Detailed information for compound 940398

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.929 | Formula: C23H28ClF3N2O2
  • H donors: 0 H acceptors: 1 LogP: 5.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)[C@@H]1Cc2c(N(C(=O)[C@H]1C)CCN(C)C)cccc2C(F)(F)F.Cl
  • InChi: 1S/C23H27F3N2O2.ClH/c1-15-18(16-8-10-17(30-4)11-9-16)14-19-20(23(24,25)26)6-5-7-21(19)28(22(15)29)13-12-27(2)3;/h5-11,15,18H,12-14H2,1-4H3;1H/t15-,18+;/m0./s1
  • InChiKey: UPRHLXHJAMBLHL-QVNYQEOOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.054 0.6726
Echinococcus multilocularis g protein coupled receptor 0.0042 0.031 0.03
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0031 0.5
Schistosoma mansoni histamine h1 receptor 0.0042 0.031 0.028
Brugia malayi Zona pellucida-like domain containing protein 0.0027 0.0133 0.0203
Schistosoma mansoni neuropeptide receptor 0.0147 0.1584 0.1559
Echinococcus granulosus integrin alpha 3 0.0121 0.1261 0.1418
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.031 0.0554
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0287 0.0939
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Schistosoma mansoni integrin alpha-ps 0.0037 0.0249 0.0219
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.031 0.0322
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.003 0.017 0.0277
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0062 0.0067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0343 0.062
Onchocerca volvulus 0.0027 0.0133 0.0401
Plasmodium falciparum plasmepsin I 0.0286 0.3263 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0737 0.8709 0.8705
Plasmodium falciparum plasmepsin IX 0.0068 0.0623 0.1832
Trypanosoma brucei Silent information regulator 2 related protein 1 0.027 0.3063 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0343 0.0336
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.027 0.3063 0.6516
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0286 0.3263 0.6409
Onchocerca volvulus 0.0047 0.037 0.1332
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.031 0.03
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.027 0.3063 0.6516
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0404 0.4684 1
Onchocerca volvulus 0.0042 0.031 0.1095
Schistosoma mansoni neuropeptide receptor 0.0042 0.031 0.028
Entamoeba histolytica hypothetical protein, conserved 0.0081 0.0789 0.2499
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.031 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0123 0.0183
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.031 0.0322
Echinococcus multilocularis lamin dm0 0.0027 0.0132 0.0109
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0062 0.0203
Brugia malayi Dopamine receptor protein 1 0.0042 0.031 0.0554
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0031 0.0101
Onchocerca volvulus 0.0042 0.031 0.1095
Brugia malayi Serotonin receptor 0.0042 0.031 0.0554
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.031 0.028
Brugia malayi G protein-coupled receptor 0.0042 0.031 0.0554
Brugia malayi Dopamine receptor protein 2 0.0042 0.031 0.0554
Echinococcus multilocularis fmrfamide receptor 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0068 0.0623 0.1174
Echinococcus multilocularis integrin alpha 3 0.0121 0.1261 0.1324
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0123 0.01
Brugia malayi Eukaryotic aspartyl protease family protein 0.0068 0.0623 0.1174
Loa Loa (eye worm) aspartyl protease 6 0.0068 0.0623 0.1174
Echinococcus multilocularis lamin 0.0027 0.0132 0.0109
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0123 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0123 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.031 0.028
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.031 0.0322
Loa Loa (eye worm) integrin alpha pat-2 0.0242 0.2733 0.5358
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0287 0.0939
Echinococcus multilocularis integrin alpha ps 0.007 0.0657 0.0674
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Brugia malayi ecdysteroid receptor 0.0026 0.0123 0.0183
Brugia malayi von Willebrand factor type A domain containing protein 0.0027 0.0133 0.0203
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0027 0.0133 0.0317
Onchocerca volvulus 0.0042 0.031 0.1095
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0123 0.0093
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0436 0.5074 0.5059
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.031 0.03
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0287 0.0847
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0287 0.0939
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1283 0.1348
Schistosoma mansoni survival motor neuron protein 0.0047 0.037 0.0341
Echinococcus granulosus dna polymerase kappa 0.004 0.0287 0.0296
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0031 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.031 0.028
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.031 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.031 0.03
Brugia malayi von Willebrand Factor 0.0027 0.0133 0.0203
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0081 0.0789 0.1629
Echinococcus multilocularis Furin 1 0.0103 0.105 0.1096
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0123 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0123 0.0363
Echinococcus multilocularis musashi 0.0027 0.0132 0.0109
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Leishmania major DNA polymerase kappa, putative 0.002 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.0068 0.0623 0.1174
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0123 0.0183
