Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor alpha 1D | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Alpha-1D adrenergic receptor, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma mansoni | amine GPCR | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0839 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0839 | 1 | 1 |
Schistosoma mansoni | notch | 0.0271 | 0.1073 | 0.1073 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1073 | 0.1073 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0271 | 0.1073 | 0.1073 |
Schistosoma mansoni | septate junction protein | 0.0271 | 0.1073 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1073 | 0.1073 |
Schistosoma mansoni | notch | 0.0271 | 0.1073 | 0.1073 |
Onchocerca volvulus | Peroxidase homolog | 0.0839 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1073 | 0.1073 |
Onchocerca volvulus | 0.0839 | 1 | 1 | |
Schistosoma mansoni | notch | 0.0271 | 0.1073 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Onchocerca volvulus | 0.0839 | 1 | 1 | |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0839 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0839 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0839 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0839 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0271 | 0.1073 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0839 | 1 | 1 |
Schistosoma mansoni | notch | 0.0271 | 0.1073 | 0.1073 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0271 | 0.1073 | 0.1073 |
Onchocerca volvulus | Dual oxidase homolog | 0.0839 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Schistosoma mansoni | notch | 0.0271 | 0.1073 | 0.1073 |
Brugia malayi | Blistered cuticle protein 3 | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0839 | 1 | 1 |
Schistosoma mansoni | slit | 0.0271 | 0.1073 | 0.1073 |
Onchocerca volvulus | Peroxidasin homolog | 0.0839 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1073 | 0.1073 |
Giardia lamblia | High cysteine protein | 0.0271 | 0.1073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Onchocerca volvulus | 0.0839 | 1 | 1 | |
Schistosoma mansoni | notch | 0.0271 | 0.1073 | 0.1073 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0839 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1073 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0271 | 0.1073 | 0.1073 |
Onchocerca volvulus | Peroxidase homolog | 0.0839 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1073 | 0.1073 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1073 | 0.1073 |
Brugia malayi | Animal haem peroxidase family protein | 0.0839 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 20 % | In vivo antinociceptive activity was determined by mouse abdominal irritant test (MAIT) in male pathogen free albino CD-1 mice | ChEMBL. | 11300868 |
Ki (binding) | = 1.1 nM | In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat | ChEMBL. | 11300868 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.