Detailed information for compound 939125

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 533.531 | Formula: C32H34Cl2N2O
  • H donors: 0 H acceptors: 1 LogP: 7.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1CCCN1C[C@]1(Cc2ccccc2)C[C@@H]2CC[C@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl
  • InChi: 1S/C32H34Cl2N2O/c33-28-13-6-4-11-26(28)31(27-12-5-7-14-29(27)34)36-24-16-17-25(36)21-32(20-24,19-23-9-2-1-3-10-23)22-35-18-8-15-30(35)37/h1-7,9-14,24-25,31H,8,15-22H2/t24-,25+,32+
  • InChiKey: OWKXLMNVGWQRGP-IXXHMTOTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opiate receptor-like 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis growth hormone secretagogue receptor type 1 opiate receptor-like 1 370 aa 349 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0307 0.036
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0033
Brugia malayi jmjC domain containing protein 0.004 0.0255 0.035
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0252 0.0501
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0664 0.1004
Onchocerca volvulus 0.0161 0.169 0.6041
Entamoeba histolytica acetyltransferase, GNAT family 0.0171 0.1803 0.5082
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0154 0.0276
Brugia malayi CHE-14 protein 0.0045 0.0319 0.0438
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0193 0.2066 0.2833
Echinococcus multilocularis chromobox protein 1 0.0074 0.0664 0.0664
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.005 0.0378 0.2303
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0279 0.0397
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3468 0.5414
Echinococcus multilocularis chromobox protein 1 0.0074 0.0664 0.0664
Entamoeba histolytica hypothetical protein 0.0037 0.0227 0.0431
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.2066 0.2436
Schistosoma mansoni hypothetical protein 0.0181 0.1921 0.2264
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0664 0.1004
Schistosoma mansoni hypothetical protein 0.0043 0.03 0.0352
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.1156 0.3173
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0055 0.0439 0.0602
Schistosoma mansoni coup transcription factor 0.0022 0.0042 0.0047
Schistosoma mansoni loxhd1 0.0042 0.0284 0.0333
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0157 0.0292
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.1156 0.1156
Loa Loa (eye worm) hypothetical protein 0.0059 0.0483 0.0663
Loa Loa (eye worm) hypothetical protein 0.0105 0.1027 0.1408
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.1027 0.1027
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0444 0.5038 0.5941
Echinococcus granulosus expressed conserved protein 0.0099 0.0952 0.1123
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0444 0.5038 1
Plasmodium vivax SET domain protein, putative 0.0032 0.0163 0.0292
Trypanosoma cruzi polo-like protein kinase, putative 0.0193 0.2066 0.3823
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0268 0.0268
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0042 0.0042
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0147 0.1527 0.2701
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0268 0.0316
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0057
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0042 0.0049
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0834 0.1144
Onchocerca volvulus 0.0253 0.277 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0042 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0042 0.0057
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0042 0.0049
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0378 0.0446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0042 0.0057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0394 0.0541
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0255 0.0301
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.2765 0.3262
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0362 0.0496
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0635 0.7294 0.8602
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3468 0.5414
Echinococcus multilocularis expressed conserved protein 0.0099 0.0952 0.0952
Brugia malayi phosphofructokinase 0.0116 0.1156 0.1585
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0071 0.0082
Brugia malayi Bromodomain containing protein 0.0049 0.0367 0.0503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0042 0.0057
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0242 0.034
Onchocerca volvulus 0.0089 0.0834 0.2904
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0545 0.0747
Echinococcus multilocularis hexokinase 0.0246 0.2695 0.2695
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0002 0.0002
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0086 0.0012
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.1839 0.1839
Brugia malayi Pre-SET motif family protein 0.0222 0.2408 0.3302
Brugia malayi hypothetical protein 0.0042 0.0284 0.0389
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0042 0.0049
Echinococcus granulosus histone acetyltransferase KAT2B 0.0615 0.7054 0.832
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.1156 0.7146
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.1156 0.3173
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0284 0.0284
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0042 0.0049
Echinococcus multilocularis protein patched 0.0045 0.0319 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0135 0.0171
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.1108 0.1305
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0319 0.046
Echinococcus granulosus zinc finger protein 0.0036 0.0217 0.0256
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.1585 0.2471
Trichomonas vaginalis CAMK family protein kinase 0.0193 0.2066 0.3209
Schistosoma mansoni hexokinase 0.0246 0.2695 0.3177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3468 0.5414
Loa Loa (eye worm) hexokinase 0.0076 0.0687 0.0942
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0242 0.034
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0618 0.0618
Brugia malayi Heterochromatin protein 1 0.0074 0.0664 0.0911