Brugia malayi transcriptional regulator, Sir2 family protein 0.027 0.3063 0.6012
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.027 0.3063 0.3262
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0081 0.0789 0.2575
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0123 0.0093
Loa Loa (eye worm) transcriptional regulator 0.027 0.3063 0.6012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0183
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0123 0.0183
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.031 0.0322
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0154 0.0504
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0081 0.0789 0.1629
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0183
Brugia malayi ORL1-like opioid receptor 0.0042 0.031 0.0554
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.031 0.0322
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0062 0.0105
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0062 0.0098
Onchocerca volvulus 0.0027 0.0133 0.0401
Brugia malayi putative neuropeptide receptor 0.0042 0.031 0.0554
Schistosoma mansoni c4b-binding protein beta chain 0.0047 0.037 0.0341
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.031 0.028
Schistosoma mansoni hypothetical protein 0.0042 0.031 0.028
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.031 0.028
Brugia malayi nuclear hormone receptor 0.0026 0.0123 0.0183
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0287 0.0552
Schistosoma mansoni integrin alpha-ps 0.007 0.0657 0.0628
Echinococcus granulosus serotonin receptor 0.0042 0.031 0.0322
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.031 0.0554
Echinococcus multilocularis 0.0352 0.4055 0.4329
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0081 0.0789 0.0815
Brugia malayi hypothetical protein 0.0068 0.0623 0.1174
Schistosoma mansoni hypothetical protein 0.0042 0.031 0.028
Brugia malayi von Willebrand factor type A domain containing protein 0.0027 0.0133 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0123 0.0183
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0674
Onchocerca volvulus 0.0047 0.037 0.1332
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.054 0.0511
Onchocerca volvulus 0.0042 0.031 0.1095
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1283 0.1444
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0088 0.0124
Onchocerca volvulus 0.0047 0.037 0.1332
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Mycobacterium ulcerans Sir2-like regulatory protein 0.0081 0.0789 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0265 0.3007 0.6397
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Treponema pallidum hypothetical protein 0.0027 0.0133 1
Onchocerca volvulus 0.0026 0.0123 0.0363
Echinococcus multilocularis serotonin receptor 0.0042 0.031 0.03
Echinococcus granulosus collagen alpha 1VII chain 0.0027 0.0133 0.0118
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0031 0.0006
Plasmodium falciparum plasmepsin V 0.0068 0.0623 0.1832
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.031 0.0322
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.031 0.028
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0623 0.0594
Loa Loa (eye worm) hypothetical protein 0.0119 0.1242 0.2402
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0287 0.0939
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.031 0.028
Loa Loa (eye worm) hypothetical protein 0.0404 0.4684 0.9226
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.031 0.0322
Brugia malayi GnHR receptor homolog 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Plasmodium falciparum thrombospondin-related anonymous protein 0.0027 0.0133 0.0317
Onchocerca volvulus 0.0042 0.031 0.1095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Brugia malayi aspartic protease BmAsp-2, identical 0.0068 0.0623 0.1174
Onchocerca volvulus 0.0068 0.0623 0.2322
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.054 0.6726
Echinococcus granulosus integrin alpha ps 0.0034 0.0213 0.0211
Loa Loa (eye worm) hypothetical protein 0.0027 0.0132 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0123 0.0183
Echinococcus granulosus voltage dependent calcium channel subunit 0.0027 0.0133 0.0118
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Plasmodium falciparum plasmepsin X 0.0068 0.0623 0.1832
Echinococcus multilocularis dna polymerase kappa 0.004 0.0287 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.027 0.3063 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0081 0.0789 0.1629
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.054 0.0548
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0132 0.0201
Brugia malayi intermediate filament protein 0.0027 0.0132 0.0201
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0623 0.0594
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0674
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0123 0.0093
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0133 0.0336
Loa Loa (eye worm) sirtuin 4 0.0081 0.0789 0.1503
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.031 0.0322
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0674
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0103 0.105 0.1022
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.031 0.0322
Brugia malayi RNA, U transporter 1 0.0082 0.0798 0.1522
Onchocerca volvulus 0.0047 0.037 0.1332
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0062 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0103 0.105 0.219
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) CUTiclin-Like family member 0.0027 0.0133 0.0203
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0623 0.0594
