Detailed information for compound 939796

Basic information

Technical information
  • TDR Targets ID: 939796
  • Name: (5Z)-4-bromo-3-(1-bromoethyl)-5-(bromomethyli dene)furan-2-one
  • MW: 360.825 | Formula: C7H5Br3O2
  • H donors: 0 H acceptors: 1 LogP: 2.57 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Br/C=C/1\OC(=O)C(=C1Br)C(Br)C
  • InChi: 1S/C7H5Br3O2/c1-3(9)5-6(10)4(2-8)12-7(5)11/h2-3H,1H3/b4-2-
  • InChiKey: PJBLEHRNJNWSMS-RQOWECAXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z)-4-bromo-3-(1-bromoethyl)-5-(bromomethylene)furan-2-one
  • (5Z)-4-bromo-3-(1-bromoethyl)-5-(bromomethylene)-2-furanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Onchocerca volvulus 0.0097 0.045 0.5
Toxoplasma gondii pyruvate carboxylase 0.0534 0.365 0.3584
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0097 0.045 0.0449
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.045 0.0433
Onchocerca volvulus 0.0097 0.045 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Onchocerca volvulus Neuropeptide F receptor homolog 0.0097 0.045 0.5
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.019 0.1133 0.1117
Onchocerca volvulus 0.0097 0.045 0.5
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.019 0.1133 0.172
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0534 0.365 0.3584
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Onchocerca volvulus 0.0097 0.045 0.5
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0534 0.365 0.3584
Brugia malayi G protein-coupled receptor 0.0097 0.045 0.0449
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni biogenic amine receptor 0.0097 0.045 0.0409
Echinococcus granulosus Biotin lipoyl attachment 0.0049 0.0102 0.0084
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0097 0.045 0.0409
Loa Loa (eye worm) G-protein coupled receptor 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0049 0.0102 0.0084
Onchocerca volvulus 0.0097 0.045 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni biogenic amine receptor 0.0097 0.045 0.0409
Schistosoma mansoni neuropeptide receptor 0.0097 0.045 0.0409
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.019 0.1133 0.2905
Brugia malayi G-protein coupled receptor 0.0097 0.045 0.0449
Onchocerca volvulus 0.0097 0.045 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0097 0.045 0.0433
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Echinococcus granulosus neuropeptide s receptor 0.0097 0.045 0.0433
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.019 0.1133 0.1094
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.019 0.1133 0.3233
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.019 0.1133 0.172
Echinococcus granulosus neuropeptide receptor 0.0097 0.045 0.0433
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0534 0.365 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0097 0.045 0.0409
Onchocerca volvulus 0.0097 0.045 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0097 0.045 0.0433
Echinococcus granulosus g protein coupled receptor 0.0097 0.045 0.0433
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0097 0.045 0.0433
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0097 0.045 0.0449
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0049 0.0102 0.0059
Brugia malayi larval opioid receptor 0.0097 0.045 0.0449
Echinococcus multilocularis neuropeptides capa receptor 0.0097 0.045 0.0433
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0097 0.045 0.0433
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0097 0.045 0.0449
Echinococcus multilocularis neuropeptide receptor 0.0097 0.045 0.0433
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.045 0.0433
Loa Loa (eye worm) neuropeptide F receptor 0.0097 0.045 0.0449
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.1402 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Echinococcus granulosus neuropeptide receptor 0.0097 0.045 0.0433
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.019 0.1133 0.2905
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0097 0.045 0.0409
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0121 0.0626 0.0585
Echinococcus granulosus g-protein coupled receptor 0.0097 0.045 0.0433
Echinococcus multilocularis orexin receptor type 2 0.0097 0.045 0.0433
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0049 0.0102 0.0084
Schistosoma mansoni hypothetical protein 0.0097 0.045 0.0409
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0097 0.045 0.0433
Trypanosoma cruzi acetyl-CoA carboxylase 0.0868 0.6093 1
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.019 0.1133 0.2905
Onchocerca volvulus 0.0097 0.045 0.5
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0121 0.0626 0.0529
Onchocerca volvulus 0.0097 0.045 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0097 0.045 0.0433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.045 0.0409
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.019 0.1133 0.1041
Schistosoma mansoni growth hormone secretagogue receptor 0.0097 0.045 0.0409
Schistosoma mansoni biogenic amine (5HT) receptor 0.0097 0.045 0.0409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.045 0.0409
