Detailed information for compound 940248

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 492.049 | Formula: C30H34ClNO3
  • H donors: 0 H acceptors: 0 LogP: 6.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)OC(C(=C2c1ccccc1OCCN1CCCC1)c1ccccc1)(C)C.Cl
  • InChi: 1S/C30H33NO3.ClH/c1-30(2)29(22-11-5-4-6-12-22)28(25-16-15-23(32-3)21-27(25)34-30)24-13-7-8-14-26(24)33-20-19-31-17-9-10-18-31;/h4-8,11-16,21H,9-10,17-20H2,1-3H3;1H
  • InChiKey: GNAWIBFAGJOHDN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.016 0.1975 0.2231
Echinococcus granulosus Niemann Pick C1 protein 0.0056 0.059 0.0992
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0064 0.069 0.3064
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0767 0.129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0458 0.0839
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0194 0.243 1
Echinococcus granulosus g protein coupled receptor 0.016 0.1975 0.3322
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0053 0.055 0.2263
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0032 0.0268 0.0268
Schistosoma mansoni hypothetical protein 0.0031 0.0256 0.0284
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0256 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.1975 0.3621
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Brugia malayi follicle stimulating hormone receptor 0.016 0.1975 0.2187
Echinococcus granulosus neuropeptide s receptor 0.016 0.1975 0.3322
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0032 0.0268 0.0219
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0032 0.0268 0.0268
Schistosoma mansoni retinoic acid receptor RXR 0.0458 0.5946 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0668 0.0988
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0275 0.0317
Loa Loa (eye worm) hypothetical protein 0.0068 0.0743 0.0839
Onchocerca volvulus 0.016 0.1975 0.2231
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0303 0.0287
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.016 0.1975 0.3621
Brugia malayi nuclear receptor RXR 0.0037 0.0328 0.0316
Echinococcus granulosus g protein coupled receptor 0.016 0.1975 0.3322
Brugia malayi Serotonin receptor 0.016 0.1975 0.2187
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0032 0.0268 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0767 0.0815
Echinococcus granulosus 7TM GPCR rhodopsin 0.016 0.1975 0.3322
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0275 0.0505
Onchocerca volvulus 0.016 0.1975 0.2231
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Schistosoma mansoni amine GPCR 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0053 0.055 0.0925
Echinococcus multilocularis neuropeptides capa receptor 0.016 0.1975 0.3621
Brugia malayi steroid hormone receptor 0.007 0.0767 0.0815
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Echinococcus granulosus geminin 0.0167 0.2061 0.3467
Schistosoma mansoni NADPH flavin oxidoreductase 0.0027 0.0196 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0399 0.1641
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Echinococcus granulosus neuropeptide FF receptor 2 0.016 0.1975 0.3322
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0636 0.0933
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.0767 0.1157
Loa Loa (eye worm) hypothetical protein 0.007 0.0767 0.0867
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Schistosoma mansoni biogenic amine (dopamine) receptor 0.016 0.1975 0.322
Mycobacterium ulcerans hypothetical protein 0.0032 0.0268 0.0219
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0064 0.069 0.1266
Brugia malayi hypothetical protein 0.0087 0.0993 0.1072
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0064 0.069 0.1161
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0064 0.069 0.2809
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.016 0.1975 0.2231
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0137 0.1667 0.3057
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus multilocularis neuropeptide receptor 0.016 0.1975 0.3621
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0032 0.0268 0.018
Brugia malayi Serotonin receptor 0.016 0.1975 0.2187
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.1975 0.3322
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.009 0.0325
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Schistosoma mansoni opsin-like receptor 0.016 0.1975 0.322
Schistosoma mansoni biogenic amine receptor 0.016 0.1975 0.322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.0767 0.0867
Echinococcus granulosus dro:myosuppressin receptor 0.016 0.1975 0.3322
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.016 0.1975 0.3322
Echinococcus granulosus biogenic amine 5HT receptor 0.016 0.1975 0.3322
Echinococcus granulosus hypothetical protein 0.016 0.1975 0.3322
Mycobacterium tuberculosis Conserved protein 0.0032 0.0268 0.018
Schistosoma mansoni neuropeptide F-like receptor 0.016 0.1975 0.322
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0042 0.0399 0.0396
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.016 0.1975 0.3621
Onchocerca volvulus 0.016 0.1975 0.2231
Brugia malayi Synaptic glycoprotein SC2 0.0064 0.069 0.0728
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0399 0.0671
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.016 0.1975 0.3322
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.0767 0.0867