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Onchocerca volvulus 0.0042 0.031 0.1095
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.031 0.028
Onchocerca volvulus 0.0027 0.0133 0.0401
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.031 0.0322
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.031 0.0322
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.031 0.03
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0789 0.2345
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.031 0.028
Plasmodium vivax thrombospondin-related anonymous protein 0.0027 0.0133 0.0317
Echinococcus multilocularis c4b binding protein beta chain 0.0047 0.037 0.0366
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0286 0.3263 0.6409
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0123 0.0093
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.031 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0287 0.0939
Entamoeba histolytica hypothetical protein 0.0027 0.0133 0.0336
Echinococcus multilocularis neuropeptide receptor 0.0147 0.1584 0.1672
Onchocerca volvulus 0.0029 0.0155 0.0488
Onchocerca volvulus 0.0042 0.031 0.1095
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0154 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0674
Trichomonas vaginalis hypothetical protein 0.0084 0.0824 0.1706
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.031 0.03
Echinococcus multilocularis orexin receptor type 2 0.0042 0.031 0.03
Plasmodium vivax aspartyl protease, putative 0.0068 0.0623 0.1832
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0155 0.0134
Plasmodium falciparum plasmepsin III 0.0068 0.0623 0.1832
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0123 0.0107
Schistosoma mansoni biogenic amine receptor 0.0042 0.031 0.028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0123 0.01
Brugia malayi transcriptional regulator, Sir2 family protein 0.0081 0.0789 0.1503
Plasmodium vivax NAD-dependent deacetylase, putative 0.0081 0.0789 0.2345
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0062 0.0063
Plasmodium falciparum plasmepsin IV 0.0286 0.3263 1
Brugia malayi RE15519p 0.0042 0.031 0.0554
Schistosoma mansoni lamin 0.0027 0.0132 0.0102
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0154 0.0383
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.031 0.03
Brugia malayi hypothetical protein 0.0047 0.037 0.0674
Onchocerca volvulus 0.0042 0.031 0.1095
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0623 0.0594
Brugia malayi follicle stimulating hormone receptor 0.0042 0.031 0.0554
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0103 0.105 0.219
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0123 0.01
Schistosoma mansoni neuropeptide receptor 0.0042 0.031 0.028
Echinococcus granulosus lamin dm0 0.0027 0.0132 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0123 0.0183
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0183
Schistosoma mansoni hypothetical protein 0.0027 0.0133 0.0103
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Trypanosoma brucei subtilisin peptidase 0.0019 0.0031 0.01
Entamoeba histolytica elongation factor-2 kinase, putative 0.0027 0.0133 0.0336
Schistosoma mansoni hypothetical protein 0.0309 0.3532 0.3512
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0123 0.0107
Brugia malayi von Willebrand factor type A domain containing protein 0.0027 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0037 0.0249 0.0432
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.031 0.028
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0081 0.0789 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0027 0.0133 0.0203
Trypanosoma brucei SIR2-like protein 4, putative 0.0081 0.0789 0.2575
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0123 0.0363
Schistosoma mansoni amine GPCR 0.0042 0.031 0.028
Onchocerca volvulus 0.0042 0.031 0.1095
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0123 0.0093
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Toxoplasma gondii aspartyl protease ASP3 0.0068 0.0623 0.1832
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0119 0.1242 0.2402
Plasmodium vivax importin-beta 2, putative 0.0029 0.0154 0.0383
Plasmodium falciparum plasmepsin VI 0.0286 0.3263 1
Echinococcus granulosus Furin 1 0.0103 0.105 0.1174
Onchocerca volvulus 0.0047 0.037 0.1332
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Loa Loa (eye worm) hypothetical protein 0.0027 0.0126 0.0189
Giardia lamblia DINP protein human, muc B family 0.002 0.0053 0.0047
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.031 0.0554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0343 0.0314
Plasmodium vivax plasmepsin IV, putative 0.0286 0.3263 1
Giardia lamblia Hypothetical protein 0.027 0.3063 0.6516
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Schistosoma mansoni hypothetical protein 0.0084 0.0824 0.0796
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0183
Brugia malayi Pre-SET motif family protein 0.0202 0.2244 0.4388
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0123 0.0107
Brugia malayi AKH receptor 0.0042 0.031 0.0554
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.031 0.03
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.027 0.3063 1
Echinococcus granulosus C type lectin domian containing protein 0.0047 0.037 0.0392
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0155 0.0134
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.031 0.03
Schistosoma mansoni thyroid hormone receptor 0.0149 0.1601 0.1575
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.031 0.028
Schistosoma mansoni hypothetical protein 0.0047 0.037 0.0341