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0097 0.045 0.0433
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0534 0.365 0.3638
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0534 0.365 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.045 0.0409
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0097 0.045 0.0433
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0534 0.365 0.5922
Echinococcus granulosus orexin receptor type 2 0.0097 0.045 0.0433
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Leishmania major acetyl-CoA carboxylase, putative 0.1402 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni neuropeptide f receptor 76f 0.0097 0.045 0.0409
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0097 0.045 0.0433
Echinococcus multilocularis g protein coupled receptor 0.0097 0.045 0.0433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.045 0.0409
Schistosoma mansoni biogenic amine receptor 0.0097 0.045 0.0409
Loa Loa (eye worm) neuropeptide F receptor 0.0097 0.045 0.0449
Loa Loa (eye worm) melatonin receptor type 1A 0.0097 0.045 0.0449
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.1402 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni neuropeptide receptor 0.0097 0.045 0.0409
Echinococcus multilocularis neuropeptide receptor 0.0097 0.045 0.0433
Onchocerca volvulus 0.0097 0.045 0.5
Plasmodium falciparum carbamoyl phosphate synthetase 0.0121 0.0626 0.0742
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0087
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Treponema pallidum pyruvate carboxylase subunit B 0.0049 0.0102 0.5
Schistosoma mansoni pyruvate carboxylase 0.0534 0.365 0.3622
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1015 0.7166 1
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0049 0.0102 0.0084
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.045 0.0409
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.019 0.1133 0.2905
Schistosoma mansoni opsin-like receptor 0.0097 0.045 0.0409
Echinococcus multilocularis somatostatin receptor 0.0097 0.045 0.0433
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Echinococcus multilocularis allatostatin A receptor 0.0097 0.045 0.0433
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.1402 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0097 0.045 0.0433
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.019 0.1133 0.2905
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni histamine h1 receptor 0.0097 0.045 0.0409
Brugia malayi G protein-coupled receptor F59B2.13 0.0097 0.045 0.0449
Echinococcus granulosus g protein coupled receptor 0.0097 0.045 0.0433
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0049 0.0102 0.0087
Brugia malayi G-protein coupled receptor 0.0097 0.045 0.0449
Echinococcus granulosus g protein coupled receptor 0.0097 0.045 0.0433
Echinococcus multilocularis neuropeptides capa receptor 0.0097 0.045 0.0433
Schistosoma mansoni adenoreceptor 0.0097 0.045 0.0409
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0097 0.045 0.0433
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.045 0.0433
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0097 0.045 0.0409
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0534 0.365 0.3622
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.045 0.0433
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0087
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0097 0.045 0.0409
Echinococcus granulosus somatostatin receptor 0.0097 0.045 0.0433
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.045 0.0433
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.045 0.0433
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0121 0.0626 0.0874
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Echinococcus multilocularis g protein coupled receptor 0.0097 0.045 0.0433
Echinococcus multilocularis neuropeptide receptor A26 0.0097 0.045 0.0433
Echinococcus multilocularis fmrfamide receptor 0.0097 0.045 0.0433
Loa Loa (eye worm) G-protein coupled receptor 0.0097 0.045 0.0449
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0534 0.365 1
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0049 0.0102 0.0087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0097 0.045 0.0433
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0121 0.0626 0.0874
Schistosoma mansoni alpha-1 adrenergic receptor 0.0097 0.045 0.0409
Schistosoma mansoni hypothetical protein 0.0097 0.045 0.0409
Brugia malayi Dopamine receptor protein 1 0.0097 0.045 0.0449
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0097 0.045 0.0409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.045 0.0409
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1015 0.7166 1
Brugia malayi putative neuropeptide receptor NPR1 0.0097 0.045 0.0449
Schistosoma mansoni opsin-like receptor 0.0097 0.045 0.0409
Echinococcus multilocularis serotonin receptor 0.0097 0.045 0.0433
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.019 0.1133 0.2905
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.045 0.0433
Schistosoma mansoni neuropeptide receptor 0.0097 0.045 0.0409