Brugia malayi Bromodomain containing protein 0.0056 0.0453 0.062
Schistosoma mansoni survival motor neuron protein 0.0051 0.0394 0.0463
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3468 0.5414
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0203 0.0811
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0042 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0042 0.0049
Mycobacterium ulcerans hypothetical protein 0.0025 0.0086 0.0118
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.2765 0.2765
Loa Loa (eye worm) hypothetical protein 0.0033 0.0173 0.0237
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0042 0.0042
Schistosoma mansoni inositol monophosphatase 0.0039 0.0252 0.0295
Onchocerca volvulus 0.0154 0.1611 0.5753
Schistosoma mansoni hypothetical protein 0.0043 0.03 0.0352
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0193 0.2066 0.2066
Loa Loa (eye worm) DnaJ domain-containing protein 0.0065 0.0558 0.0766
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.018 0.0247
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0255 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0227 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0042 0.0057
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.1046 0.1232
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0086 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0939 0.0939
Loa Loa (eye worm) hexokinase 0.0154 0.1611 0.2209
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0618 0.0729
Loa Loa (eye worm) hypothetical protein 0.0045 0.0319 0.0438
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0157 0.0281
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0252 0.2765 0.3791
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.0722 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0042 0.0057
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0086 0.0008
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0157 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0378 0.0444
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0193 0.2066 0.3209
Trichomonas vaginalis glutaminase, putative 0.0558 0.6384 1
Brugia malayi hypothetical protein 0.0161 0.169 0.2317
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0227 0.0312
Echinococcus multilocularis tumor protein p63 0.036 0.4043 0.4043
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0157 0.0292
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0279 0.087
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0362 0.0496
Schistosoma mansoni polycystin 1-related 0.0042 0.0284 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0242 0.034
Echinococcus granulosus chromobox protein 1 0.0074 0.0664 0.0784
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0444 0.5038 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0082 0.0112
Trichomonas vaginalis protein kinase inhibitor, putative 0.0065 0.0558 0.0837
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.1156 0.717
Onchocerca volvulus 0.0053 0.041 0.135
Onchocerca volvulus 0.0042 0.0284 0.0887
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0834 0.0984
Echinococcus granulosus dnaJ subfamily C 6 0.0065 0.0558 0.0659
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0154 0.0182
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0157 0.0274
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0042 0.0049
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.1156 0.1931
Echinococcus multilocularis peregrin 0.0049 0.0367 0.0367
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0071 0.0071
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0042 0.0047
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0378 0.0314
Echinococcus multilocularis hexokinase type 2 0.0246 0.2695 0.2695
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0319 0.0376
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0082 0.0142
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0157 0.0005
Brugia malayi hypothetical protein 0.0112 0.1108 0.152
Trypanosoma brucei polo-like protein kinase 0.0193 0.2066 0.4102
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0157 0.0205
Giardia lamblia Histone acetyltransferase GCN5 0.0171 0.1803 0.3243
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0086 0.0027
Schistosoma mansoni hypothetical protein 0.0031 0.0154 0.018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0552 0.085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0057
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0252 0.0252
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0461 0.5238 0.8198
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0042 0.0047
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0082 0.013
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0047 0.0064
Plasmodium falciparum histone acetyltransferase GCN5 0.0171 0.1803 0.3429
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0242 0.0475
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0086 0.0472
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0157 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0227 0.0316
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0461 0.5238 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0089 0.0834 0.1144
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.005 0.0378 0.0577
Trichomonas vaginalis CAMK family protein kinase 0.0193 0.2066 0.3209
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.2408 0.3302
Schistosoma mansoni hypothetical protein 0.0043 0.03 0.0352
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0154 0.018
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.005 0.0378 0.0577
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0163 0.0285
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.1559 0.1559
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0552 0.0651
Brugia malayi Hexokinase family protein 0.0076 0.0687 0.0942
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0203 0.121
Brugia malayi Inositol-1 0.0039 0.0252 0.0346
Brugia malayi jmjC domain containing protein 0.0102 0.099 0.1357
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0444 0.5038 0.7888