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0123 0.0183
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.031 0.0554
Echinococcus multilocularis fmrfamide receptor 0.0042 0.031 0.03
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Plasmodium falciparum importin beta, putative 0.0029 0.0154 0.0383
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0123 0.0107
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.031 0.0322
Schistosoma mansoni ran 0.0021 0.0062 0.0032
Plasmodium vivax apical sushi protein, putative 0.0047 0.037 0.1051
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.031 0.028
Onchocerca volvulus 0.0042 0.031 0.1095
Onchocerca volvulus 0.0027 0.0133 0.0401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.031 0.028
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Brugia malayi sulfakinin receptor protein 0.0042 0.031 0.0554
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0081 0.0789 0.1629
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.031 0.1095
Schistosoma mansoni opsin-like receptor 0.0042 0.031 0.028
Toxoplasma gondii aspartyl protease 0.0068 0.0623 0.1832
Toxoplasma gondii rhoptry neck protein RON9 0.0047 0.037 0.1051
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0062 0.0098
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0623 0.0594
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.031 0.0554
Brugia malayi hypothetical protein 0.0047 0.037 0.0674
Schistosoma mansoni biogenic amine receptor 0.0042 0.031 0.028
Echinococcus granulosus allatostatin A receptor 0.0042 0.031 0.0322
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0081 0.0789 0.2345
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0031 0.0001
Brugia malayi pregnancy-associated plasma protein-A 0.0047 0.037 0.0674
Schistosoma mansoni furin-1 (S08 family) 0.019 0.2097 0.2073
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0123 0.0183
Loa Loa (eye worm) transcriptional regulator 0.0081 0.0789 0.1503
Schistosoma mansoni adenoreceptor 0.0042 0.031 0.028
Plasmodium vivax SET domain protein, putative 0.0029 0.0155 0.0385
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.031 0.028
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0265 0.3007 0.343
Echinococcus multilocularis snurportin 1 0.0309 0.3532 0.3766
Trichomonas vaginalis ran, putative 0.0021 0.0062 0.0068
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0053 0.0293
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0123 0.0183
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0674
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0343 0.036
Treponema pallidum 76K protein 0.0027 0.0133 1
Brugia malayi Dopamine receptor 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0674
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0081 0.0789 0.2499
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0031 0.0001
Echinococcus granulosus chromatin regulatory protein sir2 0.027 0.3063 0.3494
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.031 0.03
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.031 0.028
Brugia malayi neuroendocrine convertase 1 precursor 0.0274 0.3116 0.6118
Mycobacterium ulcerans NAD-dependent deacetylase 0.0081 0.0789 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0287 0.0939
Schistosoma mansoni amine GPCR 0.0042 0.031 0.028
Brugia malayi von Willebrand factor type A domain containing protein 0.0027 0.0133 0.0203
Toxoplasma gondii histone deacetylase SIR2 0.0081 0.0789 0.2345
Brugia malayi Sushi domain 0.0047 0.037 0.0674
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0123 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.054 0.6726
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0265 0.3007 0.3203
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0027 0.0133 0.0317
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0343 0.0336
Brugia malayi G-protein coupled receptor 0.0042 0.031 0.0554
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.031 0.0322
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0019 0.0031 0.01
Echinococcus granulosus importin subunit beta 1 0.0029 0.0154 0.0143
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0404 0.0375
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Echinococcus multilocularis g protein coupled receptor 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Schistosoma mansoni coup transcription factor 0.0026 0.0123 0.0093
Schistosoma mansoni neuropeptide receptor 0.0042 0.031 0.028
Loa Loa (eye worm) endoprotease bli-4 0.0436 0.5074 1
Onchocerca volvulus 0.0027 0.0133 0.0401
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0123 0.0183
Onchocerca volvulus 0.0042 0.031 0.1095
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.031 0.1095
Echinococcus granulosus G protein coupled receptor kinase 1 0.0081 0.0785 0.087
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0287 0.0939
Echinococcus granulosus hypothetical protein 0.0042 0.031 0.0322
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0027 0.0133 0.0103
Giardia lamblia Sirtuin type 2 0.0081 0.0789 0.1628
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.031 0.0322
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0123 0.0183
Schistosoma mansoni opsin-like receptor 0.0042 0.031 0.028
Brugia malayi polk-prov protein 0.003 0.017 0.0277
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Plasmodium vivax aspartyl proteinase, putative 0.0068 0.0623 0.1832
Schistosoma mansoni chromatin regulatory protein sir2 0.0081 0.0789 0.076
Brugia malayi von Willebrand factor type A domain containing protein 0.0027 0.0133 0.0203
Echinococcus granulosus somatostatin receptor 0.0042 0.031 0.0322