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0399 0.1603
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.002 0.0109 0.0406
Loa Loa (eye worm) hypothetical protein 0.007 0.0767 0.0867
Onchocerca volvulus 0.0035 0.0303 0.0342
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0056 0.059 0.0666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.1975 0.322
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0256 0.0289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.1975 0.322
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0256 0.043
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0668 0.1225
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0194 0.243 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.005 0.0056
Echinococcus granulosus neuropeptide receptor A26 0.016 0.1975 0.3322
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0458 0.5946 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.016 0.1975 0.322
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0194 0.243 0.2704
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0466 0.0644
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0458 0.0517
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.016 0.1975 0.3322
Schistosoma mansoni hypothetical protein 0.0402 0.5208 0.874
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Echinococcus multilocularis Niemann Pick C1 protein 0.0056 0.059 0.1082
Loa Loa (eye worm) hypothetical protein 0.0064 0.069 0.078
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0275 0.0463
Schistosoma mansoni growth hormone secretagogue receptor 0.016 0.1975 0.322
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0458 0.077
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.016 0.1975 0.322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0458 0.0629
Loa Loa (eye worm) hypothetical protein 0.0676 0.8852 1
Brugia malayi neuropeptide F receptor 0.016 0.1975 0.2187
Giardia lamblia Hypothetical protein 0.0047 0.0469 0.1978
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0767 0.129
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0328 0.0316
Brugia malayi sulfakinin receptor protein 0.016 0.1975 0.2187
Echinococcus multilocularis G protein coupled receptor 139 0.016 0.1975 0.3621
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0064 0.069 0.2841
Echinococcus granulosus dna polymerase eta 0.0019 0.009 0.0151
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) follicle stimulating hormone receptor 0.016 0.1975 0.2231
Brugia malayi neuropeptide F receptor 0.016 0.1975 0.2187
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus granulosus single minded 2 0.0035 0.0303 0.0509
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0064 0.069 0.1026
Onchocerca volvulus 0.016 0.1975 0.2231
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0275 0.0463
Echinococcus granulosus neuropeptides capa receptor 0.016 0.1975 0.3322
Schistosoma mansoni cpg binding protein 0.003 0.0235 0.0248
Schistosoma mansoni coup transcription factor 0.007 0.0767 0.1157
Echinococcus granulosus fmrfamide receptor 0.016 0.1975 0.3322
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0743 0.0787
Schistosoma mansoni biogenic amine (5HT) receptor 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Loa Loa (eye worm) hypothetical protein 0.0056 0.059 0.0666
Schistosoma mansoni diflavin oxidoreductase 0.0027 0.019 0.0172
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0303 0.0254
Brugia malayi G-protein coupled receptor 0.016 0.1975 0.2187
Trichomonas vaginalis sulfite reductase, putative 0.0053 0.055 0.2263
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0163 0.2006 0.8256
Brugia malayi Dopamine receptor protein 2 0.016 0.1975 0.2187
Onchocerca volvulus 0.016 0.1975 0.2231
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.1975 0.3621
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.0767 0.1157
Brugia malayi Dopamine receptor protein 1 0.016 0.1975 0.2187
Schistosoma mansoni hypothetical protein 0.0167 0.2061 0.3367
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0053 0.055 0.2228
Plasmodium vivax flavodoxin domain containing protein 0.0047 0.0469 0.1896
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0762 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.016 0.1975 0.3621
Echinococcus granulosus 7tm_1 domain containing protein 0.016 0.1975 0.3322
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.0767 0.129
Brugia malayi nuclear receptor NHR-67 0.0033 0.0275 0.0256
Echinococcus multilocularis neuropeptide receptor A26 0.016 0.1975 0.3621
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0064 0.069 0.2841
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0275 0.0317
Loa Loa (eye worm) hypothetical protein 0.0087 0.0993 0.1122
Brugia malayi putative neuropeptide receptor 0.016 0.1975 0.2187
Echinococcus granulosus alpha 1A adrenergic receptor 0.016 0.1975 0.3322
Toxoplasma gondii hypothetical protein 0.012 0.1444 0.5596
Echinococcus granulosus neuropeptides capa receptor 0.016 0.1975 0.3322
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.009 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.1975 0.3322
Leishmania major DNA polymerase eta, putative 0.0019 0.009 0.0369
Brugia malayi larval opioid receptor 0.016 0.1975 0.2187
Echinococcus multilocularis somatostatin receptor 0.016 0.1975 0.3621