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0002 0.0002
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0319 0.0376
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0242 0.034
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0316 0.0456
Brugia malayi hexokinase type II 0.0078 0.0712 0.0976
Brugia malayi Hexokinase family protein 0.0154 0.1611 0.2209
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0939 0.1288
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.1027 0.1211
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.1156 0.1777
Entamoeba histolytica hypothetical protein 0.0112 0.1108 0.3032
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0157 0.0205
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0154 0.0269
Treponema pallidum hexokinase (hxk) 0.0246 0.2695 0.5273
Entamoeba histolytica hypothetical protein 0.0112 0.1108 0.3032
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0242 0.034
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.1839 0.1839
Trypanosoma cruzi hypothetical protein, conserved 0.0435 0.4921 0.9757
Leishmania major hypothetical protein, conserved 0.0435 0.4921 0.9764
Echinococcus granulosus geminin 0.0181 0.1921 0.2266
Trichomonas vaginalis CAMK family protein kinase 0.0193 0.2066 0.3209
Schistosoma mansoni chromobox protein 0.0074 0.0664 0.0782
Brugia malayi hexokinase 0.0246 0.2695 0.3695
Echinococcus granulosus RUN 0.0042 0.0284 0.0335
Schistosoma mansoni hypothetical protein 0.0051 0.0394 0.0463
Onchocerca volvulus 0.0042 0.0284 0.0887
Onchocerca volvulus 0.0051 0.0394 0.1293
Brugia malayi chromobox protein homolog 3 0.0042 0.0279 0.0382
Loa Loa (eye worm) hypothetical protein 0.0049 0.0362 0.0496
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0444 0.5038 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.1839 0.2169
Brugia malayi nuclear receptor NHR-88 0.0022 0.0042 0.0057
Schistosoma mansoni lipoxygenase 0.0185 0.1968 0.2319
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0242 0.034
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0444 0.5038 0.5942
Trichomonas vaginalis Citrate lyase beta chain, putative 0.005 0.0378 0.0553
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0149 0.0176
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3468 0.5414
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0042 0.0042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0042 0.0049
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0635 0.7294 0.7294
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0042 0.0047
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0252 0.038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0552 0.085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3468 0.5414
Onchocerca volvulus Hexokinase homolog 0.0154 0.1611 0.5753
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0242 0.0286
Trypanosoma brucei hypothetical protein, conserved 0.0435 0.4921 0.9768
Echinococcus multilocularis transcription factor btf3 0.0037 0.0227 0.0227
Schistosoma mansoni rab6-interacting 0.0042 0.0284 0.0333
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0086 0.0027
Giardia lamblia Kinase, PLK 0.0193 0.2066 0.3762
Onchocerca volvulus 0.0033 0.0173 0.048
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0552 0.0649
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0086 0.0118
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.1156 0.1585
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.1585 0.9855
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0082 0.0137
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0242 0.0475
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.1156 0.1777
Onchocerca volvulus 0.0025 0.0086 0.0161
Schistosoma mansoni hypothetical protein 0.0065 0.0558 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0135 0.0171
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0157 0.0205
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.1156 0.1585
Schistosoma mansoni alpha-glucosidase 0.015 0.1553 0.183
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0618 0.0848
Schistosoma mansoni inositol monophosphatase 0.0039 0.0252 0.0295
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.1108 0.1108
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0042 0.0057
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0242 0.0324
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.1156 0.2295
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0042 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0042 0.0057
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0086 0.0118
Brugia malayi hypothetical protein 0.0252 0.2765 0.3791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0042 0.0057
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0071 0.0084
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0086 0.0118
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0461 0.5238 0.8198
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0086 0.0008
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0042 0.0049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0252 0.0355
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0284 0.0335
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0618 0.1228
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0242 0.034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0117
Entamoeba histolytica hexokinase 1 0.0246 0.2695 0.7717
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0227 0.0316
Brugia malayi glutaminase DH11.1 0.0558 0.6384 0.8752
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0042 0.0049
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0042 0.0047
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.1156 0.1363
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.041 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0279 0.0397
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.029 0.3216 0.613
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0255 0.0299
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0284 0.0335
Brugia malayi nuclear hormone receptor 0.0022 0.0042 0.0057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0042 0.0042
Onchocerca volvulus 0.01 0.0974 0.3416