Brugia malayi Pre-SET motif family protein 0.0029 0.0155 0.0247
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0103 0.105 0.219
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0068 0.0623 0.1174
Onchocerca volvulus 0.0027 0.0132 0.0397
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0404 0.4684 1
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0027 0.0133 0.011
Brugia malayi GCC2 and GCC3 family protein 0.0047 0.037 0.0674
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0133 0.0336
Onchocerca volvulus 0.0027 0.0133 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0123 0.0183
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0287 0.0552
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.031 0.03
Onchocerca volvulus 0.0042 0.031 0.1095
Toxoplasma gondii aspartyl protease ASP1 0.0286 0.3263 1
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0027 0.0133 0.0203
Echinococcus multilocularis somatostatin receptor 0.0042 0.031 0.03
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.031 0.03
Giardia lamblia Transcriptional regulator, Sir2 family 0.0081 0.0789 0.1628
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0088 0.0191
Plasmodium vivax plasmepsin V, putative 0.0068 0.0623 0.1832
Onchocerca volvulus 0.0047 0.037 0.1332
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.031 0.03
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0068 0.0623 0.1832
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0155 0.0125
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Onchocerca volvulus 0.005 0.0404 0.1465
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0287 0.0939
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.031 0.0322
Brugia malayi nuclear receptor NHR-88 0.0026 0.0123 0.0183
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.031 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0123 0.0183
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.021 0.0686
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0287 0.0939
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0034 0.0213 0.0363
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0287 0.0847
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.031 0.0554
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0053 0.0172
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0133 0.0317
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.031 0.03
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.031 0.0554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0343 0.0314
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Brugia malayi steroid hormone receptor 0.0026 0.0123 0.0183
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Schistosoma mansoni importin beta-1 0.0029 0.0154 0.0124
Echinococcus multilocularis allatostatin A receptor 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.054 0.1682
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.031 0.0322
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.031 0.028
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0286 0.3263 0.6947
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.031 0.0554
Onchocerca volvulus 0.0042 0.031 0.1095
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.017 0.0556
Echinococcus multilocularis neuroendocrine convertase 2 0.0274 0.3116 0.332
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0031 0.0001
Echinococcus multilocularis G protein coupled receptor 139 0.0147 0.1584 0.1672
Loa Loa (eye worm) hypothetical protein 0.0123 0.1296 0.251
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0898 0.087
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0084 0.0824 0.1706
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Brugia malayi von Willebrand factor type A domain containing protein 0.0027 0.0133 0.0203
Echinococcus granulosus sex peptide receptor 0.0042 0.031 0.0322
Schistosoma mansoni chromatin regulatory protein sir2 0.027 0.3063 0.3041
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0123 0.01
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2576 0.2933
Brugia malayi von Willebrand factor type A domain containing protein 0.0027 0.0133 0.0203
Brugia malayi larval opioid receptor 0.0042 0.031 0.0554
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Echinococcus granulosus lamin 0.0027 0.0132 0.0117
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.027 0.3063 0.3494
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.9326 1
Brugia malayi hypothetical protein 0.0047 0.037 0.0674
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0343 0.062
Schistosoma mansoni hypothetical protein 0.0042 0.031 0.028
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.031 0.03
Echinococcus granulosus g protein coupled receptor 0.0042 0.031 0.0322
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0183
Plasmodium vivax aspartyl protease, putative 0.0068 0.0623 0.1832
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.054 0.1577
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.031 0.0554
Brugia malayi NAD-dependent deacetylase SIRT1 0.0404 0.4684 0.9226
Onchocerca volvulus 0.0047 0.037 0.1332
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0031 0.0001
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) CUTiclin family member 0.0027 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0404 0.4684 0.5006
Echinococcus granulosus neuropeptide receptor 0.0042 0.031 0.0322
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.031 0.028
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0062 0.0105
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0123 0.0183
Brugia malayi hypothetical protein 0.0047 0.037 0.0674
Echinococcus granulosus neuroendocrine convertase 2 0.0274 0.3116 0.3556