Mycobacterium ulcerans hypothetical protein 0.0032 0.0268 0.0219
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.1975 0.3621
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.0767 0.0815
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Brugia malayi Esterase D 0.0032 0.0268 0.0248
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.1975 0.3322
Brugia malayi flavodoxin family protein 0.0053 0.055 0.0568
Brugia malayi RNA binding protein 0.0062 0.0668 0.0702
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0163 0.2006 0.2266
Brugia malayi G protein-coupled receptor F59B2.13 0.016 0.1975 0.2187
Echinococcus multilocularis GPCR, family 2 0.0031 0.0256 0.0469
Schistosoma mansoni thyroid hormone receptor 0.007 0.0767 0.1157
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0194 0.243 1
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.0767 0.1407
Schistosoma mansoni cpg binding protein 0.003 0.0235 0.0248
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Schistosoma mansoni thyroid hormone receptor 0.007 0.0767 0.1157
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus granulosus cpg binding protein 0.003 0.0235 0.0395
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0762 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0458 0.0839
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.1975 0.3621
Schistosoma mansoni biogenic amine (dopamine) receptor 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.0037 0.0328 0.0371
Loa Loa (eye worm) FAD binding domain-containing protein 0.0053 0.055 0.0621
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.0767 0.1157
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0328 0.0407
Brugia malayi tailless protein 0.0033 0.0275 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.069 0.2841
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0668 0.0755
Trypanosoma brucei cytochrome P450, putative 0.0016 0.005 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0668 0.0988
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0064 0.069 0.1026
Brugia malayi hypothetical protein 0.0158 0.1951 0.2159
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.009 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.1975 0.322
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Loa Loa (eye worm) hypothetical protein 0.0194 0.243 0.2745
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0328 0.0601
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Echinococcus multilocularis g-protein coupled receptor 0.016 0.1975 0.3621
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.0695 0.286
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.002 0.0109 0.0449
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.0695 0.286
Loa Loa (eye worm) hypothetical protein 0.0037 0.0328 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Schistosoma mansoni nuclear receptor 0.0033 0.0275 0.0317
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0137 0.1667 0.686
Loa Loa (eye worm) DR-78 0.0033 0.0275 0.0311
Loa Loa (eye worm) CYP4Cod1 0.0016 0.005 0.0056
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.0767 0.1407
Loa Loa (eye worm) hypothetical protein 0.0037 0.0328 0.0371
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0064 0.069 0.2841
Brugia malayi nuclear hormone receptor 0.0033 0.0275 0.0256
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0652 0.0961
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.009 0.0164
Brugia malayi flavodoxin family protein 0.002 0.0109 0.0067
Echinococcus multilocularis alpha 1A adrenergic receptor 0.016 0.1975 0.3621
Brugia malayi ORL1-like opioid receptor 0.016 0.1975 0.2187
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus granulosus GPCR family 2 0.0031 0.0256 0.043
Echinococcus multilocularis g protein coupled receptor 0.016 0.1975 0.3621
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0056 0.059 0.0854
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0064 0.069 0.2567
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0303 0.0555
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.5208 0.9549
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0275 0.0505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.0767 0.0867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.1975 0.322
Brugia malayi Steroid receptor seven-up type 2 0.007 0.0767 0.0815
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.1975 0.3322
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0256 0.0469
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.016 0.1975 0.2187
Schistosoma mansoni hypothetical protein 0.016 0.1975 0.322
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0042 0.0399 0.0731
Echinococcus multilocularis sterol regulatory element binding protein 0.0056 0.059 0.1082
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0042 0.0399 0.1641
Schistosoma mansoni amine GPCR 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0101
Echinococcus granulosus tm gpcr rhodopsin 0.016 0.1975 0.3322
Entamoeba histolytica type A flavoprotein, putative 0.002 0.0109 0.0084
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0668 0.0702
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0275 0.0311
Schistosoma mansoni opsin-like receptor 0.016 0.1975 0.322
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0275 0.0256
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Onchocerca volvulus 0.016 0.1975 0.2231