Trichomonas vaginalis bromodomain-containing protein, putative 0.0189 0.2016 0.3129
Schistosoma mansoni alpha-glucosidase 0.015 0.1553 0.183
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0618 0.0813
Schistosoma mansoni alpha glucosidase 0.0039 0.0242 0.0284
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0157 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0042 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0915 0.1398
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0057
Echinococcus multilocularis hexokinase 0.0246 0.2695 0.2695
Echinococcus multilocularis RUN 0.0042 0.0284 0.0284
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0042 0.0042
Onchocerca volvulus 0.0246 0.2695 0.9724
Loa Loa (eye worm) hexokinase type II 0.0246 0.2695 0.3695
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0042 0.0057
Echinococcus granulosus peregrin 0.0049 0.0367 0.0433
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0154 0.0154
Brugia malayi Doublecortin family protein 0.0042 0.0284 0.0389
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0057
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0189 0.2016 0.3129
Brugia malayi hypothetical protein 0.0042 0.0284 0.0389
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0242 0.034
Schistosoma mansoni patched 1 0.0045 0.0319 0.0374
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0255 0.0299
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0086 0.0118
Schistosoma mansoni rab6-interacting 0.0042 0.0284 0.0333
Echinococcus granulosus tumor protein p63 0.036 0.4043 0.4768
Loa Loa (eye worm) hypothetical protein 0.0075 0.0678 0.0929
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0014
Entamoeba histolytica hypothetical protein 0.0112 0.1108 0.3032
Treponema pallidum fructose-bisphosphate aldolase 0.0312 0.3468 0.6833
Onchocerca volvulus 0.0044 0.0307 0.0971
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0086 0.0117
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0082 0.0137
Brugia malayi DnaJ domain containing protein 0.0065 0.0558 0.0766
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0552 0.3389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0042 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0042 0.0057
Loa Loa (eye worm) hypothetical protein 0.0041 0.027 0.0371
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0042 0.0047
Schistosoma mansoni chromobox protein 0.0074 0.0664 0.0782
Brugia malayi PHD-finger family protein 0.0042 0.0284 0.0389
Loa Loa (eye worm) hypothetical protein 0.0042 0.0284 0.0389
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0319 0.0319
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0552 0.103
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0231 0.0231
Trypanosoma cruzi hexokinase, putative 0.0246 0.2695 0.513
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.024 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0042 0.0057
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.3468 1
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0461 0.5238 0.8198
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.1156 0.1362
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0193 0.2066 0.3209
Echinococcus multilocularis zinc finger protein 0.0036 0.0217 0.0217
Loa Loa (eye worm) phosphofructokinase 0.0116 0.1156 0.1585
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0618 0.1083
Plasmodium vivax hexokinase, putative 0.0246 0.2695 0.5136
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0042 0.0047
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0461 0.5238 1
Loa Loa (eye worm) glutaminase 0.0558 0.6384 0.8752
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0939 0.1108
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0284 0.0284
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0154 0.0269
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0157 0.0152
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.1585 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0939 0.1106
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0157 0.0205
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0157 0.0281
Echinococcus granulosus citrate lyase subunit beta protein 0.005 0.0378 0.0446
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.1027 0.1408
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.005 0.0378 0.0577
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0042 0.0057
Entamoeba histolytica hexokinase 2 0.0246 0.2695 0.7717
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0252 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0252 0.0052
Brugia malayi beta-NAC-like protein 0.0037 0.0227 0.0312
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0057
Loa Loa (eye worm) glutaminase 2 0.0558 0.6384 0.8752
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0042 0.0042
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.1839 0.2521
Mycobacterium ulcerans hypothetical protein 0.005 0.0378 0.0577
Onchocerca volvulus 0.0246 0.2695 0.9724
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0042 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0157 0.0205
Trichomonas vaginalis set domain proteins, putative 0.0253 0.277 0.4316
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.1156 0.2168
Schistosoma mansoni hypothetical protein 0.0181 0.1921 0.2264
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0834 0.0982
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0042 0.0042
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0193 0.2066 0.2437
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0014
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0742 0.0874
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0189 0.2016 0.3836
Echinococcus multilocularis citrate lyase subunit beta protein 0.005 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0247
Trypanosoma brucei hexokinase, putative 0.0246 0.2695 0.535
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3468 0.5414
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0242 0.0332
Leishmania major hexokinase, putative 0.0246 0.2695 0.5273
Brugia malayi steroid hormone receptor 0.0022 0.0042 0.0057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0252 0.0052