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0898 0.087
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0404 0.4684 0.5362
Echinococcus granulosus c4b binding protein beta chain 0.0047 0.037 0.0392
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.031 0.028
Echinococcus multilocularis sex peptide receptor 0.0042 0.031 0.03
Brugia malayi Zona pellucida-like domain containing protein 0.0027 0.0133 0.0203
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.031 0.0554
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0123 0.01
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Echinococcus multilocularis integrin alpha ps 0.0034 0.0213 0.0197
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0103 0.105 0.219
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0091 0.0898 0.1721
Echinococcus granulosus g protein coupled receptor 0.0042 0.031 0.0322
Schistosoma mansoni memapsin-2 (A01 family) 0.0068 0.0623 0.0594
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Leishmania major sir2-family protein-like protein 0.0081 0.0789 0.25
Brugia malayi hypothetical protein 0.0047 0.037 0.0674
Leishmania major silent information regulator 2, putative 0.027 0.3063 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0031 0.0001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.037 0.0674
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0031 0.0001
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0123 0.0107
Brugia malayi aspartic protease BmAsp-1, identical 0.0068 0.0623 0.1174
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.031 0.03
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0081 0.0785 0.0812
Onchocerca volvulus 0.023 0.2581 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0286 0.3263 0.3477
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0081 0.0789 0.25
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2244 0.4388
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0154 0.0504
Schistosoma mansoni hypothetical protein 0.0122 0.1283 0.1257
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0027 0.0133 0.0317
Loa Loa (eye worm) hypothetical protein 0.0436 0.5074 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0404 0.4684 1
Schistosoma mansoni thyroid hormone receptor 0.0149 0.1601 0.1575
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.031 0.028
Onchocerca volvulus 0.0042 0.031 0.1095
Loa Loa (eye worm) proprotein convertase 2 0.0103 0.105 0.2021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0286 0.3263 0.3242
Schistosoma mansoni chromatin regulatory protein sir2 0.0081 0.0789 0.076
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.031 0.0554
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.054 0.0588
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0047 0.037 0.0674
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Plasmodium vivax aspartyl proteinase, putative 0.0286 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.031 0.0322
Plasmodium falciparum plasmepsin VII 0.0068 0.0623 0.1832
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Loa Loa (eye worm) hypothetical protein 0.0029 0.0154 0.0246
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0123 0.0093
Schistosoma mansoni hypothetical protein 0.0034 0.0213 0.0183
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0027 0.0133 0.011
Brugia malayi proprotein convertase 2 0.0274 0.3116 0.6118
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0031 0.0001
Brugia malayi neuropeptide F receptor 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0229 0.2576 0.5047
Brugia malayi hypothetical protein 0.0068 0.0623 0.1174
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.031 0.028
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Entamoeba histolytica Ran family GTPase 0.0021 0.0062 0.0103
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.031 0.0554
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.017 0.0556
Schistosoma mansoni cathepsin D (A01 family) 0.0844 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Schistosoma mansoni chromatin regulatory protein sir2 0.0081 0.0789 0.076
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0123 0.0183
Onchocerca volvulus 0.0047 0.037 0.1332
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0142 0.0129
Schistosoma mansoni amine GPCR 0.0042 0.031 0.028
Echinococcus granulosus tumor protein p63 0.0339 0.3896 0.4454
Echinococcus multilocularis beta adrenergic receptor kinase 0.0091 0.0898 0.0934
Onchocerca volvulus 0.0042 0.031 0.1095
Brugia malayi hypothetical protein 0.0047 0.037 0.0674
Echinococcus granulosus g protein coupled receptor 0.0042 0.031 0.0322
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0623 0.0594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0343 0.0314
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0183
Onchocerca volvulus 0.0047 0.037 0.1332
Brugia malayi Importin beta-1 subunit 0.0029 0.0154 0.0246
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.054 0.0511
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.031 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0123 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.031 0.0322
Schistosoma mansoni lamin 0.0027 0.0132 0.0102
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.3532 0.6942
Echinococcus multilocularis g protein coupled receptor 0.0042 0.031 0.03
Onchocerca volvulus 0.0047 0.037 0.1333
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0287 0.0847
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0183
Brugia malayi endoprotease bli-4 precursor 0.0436 0.5074 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.054 0.6726