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Onchocerca volvulus 0.016 0.1975 0.2231
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0767 0.0815
Brugia malayi conserved hypotetical protein 0.0033 0.0275 0.0256
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0325 0.0547
Echinococcus multilocularis serotonin receptor 0.016 0.1975 0.3621
Echinococcus multilocularis dna polymerase eta 0.0019 0.009 0.0164
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0275 0.0256
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.0767 0.1407
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.009 0.0369
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0137 0.1667 0.2694
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0032 0.0268 0.0219
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0256 0.0234
Brugia malayi putative neuropeptide receptor NPR1 0.016 0.1975 0.2187
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.069 0.2841
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.1975 0.3621
Loa Loa (eye worm) hypothetical protein 0.007 0.0767 0.0867
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.1975 0.3322
Entamoeba histolytica type A flavoprotein, putative 0.002 0.0109 0.0084
Trichomonas vaginalis NADPH cytochrome P450, putative 0.002 0.0109 0.0449
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0399 0.1603
Plasmodium falciparum polyprenol reductase, putative 0.0064 0.069 0.3064
Onchocerca volvulus 0.0033 0.0275 0.0311
Loa Loa (eye worm) G-protein coupled receptor 0.016 0.1975 0.2231
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0032 0.0268 0.0762
Onchocerca volvulus Neuropeptide F receptor homolog 0.016 0.1975 0.2231
Echinococcus granulosus tachykinin peptides receptor 99D 0.016 0.1975 0.3322
Loa Loa (eye worm) neuropeptide F receptor 0.016 0.1975 0.2231
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.0695 0.286
Onchocerca volvulus 0.0033 0.0275 0.0311
Schistosoma mansoni hypothetical protein 0.016 0.1975 0.322
Schistosoma mansoni hypothetical protein 0.0031 0.0256 0.0284
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.1975 0.322
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0194 0.243 1
Brugia malayi CHE-14 protein 0.0056 0.059 0.0614
Schistosoma mansoni neuropeptide receptor 0.016 0.1975 0.322
Schistosoma mansoni hypothetical protein 0.0031 0.0256 0.0284
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0194 0.243 1
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0194 0.243 1
Brugia malayi hypothetical protein 0.0037 0.0328 0.0316
Echinococcus granulosus thyrotropin releasing hormone receptor 0.016 0.1975 0.3322
Onchocerca volvulus 0.007 0.0767 0.0867
Echinococcus granulosus tar DNA binding protein 0.0062 0.0668 0.1124
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0767 0.1157
Echinococcus multilocularis neuropeptide receptor 0.016 0.1975 0.3621
Trypanosoma cruzi p450 reductase, putative 0.0053 0.055 0.2263
Loa Loa (eye worm) flavodoxin family protein 0.002 0.0109 0.0123
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0275 0.0256
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.016 0.1975 0.3621
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0328 0.0407
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0399 0.1641
Echinococcus granulosus g protein coupled receptor 0.016 0.1975 0.3322
Echinococcus granulosus tm gpcr rhodopsin 0.016 0.1975 0.3322
Echinococcus granulosus sex peptide receptor 0.016 0.1975 0.3322
Brugia malayi hypoxia-induced factor 1 0.0146 0.1787 0.1973
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0053 0.055 0.2323
Echinococcus multilocularis dna polymerase kappa 0.0019 0.009 0.0164
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.0767 0.1407
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0767 0.0815
Loa Loa (eye worm) TYRA-2 protein 0.016 0.1975 0.2231
Schistosoma mansoni neuropeptide receptor 0.016 0.1975 0.322
Entamoeba histolytica hypothetical protein 0.0037 0.0325 0.1006
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0042 0.0399 0.1321
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0137 0.1667 0.1625
Echinococcus multilocularis FTZ F1 alpha 0.007 0.0767 0.1407
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0042 0.0399 0.1527
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.0767 0.129
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0163 0.2006 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0275 0.0256
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.009 0.0369
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.016 0.1975 0.322
Brugia malayi nuclear receptor NHR-88 0.007 0.0767 0.0815
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.0767 0.1157
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1163 0.1313
Schistosoma mansoni zinc finger protein 0.0033 0.0275 0.0317
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0399 0.1641
Schistosoma mansoni cytochrome P450 reductase 0.0053 0.055 0.0786
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0275 0.0317
Onchocerca volvulus 0.016 0.1975 0.2231
Echinococcus multilocularis neuropeptide s receptor 0.016 0.1975 0.3621
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0163 0.2006 0.8256
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0275 0.0256
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) hypothetical protein 0.0064 0.069 0.078
