TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.95 | Formula: C21H32ClN3O3
H donors: 1 H acceptors: 2 LogP: 2.25 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)CC(c1ccccc1)(C(=O)OC1CN2CCC1CC2)O.Cl
InChi: 1S/C21H31N3O3.ClH/c1-22-11-13-24(14-12-22)16-21(26,18-5-3-2-4-6-18)20(25)27-19-15-23-9-7-17(19)8-10-23;/h2-6,17,19,26H,7-16H2,1H3;1H
InChiKey: LZPJTDKVLOTSHU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Muscarinic acetylcholine receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Muscarinic acetylcholine receptor	466 aa	505 aa	26.9 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Muscarinic acetylcholine receptor	466 aa	459 aa	20.0 %
Loa Loa (eye worm)	TYRA-2 protein	Muscarinic acetylcholine receptor	466 aa	497 aa	24.7 %
Echinococcus multilocularis	alpha 1A adrenergic receptor	Muscarinic acetylcholine receptor	466 aa	459 aa	21.1 %
Echinococcus granulosus	g protein coupled receptor	Muscarinic acetylcholine receptor	466 aa	480 aa	18.5 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Muscarinic acetylcholine receptor	466 aa	493 aa	34.7 %
Schistosoma mansoni	biogenic amine receptor	Muscarinic acetylcholine receptor	466 aa	463 aa	24.2 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Muscarinic acetylcholine receptor	466 aa	461 aa	23.9 %
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	Muscarinic acetylcholine receptor	466 aa	461 aa	26.0 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Muscarinic acetylcholine receptor	466 aa	510 aa	29.8 %
Schistosoma japonicum	Octopamine receptor 1, putative	Muscarinic acetylcholine receptor	466 aa	412 aa	22.6 %
Onchocerca volvulus		Muscarinic acetylcholine receptor	466 aa	472 aa	24.6 %
Schistosoma mansoni	growth hormone secretagogue receptor	Muscarinic acetylcholine receptor	466 aa	462 aa	19.9 %
Schistosoma mansoni	biogenic amine receptor	Muscarinic acetylcholine receptor	466 aa	484 aa	24.4 %
Schistosoma japonicum	Octopamine receptor, putative	Muscarinic acetylcholine receptor	466 aa	462 aa	26.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Peroxidasin homolog	0.027	0.72	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0055	0.0893	0.2199
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0365	1	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Schistosoma mansoni	notch	0.0046	0.0627	0.0627
Loa Loa (eye worm)	Notch2	0.0046	0.0627	0.0627
Echinococcus granulosus	protein jagged 2	0.0046	0.0627	0.0627
Echinococcus granulosus	slit 2 protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0227	0.5939	0.5939
Brugia malayi	notch-like transmembrane receptor	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Plasmodium vivax	bromodomain protein, putative	0.0024	0	0.5
Loa Loa (eye worm)	bromodomain containing protein	0.0163	0.4061	0.4061
Echinococcus multilocularis	neurogenic locus notch protein	0.0046	0.0627	0.0627
Echinococcus granulosus	peroxidasin	0.027	0.72	0.72
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Brugia malayi	Animal haem peroxidase family protein	0.027	0.72	0.72
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Giardia lamblia	Kinase, putative	0.0163	0.4061	1
Schistosoma mansoni	peroxidasin	0.027	0.72	0.72
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0221	0.5769	0.5769
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Trichomonas vaginalis	conserved hypothetical protein	0.0227	0.5939	0.5939
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0056	0.0945	1
Toxoplasma gondii	bromodomain-containing protein	0.0163	0.4061	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0056	0.0945	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0078	0.1586	0.1586
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0229	0.0229
Plasmodium vivax	bromodomain protein, putative	0.0024	0	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0042	0.0523	0.1882
Plasmodium falciparum	bromodomain protein 1	0.0024	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0627	0.0627
Brugia malayi	Cadherin domain containing protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0627	0.0627
Brugia malayi	EGF-like domain containing protein	0.0046	0.0627	0.0627
Schistosoma mansoni	septate junction protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0042	0.0523	0.0523
Echinococcus multilocularis	protein jagged 2	0.0046	0.0627	0.0627
Brugia malayi	hypothetical protein	0.027	0.72	0.72
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0119	0.2781	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0046	0.0628	0.6644
Brugia malayi	EGF-like domain containing protein	0.0046	0.0627	0.0627
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0056	0.0945	0.0945
Onchocerca volvulus		0.0046	0.0627	0.087
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0056	0.0945	0.0945
Echinococcus granulosus	protein jagged 2	0.0046	0.0627	0.0627
Giardia lamblia	GTOR	0.0056	0.0945	0.2328
Echinococcus multilocularis	notch	0.0046	0.0627	0.0627
Echinococcus multilocularis	fibropellin Ia	0.0046	0.0627	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0309	0.0309
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0083	0.1718	0.1718
Loa Loa (eye worm)	animal heme peroxidase	0.027	0.72	0.72
Echinococcus multilocularis	neurogenic locus notch protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0035	0.0322	0.1159
Echinococcus multilocularis	slit 2 protein	0.0046	0.0627	0.0627
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0056	0.0945	0.2328
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	0.0163	0.4061	0.4061
Brugia malayi	Animal haem peroxidase family protein	0.027	0.72	0.72
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0227	0.5939	0.5939
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0056	0.0945	0.3399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0945	0.0945