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0019 0.0031 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.031 0.028
Loa Loa (eye worm) hypothetical protein 0.0171 0.1872 0.3651
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0737 0.8709 1
Brugia malayi hypothetical protein 0.0047 0.037 0.0674
Schistosoma mansoni myosin xvIII 0.0042 0.031 0.028
Echinococcus granulosus g-protein coupled receptor 0.0042 0.031 0.0322
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0123 0.0107
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0674
Toxoplasma gondii microneme protein MIC2 0.0027 0.0133 0.0317
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0088 0.0124
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0027 0.0133 0.0317
Schistosoma mansoni opsin-like receptor 0.0042 0.031 0.028
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.031 0.0322
Loa Loa (eye worm) transcriptional regulator 0.0081 0.0789 0.1503
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0027 0.0133 0.0317
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0404 0.4684 1
Schistosoma mansoni ran 0.0021 0.0062 0.0032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0123 0.0107
Echinococcus granulosus orexin receptor type 2 0.0042 0.031 0.0322
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0287 0.0847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0123 0.0183
Schistosoma mansoni chromatin regulatory protein sir2 0.027 0.3063 0.3041
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0081 0.0789 0.1629
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.027 0.3063 1
Schistosoma mansoni amine GPCR 0.0042 0.031 0.028
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0287 0.339
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0081 0.0789 0.25
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0155 0.0125
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.031 0.028
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0123 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.031 0.0322
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.031 0.0322
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.031 0.0554
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0081 0.0789 0.0873
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0081 0.0789 0.2345
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.031 0.03
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.031 0.028
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2576 0.2738
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.031 0.03
Schistosoma mansoni integrin alpha 0.0157 0.1704 0.1679
Echinococcus multilocularis tumor protein p63 0.0339 0.3896 0.4158
Schistosoma mansoni chromatin regulatory protein sir2 0.0404 0.4684 0.4668
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.031 0.03
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0343 0.036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.031 0.03
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0019 0.0031 0.5
Brugia malayi hypothetical protein 0.0229 0.2576 0.5047
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0084 0.0824 0.1706
Mycobacterium leprae Possible secreted protease 0.0019 0.0031 0.5
Toxoplasma gondii rhoptry neck protein RON1 0.0047 0.037 0.1051
Echinococcus multilocularis serotonin receptor 0.0042 0.031 0.03
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0123 0.0093
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.1601 0.169
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0081 0.0789 0.0873
Brugia malayi G-protein coupled receptor 0.0042 0.031 0.0554
Echinococcus granulosus integrin alpha ps 0.007 0.0657 0.0722
Leishmania major importin beta-1 subunit, putative 0.0023 0.0088 0.0191
Brugia malayi Integrin alpha pat-2 precursor 0.0157 0.1704 0.3319
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0286 0.3263 1
Entamoeba histolytica hypothetical protein 0.0023 0.0088 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Plasmodium falciparum plasmepsin VIII, putative 0.0068 0.0623 0.1832
Brugia malayi neuropeptide F receptor 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0674
Plasmodium falciparum apical sushi protein 0.0047 0.037 0.1051
Schistosoma mansoni hypothetical protein 0.0027 0.0133 0.0103
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0623 0.0594
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0123 0.0093
Trypanosoma brucei unspecified product 0.0034 0.021 0.0686
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0081 0.0789 0.0815
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.031 0.03
Plasmodium vivax aspartyl protease, putative 0.0068 0.0623 0.1832
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0081 0.0789 0.25
Giardia lamblia High cysteine membrane protein Group 2 0.0162 0.1763 0.3723
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0062 0.0034
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0123 0.01
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0133 0.0203
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0103 0.105 0.219
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0132 0.0201
Echinococcus multilocularis C type lectin domian containing protein 0.0047 0.037 0.0366
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0287 0.0939
Loa Loa (eye worm) hypothetical protein 0.0087 0.0853 0.1631
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.031 0.03
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0123 0.0107
Giardia lamblia Furin precursor putative serine protease 0.0084 0.0824 0.1705
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0027 0.0133 0.022
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.031 0.03
