Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein jagged 2 | 0.0238 | 0.2923 | 0.2923 |
Echinococcus multilocularis | fibropellin Ia | 0.0238 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0238 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Echinococcus granulosus | fibropellin Ia | 0.0238 | 0.2923 | 0.2923 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0238 | 0.2923 | 0.2923 |
Echinococcus granulosus | protein jagged 1 | 0.0238 | 0.2923 | 0.2923 |
Brugia malayi | Animal haem peroxidase family protein | 0.0736 | 1 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0238 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Echinococcus multilocularis | neural cadherin | 0.0238 | 0.2923 | 0.2923 |
Onchocerca volvulus | 0.0736 | 1 | 1 | |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0238 | 0.2923 | 0.2923 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0238 | 0.2923 | 0.2923 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0238 | 0.2923 | 0.2923 |
Brugia malayi | Animal haem peroxidase family protein | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0736 | 1 | 1 |
Echinococcus multilocularis | notch | 0.0238 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0736 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0238 | 0.2923 | 0.2923 |
Echinococcus granulosus | neural cadherin | 0.0238 | 0.2923 | 0.2923 |
Echinococcus granulosus | delta-like protein 1 | 0.0238 | 0.2923 | 0.2923 |
Onchocerca volvulus | Peroxidase homolog | 0.0736 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0736 | 1 | 1 |
Echinococcus granulosus | notch | 0.0238 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0736 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0238 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.0238 | 0.2923 | 0.2923 |
Brugia malayi | Peroxidasin | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0736 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0238 | 0.2923 | 0.5 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0238 | 0.2923 | 0.2923 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0238 | 0.2923 | 0.2923 |
Echinococcus multilocularis | peroxidasin | 0.0736 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0736 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0736 | 1 | 1 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0238 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0238 | 0.2923 | 0.5 |
Echinococcus granulosus | slit 2 protein | 0.0238 | 0.2923 | 0.2923 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0238 | 0.2923 | 0.2923 |
Onchocerca volvulus | 0.0736 | 1 | 1 | |
Echinococcus granulosus | protein jagged 2 | 0.0238 | 0.2923 | 0.2923 |
Echinococcus multilocularis | protein jagged 1 | 0.0238 | 0.2923 | 0.2923 |
Onchocerca volvulus | Dual oxidase homolog | 0.0736 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0736 | 1 | 1 |
Onchocerca volvulus | 0.0736 | 1 | 1 | |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0238 | 0.2923 | 0.2923 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0736 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0736 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0736 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0736 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 39 nM | Affinity against 3[H]TCP binding to N-methyl-D-aspartate glutamate receptor in rat brain membranes | ChEMBL. | 7658445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.