Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.397 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.397 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.397 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.397 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0157 | 0.0078 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0065 | 0.008 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.0233 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0541 | 0.1289 | 0.1219 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0065 | 0.008 | 0.3408 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0034 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1518 | 0.377 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.01 | 0.0021 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0065 | 0.008 | 0.0211 |
Brugia malayi | Dihydrofolate reductase | 0.397 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.0233 | 1 |
Brugia malayi | phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Schistosoma mansoni | amidase | 0.0541 | 0.1289 | 0.1219 |
Loa Loa (eye worm) | phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.01 | 0.0021 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0541 | 0.1289 | 0.1219 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0703 | 0.1701 | 0.1634 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.01 | 0.0021 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.01 | 0.0021 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0703 | 0.1701 | 0.1634 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.01 | 0.0021 |
Echinococcus granulosus | ankyrin repeat protein | 0.0346 | 0.0792 | 0.0719 |
Brugia malayi | amidase | 0.0541 | 0.1289 | 0.1219 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.0233 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0126 | 0.0233 | 0.0155 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.397 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.01 | 0.0021 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.397 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.01 | 0.0021 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0126 | 0.0233 | 0.0417 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.0233 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1518 | 0.377 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.397 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0374 | 0.0863 | 0.0789 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0126 | 0.0233 | 0.0155 |
Brugia malayi | RNA binding protein | 0.0073 | 0.01 | 0.0021 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.01 | 0.0021 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0703 | 0.1701 | 0.1634 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1518 | 0.377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.1289 | 0.1219 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1518 | 0.377 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0065 | 0.008 | 0.0211 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.01 | 0.0021 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1518 | 0.377 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0374 | 0.0863 | 0.0789 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.01 | 0.0021 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0096 | 0.0157 | 0.6709 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0346 | 0.0792 | 0.0719 |
Brugia malayi | 6-phosphofructokinase | 0.0126 | 0.0233 | 0.0155 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0096 | 0.0157 | 0.6709 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.0233 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0541 | 0.1289 | 0.1219 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.01 | 0.0021 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.0233 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0541 | 0.1289 | 0.1219 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.01 | 0.0021 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0541 | 0.1289 | 0.1219 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0126 | 0.0233 | 0.0417 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0065 | 0.008 | 0.008 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.0233 | 1 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0126 | 0.0233 | 0.0417 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0346 | 0.0792 | 0.0719 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0126 | 0.0233 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1518 | 0.377 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.