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0123 0.0183
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0062 0.0098
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0123 0.0107
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0404 0.4684 1
Echinococcus granulosus neuropeptide s receptor 0.0042 0.031 0.0322
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0053 0.0073
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.031 0.0322
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0623 0.0594
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0287 0.0939
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0183
Echinococcus granulosus intermediate filament protein 0.0027 0.0132 0.0117
Schistosoma mansoni intermediate filament proteins 0.0027 0.0132 0.0102
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0081 0.0789 0.2499
Onchocerca volvulus 0.0027 0.0133 0.0401
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0287 0.339
Echinococcus granulosus fmrfamide receptor 0.0042 0.031 0.0322
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.031 0.0322
Trichomonas vaginalis set domain proteins, putative 0.023 0.2581 0.548
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0123 0.0183
Echinococcus granulosus snurportin 1 0.0309 0.3532 0.4034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.031 0.028
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0123 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0155 0.0125
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0203
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0062 0.0037
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0088 0.0124
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0031 0.0001
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.027 0.3063 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0031 0.0006
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0674
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0155 0.0385
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0286 0.3263 0.3725
Brugia malayi Pepsin A precursor 0.0068 0.0623 0.1174
Brugia malayi transcriptional regulator, Sir2 family protein 0.0081 0.0789 0.1503
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.031 0.028
Brugia malayi Melatonin receptor type 1A 0.0042 0.031 0.0554
Echinococcus granulosus neuropeptide receptor 0.0147 0.1584 0.179
Toxoplasma gondii histone deacetylase SIR2-like 0.0081 0.0789 0.2345
Onchocerca volvulus 0.0047 0.037 0.1332
Brugia malayi hypothetical protein 0.0027 0.0133 0.0203
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0123 0.0183
Onchocerca volvulus 0.0068 0.0623 0.2322
Brugia malayi Serotonin receptor 0.0042 0.031 0.0554
Onchocerca volvulus 0.0042 0.031 0.1095
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0737 0.8709 0.9336
Loa Loa (eye worm) hypothetical protein 0.005 0.0404 0.0741
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.031 0.028
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.031 0.028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0155 0.0247
Echinococcus granulosus furin 0.0436 0.5074 0.5812
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0824 0.1706
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0123 0.0183
Leishmania major GTP-binding protein, putative 0.0021 0.0062 0.0105
Onchocerca volvulus 0.0027 0.0132 0.0397
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.031 0.0554
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0027 0.0133 0.0203
Echinococcus multilocularis chromatin regulatory protein sir2 0.027 0.3063 0.3262
Onchocerca volvulus 0.0042 0.031 0.1095
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0084 0.0824 0.1706
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0027 0.0133 0.0317
Schistosoma mansoni biogenic amine receptor 0.0042 0.031 0.028
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0132 0.0201
Plasmodium falciparum plasmepsin II 0.0286 0.3263 1
Schistosoma mansoni amine GPCR 0.0042 0.031 0.028
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0123 0.0183
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.031 0.0322
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0123 0.0183
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0155 0.0144
Echinococcus multilocularis integrin alpha ps 0.007 0.0657 0.0674
Loa Loa (eye worm) hypothetical protein 0.0323 0.3701 0.7277
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.031 0.0554
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0265 0.3007 0.6397
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.031 0.0322
Echinococcus granulosus beta-adrenergic receptor kinase 0.0091 0.0898 0.1
Brugia malayi celfurPC protein 0.0352 0.4055 0.7979
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.031 0.0322
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0103 0.105 0.219
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554
Schistosoma mansoni chromatin regulatory protein sir2 0.027 0.3063 0.3041
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.031 0.0322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0155 0.0125
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0031 0.0001
Schistosoma mansoni hypothetical protein 0.0042 0.031 0.028
Brugia malayi hypothetical protein 0.0042 0.031 0.0554
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.031 0.03
Echinococcus multilocularis neuropeptide receptor 0.0042 0.031 0.03
Brugia malayi von Willebrand factor type A domain containing protein 0.0027 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0042 0.031 0.0554

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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