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0042 0.0399 0.0451
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0325 0.0596
Schistosoma mansoni neuropeptide receptor 0.016 0.1975 0.322
Echinococcus multilocularis neuropeptide FF receptor 2 0.016 0.1975 0.3621
Echinococcus granulosus FTZ F1 alpha 0.007 0.0767 0.129
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.016 0.1975 0.3621
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0032 0.0268 0.018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0213 0.0241
Trichomonas vaginalis NADPH cytochrome P450, putative 0.002 0.0109 0.0449
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.0767 0.0815
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0053 0.055 0.1008
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0399 0.0731
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0275 0.0505
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0458 0.0463
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0458 0.0629
Mycobacterium ulcerans hypothetical protein 0.0194 0.243 0.2392
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.0767 0.1157
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0328 0.0316
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.016 0.1975 0.322
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0064 0.069 0.3064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.009 0.0369
Echinococcus granulosus dnaJ subfamily B 0.0402 0.5208 0.8759
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.009 0.0369
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Echinococcus multilocularis synaptic glycoprotein sc2 0.0064 0.069 0.1266
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0458 0.077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.1975 0.322
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0767 0.0815
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0275 0.0317
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0275 0.0463
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.0767 0.1407
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.009 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.1975 0.322
Brugia malayi hypothetical protein 0.0037 0.0328 0.0316
Entamoeba histolytica hypothetical protein 0.0037 0.0325 0.1006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0767 0.1407
Echinococcus multilocularis fmrfamide receptor 0.016 0.1975 0.3621
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.002 0.0109 0.0449
Entamoeba histolytica type A flavoprotein, putative 0.002 0.0109 0.0084
Loa Loa (eye worm) esterase D 0.0032 0.0268 0.0303
Entamoeba histolytica hypothetical protein 0.0037 0.0325 0.1006
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0163 0.2006 1
Schistosoma mansoni hypothetical protein 0.0068 0.0743 0.1116
Leishmania major DNA polymerase kappa, putative 0.0019 0.009 0.0369
Brugia malayi Melatonin receptor type 1A 0.016 0.1975 0.2187
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.0053 0.055 0.0621
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.009 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.009 0.004
Echinococcus granulosus S formylglutathione hydrolase 0.0032 0.0268 0.0451
Brugia malayi ecdysteroid receptor 0.0676 0.8852 1
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0767 0.0815
Loa Loa (eye worm) hypothetical protein 0.0037 0.0328 0.0371
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0042 0.0399 0.0671
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0275 0.0463
Plasmodium vivax polyprenol reductase, putative 0.0064 0.069 0.3064
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Treponema pallidum flavodoxin 0.002 0.0109 0.5
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0042 0.0399 0.1603
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.0767 0.0815
Echinococcus multilocularis allatostatin A receptor 0.016 0.1975 0.3621
Loa Loa (eye worm) RNA binding protein 0.0062 0.0668 0.0755
Brugia malayi PAS domain containing protein 0.0047 0.0466 0.0473
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0163 0.2006 0.8189
Echinococcus multilocularis fmrfamide receptor 0.016 0.1975 0.3621
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.0767 0.129
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0163 0.2006 0.3273
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.002 0.0109 0.0449
Leishmania major hypothetical protein, conserved 0.002 0.0109 0.0449
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.0767 0.0867
Leishmania major p450 reductase, putative 0.0053 0.055 0.2263
Echinococcus granulosus neuropeptide receptor 0.016 0.1975 0.3322
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.005 0.0205
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0551 0.1609
Brugia malayi FAD binding domain containing protein 0.0053 0.055 0.0568
Echinococcus granulosus neuropeptide Y receptor 0.016 0.1975 0.3322
Echinococcus granulosus peptide allatostatin:somatostatin 0.016 0.1975 0.3322
Giardia lamblia Rab geranylgeranyltransferase 0.0042 0.0399 0.1613
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0256 0.043
Loa Loa (eye worm) neuropeptide F receptor 0.016 0.1975 0.2231
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.016 0.1975 0.2231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.016 0.1975 0.322
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.1975 0.3621
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.0767 0.129