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0461 0.5238 1
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0284 0.0523
Echinococcus granulosus hexokinase 0.0246 0.2695 0.3179
Brugia malayi PHD-finger family protein 0.0031 0.0154 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0242 0.0031
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0042 0.0047
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0252 0.0344
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0042 0.0047
Loa Loa (eye worm) bromodomain containing protein 0.0034 0.0193 0.0264
Schistosoma mansoni hypothetical protein 0.0033 0.018 0.021
Schistosoma mansoni microtubule-associated protein tau 0.0736 0.8478 1
Schistosoma mansoni kinase 0.0098 0.0945 0.1113
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.2668 0.3658
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0086 0.0472
Brugia malayi glucose-6-phosphate dehydrogenase 0.0444 0.5038 0.6907
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0185 0.1968 0.2321
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0042 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0939 0.1106
Onchocerca volvulus 0.0246 0.2695 0.9724
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0227 0.0431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0362 0.0496
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0284 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0042 0.0057
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0252 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0042 0.0057
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0227 0.0409
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0664 0.0911
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0042 0.0047
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.024 0.024
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0319 0.0438
Onchocerca volvulus Serine\/threonine kinase homolog 0.0193 0.2066 0.742
Plasmodium vivax SET domain containing protein 0.0019 0.0014 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0157 0.0205
Loa Loa (eye worm) hypothetical protein 0.0168 0.177 0.2427
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0252 0.0456
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0252 0.0355
Echinococcus multilocularis hexokinase 0.0246 0.2695 0.2695
Loa Loa (eye worm) hypothetical protein 0.0078 0.0712 0.0976
Loa Loa (eye worm) hypothetical protein 0.0061 0.0507 0.0696
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.1108 0.1307
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0086 0.0118
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0082 0.0112
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0444 0.5038 0.5038
Echinococcus multilocularis dnaJ subfamily C 6 0.0065 0.0558 0.0558
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0242 0.034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0057
Echinococcus granulosus histone acetyltransferase KAT2B 0.0189 0.2016 0.2377
Trypanosoma cruzi hypothetical protein, conserved 0.0435 0.4921 0.9757
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0154 0.0211
Brugia malayi 6-phosphofructokinase 0.0116 0.1156 0.1585
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0316 0.1006
Schistosoma mansoni lipoxygenase 0.0109 0.1074 0.1265
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0378 0.0314
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0154 0.1608 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0378 0.0378
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0618 0.0727
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0618 0.1585
Schistosoma mansoni hypothetical protein 0.0042 0.0284 0.0333
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0042 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0939 0.0939
Echinococcus multilocularis microtubule associated protein 2 0.0736 0.8478 0.8478
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0189 0.2016 0.3832
Leishmania major basic transcription factor 3a, putative 0.0037 0.0227 0.0294
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0042 0.0057
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0298 0.0351
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0618 0.0813
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0185 0.1968 0.1968
Trichomonas vaginalis CAMK family protein kinase 0.0193 0.2066 0.3209
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0444 0.5038 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0086 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0163 0.019
Mycobacterium tuberculosis Conserved protein 0.005 0.0378 0.2303
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0618 0.0848
Loa Loa (eye worm) hypothetical protein 0.0042 0.0279 0.0382
Entamoeba histolytica serine/threonine protein kinase, putative 0.0193 0.2066 0.5861
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0163 0.0163
Brugia malayi 6-phosphofructokinase 0.0116 0.1156 0.1585
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0157 0.0205
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0444 0.5038 0.6907
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0117
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.1156 0.1362
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0086 0.0008
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.1156 0.3173
Plasmodium falciparum hexokinase 0.0246 0.2695 0.5136
Onchocerca volvulus Alhambra homolog 0.0031 0.0154 0.0413
Mycobacterium ulcerans glutaminase 0.0558 0.6384 1
Schistosoma mansoni glutaminase 0.0558 0.6384 0.7529
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.1027 0.2792
Echinococcus granulosus hexokinase 0.0246 0.2695 0.3179
Brugia malayi acetyltransferase, GNAT family protein 0.0635 0.7294 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.099 0.1167
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.029 0.3216 0.503
Schistosoma mansoni hypothetical protein 0.0112 0.1108 0.1305
Mycobacterium ulcerans hypothetical protein 0.005 0.0378 0.0577
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0042 0.0047
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0252 0.0504