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Brugia malayi	Cadherin domain containing protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0309	0.0309
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0627	0.0627
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0163	0.4061	0.4061
Schistosoma mansoni	hypothetical protein	0.0046	0.0627	0.0627
Echinococcus granulosus	notch	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0945	0.0945
Echinococcus granulosus	protein jagged 1	0.0046	0.0627	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.0718	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Echinococcus granulosus	neurogenic locus notch protein 4	0.0046	0.0627	0.0627
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0546	0.0546
Loa Loa (eye worm)	blistered cuticle protein 3	0.027	0.72	0.72
Plasmodium vivax	bromodomain protein, putative	0.0024	0	0.5
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0365	1	1
Schistosoma mansoni	notch	0.0046	0.0627	0.0627
Loa Loa (eye worm)	phosphatidylinositol 3	0.0056	0.0945	0.0945
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0046	0.0628	0.6644
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0119	0.2781	0.2781
Brugia malayi	Calcium binding EGF domain containing protein	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0483	0.0483
Loa Loa (eye worm)	notch protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0228	0.0228
Schistosoma mansoni	notch	0.0046	0.0627	0.0627
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0042	0.0523	0.1289
Onchocerca volvulus	Neurogenic locus notch homolog	0.0046	0.0627	0.087
Brugia malayi	Delta serrate ligand family protein	0.0046	0.0627	0.0627
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0119	0.2781	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0056	0.0945	0.2328
Loa Loa (eye worm)	hypothetical protein	0.0365	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0112	0.258	0.6354
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Entamoeba histolytica	bromodomain-containing protein	0.0163	0.4061	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0056	0.0945	0.3399
Onchocerca volvulus	Chorion peroxidase homolog	0.027	0.72	1
Brugia malayi	Animal haem peroxidase family protein	0.027	0.72	0.72
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0228	0.0228
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Trichomonas vaginalis	conserved hypothetical protein	0.0163	0.4061	0.4061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Brugia malayi	GCC2 and GCC3 family protein	0.0046	0.0627	0.0627
Onchocerca volvulus	Peroxidase homolog	0.027	0.72	1
Onchocerca volvulus	Dual oxidase homolog	0.027	0.72	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Brugia malayi	Calcium binding EGF domain containing protein	0.0046	0.0627	0.0627
Brugia malayi	EGF-like domain containing protein	0.0046	0.0627	0.0627
Brugia malayi	Muscle positioning protein 4	0.0046	0.0627	0.0627
Onchocerca volvulus		0.0046	0.0627	0.087
Giardia lamblia	High cysteine protein	0.0046	0.0627	0.1543
Brugia malayi	Calcium binding EGF domain containing protein	0.0046	0.0627	0.0627
Toxoplasma gondii	EGF family domain-containing protein	0.0046	0.0627	0.1543
Onchocerca volvulus	Slit protein homolog	0.0046	0.0627	0.087
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0102	0.2276	0.2276
Echinococcus granulosus	bromodomain containing 2	0.0365	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0119	0.2781	0.2781
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0078	0.1586	0.1586
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Plasmodium falciparum	bromodomain protein 2, putative	0.0024	0	0.5
Echinococcus granulosus	delta-like protein 1	0.0046	0.0627	0.0627
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Schistosoma mansoni	hypothetical protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Echinococcus multilocularis	peroxidasin	0.027	0.72	0.72
Trichomonas vaginalis	bromodomain containing protein, putative	0.0163	0.4061	0.4061
Echinococcus granulosus	neurogenic locus notch protein	0.0046	0.0627	0.0627
Onchocerca volvulus		0.027	0.72	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Onchocerca volvulus		0.027	0.72	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0042	0.0523	0.5536
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0095	0.2088	0.5142
Echinococcus multilocularis	neurogenic locus protein delta	0.0046	0.0627	0.0627
Loa Loa (eye worm)	phosphatidylinositol 3	0.0197	0.5076	0.5076
Echinococcus granulosus	fibropellin Ia	0.0046	0.0627	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0229	0.0229
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0083	0.1718	0.1718
Schistosoma mansoni	hypothetical protein	0.0046	0.0627	0.0627
Plasmodium vivax	SET domain containing protein	0.0024	0	0.5
Schistosoma mansoni	slit	0.0046	0.0627	0.0627
Entamoeba histolytica	hypothetical protein	0.0095	0.2088	0.5142
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0119	0.2781	0.2781
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0229	0.0229
Brugia malayi	Peroxidasin	0.027	0.72	0.72
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0229	0.0229
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0056	0.0945	0.0945
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0227	0.5939	0.5939
Echinococcus multilocularis	neural cadherin	0.0046	0.0627	0.0627
Echinococcus granulosus	neurogenic locus protein delta	0.0046	0.0627	0.0627
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0029	0.0125	0.1319
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0399	0.0399
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.003	0.0182	0.0448
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0042	0.0523	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Brugia malayi	Bromodomain containing protein	0.0365	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0319	0.0319
