reductase. | ChEMBL. | 3634830 |
Relative potency (binding) | = 14 | Inhibition of solubilized, purified rat liver HMG-CoA reductase, relative to compactin(100). | ChEMBL. | 3634830 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.