Chlamydia trachomatis sulfite reductase 0.0033 0.0277 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0053 0.055 0.2263
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0668 0.0988
Brugia malayi Serotonin/octopamine receptor family protein 7 0.016 0.1975 0.2187
Loa Loa (eye worm) hypothetical protein 0.0099 0.1163 0.1313
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1163 0.1264
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0064 0.069 0.2841
Schistosoma mansoni peptide (allatostatin)-like receptor 0.016 0.1975 0.322
Onchocerca volvulus 0.016 0.1975 0.2231
Echinococcus multilocularis biogenic amine (5HT) receptor 0.016 0.1975 0.3621
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0064 0.069 0.2567
Onchocerca volvulus 0.016 0.1975 0.2231
Onchocerca volvulus 0.0064 0.069 0.078
Leishmania major cytochrome p450-like protein 0.0016 0.005 0.0205
Echinococcus multilocularis neuropeptides capa receptor 0.016 0.1975 0.3621
Mycobacterium tuberculosis Probable conserved exported protein 0.0032 0.0268 0.018
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0275 0.0317
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0163 0.2006 0.3375
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.009 0.0045
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0053 0.055 0.2263
Schistosoma mansoni patched 1 0.0056 0.059 0.0854
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.0767 0.1157
Schistosoma mansoni myosin xvIII 0.016 0.1975 0.322
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.005 0.0205
Schistosoma mansoni histamine h1 receptor 0.016 0.1975 0.322
Echinococcus multilocularis serotonin receptor 0.016 0.1975 0.3621
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.1975 0.3322
Brugia malayi G protein-coupled receptor 0.016 0.1975 0.2187
Loa Loa (eye worm) hypothetical protein 0.0163 0.2006 0.2266
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0137 0.1667 0.6846
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0767 0.0815
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0275 0.0311
Brugia malayi CXXC zinc finger family protein 0.0028 0.0213 0.0186
Echinococcus granulosus g-protein coupled receptor 0.016 0.1975 0.3322
Echinococcus granulosus neuropeptide Y receptor 0.016 0.1975 0.3322
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0163 0.2006 0.3679
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0163 0.2006 0.8256
Echinococcus multilocularis orexin receptor type 2 0.016 0.1975 0.3621
Schistosoma mansoni adenoreceptor 0.016 0.1975 0.322
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0767 0.0815
Loa Loa (eye worm) G-protein coupled receptor 0.016 0.1975 0.2231
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.0767 0.0867
Brugia malayi RE15519p 0.016 0.1975 0.2187
Echinococcus granulosus dna polymerase kappa 0.0019 0.009 0.0151
Loa Loa (eye worm) hypothetical protein 0.0037 0.0328 0.0371
Toxoplasma gondii hypothetical protein 0.0042 0.0399 0.0931
Echinococcus granulosus biogenic amine 5HT receptor 0.016 0.1975 0.3322
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.016 0.1975 0.2231
Entamoeba histolytica type A flavoprotein, putative 0.002 0.0109 0.0084
Echinococcus granulosus Protein patched homolog 1 0.0056 0.059 0.0992
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.016 0.1975 0.3621
Echinococcus granulosus sterol regulatory element binding protein 0.0056 0.059 0.0992
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0137 0.1667 0.1837
Echinococcus granulosus orexin receptor type 2 0.016 0.1975 0.3322
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0042 0.0399 0.1527
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0137 0.1667 0.2804
Onchocerca volvulus 0.0042 0.0399 0.0451
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0053 0.055 0.1008
Echinococcus multilocularis g protein coupled receptor 0.016 0.1975 0.3621
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.016 0.1975 0.3621
Brugia malayi ecdysone receptor 0.0033 0.0275 0.0256
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.0767 0.129
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0194 0.243 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Mycobacterium tuberculosis Possible conserved membrane protein 0.0032 0.0268 0.018
Echinococcus granulosus serotonin receptor 0.016 0.1975 0.3322
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0053 0.055 0.0925
Echinococcus granulosus tm gpcr rhodopsin 0.016 0.1975 0.3322
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0047 0.0469 0.1929
Echinococcus multilocularis protein patched 0.0056 0.059 0.1082
Onchocerca volvulus 0.016 0.1975 0.2231
Brugia malayi AKH receptor 0.016 0.1975 0.2187
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.009 0.0369
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0458 0.0629
Entamoeba histolytica hypothetical protein 0.0037 0.0325 0.1006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0275 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Giardia lamblia Synaptic glycoprotein SC2 0.0064 0.069 0.3134
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0053 0.055 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.059 0.2428
Entamoeba histolytica hypothetical protein 0.0064 0.069 0.2567
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.016 0.1975 0.2187
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0194 0.243 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.002 0.0109 0.0449