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0046	0.0627	0.0627
Onchocerca volvulus		0.0046	0.0627	0.087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0228	0.0228
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0056	0.0945	0.0945
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Brugia malayi	EGF-like domain containing protein	0.0046	0.0627	0.0627
Onchocerca volvulus		0.0046	0.0627	0.087
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0119	0.2781	0.2781
Brugia malayi	Blistered cuticle protein 3	0.027	0.72	0.72
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Loa Loa (eye worm)	animal heme peroxidase	0.027	0.72	0.72
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0546	0.0546
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0221	0.5769	0.5769
Schistosoma mansoni	hypothetical protein	0.0046	0.0627	0.0627
Plasmodium vivax	hypothetical protein, conserved	0.0024	0	0.5
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0042	0.0523	0.1289
Onchocerca volvulus		0.0163	0.4061	0.5639
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0078	0.1586	0.1586
Onchocerca volvulus		0.027	0.72	1
Brugia malayi	EGF-like domain containing protein	0.0046	0.0627	0.0627
Echinococcus multilocularis	bromodomain containing 2	0.0365	1	1
Brugia malayi	hypothetical protein	0.0138	0.3349	0.3349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0546	0.0546
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0025	0.0035	0.0371
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Loa Loa (eye worm)	animal heme peroxidase	0.027	0.72	0.72
Schistosoma mansoni	hypothetical protein	0.0046	0.0627	0.0627
Echinococcus multilocularis	neurogenic locus protein delta	0.0046	0.0627	0.0627
Schistosoma mansoni	notch	0.0046	0.0627	0.0627
Plasmodium falciparum	bromodomain protein, putative	0.0024	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0433	0.0433
Onchocerca volvulus	Peroxidase homolog	0.027	0.72	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0119	0.2781	0.6848
Entamoeba histolytica	bromodomain-containing protein	0.0163	0.4061	1
Entamoeba histolytica	bromodomain-containing protein	0.0163	0.4061	1
Onchocerca volvulus	Peroxidasin homolog	0.027	0.72	1
Brugia malayi	Animal haem peroxidase family protein	0.027	0.72	0.72
Trichomonas vaginalis	bromodomain containing protein, putative	0.0227	0.5939	0.5939
Schistosoma mansoni	cell polarity protein	0.0046	0.0627	0.0627
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0056	0.0945	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0056	0.0945	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0042	0.0523	0.0523
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0043	0.0546	0.1345
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0319	0.0319
Schistosoma mansoni	laminin gamma-3 chain	0.0046	0.0627	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0546	0.0546
Loa Loa (eye worm)	animal heme peroxidase	0.027	0.72	0.72
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Onchocerca volvulus		0.0046	0.0627	0.087
Echinococcus multilocularis	protein jagged 1	0.0046	0.0627	0.0627
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0046	0.0627	0.0627
Echinococcus granulosus	protein jagged 1	0.0046	0.0627	0.0627
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0221	0.5769	0.5769
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0945	0.0945
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0546	0.0546
Loa Loa (eye worm)	phosphatidylinositol 3	0.0035	0.0322	0.0322
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0024	0	0.5
Schistosoma mansoni	bromodomain-containing protein 3 brd3	0.0365	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0042	0.0523	0.0523
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0046	0.0627	0.087
Onchocerca volvulus	Putative cubilin	0.0046	0.0627	0.087
Schistosoma mansoni	notch	0.0046	0.0627	0.0627
Trypanosoma cruzi	target of rapamycin kinase 3	0.0046	0.0628	0.2258
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Schistosoma mansoni	peroxidasin	0.027	0.72	0.72
Echinococcus multilocularis	protein jagged 1	0.0046	0.0627	0.0627
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Schistosoma mansoni	hypothetical protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0627	0.0627
Brugia malayi	EGF-like domain containing protein	0.0046	0.0627	0.0627
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0059	0.1026	0.2526
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Brugia malayi	Animal haem peroxidase family protein	0.027	0.72	0.72
Echinococcus granulosus	neurogenic locus notch protein	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Brugia malayi	EGF-like domain containing protein	0.0046	0.0627	0.0627
Trichomonas vaginalis	conserved hypothetical protein	0.0202	0.5227	0.5227
Echinococcus granulosus	neural cadherin	0.0046	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1586	0.1586
Loa Loa (eye worm)	hypothetical protein	0.027	0.72	0.72
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Schistosoma mansoni	notch	0.0046	0.0627	0.0627
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0042	0.0523	0.0523
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0163	0.4061	0.4061
Schistosoma mansoni	hypothetical protein	0.0046	0.0627	0.0627
Echinococcus multilocularis	Bromodomain containing protein	0.0163	0.4061	0.4061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0627	0.0627
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0024	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 9190 nM	Displacement of [3H]-QNB from rat ileum Muscarinic acetylcholine receptor	ChEMBL.	2296026

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1202957

Bibliographic References

No literature references available for this target.

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Detailed information for compound 939601