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Onchocerca volvulus 0.0097 0.045 0.5
Echinococcus granulosus allatostatin A receptor 0.0097 0.045 0.0433
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0239 0.1492 0.5
Mycobacterium ulcerans pyruvate carboxylase 0.0534 0.365 1
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Brugia malayi Carboxyl transferase domain containing protein 0.1353 0.9641 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0097 0.045 0.0409
Schistosoma mansoni biogenic amine (5HT) receptor 0.0097 0.045 0.0409
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0534 0.365 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Toxoplasma gondii carbamoylphosphate synthetase 0.0121 0.0626 0.0529
Brugia malayi Dopamine receptor protein 2 0.0097 0.045 0.0449
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0097 0.045 0.0433
Brugia malayi GnHR receptor homolog 0.0097 0.045 0.0449
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0 0.5
Schistosoma mansoni myosin xvIII 0.0097 0.045 0.0409
Trypanosoma brucei acetyl-CoA carboxylase 0.1402 1 1
Echinococcus multilocularis serotonin receptor 0.0097 0.045 0.0433
Brugia malayi sulfakinin receptor protein 0.0097 0.045 0.0449
Echinococcus granulosus biogenic amine 5HT receptor 0.0097 0.045 0.0433
Echinococcus granulosus neuropeptide Y receptor 0.0097 0.045 0.0433
Brugia malayi AKH receptor 0.0097 0.045 0.0449
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.019 0.1133 0.2905
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0097 0.045 0.0433
Echinococcus multilocularis G protein coupled receptor 139 0.0097 0.045 0.0433
Loa Loa (eye worm) TYRA-2 protein 0.0097 0.045 0.0449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.045 0.0409
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.019 0.1133 0.2905
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni amine GPCR 0.0097 0.045 0.0409
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0121 0.0626 0.0742
Echinococcus multilocularis g-protein coupled receptor 0.0097 0.045 0.0433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.045 0.0409
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0097 0.045 0.0449
Leishmania major carboxylase, putative 0.0534 0.365 0.3584
Echinococcus granulosus G protein coupled receptor 139 0.0097 0.045 0.0433
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Onchocerca volvulus 0.0097 0.045 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0097 0.045 0.0409
Schistosoma mansoni aspartate carbamoyltransferase 0.0121 0.0626 0.0585
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.045 0.0433
Echinococcus granulosus tm gpcr rhodopsin 0.0097 0.045 0.0433
Echinococcus multilocularis neuropeptide Y receptor 0.0097 0.045 0.0433
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Brugia malayi neuropeptide F receptor 0.0097 0.045 0.0449
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0097 0.045 0.0409
Echinococcus granulosus neuropeptide Y receptor 0.0097 0.045 0.0433
Schistosoma mansoni opsin-like receptor 0.0097 0.045 0.0409
Echinococcus multilocularis neuropeptide Y receptor 0.0097 0.045 0.0433
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.019 0.1133 0.1041
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0097 0.045 0.0449
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0534 0.365 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.045 0.0433
Echinococcus granulosus sex peptide receptor 0.0097 0.045 0.0433
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1353 0.9641 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0097 0.045 0.0433
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0534 0.365 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0097 0.045 0.0433
Chlamydia trachomatis biotin carboxylase 0.0485 0.3291 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0097 0.045 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni hypothetical protein 0.0097 0.045 0.0409
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.019 0.1133 0.2905
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0097 0.045 0.0409
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.045 0.0433
Onchocerca volvulus 0.0097 0.045 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Brugia malayi ORL1-like opioid receptor 0.0097 0.045 0.0449
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0097 0.045 0.0433
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.019 0.1133 0.2905
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0097 0.045 0.0409
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0097 0.045 0.0433
Brugia malayi Serotonin receptor 0.0097 0.045 0.0449
Onchocerca volvulus 0.0097 0.045 0.5
Schistosoma mansoni neuropeptide receptor 0.0097 0.045 0.0409
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.019 0.1133 0.172
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0534 0.365 0.3584
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0049 0.0102 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.045 0.0433
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0097 0.045 0.0433
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.019 0.1133 0.1117