Echinococcus multilocularis S formylglutathione hydrolase 0.0032 0.0268 0.0491
Echinococcus multilocularis neuropeptide Y receptor 0.016 0.1975 0.3621
Loa Loa (eye worm) hypothetical protein 0.0137 0.1667 0.1883
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0064 0.0695 0.3159
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.016 0.1975 0.3322
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.016 0.1975 0.2187
Leishmania major cytochrome P450 reductase, putative 0.0047 0.0469 0.1929
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.016 0.1975 0.3621
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.009 0.0045
Echinococcus multilocularis methionine synthase reductase 0.0033 0.0277 0.0508
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Onchocerca volvulus 0.016 0.1975 0.2231
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0033 0.0277 0.032
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0053 0.055 0.2228
Loa Loa (eye worm) steroid hormone receptor 0.007 0.0767 0.0867
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0053 0.055 0.2228
Giardia lamblia Rab geranylgeranyltransferase 0.0163 0.2006 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.009 0.0325
Loa Loa (eye worm) hypothetical protein 0.007 0.0767 0.0867
Trichomonas vaginalis NADPH cytochrome P450, putative 0.002 0.0109 0.0449
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1787 0.2019
Schistosoma mansoni nuclear receptor 0.0033 0.0275 0.0317
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0275 0.0463
Brugia malayi nuclear receptor RXR 0.0033 0.0275 0.0256
Brugia malayi gonadotropin-releasing hormone receptor 2 0.016 0.1975 0.2187
Echinococcus multilocularis protein dispatched 1 0.0056 0.059 0.1082
Schistosoma mansoni single-minded 0.0047 0.0466 0.0644
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.016 0.1975 0.322
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0064 0.069 0.2233
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.016 0.1975 0.2231
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0194 0.243 1
Entamoeba histolytica type A flavoprotein, putative 0.002 0.0109 0.0084
Brugia malayi nuclear hormone receptor 0.007 0.0767 0.0815
Echinococcus granulosus allatostatin A receptor 0.016 0.1975 0.3322
Schistosoma mansoni biogenic amine (5HT) receptor 0.016 0.1975 0.322
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.016 0.1975 0.3621
Onchocerca volvulus 0.016 0.1975 0.2231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.0767 0.0867
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.0767 0.1407
Echinococcus multilocularis sex peptide receptor 0.016 0.1975 0.3621
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0042 0.0399 0.1641
Schistosoma mansoni hypothetical protein 0.0167 0.2061 0.3367
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0064 0.069 0.2233
Echinococcus multilocularis G-protein coupled receptor, putative 0.016 0.1975 0.3621
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0137 0.1667 0.686
Schistosoma mansoni biogenic amine receptor 0.016 0.1975 0.322
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0421 0.5454 1
Brugia malayi hypothetical protein 0.0037 0.0325 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.0767 0.0815
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.1975 0.322
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0256 0.0469
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.0767 0.0867
Echinococcus granulosus neuropeptide receptor 0.016 0.1975 0.3322
Schistosoma mansoni hypothetical protein 0.016 0.1975 0.322
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0399 0.1641
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0053 0.055 0.2228
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1163 0.1264
Brugia malayi GnHR receptor homolog 0.016 0.1975 0.2187
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Schistosoma mansoni biogenic amine receptor 0.016 0.1975 0.322
Onchocerca volvulus 0.0028 0.0213 0.0241
Loa Loa (eye worm) melatonin receptor type 1A 0.016 0.1975 0.2231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.1975 0.322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.0767 0.0867
Onchocerca volvulus 0.016 0.1975 0.2231
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Brugia malayi Tachykinin-like peptides receptor 99D 0.016 0.1975 0.2187
Echinococcus granulosus G protein coupled receptor 139 0.016 0.1975 0.3322
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0328 0.0371
Plasmodium falciparum nitric oxide synthase, putative 0.0053 0.055 0.2323
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0399 0.1641
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0668 0.0755
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0064 0.069 0.2841
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.009 0.0369
Brugia malayi TAR-binding protein 0.0062 0.0668 0.0702
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.016 0.1975 0.2231
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.0767 0.0815
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.0767 0.1157
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0275 0.0505
Mycobacterium ulcerans hypothetical protein 0.0032 0.0268 0.0219
Schistosoma mansoni opsin-like receptor 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.0767 0.0867