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0242 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0193 0.2066 0.3209
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0086 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0086 0.0117
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.1156 0.1798
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0086 0.0117
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0284 0.0335
Echinococcus granulosus microtubule associated protein 2 0.0736 0.8478 1
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.1156 0.2168
Brugia malayi ecdysteroid receptor 0.0022 0.0042 0.0057
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.0722 0.0852
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0227 0.0451
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.1839 0.2521
Toxoplasma gondii hexokinase 0.0246 0.2695 0.5132
Trypanosoma brucei hexokinase 0.0246 0.2695 0.535
Loa Loa (eye worm) hypothetical protein 0.0053 0.0417 0.0571
Loa Loa (eye worm) hexokinase 0.0246 0.2695 0.3695
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0284 0.0523
Loa Loa (eye worm) inositol-1 0.0039 0.0252 0.0346
Echinococcus multilocularis geminin 0.0181 0.1921 0.1921
Echinococcus granulosus transcription factor btf3 0.0037 0.0227 0.0268
Schistosoma mansoni hypothetical protein 0.0043 0.03 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0042 0.0057
Plasmodium falciparum phd finger protein, putative 0.0031 0.0154 0.0276
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0552 0.0649
Schistosoma mansoni bromodomain containing protein 0.002 0.0024 0.0026
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0552 0.0552
Loa Loa (eye worm) hexokinase 0.0246 0.2695 0.3695
Brugia malayi serine/threonine-protein kinase plk-2 0.0193 0.2066 0.2833
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0552 0.085
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0242 0.0332
Giardia lamblia Fructose-bisphosphate aldolase 0.0312 0.3468 0.6519
Brugia malayi Hexokinase family protein 0.0246 0.2695 0.3695
Schistosoma mansoni zinc finger protein 0.0036 0.0217 0.0254
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0227 0.0416
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0834 0.0834
Echinococcus granulosus chromobox protein 1 0.0074 0.0664 0.0784
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.2668 0.3658
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0316 0.0456
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0378 0.0599
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0086 0.0012
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0193 0.2066 0.4005
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0082 0.0162
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0227 0.0416
Loa Loa (eye worm) hypothetical protein 0.0078 0.0712 0.0976
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0143 0.1476 0.2597
Leishmania major hexokinase, putative 0.0246 0.2695 0.5273
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0939 0.1288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0042 0.0057
Trypanosoma brucei glucosidase, putative 0.0039 0.0242 0.0481
Echinococcus granulosus hexokinase 0.0246 0.2695 0.3179
Loa Loa (eye worm) hypothetical protein 0.005 0.0378 0.0518
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0298 0.0298
Trypanosoma brucei hexokinase 0.0246 0.2695 0.535
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0082 0.013
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0242 0.0437
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0082 0.0447
Trypanosoma cruzi polo-like protein kinase, putative 0.0193 0.2066 0.3823
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0157 0.0274
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0461 0.5238 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.169 0.2317
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0915 0.1398
Brugia malayi MH2 domain containing protein 0.0244 0.2668 0.3658
Schistosoma mansoni transcription factor btf3 0.0037 0.0227 0.0266
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0157 0.0281
Echinococcus multilocularis protein dispatched 1 0.0051 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0053 0.041 0.0562
Brugia malayi Pre-SET motif family protein 0.0032 0.0163 0.0223
Loa Loa (eye worm) acetyltransferase 0.0635 0.7294 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0939 0.1108
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.3468 1
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.1559 0.1839
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.1156 0.1777
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0378 0.0444
Trypanosoma cruzi hexokinase, putative 0.0246 0.2695 0.513
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0284 0.0284
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0042 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.1156 0.1777
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0252 0.0355
Brugia malayi Bromodomain containing protein 0.0095 0.0915 0.1254
Entamoeba histolytica hypothetical protein 0.0112 0.1108 0.3032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0057
Schistosoma mansoni hypothetical protein 0.0022 0.0047 0.0053
Echinococcus granulosus hexokinase type 2 0.0246 0.2695 0.3179
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0284 0.0389
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0444 0.5038 1
Schistosoma mansoni bromodomain containing protein 0.0083 0.0767 0.0903
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0042 0.0057
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0552 0.0949
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3468 0.5414
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0189 0.2016 0.3832
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0939 0.1106
Loa Loa (eye worm) hypothetical protein 0.0031 0.0154 0.0211

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cells ChEMBL. 18990569
Ki (binding) = 336 nM Displacement of [125I][Tyr14]nociceptin FQ from human cloned nociceptin receptor expressed in CHO cells ChEMBL. 18990569

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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