Echinococcus multilocularis sex peptide receptor 0.0097 0.045 0.0433
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0097 0.045 0.0409
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Brugia malayi follicle stimulating hormone receptor 0.0097 0.045 0.0449
Echinococcus granulosus serotonin receptor 0.0097 0.045 0.0433
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0097 0.045 0.0449
Echinococcus multilocularis neuropeptide FF receptor 2 0.0097 0.045 0.0433
Schistosoma mansoni amine GPCR 0.0097 0.045 0.0409
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0121 0.0626 0.0585
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0097 0.045 0.0433
Onchocerca volvulus 0.0097 0.045 0.5
Brugia malayi hypothetical protein 0.0097 0.045 0.0449
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0534 0.365 0.5922
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.045 0.0433
Schistosoma mansoni acetyl-CoA carboxylase 0.1402 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0097 0.045 0.0433
Brugia malayi Tachykinin-like peptides receptor 99D 0.0097 0.045 0.0449
Schistosoma mansoni hypothetical protein 0.0097 0.045 0.0409
Brugia malayi neuropeptide F receptor 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.019 0.1133 0.1041
Echinococcus multilocularis Biotin lipoyl attachment 0.0049 0.0102 0.0084
Schistosoma mansoni amine GPCR 0.0097 0.045 0.0409
Brugia malayi Serotonin receptor 0.0097 0.045 0.0449
Echinococcus granulosus fmrfamide receptor 0.0097 0.045 0.0433
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0097 0.045 0.0433
Schistosoma mansoni amine GPCR 0.0097 0.045 0.0409
Schistosoma mansoni amine GPCR 0.0097 0.045 0.0409
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Echinococcus multilocularis fmrfamide receptor 0.0097 0.045 0.0433
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.019 0.1133 0.2905
Echinococcus granulosus alpha 1A adrenergic receptor 0.0097 0.045 0.0433
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.045 0.0433
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0049 0.0102 0.0059
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0534 0.365 1
Schistosoma mansoni neuropeptide F-like receptor 0.0097 0.045 0.0409
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0097 0.045 0.0409
Onchocerca volvulus 0.0097 0.045 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0097 0.045 0.0433
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0097 0.045 0.0433
Echinococcus granulosus neuropeptides capa receptor 0.0097 0.045 0.0433
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0097 0.045 0.0449
Brugia malayi Dopamine receptor 0.0097 0.045 0.0449
Brugia malayi putative neuropeptide receptor 0.0097 0.045 0.0449
Echinococcus granulosus neuropeptides capa receptor 0.0097 0.045 0.0433
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0049 0.0102 0.0059
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0097 0.045 0.0409
Leishmania major propionyl-coa carboxylase beta chain, putative 0.019 0.1133 0.1041
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0534 0.365 0.3622
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0049 0.0102 0.0059
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Onchocerca volvulus 0.0097 0.045 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0097 0.045 0.0433
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0121 0.0626 0.1476
Echinococcus granulosus tm gpcr rhodopsin 0.0097 0.045 0.0433
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0239 0.1492 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0097 0.045 0.0433
Brugia malayi RE15519p 0.0097 0.045 0.0449
Echinococcus granulosus rhodopsin orphan GPCR 0.0097 0.045 0.0433
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0097 0.045 0.0433
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0097 0.045 0.0433
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0097 0.045 0.0409
Echinococcus granulosus hypothetical protein 0.0097 0.045 0.0433
Echinococcus multilocularis G-protein coupled receptor, putative 0.0097 0.045 0.0433
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0049 0.0102 0.0087
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0534 0.365 0.3638
Echinococcus multilocularis g protein coupled receptor 0.0097 0.045 0.0433
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Echinococcus granulosus dro:myosuppressin receptor 0.0097 0.045 0.0433
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.019 0.1133 0.2905
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0121 0.0626 0.1476
Leishmania major carbamoyl-phosphate synthase, putative 0.0121 0.0626 0.0529
Loa Loa (eye worm) hypothetical protein 0.0097 0.045 0.0449
Trypanosoma brucei unspecified product 0.0351 0.2311 0.2232
Echinococcus granulosus neuropeptide FF receptor 2 0.0097 0.045 0.0433
Echinococcus granulosus biogenic amine 5HT receptor 0.0097 0.045 0.0433
Echinococcus granulosus 7TM GPCR rhodopsin 0.0097 0.045 0.0433
Brugia malayi Melatonin receptor type 1A 0.0097 0.045 0.0449

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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