Brugia malayi hypothetical protein 0.016 0.1975 0.2187
Mycobacterium ulcerans hypothetical protein 0.0032 0.0268 0.0219
Brugia malayi G-protein coupled receptor 0.016 0.1975 0.2187
Brugia malayi nuclear receptor NHR-88 0.0033 0.0275 0.0256
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0163 0.2006 0.2223
Loa Loa (eye worm) hypothetical protein 0.007 0.0767 0.0867
Schistosoma mansoni amine GPCR 0.016 0.1975 0.322
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0053 0.055 0.2263
Brugia malayi Dopamine receptor 0.016 0.1975 0.2187
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.016 0.1975 0.322
Echinococcus multilocularis cpg binding protein 0.003 0.0235 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.0767 0.0815
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Schistosoma mansoni neuropeptide f receptor 76f 0.016 0.1975 0.322
Brugia malayi hypothetical protein 0.0033 0.0275 0.0256
Schistosoma mansoni hypothetical protein 0.0037 0.0325 0.0402
Onchocerca volvulus 0.016 0.1975 0.2231
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0668 0.0988
Echinococcus multilocularis geminin 0.0167 0.2061 0.378
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.1975 0.3322
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0275 0.0311
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0767 0.1407
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.005 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.009 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.0767 0.0815
Schistosoma mansoni neuropeptide F-like receptor 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.0158 0.1951 0.2204
Schistosoma mansoni hypothetical protein 0.0031 0.0256 0.0284
Brugia malayi FAD binding domain containing protein 0.0033 0.0277 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Echinococcus multilocularis dro:myosuppressin receptor 0.016 0.1975 0.3621
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0325 0.0402
Loa Loa (eye worm) FAD binding domain-containing protein 0.0033 0.0277 0.0313
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0275 0.0463
Echinococcus multilocularis neuropeptide Y receptor 0.016 0.1975 0.3621
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0275 0.0256
Echinococcus granulosus somatostatin receptor 0.016 0.1975 0.3322
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.009 0.0325
Giardia lamblia Nitric oxide synthase, inducible 0.0047 0.0469 0.1978
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Schistosoma mansoni alpha-1 adrenergic receptor 0.016 0.1975 0.322
Echinococcus multilocularis g protein coupled receptor 0.016 0.1975 0.3621
Schistosoma mansoni hypothetical protein 0.016 0.1975 0.322
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0032 0.0268 0.018
Onchocerca volvulus Bile acid receptor homolog 0.0676 0.8852 1
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0399 0.1603
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0275 0.0505
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0137 0.1667 0.686
Onchocerca volvulus 0.016 0.1975 0.2231
Loa Loa (eye worm) hypothetical protein 0.007 0.0767 0.0867
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0668 0.0988
Schistosoma mansoni amine GPCR 0.016 0.1975 0.322
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0032 0.0268 0.018
Loa Loa (eye worm) hypothetical protein 0.0087 0.0993 0.1122
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Schistosoma mansoni nuclear hormone receptor 0.007 0.0767 0.1157
Echinococcus multilocularis tachykinin peptides receptor 99D 0.016 0.1975 0.3621
Loa Loa (eye worm) hypothetical protein 0.007 0.0767 0.0867
Schistosoma mansoni cpg binding protein 0.0028 0.0213 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.0767 0.0815
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.012 0.1444 0.5941
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.016 0.1975 0.3621
Schistosoma mansoni amine GPCR 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0256 0.0289
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.016 0.1975 0.3621
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.009 0.0325
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.1975 0.3621
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.1975 0.3621
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.016 0.1975 0.322
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0275 0.0311
Echinococcus granulosus synaptic glycoprotein sc2 0.0064 0.069 0.1161
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.016 0.1975 0.3322
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0328 0.0552
Loa Loa (eye worm) hypothetical protein 0.016 0.1975 0.2231
Schistosoma mansoni eyes absent homolog 0.0087 0.0993 0.1543
Trypanosoma brucei unspecified product 0.0019 0.009 0.0325
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.009 0.0369
Brugia malayi hypothetical protein 0.0033 0.0275 0.0256
Schistosoma mansoni neuropeptide receptor 0.016 0.1975 0.322
Loa Loa (eye worm) hypothetical protein 0.0033 0.0275 0.0311
Echinococcus granulosus methionine synthase reductase 0.0033 0.0277 0.0466

Activities

Activity type Activity value Assay description Source Reference
RBA (binding) Relative binding affinity for uterine cytosol 17-beta-estradiol receptor from immature rats; N-Nil ChEMBL. 6834394

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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